Emerging Therapies for COVID-19: The Value of Information From More Clinical TrialsCOVID-19에 대한 새로운 치료법: 더 많은 임상 시험에서 얻은 정보의 가치Article Published on 2022-08-012022-09-11 Journal: Value in health : the journal of the International [Category] 임상, 진단, [키워드] Analysis approval approved Baricitinib benefit Casirivimab clinical clinician Cohort consequence Cost-benefit analysis COVID-19 COVID-19 pandemic decision support techniques Dexamethasone drug approval. effective Emergency use authorization Evidence Health healthcare hospitalized patient hospitalized patients Hydroxychloroquine Imdevimab implementation information interferon interferon beta Interferon beta-1a Lopinavir Lopinavir-ritonavir outcome pandemic Perspective Randomized controlled trial RCT RCTs Remdesivir Research Ritonavir seeking Support therapy threshold Tocilizumab usual care value with COVID-19 [DOI] 10.1016/j.jval.2022.03.016 PMC 바로가기 [Article Type] Article
Theaflavin 3-gallate inhibits the main protease (M pro) of SARS-CoV-2 and reduces its count in vitroTheaflavin 3-gallate는 SARS-CoV-2의 주요 프로테아제(M pro)를 억제하고 시험관 내에서 그 수를 감소시킵니다.Article Published on 2022-07-302022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] active site Analysis Anti-viral Atazanavir darunavir demonstrated docking score drug target exhibited flavin gallate in viral in vitro inhibit inhibited inhibitor Interaction isolate Lopinavir M pro Molecular docking study Particle protease Protein reduce reduced reduction Replication Repurposed drug Repurposed drugs residue SARS-CoV-2 SARS-CoV-2 virus target the SARS-CoV-2 virus theaflavin Vero Cell Vero cells Viral particles viral replication viral transcript viral transcripts [DOI] 10.1038/s41598-022-17558-5 PMC 바로가기 [Article Type] Article
[Treatments for SARS-CoV-2 infection: A retrospective study of drug-drug interactions and safety][SARS-CoV-2 감염 치료: 약물간 상호작용과 안전성에 대한 후향적 연구]Review Published on 2022-07-012022-09-11 Journal: Annales pharmaceutiques françaises [Category] COVID19(2023년), SARS, 치료제, [키워드] Adverse Adverse drug reaction Adverse drug reactions adverse effect adverse effects adverse event adverse events analyzed association Azithromycin Causality caused conducted COVID-19 disease drug drug reaction drug-drug interaction Drug-drug interactions Effets secondaires et réactions indésirables d’origine médicamenteuse English epidemic wave French Hydroxychloroquine Incompatibilité entre médicaments Infection Lopinavir Lopinavir/ritonavir medical record Patient patients patients treated reported Retrospective study risk Ritonavir SARS-CoV-2 SARS-CoV-2 drug SARS-COV-2 infection [DOI] 10.1016/j.pharma.2021.11.001 PMC 바로가기 [Article Type] Review
Insights from a computational analysis of the SARS-CoV-2 Omicron variant: Host-pathogen interaction, pathogenicity, and possible drug therapeuticsSARS-CoV-2 Omicron 변이체의 컴퓨터 분석에서 얻은 통찰력: 숙주-병원체 상호작용, 병원성 및 가능한 약물 치료법Article Published on 2022-07-012022-09-11 Journal: Immunity, Inflammation and Disease [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 Affect Alter Analysis analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 approach binding affinity Characteristics Comparisons computational analysis correlated correlation correlations COVID-19 COVID-19 case COVID-19 cases docking docking result docking results drug Drug efficacy drugs drugs efficacy effective Effectiveness epidemiological evaluate evaluated Factor genomic sequence Host host-pathogen interaction human receptors insight Interaction lack less Lopinavir molecular docking molecular dynamics Molecular dynamics simulation Mutation mutational spectrum Nirmatrelvir NRP1 occurred omicron Omicron variant pathogenic pathogenicity Phylogenetic tree protease Protein Proteins raised Receptor-binding domain reconstructed Research response significant difference significant differences tested the receptor-binding domain the SARS-CoV-2 therapeutic approaches variant [DOI] 10.1002/iid3.639 PMC 바로가기 [Article Type] Article
Revealing the toxicity of lopinavir- and ritonavir-containing water and wastewater treated by photo-induced processes to Danio rerio and Allivibrio fischeriDanio rerio 및 Allivibrio fischeri에 광유도 공정으로 처리된 로피나비르 및 리토나비르 함유 용수 및 폐수의 독성 공개Article Published on 2022-06-102022-09-11 Journal: The Science of the total environment [Category] 치료제, [키워드] Affect affecting antiviral drug antiviral drugs Bacteria Behavior Chronic toxicity Concentration Contact contact with coronavirus disease Coronavirus disease 2019 COVID-19 Danio drug Ecotoxicity edema Efficiency form hospital Impact increase in indicate Inflammation Lopinavir LOPINAVIR AND RITONAVIR Organisms oxidative stress oxygen parameter Photocatalysis Photolysis physicochemical plants predicted problem protocols reduce Ritonavir shortening significantly survival tail toxic effect Toxicity treated Treatment wastewater water zebrafish [DOI] 10.1016/j.scitotenv.2022.153967 PMC 바로가기 [Article Type] Article
