lethal disease – Page 2 – Communicable Diseases Research

Cellular tropism of SARS-CoV-2 in the respiratory tract of Syrian hamsters and B6.Cg-Tg(K18-ACE2)2Prlmn/J transgenic mice

Article

Published on 2021-09-012022-10-28
Journal: Veterinary pathology [Category] COVID-19, COVID19(2023년), Fulltext, MERS, SARS,

Type I and III IFNs produced by the nasal epithelia and dimmed inflammation are features of alpacas resolving MERS-CoV infection

Research Article

Published on 2021-05-242022-10-29
Journal: PLoS Pathogens [Category] COVID-19,

[키워드] Adaptive immune response anti-inflammatory cytokine anti-inflammatory effect antiviral drug Asymptomatic Asymptomatic carriers CCL2 CCL3 chemokine clearance clinical manifestation Concomitant contribute correlated Cytokine storm disease driving effective elicited epithelia etiological agent expression feature high mortality Host humans IFN IL10 immune response gene immunological pathway Infection Infectious virus infiltration Inflammation Inflammatory responses innate immune response interferon interferon response interferons (IFNs ISG ISGs lethal disease leukocyte leukocytes lung MERS-CoV MERS-CoV infection Middle East Mild mucosa nasal nasal mucosa NF-κB post inoculation pro-inflammatory cytokine pro-inflammatory gene produced provoke Regulation reservoir Respiratory disease respiratory syndrome coronavirus respiratory tract Simultaneous stimulated syndrome tissue damage tissues transcribed Transcription transcriptional regulation triggering Type type I Type III IFN understanding upregulation Vaccines viral infection virus virus clearance while
[DOI] 10.1371/journal.ppat.1009229 PMC 바로가기 [Article Type] Research Article

Therapeutic Potentials of Antiviral Plants Used in Traditional African Medicine With COVID-19 in Focus: A Nigerian Perspective

Pharmacology

Published on 2021-04-262022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] 2019-nCoV acute respiratory syndrome addition adopted African anti-SARS-CoV-2 Antiviral antiviral drug approach available data carried caused Chinese Combination Community coronavirus coronavirus disease country COVID-19 drug Drug discovery effort Evidence global public health herb-drug interaction herbal immuno-stimulants in silico In vitro assay in vivo experiment increasingly information Interaction Intervention knowledge lethal disease management Medicine non-specific pandemic Phytomedicines plant Potential preventive measures provided recorded reported Research Respiratory disease risk SARS-CoV-2 supportive care TAM Traditional Traditional African Medicine Treatment Vaccines World War II
[DOI] 10.3389/fphar.2021.596855 PMC 바로가기 [Article Type] Pharmacology

Potential Mechanisms of Cardiac Injury and Common Pathways of Inflammation in Patients With COVID-19

COVID-19 환자의 심장 손상 및 일반적인 염증 경로의 잠재적 기전

Review

Published on 2021-03-012022-09-11
Journal: Critical pathways in cardiology [Category] SARS, 바이오마커, 유전자 메커니즘,

[키워드] acute infectious disease Acute myocarditis acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 receptor Apoptosis association autopsy studies binding affinity biologic Biomarker Biomarkers C-reactive protein cardiac cardiac injury cardiovascular complication cardiovascular complications Clinical studies clinical study common controlled clinical studies coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytokine cytokine secretion demonstrated despair disease pathogenesis effort Epidemic Genetic genetic recombination High-sensitivity C-reactive protein higher risk histopathological hypoxia in-hospital mortality Inflammation Injury lack lethal disease linear correlation management mechanism morbidity and mortality Myocardial myocarditis other coronaviruses outbreak Outbreaks pandemic Pathogenesis Patient patients hospitalized plasma poor prognosis positive linear correlation Potential potential mechanism Protein Randomized Receptor binding Recombination remains uncertain reported Research risk factor Risk factors significantly spike Spike protein Strong systemic inflammation the disease therapeutic tissue damage Treatment troponin T virus virus spike protein with COVID-19
[DOI] 10.1097/HPC.0000000000000227 PMC 바로가기 [Article Type] Review

Small animal jet injection technique results in enhanced immunogenicity of hantavirus DNA vaccines

Research article

Published on 2021-02-012022-10-05
Journal: Vaccine [Category] 비임상,

K18-hACE2 mice develop respiratory disease resembling severe COVID-19

K18-hACE2 쥐, 심각한 COVID-19와 유사한 호흡기 질환 발병

Research Article

Published on 2021-01-192022-08-13
Journal: PLoS Pathogens [Category] COVID-19, Medicine and Health Sciences,

