Localization – Page 2 – Communicable Diseases Research

Lipid and Nucleocapsid N-Protein Accumulation in COVID-19 Patient Lung and Infected Cells

COVID-19 환자 폐 및 감염된 세포에서 지질 및 뉴클레오캡시드 N-단백질 축적

Research Article

Published on 2022-02-162022-09-10
Journal: Microbiology Spectrum
[Category] COVID19(2023년), MERS, SARS, 치료기술, 치료법,

Exploring Mitochondrial Localization of SARS-CoV-2 RNA by Padlock Assay: A Pilot Study in Human Placenta

Communication

Published on 2022-02-142022-10-29
Journal: International Journal of Molecular Sciences
[Category] COVID-19, COVID19(2023년), MERS, SARS,

Subcellular Detection of SARS-CoV-2 RNA in Human Tissue Reveals Distinct Localization in Alveolar Type 2 Pneumocytes and Alveolar Macrophages

Research Article

Published on 2022-02-082022-10-29
Journal: mBio
[Category] COVID-19, MERS,

[키워드] AGER alveolar Alveolar macrophages amplification AT1 AT2 Autopsy caused Cell Cell culture cell line Cellular imaging coronavirus disease COVID-19 detection diagnostics Drug screening FFPE fixation fluorescent image analysis formalin Human human lung tissue human tissue identify infected patients infected with SARS-CoV-2 Infection Localization lung Lymph node macrophage marker Marco marker gene marker genes novel coronavirus SARS-CoV-2 observé ORF1a paraffin embedding pathology performed Placenta platform pneumocyte probe Region regions RNA RNA FISH SARS-CoV-2 SARS-CoV-2 RNA SFTPC Single Cell specimens subcellular subcellular localization subgenomic mRNAs tissue tissues Type viral life cycle Viral RNA widespread
[DOI] 10.1128/mbio.03751-21 PMC 바로가기 [Article Type] Research Article

Strong SARS-CoV-2 N-Specific CD8 + T Immunity Induced by Engineered Extracellular Vesicles Associates with Protection from Lethal Infection in Mice

강력한 SARS-COV-2 N- 특이 적 CD8 + T 면역에 의해 유도 된 세포 외 소포에 의해 유도 된 면역은 마우스에서 치명적인 감염으로부터 보호됩니다.

Article

Published on 2022-02-062022-09-10
Journal: Viruses
[Category] COVID19(2023년), MERS, SARS, 변종,

[키워드] airways anti-SARS-CoV-2 vaccine antibody waning Antigen Associate Bronchoalveolar lavage fluid CD8 CD8⁺ T cell immunity cells characterized Combination described distribution DNA dose Efficacy Efficiency Evidence EVs expected expressing extracellular vesicle Extracellular vesicles fused highest idea immune memory immune response Immunity immunization immunized mice induce induced injection Intramuscular injection lethal lethal doses limitation Localization long-lasting lung Lungs Lymphocytes memory cell mice N-terminus Nef percentage platform prophylactic strategy protection Protein remained SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-COV-2 infection spleen Strong T cell T cells T lymphocyte T lymphocytes target tissue Vaccines variants vector vectors Viral viral variant Viral variants were infected
[DOI] 10.3390/v14020329 PMC 바로가기 [Article Type] Article

Well-differentiated liver cancers reveal the potential link between ACE2 dysfunction and metabolic breakdown

잘 분화된 간암은 ACE2 기능 장애와 대사 장애 사이의 잠재적 연관성을 보여줍니다

Article

Published on 2022-02-032022-09-10
Journal: Scientific Reports
[Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 치료기술,

[키워드] ACE2 acute respiratory syndrome coronavirus Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 bile canaliculi bioinformatics bystander Cancer Cancer cells cancers Cell co-expression network coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 dataset DNA dysfunction endothelial cells enzyme Epigenetics analysis Express FIVE followed by functions Gene expression analysis Genomic analysis hepatic function hepatocytes High-resolution human liver Image analysis imaging immunohistochemistry Immunological techniques in vitro Inflammation liver Liver cancer Liver disease livers Localization Microarray Microscopy mRNA multiplex mutated oxidative stress POLE predicted promoter protein expression Quantitative receptor respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection in vitro Sequencing Serine serine protease severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 tissue TMPRSS2 TMPRSS2 expression transcriptomic transmembrane serine protease transmembrane serine protease 2 Tumor tumors Viral whole mount β-catenin
[DOI] 10.1038/s41598-021-03710-0 PMC 바로가기 [Article Type] Article

