Allelic imbalance of HLA-B expression in human lung cells infected with coronavirus and other respiratory viruses코로나바이러스 및 기타 호흡기 바이러스에 감염된 인간 폐 세포에서 HLA-B 발현의 대립형질 불균형Article Published on 2022-08-012022-09-11 Journal: European Journal of Human Genetics [Category] SARS, 변종, 유전자 메커니즘, [키워드] accompanied allelic Analysis Antigen Antiviral association cells characterized contribute coronavirus cytokine Diseases epithelial cells experimental evidence expression genotypes heterozygous HLA HLA allele HLA alleles HLA-B human lung human lung cell human lung epithelial cells IFNβ in silico independent data set infected with SARS-CoV-2 less leucocyte loci lung cell lung cells other respiratory virus overexpression performed predicted respiratory viral infection respiratory viral infections respiratory virus RNA-seq data SARS-CoV-2 tissues viral infectious disease viral infectious diseases with COVID-19 [DOI] 10.1038/s41431-022-01070-5 PMC 바로가기 [Article Type] Article
Whole-genome sequencing reveals host factors underlying critical COVID-19전체 게놈 시퀀싱은 중요한 COVID-19의 기저에 있는 숙주 요인을 밝힙니다Article Published on 2022-07-012022-09-11 Journal: Nature [Category] COVID19(2023년), MERS, SARS, 바이오마커, 변종, 유전자 메커니즘, 임상, 진단, 치료기술, 치료제, [키워드] Adhesion Molecule Antigen association associations ATP11A BCL11A caused CD209 Coagulation coagulation factor Colocalization Control COVID-19 Critical Critical care Critical disease Critical illness Critically ill disease disease severity Evidence expression Factor failure FUT2 Gene Expression Genetic variation genetics Genome genomes GenOMICC Hospitalization Host ICAM5 identify IL10RB Immune-mediated increased expression independent individual infection with SARS-CoV-2 inflammatory lung injury influence interferon intravascular coagulation involved leucocyte life-threatening Lung injury mechanism mechanisms membrane mendelian randomization MUC1 mucin myeloid cell pathophysiology PLSCR1 provide pulmonary inflammation reduced replicate reveal SELE Sequencing significantly Support targets transcriptome-wide underlying disease variant variants Viral viral replication whole-genome sequencing [DOI] 10.1038/s41586-022-04576-6 PMC 바로가기 [Article Type] Article
The ratio of serum LL-37 levels to blood leucocyte count correlates with COVID-19 severity Research Published on 2022-06-012022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 바이오마커, 진단, 치료기술, 치료법, [키워드] Analysis antimicrobial peptide association Blood correlation COVID-19 patient COVID-19 progression Critical CRP demonstrated disease severity Effect Evidence expression granulocyte group Hospital admission IL-6 Inflammation investigated Laboratory parameters LDH leucocyte leukocyte LL-37 Patient PCT produced progression released risk of COVID-19 SARS-CoV-2 serum Serum level severity severity of COVID-19 significantly stimulate Vitamin D vitamin D serum with COVID-19 [DOI] 10.1038/s41598-022-13260-8 [Article Type] Research
Complete blood cells count abnormalities in COVID-19 patients and their prognostic significance: Single center study in Makkah, Saudi Arabia전체 혈액 세포는 COVID-19 환자의 이상과 그 예후 중요성을 계산합니다: 사우디 아라비아 Makkah의 단일 센터 연구Article Published on 2022-06-012022-09-11 Journal: Saudi medical journal [Category] COVID19(2023년), SARS, 치료기술, [키워드] abnormality Admission age Anemia Blood blood cell blood count C-reactive protein clinical disease clinically Complete complete blood count coronavirus disease COVID-19 COVID-19 patient COVID-19 severity CRP Decision making decrease detectable disease effective intervention elevated evaluate feature female ferritin force group Inclusion Inflammation Inflammatory marker inflammatory markers leucocyte leucocytosis lymphopenia male management moderate N/L N/L ratio neutrophil neutrophil count neutrophilia non-survivor Non-survivors occurred Older age Organ failure outcome parameter Patient patients Peripheral blood Platelets platelets count prognostic prognostic significance. Rapid test regimen regimens Respiratory disease respiratory diseases Saudi Arabia security Serum ferritin Serum level Severe case severe COVID-19 disease severity Significant significant decrease significantly viral infection were excluded [DOI] 10.15537/smj.2022.43.6.20210893 PMC 바로가기 [Article Type] Article
Oxidative stress-induced endothelial dysfunction and decreased vascular nitric oxide in COVID-19 patientsObservational Study Published on 2022-03-012022-10-05 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 바이오마커, 임상, [키워드] adult COVID-19 patient angiotensin Angiotensin II angiotensin-converting enzyme 2 appear Bioavailability cardiovascular risk factor contrary control subject correlated correlation COVID-19 COVID-19 patient COVID-19 patients disease severity endothelial Endothelial cell Endothelial dysfunction endothelial injury exacerbated highlight hospital hospitalized COVID-19 patients ICU ICU patient induce leucocyte marker Microvascular thrombosis nitric oxide non-ICU observational study occur oxidative stress Oxygenation PaO parameter pathogenic Patient peroxide plasma Plasma level R 2 receptor redox status reduced Research Respiratory failure resulting SARS-CoV-2 SARS-COV-2 infection septic patients Septic shock Serum level target thrombosis Vascular widespread [DOI] 10.1016/j.ebiom.2022.103893 PMC 바로가기 [Article Type] Observational Study