[키워드] angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal model animal models Asymptomatic Author both groups Brain cerebral cortex chemokines clinical manifestation Course COVID-19 COVID-19 pandemic COVID-19 pathogenesis cytokeratin 18 promoter develop disease disease course disease manifestation dose-dependent DPI etiological agent expressing Extrapulmonary hACE2 hippocampus Human human SARS-CoV-2 humanized immunological disease immunological diseases in both group Infection infectious virus titer inoculated inoculation interstitial pneumonia intestinal tract K18 K18-hACE2 mice lethal disease low dose Lower respiratory tract lung Lungs lymphocyte lymphocyte infiltration Macrophage mice Mild mild to moderate moderate disease nasal turbinates Pathogenesis pathology patients Pneumocytes post inoculation progression proinflammatory Pulmonary pathology rapid inflammatory response receptor replication of SARS-CoV-2 reported respiratory Respiratory disease respiratory tract infection resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication Severe case severe cases severe COVID-19 subset Support survival susceptible TCID Th1 Th1 and proinflammatory cytokines/chemokines the SARS-CoV-2 These data Trachea transgenic mice upper and lower respiratory tract upper and lower respiratory tract infection upregulation Viral Viral RNA shedding virus replication virus titers weight loss while
[DOI] 10.1371/journal.ppat.1009195 PMC 바로가기 [Article Type] Research Article

COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice

K18-hACE2 마우스의 후각 상실을 포함한 COVID-19 치료 및 발병 기전

Article

Published on 2021-01-012022-09-11
Journal: Nature [Category] Fulltext, SARS, 임상, 치료기술, 치료법,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 animals Anosmia Asymptomatic Brain cause clinical disease convalescent plasma coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pathogenesis COVID-19 treatment disease evidence of example feature hACE2 in some Infection infection with SARS-CoV-2 investigated K18-hACE2 mice K18-hACE2 transgenic mice lethal disease lung mice Mild Mild disease morbidity and mortality pandemic Pathogenesis Patient patient with COVID-19 patients Prevent prevented respiratory respiratory symptom SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe disease severe pneumonia severity of COVID-19 the disease therapeutic interventions thrombosis Vasculitis
[DOI] 10.1038/s41586-020-2943-z PMC 바로가기 [Article Type] Article

Inflammation as a Driver of Prostate Cancer Metastasis and Therapeutic Resistance

Review

Published on 2020-10-152022-10-31
Journal: Cancers [Category] COVID-19,

[키워드] advanced disease Angiogenesis anoikis Aspirin association Bacterial Biomarker biomarker signature Cancer controls Critical cytokine disease Disease progression drug effective effector elevated EMT phenotype Evidence expression facilitate functional Genetic variation growth high mortality rate IL-6 Inflammation Inflammatory Inflammatory cytokine inhibitors lethal disease low dose macrophages malignancy men Metastasis metastatic disease Mortality mutagenic Occurrence Patient patients phenotypic Predictive primary tumor progression promote Prostate Prostate cancer reduce reduction in resistance resulting risk risk reduction simple Support survival survival signaling systemic impact TGF-β therapeutic therapy Treatment treatment resistance tumor microenvironment tumor relapse vascularity viral infections
[DOI] 10.3390/cancers12102984 PMC 바로가기 [Article Type] Review

Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers During the COVID-19 Pandemic: A Modeling Analysis

Research Article

Published on 2020-10-082022-10-28
Journal: PLoS Computational Biology [Category] COVID-19, MERS, SARS,

[키워드] ACE2 ACE2 protein acute inflammatory response Angiotensin II angiotensin-converting enzyme inhibitor approach ARB binding blocker cardiovascular disease cardiovascular diseases Cell cell entry cell membrane chronic inflammation Chronic kidney disease coronavirus COVID-19 COVID-19 pandemic diabete diabetes disease disease severity dosage drug Effects enzyme epidemiological data epithelial cell Evidence exacerbated Factors heart failure help host cell host cells host’s immune response hypertension implication increase in induce Infection Inflammation inhibitor Invasion lack lethal disease Lungs mathematical medication medications Model modeling Mortality pandemic Pandemics pathogenesis of COVID-19 Patient physician predict RAS receptor renin-angiotensin system risk SARS- CoV-2 SARS-CoV SARS-CoV-2 severe COVID-19 subsequent suggested the spike protein therapy tissue damage tissues treated Treatment virus while
[DOI] 10.1371/journal.pcbi.1008235 PMC 바로가기 [Article Type] Research Article

Protein based biomarkers for non-invasive Covid-19 detection

Short communication

Published on 2020-08-012022-10-05
Journal: Sensing and Bio-Sensing Research [Category] 바이오마커, 치료기술,

[키워드] approach Biomarker Biomarkers biosensors clinical analysis COVID-19 COVID-19 patient develop Diagnosis diagnostics early diagnosis invasive lethal disease Microfluidics Non-invasive RT-PCR secretion Transmission virus virus transmission
[DOI] 10.1016/j.sbsr.2020.100362 [Article Type] Short communication