Epigenetic Regulation and Chromatin Remodeling in Malaria ParasitesArticle Published on 2023-09-302024-09-10 Journal: Annu Rev Microbiol [Category] 말라리아, [키워드] chromatin architecture epigenetics lncRNA long noncoding RNA Plasmodium single cell. PMC 바로가기
Identification of a long noncoding RNA required for temperature induced expression of stage-specific rRNA in malaria parasitesarticle Published on 2023-08-312024-09-01 Journal: Gene [Category] 말라리아, [키워드] Gene Expression long noncoding RNA Temperature induction Transcription [Article Type] article
Single-cell RNA sequencing uncovers the nuclear decoy lincRNA PIRAT as a regulator of systemic monocyte immunity during COVID-19Article Published on 2022-09-062022-11-15 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 진단, [키워드] alarmin antiviral response approach binding blood leukocyte characterized COVID-19 COVID-19 pathogenesis differentially expressed down-regulation driver expression humans Immunity immunopathology JAK-STAT pathway knockout lincRNA lncRNA long noncoding RNA LUCAT1 monocyte Monocytes naïve NF-κB NF-κB-dependent gene noncoding RNA nuclear promote promoter pseudogene PU.1 Release remained RNA RNA sequencing SARS-CoV-2 SARS-COV-2 infection severe COVID-19 Single-cell RNA sequencing single-cell RNA-seq Stat1 suggested systemic immune response target Transcription transcription factor transcription factors transcriptional transgene viral infection [DOI] 10.1073/pnas.2120680119 PMC 바로가기
Of mice and human-specific long noncoding RNAs마우스 및 인간 특이적 긴 비암호화 RNAReview Published on 2022-06-012022-09-11 Journal: Mammalian genome : official journal of the Interna [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 gene acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach BAC Bacterial bacterial artificial chromosome Cell culture cell culture system cell culture systems chromosome complement conducted coronavirus coronavirus disease Coronavirus disease-19 COVID-19 effort ENCODE etiologic agent example exceeded Genome highlight in vivo integration lncRNA long noncoding RNA mechanism mice MOST mouse offer pandemic protein-coding genes random receptor Regulation SARS-CoV-2 severe acute respiratory syndrome Coronavirus upstream Vascular [DOI] 10.1007/s00335-022-09943-2 PMC 바로가기 [Article Type] Review
Characterization of Altered Gene Expression and Histone Methylation in Peripheral Blood Mononuclear Cells Regulating Inflammation in COVID-19 PatientsCOVID-19 환자의 염증을 조절하는 말초 혈액 단핵 세포에서 변경된 유전자 발현 및 히스톤 메틸화의 특성화Article Published on 2022-04-152022-09-11 Journal: Journal of immunology (Baltimore, Md. : 1950) [Category] 유전자 메커니즘, [키워드] alteration Altered Analysis approved arginase Bone marrow cause caused characterization chromosome correlated COVID-19 COVID-19 disease COVID-19 patients COVID-19 treatment Cytokines death Dexamethasone dysregulated Epigenetic expression expression pattern expression patterns expressions gene expression profile Gene expression profiles Genes healthy control healthy controls histone histone methylation hospitalized COVID-19 patient hospitalized COVID-19 patients IL-1 IL-17 IL-1B IL-6 indicated Inflammation information inhibitor investigated kinase kinases long noncoding RNA majority mechanisms member Methylation miRNA pandemic of COVID-19 pathway Pathway analysis Pathways PBMC PBMCs peripheral Potential biomarker potential biomarkers proinflammatory cytokines protein S provide receptor Regulating Regulation significantly target targets TEC TGF-β therapeutic target therapeutic targets treat Treatment upregulated variations von Willebrand factor was increased [DOI] 10.4049/jimmunol.2101099 PMC 바로가기 [Article Type] Article
Differential Expression of lncRNAs and miRNAs Between Self-Rooting Juvenile and Donor Clones Unveils Novel Insight Into the Molecular Regulation of Rubber Biosynthesis in Hevea brasiliensisOriginal Research Published on 2022-01-052023-08-30 Journal: Frontiers in Plant Science [Category] E형 간염, [키워드] Hevea brasiliensis long noncoding RNA miRNA rubber biosynthesis self-rooted juvenile clones [DOI] 10.3389/fpls.2021.740597 PMC 바로가기 [Article Type] Original Research