HIV protease inhibitors Nelfinavir and Lopinavir/Ritonavir markedly improve lung pathology in SARS-CoV-2-infected Syrian hamsters despite lack of an antiviral effectHIV 프로테아제 억제제 Nelfinavir 및 Lopinavir/Ritonavir는 항바이러스 효과가 없음에도 불구하고 SARS-CoV-2에 감염된 시리아 햄스터의 폐 병리를 현저하게 개선합니다Article Published on 2022-06-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] accompanied activated neutrophil Activated neutrophils Adhesion Molecule adhesion molecules Alter Antiretroviral therapy antiviral activity Antiviral effect appear Blood Combination component CXCL8 did not reduce expression hamster hamsters highly active HIV HIV protease inhibitor human neutrophil human neutrophils immunomodulatory effect IMPROVE in vitro increase in independent independent of induce Infectious virus infiltration of neutrophil infiltration of neutrophils interstitium lack Lopinavir Lopinavir/ritonavir lung Lung pathology Migration nelfinavir neutrophil Neutrophils non-infected Protease inhibitor protease inhibitors protective effect receptor reported Ritonavir SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 titre Treatment treatment of HIV Viral viral RNA load [DOI] 10.1016/j.antiviral.2022.105311 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Infection-Of Music and Mechanics of Its Spikes! A PerspectiveArticle Published on 2022-05-242022-11-15 Journal: ACS Nano [Category] COVID19(2023년), SARS, 치료제, [키워드] ACE2 arising Biochemistry cellular Cobicistat coronavirus COVID-19 COVID-19 pandemic D614G darunavir Disulfide dorian Egmont endocytosis GSH GSSG hydrogen bonds Lipid rafts Lopinavir manifestation Mechanics mechanobiology music Pandemics peptide piezoelectricity produced Remdesivir Research Ritonavir SARS-CoV-2 spikes the SARS-CoV-2 virus Vaccine Vaccines virus virus propagation while [DOI] 10.1021/acsnano.1c11491 PMC 바로가기
Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses코로나19 입원 환자를 위한 렘데시비르 및 기타 3가지 약물: WHO 연대 무작위 시험의 최종 결과 및 업데이트된 메타 분석Meta-Analysis Published on 2022-05-212022-09-11 Journal: Lancet (London, England) [Category] 신약개발, 임상, 치료제, [키워드] 1:1 allocation Analysis antiviral drugs assigned average both groups Characteristics Compliance controls country COVID-19 COVID-19 diagnosis database death died discharge discharged disease severity drug drugs eligible patient Endpoint enrolled exclusion Final futility hospital Hospital mortality hospitalised hospitalised patient Hospitalised patients Hydroxychloroquine in both groups in-hospital mortality Inpatient Inpatients interferon ISRCTN Kaplan-Meier Local Lopinavir meta-analyses Meta-analysis Mortality mortality analysis mortality rate ratio no significant effect occurred Open-label outcome oxygen participant Patient patients patients with COVID-19 Placebo placebos primary endpoint progressed progression proportion randomisation Randomised trial Randomly rate ratio receive recruited regions Registered Remdesivir reported secondary Secondary endpoints solidarity Solidarity trial Standard of care study drug the WHO treatment period Trial Ventilated Ventilation were given WHO [DOI] 10.1016/S0140-6736(22)00519-0 PMC 바로가기 [Article Type] Meta-Analysis
Optimal Drug Regimen and Combined Drug Therapy and Its Efficacy in the Treatment of COVID-19: A Within-Host Modeling Study최적의 약물 요법과 복합 약물 요법과 COVID-19 치료의 효능: 숙주 내 모델링 연구Article Published on 2022-05-192022-09-11 Journal: Acta biotheoretica [Category] COVID19(2023년), SARS, 치료제, [키워드] Administered administration Arbidol average basic reproduction number Cell Combination combination therapies combination therapy Combined Comparative Comparative effectiveness study COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 pathogenesis death drug Drug interventions drugs Effectiveness Efficacy help include infected cells infection-related mortality Inflammatory mediators interferon Intervention life-threatening Lopinavir Lopinavir/ritonavir mathematical medical intervention modeling number of infected Optimal control problem Optimal drug Regimen physician reduce regimen Remdesivir Ritonavir significantly Stage susceptible cell Treatment treatment of COVID-19 Viral load were used [DOI] 10.1007/s10441-022-09440-8 PMC 바로가기 [Article Type] Article
Effects of Drugs Formerly Suggested for COVID-19 Repurposing on Pannexin1 Channels이전에 COVID-19 용도 변경을 위해 제안된 약물이 Pannexin1 채널에 미치는 영향Article Published on 2022-05-182022-09-11 Journal: International Journal of Molecular Sciences [Category] 신약개발, 유전자 메커니즘, [키워드] Alter Analysis Anti-inflammatory Anti-inflammatory drugs Antiviral antiviral and anti-inflammatory drugs Azithromycin candidate Chain Reaction channel Chloroquine clinical trial clinical trials Combination COVID-19 COVID-19 patients Dexamethasone Diseases drug drug candidate drug target Effect effort extracellular ATP Favipiravir functional Hydroxychloroquine immune response Immunoblot analysis Inflammation inhibit inhibitor Lopinavir mechanism mRNA expression mRNA levels outcome pandemic pannexin1. Pathogenesis pathogenesis of COVID-19 polymerase chain polymerase chain reaction Protein Quantitative Remdesivir repurposing ribavirin Ritonavir selected tested Treatment viral infections were used without affecting [DOI] 10.3390/ijms23105664 PMC 바로가기 [Article Type] Article