Binding of phosphatidylserine-positive microparticles by PBMCs classifies disease severity in COVID-19 patientsPBMC에 의한 포스파티딜세린 양성 미세입자의 결합은 COVID-19 환자의 질병 중증도를 분류합니다Article Published on 2021-12-012022-09-11 Journal: Journal of Extracellular Vesicles [Category] 유전자 메커니즘, [키워드] activated addition Affect Apoptosis blood cell Blood cells Blood coagulation carried cascade CD8 CD8+ CD8+ T cells cells Clinical course Coagulation complement complement system correlated strongly COVID-19 COVID-19 diagnosis COVID-19 patient COVID-19 patients disease severity distribution dying cells Frequency gene expression signature immune cells immune dysfunction Inflammation Inflammatory responses initial investigated Laboratory leucocyte lymphocyte Lymphocytes lymphopenia marker memory T cells Microparticle occur Patient PBMC PBMCs PD-L1 Phosphatidylserine Platelet platelet-derived microparticle Platelets SARS-CoV-2 severe lymphopenia T cell T cells Thromboinflammation thrombotic [DOI] 10.1002/jev2.12173 PMC 바로가기 [Article Type] Article
Immune complexes, innate immunity, and NETosis in ChAdOx1 vaccine-induced thrombocytopeniaChAdOx1 백신 유도 혈소판 감소증에서 면역 복합체, 선천 면역 및 NETosisArticle Published on 2021-10-142022-09-12 Journal: European heart journal [Category] MERS, SARS, 진단, [키워드] accompanied Activation adenoviral vector vaccine analysed Analysis antibody ChAdOx1 ChAdOx1 nCoV-19 circulating complex complexes COVID-19 cytokine degranulation dsDNA endothelial damage first dose FIVE flow cytometry IgG immune immune activation Immune cell immune complex immune response immunohistochemistry Immunological response immunoprecipitation infiltration of neutrophils Inflammatory marker innate immune innate immune activation innate immune response Innate immunity leucocyte marker NETosis NETs neutrophil Neutrophil extracellular trap Neutrophils pathogenic pathway Patient patients performed plasma sample Platelet receiving reported retrieved systemic inflammation thrombotic Thrombus thrombus formation tissue Trigger vaccine-induced immune thrombotic thrombocytopenia Virus Disease [DOI] 10.1093/eurheartj/ehab506 PMC 바로가기 [Article Type] Article
Risk factors for mortality in hemodialysis patients with COVID-19: a systematic review and meta-analysisResearch Article Published on 2021-10-112022-10-28 Journal: Renal failure [Category] COVID-19, [키워드] 95% CI albumin albumin levels clinical Clinical prognosis clinical risk factor clinician cough COVID-19 death Dyspnea early stage Egger’s test Evidence Factor Features Fever fixed help Hemodialysis heterogeneity high mortality higher risk identify leucocyte male marker Meta-analysis Mortality New non-survivor outcome Patient patients patients with COVID-19 performed Platelet proportion random-effects model Respiratory disease Result risk risk factor severe COVID-19 significantly lower survivor systematic review was used [DOI] 10.1080/0886022X.2021.1986408 PMC 바로가기 [Article Type] Research Article
Implementation of serological and molecular tools to inform COVID-19 patient management: protocol for the GENCOV prospective cohort studyCOVID-19 환자 관리를 알리는 혈청학적 및 분자적 도구의 구현: GENCOV 전향적 코호트 연구를 위한 프로토콜Article Published on 2021-09-302022-09-11 Journal: BMJ Open [Category] SARS, 변종, 진단, [키워드] Adult patients antibody Antibody Response antibody titres Antigen approved association B-cell baseline blood sample Blood samples Characteristics clinical Clinical data clinical trials Clinical Trials Ontario collected conducted correlated COVID-19 COVID-19 patient COVID-19 symptoms determine Diagnosis diagnostics disease severity Ethics evaluate genetic difference genetic differences genetic marker Genetic markers genetics Genome Genome sequencing genomic variant Greater Toronto Area hospitals Host host genome identify immune response immunology Infection information isotype leucocyte Lineage molecular molecular diagnostics Observational cohort study outcome outcomes participant Patient patients with COVID-19 peer-reviewed physiological response prospective cohort study protocol receiving receptor Regression regression models Research Research Ethics review SARS-COV-2 infection SARS-CoV-2 virus sequence information sequenced Sequencing serological severity severity of COVID-19 Symptom System T-cell the antibody response the SARS-CoV-2 virus Variability Viral viral genomes viral neutralisation virus genome [DOI] 10.1136/bmjopen-2021-052842 PMC 바로가기 [Article Type] Article
The Cross-Talk between Thrombosis and Inflammatory Storm in Acute and Long-COVID-19: Therapeutic Targets and Clinical CasesCase Report Published on 2021-09-232022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] activate Activation acute phase acute respiratory syndrome addition Adhesion Molecule administration adopted alteration anti-inflammatory properties Anticoagulant anticoagulant therapy Anticoagulants blood chemistry cardiovascular risk Cell characterized circulating clinical clinical expression Coagulation coagulation cascade Coagulation factors coagulation parameter Coagulopathy complicate component Coronavirus-2 COVID-19 COVID-19 patient COVID-19 patients criteria cross-talk cytokine cytokine expression Cytokines death rate Disseminated intravascular coagulation DOAC DOACs Efficacy endothelial damage evaluate factor Xa Growth factors IMPROVE Inflammation Inflammatory inhibit leucocyte LMWH Local long-COVID-19 oral anticoagulant outcomes PARs Patient patients persistence PF4 Platelet promote inflammation prothrombotic state receptor SARS-CoV-2 storm suggested Survivors Symptom syndrome target thrombin Treatment Venous Thromboembolism VTE [DOI] 10.3390/v13101904 PMC 바로가기 [Article Type] Case Report
