Unraveling the genetic evolution of SARS-CoV-2 Recombinants using mutational dynamics across the different lineagesMedicine Original Research Published on 2024-01-152024-09-05 Journal: Frontiers in Medicine [Category] update2024, [키워드] breakpoints lineages Linkage disequilibrium mutations Recombination SARS-CoV-2 [DOI] 10.3389/fmed.2023.1294699 PMC 바로가기 [Article Type] Medicine Original Research
Evidence of epistasis in regions of long-range linkage disequilibrium across five complex diseases in the UK Biobank and eMERGE datasetsArticle Published on 2023-04-062024-09-04 Journal: American Journal of Human Genetics [Category] 대상포진, [키워드] complex human disease epistasis Essential genes Evolution interchromosomal Linkage disequilibrium long-range Pleiotropy variable expressivity [DOI] 10.1016/j.ajhg.2023.03.007 PMC 바로가기 [Article Type] Article
Mutational dynamics across VOCs in International travellers and Community transmission underscores importance of Spike-ACE2 interaction국제 여행자의 VOC와 지역 사회 전파에 걸친 돌연변이 역학은 Spike-ACE2 상호 작용의 중요성을 강조합니다.Article Published on 2022-09-012022-09-11 Journal: Microbiological research [Category] COVID19(2023년), SARS, 변종, [키워드] A570D Alpha analysed B.1.617.2 binding binding affinity change Community community transmission comparable COVID-19 case COVID-19 pandemic D1118H D950N Delta demonstrated different time point different time points disequilibrium early phase emergence Evolution functional G142D Genomic surveillance India Interaction International investigated L452R Lineage linkage Linkage disequilibrium Mutation mutation analysis mutations N501Y notable omicron ORF1 ORF1ab overlap predict raised S982A SARS-CoV-2 selective spike spike mutations spike-ACE2 Spread Structural analysis Transmissibility Transmission transmission pattern unique vaccination variants variants of concern VoC VOCs [DOI] 10.1016/j.micres.2022.127099 PMC 바로가기 [Article Type] Article
The clinically relevant CYP2C8*3 and CYP2C9*2 haplotype is inherited from Neandertals Research Published on 2022-07-022022-10-05 Journal: The Pharmacogenomics Journal [Category] 유전자 메커니즘, [키워드] alleles chromosome 10 clinically compounds CYP2C8 CYP2C9 cytochrome P450 enzyme drug drugs exhibit genes encoding Haplotype influence Linkage disequilibrium locus metabolism reduced therapeutic doses Toxicity Variation [DOI] 10.1038/s41397-022-00284-6 [Article Type] Research
Shared genomic architectures of COVID-19 and antisocial behaviorCOVID-19의 공유 게놈 구조와 반사회적 행동Article Published on 2022-05-102022-09-11 Journal: Translational Psychiatry [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aggression antisocial antisocial behavior average average income baby calculate cause chronic obstructive chronic obstructive pulmonary disease coronavirus coronavirus disease Coronavirus disease 2019 correlated correlation COVID-19 Diseases estimate exposure to false-discovery rate Genetic genetics Genome-wide association studies Genome-wide association study genomic Health higher risk Linkage disequilibrium matrix measure mind obstructive pulmonary disease omicron overlap pandemic pulmonary disease SARS-CoV-2 severe acute respiratory syndrome Coronavirus text traits Vaccine variant verbal with COVID-19 [DOI] 10.1038/s41398-022-01948-4 PMC 바로가기 [Article Type] Article
Genetic association of TMPRSS2 rs2070788 polymorphism with COVID-19 case fatality rate among Indian populations인도 인구 중 COVID-19 사례 사망률과 TMPRSS2 rs2070788 다형성의 유전적 연관성Article Published on 2022-03-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 바이오마커, 변종, 유전자 메커니즘, [키워드] ACE2 ACE2 gene ACE2 receptor Analysis analyzed antagonistic approach Asia Asians association Biomarker Case fatality rate causative agent CFR COVID-19 COVID-19 infection COVID-19 susceptibility disease disease susceptibility disparity East engage eQTL analysis expression Fatality rate Frequency G allele Genetic genetic association Genotype Haplotype help Host host cell increased expression India individual information intensity linkage Linkage disequilibrium lung Next-generation sequencing NGS observation pandemic pathogenicity Phylogenetic polymorphism Population populations positive predict priming risk rs2070788. S protein SARS-CoV-2 Serine serine protease severity significantly higher SNP South South Asian susceptibility tested the SARS-CoV-2 TMPRSS2 variant Variation West with COVID-19 [DOI] 10.1016/j.meegid.2022.105206 PMC 바로가기 [Article Type] Article
Shared genomic architecture between COVID-19 severity and numerous clinical and physiologic parameters revealed by LD score regression analysisArticle Published on 2022-02-032022-10-04 Journal: Scientific Reports [Category] MERS, 바이오마커, 유전자 메커니즘, [키워드] analyses Analysis Apolipoprotein A association associations asymptomatic infection attenuate Biomarker Blood BMI clinical evaluation clinical manifestations conducted correlation COVID-19 pandemic COVID-19 severity death diabete Epidemiology Genetic genetic architecture Genetic predisposition to disease Genome-wide association studies genomic genomic region HDL Hospitalization Linkage disequilibrium Mendelian randomization study parameter parameters Phenotypes positive produced Protective provide regression analysis Removing Research retinol risk factor robust sensitivity analysis severe COVID-19 Shortness of breath smoking therapeutic target [DOI] 10.1038/s41598-022-05832-5 PMC 바로가기 [Article Type] Article
Genomic Perspectives on the Emerging SARS-CoV-2 Omicron VariantArticle Published on 2022-02-012022-11-16 Journal: Genomics, Proteomics & Bioinformatics [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] addition Affect alteration amino acid residue amino acid residues analyzed antigenicity B.1.1.529 circulating codon collected database detect Efficiency Genome genomic Genomics imperative IMPROVE Linkage disequilibrium Mutation nonsynonymous mutation occur omicron other variant Patient prevalent primer Protein Replication SARS-CoV-2 SARS-CoV-2 variants second sequence Surveillance the Spike variant variant of concern variants Viral genome sequencing viral nucleic acid was reduced World Health Organization [DOI] 10.1016/j.gpb.2022.01.001 PMC 바로가기
Host genetic factors of COVID-19 susceptibility and disease severity in a Thai population Research Published on 2022-01-112022-10-05 Journal: Journal of Human Genetics [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] association cells chromosome Cohort Comorbidity Control COVID-19 COVID-19 disease COVID-19 susceptibility disease disease severity EEA1 Factor Genetic genome-wide significance genotyped Host Host genetic factor Human IL17B immune response in viral Infection Inflammation involved likelihood Linkage disequilibrium LOC643339 loci locus long non-coding RNA Odds ratio Pathogenesis Patient Pneumonia populations recruited required shown Single nucleotide polymorphism small sample size SNP suggested susceptibility threshold with COVID-19 [DOI] 10.1038/s10038-021-01009-6 [Article Type] Research
Unravelling Rubber Tree Growth by Integrating GWAS and Biological Network-Based ApproachesOriginal Research Published on 2021-12-212023-08-30 Journal: Frontiers in Plant Science [Category] E형 간염, [키워드] Hevea brasiliensis GBS GWAS Linkage disequilibrium metabolic networks QTL RNA-Seq WGCNA [DOI] 10.3389/fpls.2021.768589 PMC 바로가기 [Article Type] Original Research