Evaluation of circulating leucocyte populations both in subjects with previous SARS-COV-2 infection and in healthy subjects after vaccinationObservational Study Published on 2022-03-012022-10-05 Journal: Journal of Immunological Methods [Category] SARS, 임상, [키워드] addition binding CD4 CD8 Cell circulating COVID-19 COVID-19 infection COVID-19 mRNA BNT162b2 COVID-19 mRNA BNT162b2 (Pfizer-BioNTech) vaccine Cytometry decrease develop effector effector cell Flow Flow cytometry characterization groups healthy healthy subject healthy subjects immune mechanism immune response immune system increased expression Infection initial Innate innate immune response leucocyte leukocyte pathogen Pfizer-BioNTech Population promote receptor reduction subject subjects T cell T cell immune response T cell response T cells TEMRA terminal vaccination Vaccine viral clearance viral replication [DOI] 10.1016/j.jim.2022.113230 PMC 바로가기 [Article Type] Observational Study
Selection and T-cell antigenicity of synthetic long peptides derived from SARS-CoV-2Animal Published on 2022-01-112022-10-30 Journal: The Journal of General Virology [Category] COVID-19, [키워드] activate Activation Alpha Antigen antigenicity approach autologous beta coronavirus caused CD4+ CD8+ T cell Cluster conserved coronavirus demonstrated dendritic cell effective vaccine epitope HLA class I immunogenic in vitro individual induce leucocyte mononuclear cell other coronavirus outbreak pandemic PBMC peptide Peripheral blood Protein proteome Region SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 peptide SARS-CoV-2 peptides Selection T-cell T-cell Response T-cells the SARS-CoV-2 the Spike Vaccine variants of SARS-CoV-2 virus [DOI] 10.1099/jgv.0.001698 PMC 바로가기 [Article Type] Animal
Cavitary lung lesions in a neonate: Potential manifestation of COVID-19 related multisystem inflammatory syndrome신생아의 공동 폐 병변: COVID-19 관련 다기관 염증 증후군의 잠재적 징후Case Reports Published on 2022-01-012022-09-12 Journal: Pediatric pulmonology [Category] MERS, SARS, 진단, [키워드] antibody C-reactive protein cavitary Chest children COVID-19 COVID-19 infection CRP Culture Diagnosis elevated evaluated Evidence fast breathing ferritin Fever hyperinflammatory state Infant Inflammatory Intravenous immunoglobulin lactate dehydrogenase lesion leucocyte lung lung lesion MIS MIS-C Multisystem inflammatory syndrome Neonate nodule polymerase chain positive Potential Pregnancy procalcitonin pulmonary cavities resolution of symptoms syndrome thromboembolic complication thromboembolic complications Thromboembolism tomography treated Treatment [DOI] 10.1002/ppul.25732 PMC 바로가기 [Article Type] Case Reports
Combined Blood Indexes of Systemic Inflammation as a Mirror to Admission to Intensive Care Unit in COVID-19 Patients: A Multicentric StudyResearch Article Published on 2021-12-132022-10-31 Journal: Journal of Epidemiology and Global Health [Category] COVID-19, MERS, SARS, [키워드] Absolute lymphocyte count acute respiratory distress Admission AISI ALC AMC Blood Cell Combined COVID-19 COVID-19 patient COVID-19 patients CRP cut-off value D-dimer death Egypt elevated groups Health hematological highest ICU ICU admission independent predictor index Inflammatory response intensive care intensive care unit less leucocyte lymphocyte mechanism Mirror multivariate logistic regression neutrophil non-ICU oxygen pandemic patients with COVID-19 Platelet pro-inflammatory Result sensitivity severity SII specificity Spread supplementary material survival syndrome systemic systemic immune-inflammation index systemic inflammation systemic inflammatory response Total [DOI] 10.1007/s44197-021-00021-5 PMC 바로가기 [Article Type] Research Article
Immune Response after SARS-CoV-2 Vaccination in Kidney Transplant Patients신장 이식 환자에서 SARS-CoV-2 백신 접종 후 면역 반응Article Published on 2021-12-032022-09-12 Journal: Medicina [Category] SARS, 진단, [키워드] Adequacy anti-SARS-CoV-2 antibody Antibody Response antibody response against Antibody titer Antibody titers Better binding antibody unit binding antibody units BNT162b2 CD19 CD19+ CD4/CD8 CD8+ cell CD8+ cells Cell Cellular immune response coefficient conducted correlated COVID-19 COVID-19 vaccination COVID-19 vaccine develop dose evaluate Factor Follow-up hemoglobin humoral Humoral and cellular immune responses immune responses Immunosuppression increase Kidney function kidney transplant Kidney transplantation leucocyte Logistic regression analysis material medication multivariate Multivariate binary logistic regression analysis mycophenolate mycophenolate mofetil objective of BNT162b2 Patient patients Pfizer-BioNTech positive correlation Predictive Prospective Study responders response Result SARS-CoV-2 seropositive significant negative correlation Spearman Spearman’s correlation Transplant vaccination Vaccine [DOI] 10.3390/medicina57121327 PMC 바로가기 [Article Type] Article