Identification of the binding interactions of some novel antiviral compounds against Nsp1 protein from SARS-CoV-2 (COVID-19) through high throughput screening고처리량 스크리닝을 통한 SARS-CoV-2(COVID-19)의 Nsp1 단백질에 대한 일부 신규 항바이러스 화합물의 결합 상호작용 확인Article Published on 2022-09-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료제, [키워드] 40S Analysis Antiviral compound bind binding affinity binding interaction Cell ChEMBL complexes COVID-19 docking drug designing drug library effective Factors human host identification in-silico Ligand ligands molecular molecular docking molecular dynamics Molecular dynamics simulation molecular dynamics simulations nsp1 predict Protein Proteins responsible ribosomal subunit RNA RNA dependent RNA polymerase RNA polymerase RNA virus SARS-CoV-2 SARS-CoV-2 pandemic screened Spike protein spreading tested the spike protein Treatment Virtual screening virulence virulence factor virulence factors virus [DOI] 10.1080/07391102.2021.1887763 PMC 바로가기 [Article Type] Article
Artificially expanded genetic information systems (AEGISs) as potent inhibitors of the RNA-dependent RNA polymerase of the SARS-CoV-2SARS-CoV-2의 RNA 의존성 RNA 중합효소의 강력한 억제제로서 인공적으로 확장된 유전 정보 시스템(AEGIS)Article Published on 2022-09-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 유전자 메커니즘, 치료제, [키워드] AEGIS affected Antiviral agents antiviral agents. binding binding site candidate COVID-19 drug Economy examined genetic information help host cells identify in vivo Infection Information Systems inhibit inhibitor ligands MD simulations mechanism molecular docking monophosphate nucleotide nucleotides Original position outbreak pandemic potential therapeutic agent potential therapeutic agents RdRP RDV Remdesivir Replication responsible RNA RNA-dependent RNA polymerase SARS-CoV-2 SARS-COV-2 infection sequence shown the SARS-CoV-2 therapeutic toxicities Toxicity Transmission unavailability Viral RNA virus [DOI] 10.1080/07391102.2021.1883112 PMC 바로가기 [Article Type] Article
Heterogeneity in IgG-CD16 signaling in infectious disease outcomesArticle Published on 2022-08-012022-11-15 Journal: Immunological reviews [Category] 진단, [키워드] acute infections allele binding contribute coronavirus disease COVID-19 dengue disease disease downstream driven by effector functions. expression Fc afucosylation form functions glycosylation heterogeneity IgG IgG antibody IgG1 IgG1 antibodies immune complex Immune homeostasis Infection Infectious disease Inflammation Inflammatory response inflammatory signaling ligands mechanism modulate outcome Pathogenesis pathogenic required Signaling viral infection while [DOI] 10.1111/imr.13109 PMC 바로가기
Intranasal administration of a virus like particles-based vaccine induces neutralizing antibodies against SARS-CoV-2 and variants of concern입자 기반 백신과 같은 바이러스의 비강 투여는 SARS-CoV-2 및 우려되는 변이체에 대한 중화 항체를 유도합니다.Article Published on 2022-08-012022-09-11 Journal: Allergy [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] administration Aerosols antibody antibody response against candidate vaccine Cell clinical trial contagious COVID-19 displaying elicited epitope evaluated help helper cell IgA antibodies IgA antibody immune response immunogenicity induce intranasal ligands local immune response lung tissue maintain Mask Masks mucosal mucosal immune murine model neutralize neutralizing antibody plasma Plasma cell platform Protective RBD RBD of SARS-CoV-2 recognize reduce required respiratory respiratory droplet Respiratory droplets SARS-CoV-2 Seven systemic and local T helper cell TLR7 TLR7/8 Transmission transmitted tropism tropism of SARS-CoV-2 Vaccine vaccine platform Vaccines variants of concern Viral viral shedding virus Virus-like particle virus-like particles VLPs VOCs [DOI] 10.1111/all.15311 PMC 바로가기 [Article Type] Article
Context-dependent tumor-suppressive BMP signaling in diffuse intrinsic pontine glioma regulates stemness through epigenetic regulation of CXXC5 Research Published on 2022-08-012022-10-05 Journal: Nature cancer [Category] 변종, [키워드] Activation ACVR1 antitumor efficacy BMP CHRDL1 Clinical data CXXC5 disease Effect Epigenetic feature Impact implicated incurable intrinsic Ligand ligands Mutation Pathogenesis positive promote Protein regulate Regulation Signaling signaling pathway Tumor tumor cell tumor suppressor wild-type [DOI] 10.1038/s43018-022-00408-8 [Article Type] Research
