lncRNA – Page 2 – Communicable Diseases Research

Therapeutic prospects of ceRNAs in COVID-19

Article

Published on 2022-09-202022-11-15
Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 치료제,

Single-cell RNA sequencing uncovers the nuclear decoy lincRNA PIRAT as a regulator of systemic monocyte immunity during COVID-19

Article

Published on 2022-09-062022-11-15
Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 진단,

[키워드] alarmin antiviral response approach binding blood leukocyte characterized COVID-19 COVID-19 pathogenesis differentially expressed down-regulation driver expression humans Immunity immunopathology JAK-STAT pathway knockout lincRNA lncRNA long noncoding RNA LUCAT1 monocyte Monocytes naïve NF-κB NF-κB-dependent gene noncoding RNA nuclear promote promoter pseudogene PU.1 Release remained RNA RNA sequencing SARS-CoV-2 SARS-COV-2 infection severe COVID-19 Single-cell RNA sequencing single-cell RNA-seq Stat1 suggested systemic immune response target Transcription transcription factor transcription factors transcriptional transgene viral infection
[DOI] 10.1073/pnas.2120680119 PMC 바로가기

A nuclear redox sensor modulates gene activation and var switching in Plasmodium falciparum

Article

Published on 2022-08-162024-08-29
Journal: Microbial Cell Factories [Category] 말라리아,

[키워드] lncRNA malaria Plasmodium falciparum thioredoxin peroxidase var genes

Deregulation of ceRNA Networks in Frontal Cortex and Choroid Plexus of Brain during SARS-CoV-2 Infection Aggravates Neurological Manifestations: An Insight from Bulk and Single-Cell Transcriptomic Analyses

SARS-CoV-2 감염 중 뇌의 전두엽 피질 및 맥락총 신경총에서 ceRNA 네트워크의 규제 완화는 신경 증상을 악화시킵니다: 대량 및 단일 세포 전사체 분석의 통찰력

Article

Published on 2022-08-012022-09-11
Journal: Advanced Biology [Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] Analysis analyzed Brain cell type cell types choroid Choroid plexus competing competing endogenous RNA network cortex deregulated differentially expressed downregulated downregulation downstream excitatory explain Frontal Gene Expression help Human brain impairment indicated Initially insight landscape lncRNA MALAT1 mapping mechanism MIRLET7BHG miRNA miRNAs mRNA NEAT1 network neurological Neuron neurons NorAD pathway enrichment Plexus reconstructed regulatory circuit RNA RNA-Seq SARS-CoV-2 single-cell RNA-seq STXBP5 STXBP5-AS1 therapeutic Therapeutics transcriptomic upregulated upregulation Variability
[DOI] 10.1002/adbi.202101310 PMC 바로가기 [Article Type] Article

RNA solutions to treat inborn errors of metabolism

신진대사의 선천적 오류를 치료하기 위한 RNA 솔루션

Review

Published on 2022-08-012022-09-11
Journal: Molecular genetics and metabolism [Category] 유전자 메커니즘,

LncRNA TMPO-AS1 promotes esophageal squamous cell carcinoma progression by forming biomolecular condensates with FUS and p300 to regulate TMPO transcription

Research

Published on 2022-06-272022-10-05
Journal: Experimental & Molecular Medicine [Category] 바이오마커,

Of mice and human-specific long noncoding RNAs

마우스 및 인간 특이적 긴 비암호화 RNA

Review

Published on 2022-06-012022-09-11
Journal: Mammalian genome : official journal of the Interna [Category] COVID19(2023년), SARS, 유전자 메커니즘,

The interplay between lncRNAs, RNA-binding proteins and viral genome during SARS-CoV-2 infection reveals strong connections with regulatory events involved in RNA metabolism and immune response

SARS-CoV-2 감염 동안 lncRNA, RNA 결합 단백질 및 바이러스 게놈 사이의 상호 작용은 RNA 대사 및 면역 반응과 관련된 조절 사건과의 강력한 연결을 보여줍니다

Article

Published on 2022-05-092022-09-11
Journal: Theranostics [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단,

[키워드] analyzed association BISPR Cell cellular cellular response characterized Cohort cohort of patient Combination complex component composed connection coronavirus Correlation analysis Defense defense mechanisms determine element event experimental evidence FMR1 FMR1-IT1 functional Host host cells human host cell human host cells human RNA identify immune response in silico infected cell Infection infectious agent Interaction interactions interferon interferon response intrinsic involved lncRNA long non-coding RNA mechanism metabolism MIR155HG modulate molecular ncRNAs Non-coding RNAs NRIR performed progression Protein rationale Regulation Regulatory regulatory network regulatory network. replicative reveal RNA RNA viruses RNA-binding protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral load sequestering Specific Surveillance the interferon transcriptional transcriptomic triggered USP30 USP30-AS1 Viral viral genome viral infections viral RNA genome
[DOI] 10.7150/thno.73268 PMC 바로가기 [Article Type] Article

Competitive Endogenous RNA Network Activates Host Immune Response in SARS-CoV-2-, panH1N1 (A/California/07/2009)-, and H7N9 (A/Shanghai/1/2013)-Infected Cells

경쟁적인 내인성 RNA 네트워크는 SARS-CoV-2-, panH1N1(A/California/07/2009) 및 H7N9(A/Shanghai/1/2013)에 감염된 세포에서 숙주 면역 반응을 활성화합니다

Article

Published on 2022-01-302022-09-11
Journal: Cells [Category] Fulltext, 신종인플루엔자, 유전자 메커니즘, 치료기술,

[키워드] activate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis analyzed Apoptosis autophagy Avian Influenza binding Cell cellular coronavirus Coronaviruses downregulated gene endogenous expression H1N1 H7N9 Hope host cell host cells in viral indicated infected cells Infection Influenza influenza A influenza A virus influenza A viruses Influenza virus inhibit Interaction involved IRF1 IRF1 mRNA lncRNA metabolic pathways molecular mechanism molecular mechanisms mRNA network noncoding RNA Other outbreak p53 p53 signaling pathway pandemic pathogenicity pathway pertussis provide Regulation Research respiratory respiratory virus response responsible RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2- severe acute respiratory syndrome Coronavirus signaling pathway susceptibility therapeutic agent therapeutic agents these viruses three group three groups Transcriptome Tuberculosis unique upregulated upregulated gene upregulation Viral viral pathogenicity virus viruses
[DOI] 10.3390/cells11030487 PMC 바로가기 [Article Type] Article

Diversity of Dysregulated Long Non-Coding RNAs in HBV-Related Hepatocellular Carcinoma

Review

Published on 2022-01-282023-06-03
Journal: Frontiers in Immunology [Category] B형 간염, Fulltext,

[키워드] ceRNA epigenetic regulation HBV-related HCC lncRNA miRNA precursor processing protein interactions transcriptional regulation
[DOI] 10.3389/fimmu.2022.834650 PMC 바로가기 [Article Type] Review