Linkage disequilibrium – Page 2 – Communicable Diseases Research

Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity

흔한, 저주파, 희귀 및 초희귀 코딩 변종은 COVID-19 심각성에 기여합니다

Original Investigation

Published on 2021-12-102022-09-10
Journal: Human Genetics [Category] SARS, 변종, 진단,

Highly accurate whole-genome imputation of SARS-CoV-2 from partial or low-quality sequences

Technical Note

Published on 2021-12-022022-10-31
Journal: GigaScience [Category] COVID-19, SARS,

Leveraging Genetic Data to Elucidate the Relationship Between COVID‐19 and Ischemic Stroke

유전 데이터를 활용하여 COVID-19와 허혈성 뇌졸중 사이의 관계 설명

Original Research

Published on 2021-11-102022-09-10
Journal: Journal of the American Heart Association [Category] MERS, 변종,

[키워드] 95% CI Analysis associations body mass body mass index C‐reactive protein cardiovascular disease chronic inflammation correlation COVID‐19 COVID‐19 Critical cross‐trait linkage disequilibrium score regression death defined Epidemiology estimate Evidence evidence of false discovery rate Genetic genetic data genetics Hospitalization host response Inclusion increase in increased risk increased the risk independent independent of investigated Ischemic Ischemic Stroke Linkage disequilibrium mendelian randomization Mendelian randomization analysis multivariable Odds ratio outcome outcomes P ‐value pleiotropic predicted relationship reported respiratory Respiratory Support Result resulting risk risk factor Risk factors robust sensitivity analysis smoking statistical statistical sensitivity stroke Subtypes Support These data variants was performed was used
[DOI] 10.1161/JAHA.121.022433 PMC 바로가기 [Article Type] Original Research

Genomic diversity of SARS-CoV-2 in Malaysia

Bioinformatics

Published on 2021-11-032022-10-28
Journal: PeerJ [Category] COVID-19,

[키워드] A701V accumulated Algorithm analysed analyses approved Asian association circulating Clustering complexes Consequences Continuous country COVID-19 pandemic D614G distribution Emergency use epidemiological examined Genes Genetic genetic change genetic diversity Genome genomic GISAID Health help immune evasion isolate Lineage lineages Linkage disequilibrium Malaysia massive minimum Mutation mutations new SARS-CoV-2 Non-synonymous nucleotide substitution ORF1ab performed populations Public ranged researchers Result SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 virus sequence sequenced Seven Spread Surveillance tree Vaccine variant viral genome Viral genome sequencing viral nucleotide virus
[DOI] 10.7717/peerj.12449 PMC 바로가기 [Article Type] Bioinformatics

Disparities in COVID-19 severities and casualties across ethnic groups around the globe and patterns of ACE2 and PIR variants

전 세계 인종 그룹에 따른 COVID-19 심각도 및 사상자의 격차와 ACE2 및 PIR 변종의 패턴

Article

Published on 2021-08-012022-09-11
Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 변종, 유전자 메커니즘,

[키워드] ACE2 ACE2 gene ACE2 variant ACE2 variants acute respiratory syndrome acute respiratory syndrome coronavirus affected angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 cardiovascular complications CFR chronic lung disease Comorbidity contagious contribute coronavirus disease Coronavirus-2 correlation COVID-19 COVID-19 case COVID-19 severity diabetes disease-associated disparity distribution East ethnic group Ethnic groups European Fatality rate frequencies genetic variants Geographic Geographic distribution globe Haplotype host cell host cells hypertension individual Infection linkage Linkage disequilibrium Lung disease PIR populations prevalent protective role receptor SARS-CoV-2 SARS-CoV-2 entry severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severity South Asian Strong variant variants virus with COVID-19
[DOI] 10.1016/j.meegid.2021.104888 PMC 바로가기 [Article Type] Article

Detection of Phenotype-Related Mutations of COVID-19 via the Whole Genomic Data

전체 게놈 데이터를 통한 COVID-19의 표현형 관련 돌연변이 검출

Article

Published on 2021-07-012022-09-11
Journal: IEEE/ACM transactions on computational biology and [Category] SARS, 변종, 치료기술,

SARS-CoV-2: Possible recombination and emergence of potentially more virulent strains

SARS-CoV-2: 잠재적으로 더 치명적인 균주의 가능한 재조합 및 출현

Research Article

Published on 2021-05-252022-08-13
Journal: PLoS ONE [Category] Biochemistry, COVID-19, SARS,

