Remdesivir treatment in hospitalized patients affected by COVID-19 pneumonia: A case-control studyCOVID-19 폐렴에 감염된 입원 환자의 렘데시비르 치료: 사례-대조군 연구Observational Study Published on 2022-08-012022-10-30 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 임상, 치료제, [키워드] Admission adverse event adverse events affected Analysis analyzed Antiviral antiviral therapy Antiviral treatment baseline characteristics case-control study Clinical outcome clinical outcomes control group coronavirus disease Coronavirus disease 2019 COVID-19 Efficacy Hospitalization hospitalized patient hospitalized patients ICU ICU admission in vitro activity intensive care intensive care unit lower mortality mortality rate Multivariate analysis observational study Odds ratio patients treated Remdesivir reported retrospective risk SARS-CoV-2 severe coronavirus disease significantly lower subject supportive therapies survival survival analysis treated Treatment two groups viruses with COVID-19 [DOI] 10.1002/jmv.27768 PMC 바로가기 [Article Type] Observational Study
Sofosbuvir with daclatasvir and the outcomes of patients with COVID-19: a systematic review and meta-analysis with GRADE assessmentdaclatasvir와 Sofosbuvir 및 COVID-19 환자의 결과: GRADE 평가를 통한 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-07-012022-09-11 Journal: Postgraduate medical journal [Category] 임상, [키워드] Admission certainty of evidence chance clinical clinical pharmacology clinical recovery clinically control group Controlled trial COVID-19 daclatasvir database databases death defined estimate evaluate the effect ICU ICU admission IMV inception increase in Infectious diseases intensive care intensive care unit internal medicine intervention group Invasive mechanical ventilation lower mortality Meta-analysis moderate Mortality mortality rate outcome Patient patients with COVID-19 performed Primary outcome randomised controlled trial reduce mortality rate reduced reported risk ratio risk ratios risk reduction RRs secondary outcome Secondary outcomes sofosbuvir sofosbuvir/daclatasvir Standard of care systematic literature search systematic review Virology [DOI] 10.1136/postgradmedj-2021-140287 PMC 바로가기 [Article Type] Meta-Analysis
Does metformin affect outcomes in COVID-19 patients with new or pre-existing diabetes mellitus? A systematic review and meta-analysisReview Published on 2022-06-012022-10-04 Journal: British Journal of Clinical Pharmacology [Category] 신약개발, [키워드] adjusted Affect affected approach biguanides carried certainty cohort study coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 patient database diabete Diabetes Mellitus Effect Evidence exhibiting global public health glycaemic control highlight immune responses IMPROVE lower mortality Meta-analysis metformin Mortality Odds ratio outcome outcomes Patient patients with COVID-19 patients with diabete Poor Primary outcome Quantitative random-effect Randomised trial recent Registered reported risk of bia robust SARS-CoV-2 searched shown significantly systematic review Treatment type 2 diabetes weakened Web of Science [DOI] 10.1111/bcp.15258 PMC 바로가기 [Article Type] Review
Gastrointestinal manifestations of COVID-19 in a single center in the Eastern Province of Saudi ArabiaObservational Study Published on 2022-05-012022-10-04 Journal: Saudi journal of gastroenterology : official journ [Category] COVID19(2023년), SARS, 임상, [키워드] 95% CI abdominal pain acute respiratory distress Altered mental status AOR association conducted COVID-19 COVID-19 infection Cytokine storm syndrome death diarrhea Gastrointestinal gastrointestinal manifestations GI symptom higher risk hospital hospitalized COVID-19 patient less lower mortality lung field lung infiltration manifestation Manifestations Middle East Mortality mortality rate multiorgan failure nausea Novel coronavirus outcome Patient patients PCR test positive Prevalence reported retrospective Saudi Arabia severe COVID-19 disease severity single center Symptom syndrome university hospital vomiting [DOI] 10.4103/sjg.sjg_547_21 PMC 바로가기 [Article Type] Observational Study