A Social Distance Estimation and Crowd Monitoring System for Surveillance Cameras

감시 카메라를 위한 사회적 거리 추정 및 군중 모니터링 시스템

Article

Published on 2022-01-062022-09-10
Journal: Sensors (Basel, Switzerland)
[Category] SARS, 치료기술,

An outbreak of SARS-CoV-2 with high mortality in mink ( Neovison vison) on multiple Utah farms

여러 유타 농장에서 밍크(Neovison vison)의 사망률이 높은 SARS-CoV-2 발생

Research Article

Published on 2021-11-122022-09-12
Journal: PLoS Pathogens
[Category] MERS, SARS, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Animal host animal hosts animals anorexia bat bats breadth caused Chain Reaction clinical disease collected coronavirus damage death demonstrated disease distribution early phase edema effort epithelial F486L FIVE Gross high mortality hosts Human humans In situ hybridization indicate information interstitial pneumonia Localization localized infection lower respiratory system lung Lymph node measure mink moderate molecular Mortality multiple organ multiple organs Mutation nasal turbinates necropsy Neovison Novel coronavirus occurred outbreak pathology perivasculitis polymerase chain polymerase chain reaction Polymorphisms potential transmission PPE Prevent provided pulmonary congestion Pulmonary edema RBD mutation reported reservoir reservoirs Respiratory disease respiratory tract reveal reverse transcriptase Reverse transcriptase polymerase chain reaction RT-PCR SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-COV-2 infection SARS-CoV-2 strain SARS-CoV-2 viral RNA sequenced severe acute respiratory syndrome Coronavirus severe respiratory disease Spread strain susceptible symptomatic the disease The United States tissue tissues tracheobronchial Transmission unique United States upper respiratory tract Utah Vasculitis viral infection Viral RNA Viral transmission virus virus transmission while whole genome Whole genome sequencing Y453F
[DOI] 10.1371/journal.ppat.1009952 PMC 바로가기 [Article Type] Research Article

Effect of Ivermectin and Atorvastatin on Nuclear Localization of Importin Alpha and Drug Target Expression Profiling in Host Cells from Nasopharyngeal Swabs of SARS-CoV-2- Positive Patients

SARS-COV-2- 양성 환자의 비 인두 면봉으로부터의 숙주 세포에서 수입 알파 및 약물 표적 발현 프로파일 링에 대한 Ivermectin 및 Atorvastatin의 효과

Article

Published on 2021-10-152022-09-10
Journal: Viruses
[Category] SARS, 신약개발, 유전자 메커니즘, 치료법, 치료제,

[키워드] Actin Affect alteration analyzed antihelmintic drug atorvastatin Cdc42 cellular Combination concentrations confocal microscopy COVID-19 COVID-19 patient COVID-19 patients cytoplasmic distribution drug Drug repurposing drug target drugs Effect expression function Gene Expression host cell host cell antiviral response host cells impair Importin in vitro model Infection inhibit involved Ivermectin KPNA3 KPNA5 KPNA7 KPNB1 lipophilic statin Localization mechanism Nasopharyngeal swab nasopharyngeal swabs NF-κB NF-κB activation Non-COVID-19 patients nuclear Nuclear localization Pathogenesis Patient pleiotropic effect poly(I:C) Profiling Result Rho GTPase Rho GTPases RHOA RNA viruses SARS-CoV-2 SARS-COV-2 infection Signaling target transcriptional Transport Treatment triggered Vesicle Viral viral double-stranded RNA
[DOI] 10.3390/v13102084 PMC 바로가기 [Article Type] Article

SARS-CoV-2 is localized in cardiomyocytes: a postmortem biopsy case

SARS-CoV-2는 심근세포에 국한됨: 사후 생검 사례

Case Reports

Published on 2021-10-012022-09-11
Journal: International Journal of Infectious Diseases
[Category] SARS, 치료기술,

Monocular Pedestrian 3D Localization for Social Distance Monitoring

Article

Published on 2021-09-022022-10-29
Journal: Sensors (Basel, Switzerland)
[Category] Coronavirus, SARS,