Clinical value of blood markers to assess the severity of coronavirus disease 2019코로나 바이러스 질병의 심각성을 평가하기위한 혈액 마커의 임상 적 가치 2019Research Article Published on 2021-09-062022-09-10 Journal: BMC Infectious Diseases [Category] SARS, 바이오마커, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus AUROC baseline Blood blood cell Characteristics clinical Clinical symptoms conducted connection coronavirus coronavirus disease Coronavirus disease 2019 correlated cough COVID-19 CRP Culture cultures diagnosed with COVID-19 enrolled expectoration fatigue hemoglobin highest hospital IL-6 IL-8 independent Influenza leucocyte lymphocyte marker myalgia Neutrophils non-severe group parameter patients Platelet Platelet count platelet counts Platelets platelets count positively correlated Predictive proportion Receiver operator characteristic respiratory Result risk SARS-CoV-2 Seasonal influenza secretion severe cases severe group severity severity of COVID-19 significantly increased sputum suggested Symptom the patient [DOI] 10.1186/s12879-021-06623-5 PMC 바로가기 [Article Type] Research Article
Improving turnaround times for HLA-B*27 and HLA-B*57:01 gene testing: a Barts Health NHS Trust quality improvement projectHLA-B*27 및 HLA-B*57:01 유전자 검사의 처리 시간 개선: Barts Health NHS Trust 품질 개선 프로젝트Article Published on 2021-09-012022-09-11 Journal: BMJ open quality [Category] SARS, 치료기술, 치료제, [키워드] abacavir activities ankylosing spondylitis anticipated Antigen changes in clinical transplantation clinician comparable conducted control charts/run charts COVID-19 Diagnosis diagnostic diagnostic services disorder Genetic Hawthorne effect HLA-B hypersensitivity hypersensitivity disorder Improving increase increase in involved Laboratory Laboratory medicine leucocyte NHS over pathology Patient personalised proportion Quality improvement reduced reducing retained spondylitis sustained tested Time-to-treatment Trust turnaround time Variation Volume [DOI] 10.1136/bmjoq-2021-001538 PMC 바로가기 [Article Type] Article
COVID-19 and Tuberculosis Coinfection: An Overview of Case Reports/Case Series and Meta-AnalysisMedicine Published on 2021-08-242022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] 95% confidence interval Antibiotics antiviral therapy calculated CIs Clinical characteristics clinical feature Clinical features CNKI Co-infection confirmed case Coronavirus disease 2019 Corticosteroids country COVID-19 COVID-19 patients database death Deceased described died Dyspnea Evidence greater Hydroxychloroquine hypertension Infectious disease lesion leucocyte male median age moderate non-survivor Odds ratio outcome Patient patients predictor Prognosis public health Risk factors searched Sery severe COVID-19 severe disease survivor Symptom therapy Threats Treatment Tuberculosis worse prognosis [DOI] 10.3389/fmed.2021.657006 PMC 바로가기 [Article Type] Medicine
Swab and Sputum SARS-CoV-2 RNA-Negative, CT-Positive, Symptomatic Contacts of COVID-19 Cases: A Hypothesis-Generating Prospective Population-Based Cohort Study of Eight ClustersMedicine Published on 2021-08-172022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Administered albumin level antibacterial therapy Asymptomatic Bronchoalveolar lavage C-reactive protein case quarantine and contact tracing Characteristics China close contact Cluster confirmed COVID-19 case confirmed COVID-19 cases Confirmed COVID-19 infection Contact Corticosteroid Course COVID-19 COVID-19 case COVID-19 cases COVID-19 patient CT finding CT findings D-dimer level described diagnosing diarrhea discharge eight enrolled eosinophil erythrocyte sedimentation rate feature group had no illness onset laboratory-confirmed less leucocyte monocyte multi-cluster study neutrophil Non-COVID-19 non-COVID-19 pneumonia cases Oxygen therapy Patient patients pneumonia case population-based cohort positive positive COVID-19 Prospective prospective population-based cohort study remained respiratory specimens RNA negative CT positive symptomatic contacts rRT-PCR SARS-CoV-2 SARS-CoV-2 RNA specific antibodies specimen sputum Symptom symptomatic symptomatic contact test negative tested the disease the SARS-CoV-2 three group throat swab total protein Transmission transmitted virus RNA while [DOI] 10.3389/fmed.2021.685544 PMC 바로가기 [Article Type] Medicine
Pathogenic Mechanisms of Vaccine-Induced Immune Thrombotic Thrombocytopenia in People Receiving Anti-COVID-19 Adenoviral-Based Vaccines: A Proposal항-COVID-19 아데노바이러스 기반 백신을 접종받는 사람들에서 백신 유도 면역 혈전성 혈소판 감소증의 병원성 기전: 제안Immunology Published on 2021-08-132022-09-11 Journal: Frontiers in Immunology [Category] MERS, 유전자 메커니즘, 진단, [키워드] ACE2 receptor activate adenoviral vectors administration affected amplify antibodies binding blood stream cell activation characterized Combination complexes component endothelia erythrocytes erytrocyte extracellular DNA favor heparin IL-6 immune immune response immune responses individual Infection Inflammatory injection leucocyte life-threatening mandatory mast cell Mast cells mechanism natural antibodies occur pathophysiological mechanism PF-4 PF4 Platelet platelet activation Platelets promote Protein receiving serum IgG spike Spike protein Spread Symptom syndrome thrombocytopenia thrombotic thrombotic event Thrombotic events Thrombotic thrombocytopenia Trigger triggering Vaccine Vaccines vector VITT [DOI] 10.3389/fimmu.2021.728513 PMC 바로가기 [Article Type] Immunology