An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility

인간 질병과 분자 표현형의 공유 유전 구조를 연결하는 아틀라스는 COVID-19 감수성에 대한 통찰력을 제공합니다

Software

Published on 2021-05-172022-09-10
Journal: Genome Medicine [Category] SARS, 유전자 메커니즘,

[키워드] ABO Analysis application association Bacterial infection Biomarker calculate capture CD209 cellular clinical utility Colocalization common diseases complex COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 patient COVID-19 susceptibility Cross-phenotype association database DC-SIGN demonstrated Diseases DPP9 driven by enrichment examined explain exploration facilitate fibrosis genetic architecture Genetic variation genome-wide association glycosylation Gout GWAS GWAS summary statistics healthy control healthy controls Hi-HOST human disease human diseases hypothese hypotheses identify Idiopathic pulmonary fibrosis information LD-score lead Linkage disequilibrium locus Macular telangiectasia mechanism molecular molecular phenotype overlap pathophysiology Peripheral blood Phenotypes phenotypic PheWAS plasma protein Pleiotropy portal provide pulmonary fibrosis receptor regulate reported Result rs12610495 rs2869462 rs505922 SARS-CoV-2 severe COVID-19 SIGN SNP supplementary material therapeutic approaches traits transcriptomics translation while
[DOI] 10.1186/s13073-021-00904-z PMC 바로가기 [Article Type] Software

Virus-derived variation in diverse human genomes

다양한 인간 게놈의 바이러스 유래 변이

Research Article

Published on 2021-04-262022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] acquisition addition Analysis applied biosafety can not cell line cell lines chromosomal chromosome chromosomes coevolution complex computational tool computational tools contributing to dataset described example expand experiment full-length gene conversion Gene Expression gene transfer generate genetic material Genetic variant Genetic variation Genome genome region Haplotype HERV HERV-K HHV-6 HIV-1 Host Human human endogenous retrovirus human endogenous retrovirus-K human endogenous retroviruses Human genome Human genomes human herpesvirus 6 Human immunodeficiency virus human T lymphotropic virus humans inaccessible include Infection introgression LCLs Linkage disequilibrium loci lymphoblastoid cell lymphoblastoid cell lines make up mapped nucleotide Perspective progenitor cell progenitor cells reads Reference materials sequence sequenced sequences Sequencing short-read sequencing Single nucleotide variant single nucleotide variants SMRV SNVs squirrel monkey squirrel monkey retrovirus Structural variant subjects SVs These cells transfer variant variants Variation virus virus infection viruses WGS whole genome Whole genome sequencing
[DOI] 10.1371/journal.pgen.1009324 PMC 바로가기 [Article Type] Research Article

Improving the Understanding of the Immunopathogenesis of Lymphopenia as a Correlate of SARS-CoV-2 Infection Risk and Disease Progression in African Patients: Protocol for a Cross-sectional Study

Protocol

Published on 2021-03-042022-10-29
Journal: JMIR Research Protocols [Category] COVID-19,

[키워드] “COVID-19 African alleles amplification analyses Analysis Apoptosis apoptotic pathways association Bax BCL-2 BCL2L12 Biomarker carried caspase 3 categories caused CD4 collected Comorbidity complete blood count Concentration country COVID-19 COVID-19 complication COVID-19 pandemic cross-sectional Cytokine storm determinant determine Disease progression distribution DNA EDTA ELISA enrolled enzyme-linked immunosorbent expected expression expression level flow cytometry Frequency genetic determinants Genomic DNA genotyped genotypes genotypic genotyping Haplotype Hardy-Weinberg equilibrium Health health system help Hospitalized hospitalized patient Hypovitaminosis D Identifier Immunopathogenesis IMPROVE Improving include individual infected patients infected with SARS-CoV-2 information Lagos Linkage disequilibrium Lymphocyte count lymphopenia MONITOR Nigeria objective Other outcome participant Participants Patient PCR performed phenotypic polymerase chain polymorphism Prevalence Prognosis questionnaire R statistical software report Repurposed drug Result reverse transcribed reverse transcription PCR risk stratification RNA RNA sample RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2–positive Sequencing serum sample serum vitamin D severe infections soluble Fas ligand Stratification study outcome T cell assay T lymphocyte Total Travel Treatment treatment regimen understanding vascular cell adhesion VDR venous blood Vitamin D receptor Vitamin D status with COVID-19
[DOI] 10.2196/21242 PMC 바로가기 [Article Type] Protocol