Noncoding RNA therapeutics — challenges and potential solutions Reviews Published on 2021-06-182022-10-05 Journal: Nature Reviews Drug Discovery [Category] 바이오마커, 치료제, [키워드] Antisense oligonucleotide approach boost cancers clinical testing demonstrated Effect Efficacy effort FDA approval long noncoding RNA microRNA miRNAs ncRNA ncRNAs noncoding RNA other diseases over RNA therapeutics RNAs specificity Tolerability Toxicity Treatment Trial [DOI] 10.1038/s41573-021-00219-z [Article Type] Reviews
Identification of PBMC-based molecular signature associational with COVID-19 disease severityResearch article Published on 2021-04-212022-10-05 Journal: Heliyon [Category] 바이오마커, [키워드] administration admitted to ICU affected Analysis antiviral response associational Biomarker Biomarkers canonical clinical implications coding mRNA COVID-19 COVID-19 patient dataset disease disease severity Effect expressed function global pandemic identification implication individual interferon lncRNA long noncoding RNA molecular mRNA Non-COVID-19 Patient patients patients with COVID-19 PBMC PBMCs Protein SARS-CoV-2 severe COVID-19 severity significantly Stratification subset suppressed Therapeutic approach therapeutic option therapy Transcriptome turn upstream with COVID-19 [DOI] 10.1016/j.heliyon.2021.e06866 [Article Type] Research article
Co-expression network analysis identifies innate immune signatures for Albizia julibrissin saponin active fraction-adjuvanted avian influenza vaccineArticle Published on 2021-04-012023-06-22 Journal: International immunopharmacology [Category] 조류인플루엔자, [키워드] adjuvant Albizia julibrissin saponin Avian influenza vaccine innate immune response long noncoding RNA Weighted gene co-expression network analysis. [DOI] 10.1016/j.intimp.2021.107417
Whole-Transcriptome RNA Sequencing Reveals Significant Differentially Expressed mRNAs, miRNAs, and lncRNAs and Related Regulating Biological Pathways in the Peripheral Blood of COVID-19 Patients전체 전사체 RNA 시퀀싱은 COVID-19 환자의 말초 혈액에서 유의미하게 차별적으로 발현된 mRNA, miRNA, lncRNA 및 관련 조절 생물학적 경로를 나타냅니다Research Article Published on 2021-04-012022-09-10 Journal: Mediators of Inflammation [Category] MERS, SARS, 유전자 메커니즘, [키워드] “cytokine storm” acute respiratory syndrome acute respiratory syndrome coronavirus AKT1 Analysis Antigen antigen processing Biological biosynthetic characterized China coding collected competing control group controls coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID-19 sample COVID-19 samples CXCL8 cytokine cytokine production Cytokine storm cytotoxicity diagnostic biomarker Diagnostic biomarkers differentially expressed downregulated enrichment analysis excessive cytokine production FCGR2A Functional enrichment analyses Gene ontology glycogen ground-glass opacity healthy controls healthy donor healthy donors highlight hub genes indicated Inflammation Interaction involved leukocyte leukocytes lncRNA long noncoding RNA lung tissues lymphocyte Lymphocytes mechanism Messenger RNA messenger RNAs microRNA MicroRNAs Migration miRNA miRNAs mRNA mRNAs noncoding RNA Noncoding RNAs pandemic Pathogenesis peripheral Peripheral blood positive potential mechanism potential mechanisms PPI presenting protein-protein interaction Regulating Regulation Regulatory respiratory resulting RNA SARS-CoV-2 selected Sequencing severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 signaling pathway Significant significantly STAT3 systemic inflammation T cell T cell activation target the healthy therapeutic tissue TLR2 TNFRSF1B upregulated [DOI] 10.1155/2021/6635925 PMC 바로가기 [Article Type] Research Article
Perversely expressed long noncoding RNAs can alter host response and viral proliferation in SARS-CoV-2 infectionResearch Article Published on 2020-10-272022-10-31 Journal: Future Virology [Category] COVID-19, [키워드] Alter Analysis analyzed Cell cellular COVID-19 deregulated determine differentially expressed Differentially expressed genes disease expressed Gene Expression host response identify immune response in viral infections involved lncRNA long noncoding RNA lung epithelial cell material miRNA outcome proliferation protein-coding genes Regulation RNA-seq dataset SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 proteins survival viral infection viral pathogenesis viral proliferation [DOI] 10.2217/fvl-2020-0188 PMC 바로가기 [Article Type] Research Article
Protein Coding and Long Noncoding RNA (lncRNA) Transcriptional Landscape in SARS-CoV-2 Infected Bronchial Epithelial Cells Highlight a Role for Interferon and Inflammatory ResponseArticle Published on 2020-07-072022-10-31 Journal: Genes [Category] COVID-19, SARS, [키워드] activated Activation acute inflammatory response acute respiratory syndrome Analysis Antiviral antiviral response bioinformatics Biomarkers bronchial bronchial epithelial bronchial epithelial cell category caused Cell cell death cells Community coronavirus Course COVID-19 differentially expressed disease expressed gene expression functional functional annotation gene expressions gene target hallmark highlight host cells host response Ifi44 IFI44L IFIT1 IFIT2 IFIT3 IFITM1 IFN IFN response IgG immune response Immunoglobulin in vitro induction Infection innate response interferon Interferon lambda investigated involved IPA IRF9 landscape lncRNA lncRNAs Long long noncoding RNA lung tissue MAPK MX1 Necrosis network analysis NHBE OAS2 OAS3 Ontology pathogenesis of COVID-19 pathogenic Pathway analysis Patient Replication Research response RNA role SARS-CoV-2 SARS-COV-2 infection spread of COVID-19 suppressed tissue TNF Transcriptome upregulated upstream viral infection Viral protein with COVID-19 [DOI] 10.3390/genes11070760 PMC 바로가기 [Article Type] Article
Correlation of Long Noncoding RNA SEMA6A-AS1 Expression with Clinical Outcome in HBV-Related Hepatocellular CarcinomaArticle Published on 2020-03-012023-06-13 Journal: Clinical therapeutics [Category] B형 간염, [키워드] hepatitis B virus X protein Hepatocellular carcinoma long noncoding RNA semaphorin 6A antisense RNA 1. [DOI] 10.1016/j.clinthera.2020.01.012
Xist RNA in action: Past, present, and future활동 중인 Xist RNA: 과거, 현재, 미래Review Published on 2019-09-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] affected chromatin chromosomal dosage embryonic embryonic development Epigenetic event female focus functional gene silencing genomic genomic imprinting inactivation initiate interaction partner knowledge long noncoding RNA male mammal mammals memory modifying factors multitude Perspective plethora recruit Research RNA Sex transcribed transcript Trigger triggers X chromosome X-linked Xist [DOI] 10.1371/journal.pgen.1008333 PMC 바로가기 [Article Type] Review