Neuropilin (NRPs) Related Pathological Conditions and Their Modulators뉴로필린(NRP) 관련 병리학적 상태 및 조절인자Review Published on 2022-07-292022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 addition Analysis antagonists Cancer clinical disease Community computer-aided drug design condition COVID-19 COVID-19 research Diversity foci form homologous human body in silico in silico drug design joint Last Ligand ligands modulator neuropathic neuropathic pain neuropilin neuropilins NRP1 Pain pathological pathological conditions pathological role peptidomimetics physiological receptor receptor modulator design small molecule small-molecule antagonists. splice the SARS-CoV-2 therapeutic tissue transmembrane glycoprotein variant variety vertebrates viral entry [DOI] 10.3390/ijms23158402 PMC 바로가기 [Article Type] Review
DNA aptamers inhibit SARS-CoV-2 spike-protein binding to hACE2 by an RBD- independent or dependent approachDNA 앱타머는 RBD-독립적 또는 의존적 접근에 의해 hACE2에 대한 SARS-CoV-2 스파이크-단백질 결합을 억제합니다Article Published on 2022-07-182022-09-11 Journal: Theranostics [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] affinity anti-RBD anti-S2 Anti-spike approach aptamer best binding binding affinities binding affinity block can be used Candidates cells conserved coronavirus COVID-19 pandemic Delta develop diagnostic DNA DNA aptamer Efficacy ELISA fusion aptamer hACE2 IMPROVE independent Infection inhibit inhibit SARS-CoV-2 inhibitor Interaction Ligand ligands linker molecular New coronavirus omicron optimization outbreak Prevent RBD recognize reported S2-protein SARS-CoV-2 selection process sequence spike-protein the RBD therapeutic variant variants were measured WT spike [DOI] 10.7150/thno.74428 PMC 바로가기 [Article Type] Article
Inhibitor induced conformational changes in SARS-COV-2 papain-like protease억제제는 SARS-COV-2 파파인 유사 프로테아제에서 구조적 변화를 유도했습니다.Article Published on 2022-07-082022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료제, [키워드] Accessibility Analysis complexes conformation conformational change conformational changes contribute crystal structures expand IMPROVE inhibitor inhibitors Interaction interactions Ligand ligands molecular molecular dynamics Molecular dynamics simulation molecular dynamics simulations myriad Papain Papain-like protease PCA protease reported SARS-CoV-2 trajectory [DOI] 10.1038/s41598-022-15181-y PMC 바로가기 [Article Type] Article
In Silico Studies on Zinc Oxide Based Nanostructured Oil Carriers with Seed Extracts of Nigella sativa and Pimpinella anisum as Potential Inhibitors of 3CL Protease of SARS-CoV-2SARS-CoV-2의 3CL 프로테아제의 잠재적 억제제로서 Nigella sativa 및 Pimpinella anisum의 종자 추출물을 포함하는 산화아연 기반 나노구조 오일 운반체에 대한 실리코 연구Article Published on 2022-07-042022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 변종, [키워드] 3CL 3CLpro acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition applicability candidate carrier characterized clinical trials Compound compounds conformational change coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 docking explained Extract Health histogram imperative inhibitor investigated Ligand ligands MD simulation mixture molecular molecular docking molecular docking studies molecular dynamic simulation molecular dynamics Molecular dynamics simulation MPro nanostructure Nigella Nigella Sativa Oil oleuropein Oxide pandemic Pimpenella anisum Potential protease Protein Research RMSD RMSF SARS-CoV-2 SARS-CoV-2 main protease seed selected stability structural proteins the SARS-CoV-2 trajectory Vaccines variant Zinc zinc oxide zinc oxide nanoparticles [DOI] 10.3390/molecules27134301 PMC 바로가기 [Article Type] Article
In silico exploration of disulfide derivatives of Ferula foetida oleo-gum (Covexir®) as promising therapeutics against SARS-CoV-2SARS-CoV-2에 대한 유망한 치료제로서 Ferula foetida oleo-gum(Covexir®)의 이황화물 유도체의 실리코 탐사Article Published on 2022-07-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, [키워드] binding free energy binding mechanism complexes conducted coronavirus COVID-19 Cys145 demonstrated derivative Disulfide drug electron density energy Energy decomposition Ferula Ferula foetida free energy GLN189 His41 inhibitor inhibitors Interaction ligands main role MM/PBGBSA free Energy omicron Omicron variant Quantum mechanics Quantum mechanics calculations. researcher residue SARS-CoV-2 SARS-CoV-2 main protease significantly Spread Vaccine van der Waal variant [DOI] 10.1016/j.compbiomed.2022.105566 PMC 바로가기 [Article Type] Article