A Low-Producing Haplotype of Interleukin-6 Disrupting CTCF Binding Is Protective against Severe COVID-19CTCF 결합을 방해하는 인터루킨-6의 저생산 일배체형은 심각한 COVID-19를 예방합니다Research Article Published on 2021-10-122022-09-10 Journal: mBio [Category] MERS, 변종, [키워드] 95% confidence interval allele Analysis antisense Asia Asian bidirectional transcription carrier carriers Chinese conserved correlated COVID-19 COVID-19 patient COVID-19 severity CTCF defined Disease progression disturbance element Endemic enhancer expression functional genetic polymorphisms Genotype Haplotype Human humans hyperinflammation IL-6 IL-6 blockade IL-6 expression induce Inflammatory responses inflammatory stimuli interleukin-6 intronic SNP intronic SNPs loci locus long noncoding RNA lower risk Mild Neanderthal Odds ratio outcome patients polymorphism Polymorphisms promoter Protective Quantitative reduced severe symptom severe symptoms severity significantly single-nucleotide Single-nucleotide polymorphisms SNP SNPs T allele therapy transcribed Variability variant Viral viral infection with COVID-19 [DOI] 10.1128/mBio.01372-21 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 transgressing LncRNAs uncovers the known unknownsLncRNA를 횡단하는 SARS-CoV-2는 알려진 미지의 것을 밝힙니다.Editorial Published on 2021-10-012022-09-11 Journal: Physiological Genomics [Category] SARS, 유전자 메커니즘, [키워드] asked disease pathogenesis endocytosis functional Functional genomics Host host pathogenesis hypothetical lncRNA lncRNAs long noncoding RNA mechanism molecules Open reading frame ORFs Pathogenesis Pathways Perspective Region regulate Regulatory SARS-CoV-2 SARS-CoV-2 pathogenesis the disease transgression. viral infection viral pathogenesis Viral protein Viral proteins [DOI] 10.1152/physiolgenomics.00075.2021 PMC 바로가기 [Article Type] Editorial
Long Noncoding RNAs as Emerging Regulators of COVID-19COVID-19의 새로운 조절자로서의 긴 비코딩 RNAReview Published on 2021-08-022022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 치료제, [키워드] (Tocilizumab) acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Antiviral antiviral immune response antiviral immune responses antiviral role biological processe biological processes cellular changes in Clinical treatment coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 treatment death Dexamethasone disease drug Evidence expression glucocorticoid Glucocorticoids help Host host transcriptome immune dysfunction Immune escape immune responses incidence rate indicate Infection Inflammatory response inhibiting interferons involved lncRNA lncRNAs Long long noncoding RNA mechanisms monoclonal antibodies monoclonal antibody Occurrence pandemic pathology regulate Regulation regulator Research respiratory resulting RNA SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Spread subsequent therapeutic thrombosis Tocilizumab Transcriptome Treatment type I interferon type I interferons up-regulate Viral viral gene viral genes viral infections viral replication virus infection virus infections [DOI] 10.3389/fimmu.2021.700184 PMC 바로가기 [Article Type] Review
Long and short non-coding RNA and radiation response: a reviewReview article Published on 2021-07-012022-10-05 Journal: Translational research : the journal of laboratory [Category] 비임상, [키워드] alteration anti-sense oligonucleotides arising ASOanti-sense oligonucleotides binding biofluids Biomarker CADcoronary artery disease Cancer Cell cellular processe cellular stress response changes in circRNAcircular RNA circular RNA Coronary artery disease DCAdicentric chromosome assay diabete diagnostic dicentric chromosome assay disease Disease progression DNA Effect EMTepithelial-to-mesenchymal transition epithelial-to-mesenchymal transition evaluate examined expression level expression profile form Future gray (unit) Gygray (unit) interactions introduced invasive ionizing radiation IRionizing radiation lncRNA lncRNAlong noncoding RNA Long long noncoding RNA Messenger RNA microRNA miRNA miRNAmicroRNA modulate modulation mRNA mRNAMessenger RNA mRNAs ncRNA ncRNAnoncoding RNA ncRNAs non-coding RNA Non-small cell lung cancer noncoding RNA NSCLCnon-small cell lung cancer oxidative stress PBMCperipheral blood mononuclear cells Peripheral blood mononuclear cells piRNApiwi-interacting RNA piwi-interacting RNA prognostic biomarker Proteins Radiation radiation exposure Radiotherapy reactive oxygen species regulate reported Research RNA RNA expression RNA interference RNAiRNA interference ROSreactive oxygen species serum short hairpin RNA shown shRNAshort hairpin RNA siRNAsmall interfering RNA Small interfering RNA small nuclear RNA small nucleolar RNA snoRNAsmall nucleolar RNA snRNAsmall nuclear RNA stability Stress TBItotal body irradiation therapeutic use thought total body irradiation transfer RNA tRNAtransfer RNA untranslated region UTRuntranslated region [DOI] 10.1016/j.trsl.2021.02.005 [Article Type] Review article