Organ dysfunction and death in patients admitted to hospital with COVID-19 in pandemic waves 1 to 3 in British Columbia, Ontario and Quebec, Canada: a cohort studyObservational Study Published on 2022-04-192022-10-04 Journal: CMAJ open [Category] COVID19(2023년), SARS, 임상, [키워드] 28-day mortality 95% CI 95% confidence interval acute COVID-19 adjusted Admission angiotensin receptor blocker ARB association average baseline characteristics changes in cohort study Community Comorbidity conducted COVID-19 pandemic death demographic characteristics Dexamethasone dysfunction examined excluded hospital Hospital admission IMPROVE in-hospital mortality Invasive mechanical ventilation less Logistic lower mortality management Mortality multicentre Observational cohort study Odds ratio organ support outcome outcomes pandemic Patient Pragmatic readmission Regression model remained renal dysfunction renal replacement therapy RRT severity of illness significantly lower therapy Vasopressor with COVID-19 [DOI] 10.9778/cmajo.20210216 PMC 바로가기 [Article Type] Observational Study
The demographic and geographic impact of the COVID pandemic in Bulgaria and Eastern Europe in 2020 Research Published on 2022-04-152022-10-05 Journal: Scientific Reports [Category] 유전자 메커니즘, [키워드] affected age Bulgaria cardiovascular diseases caused consequence country Course COVID COVID-19 pandemic death deaths declined demographics EMR Europe European European country independent intensity introduced lack lockdown lower mortality measure Measures medical resource Medical resources Metrics Mortality mortality rate pandemic Predictive Prevalence reduction regions Significant the epidemic trajectory unique [DOI] 10.1038/s41598-022-09790-w [Article Type] Research
Mechanisms and clinical evidence to support melatonin’s use in severe COVID-19 patients to lower mortalityReview article Published on 2022-04-012022-10-05 Journal: Life sciences [Category] COVID19(2023년), SARS, 변종, 신약개발, 임상, [키워드] activity adaptive Adaptive immunity added antibody formation approved Cell clinical evidence clinical trial country COVID-19 downregulate driven by Emergency use ENhance FDA fraction help high mortality Host Host immune response immune reaction include Inflammation inhibit innate immune response Innate immunity intubation less limit lower mortality main protease medication Medicine melatonin Mortality Nirmatrelvir pandemic promote reduce reducing mortality Replication Ritonavir safety margin SARS-CoV-2 SARS-COV-2 infection seasonal flu severe COVID-19 severe COVID-19 patient severe COVID-19 patients severity significantly Support suppress the cytokine storm the SARS-CoV-2 therapy tracheal treat Treatment Viral virulence virus virus infection [DOI] 10.1016/j.lfs.2022.120368 [Article Type] Review article
Vaccination status among patients with the need for emergency hospitalizations related to COVID-19코로나19 관련 긴급 입원이 필요한 환자의 예방접종 현황Article Published on 2022-04-012022-09-11 Journal: The American journal of emergency medicine [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI 95% confidence interval age Alpha Alpha variant Analysis Characteristics chronic obstructive chronic obstructive pulmonary disease Comorbidities Comorbidity CoronaVac COVID-19 COVID-19 patients COVID-19 vaccines curiosity Delta delta variant diabetes Diabetes Mellitus died disease dose Efficacy Emergency emergency department emergency medicine emergency room Emergency use evaluate Factor Gender Hospitalization hospitalizations hypertension intensive care intensive care unit intervals lower mortality male matter moderate Mortality mortality rates multivariate logistic regression multivariate logistic regression analysis obstructive pulmonary disease Odds ratio Older other variant other variants Patient patients hospitalized performed Pfizer-BioNTech pulmonary disease reduce Regression analyses Retrospective study rRT-PCR SARS-COV-2 infection severe COVID-19 significantly significantly higher the patient the vaccine thought vaccination Vaccination Status Vaccine vaccine efficacy variant was performed women [DOI] 10.1016/j.ajem.2022.01.067 PMC 바로가기 [Article Type] Article
Metformin is associated with favorable outcomes in patients with COVID-19 and type 2 diabetes mellitus Research Published on 2022-04-012022-10-05 Journal: Scientific Reports [Category] 치료법, [키워드] 95% CI adjusted Admission analyzed anti-inflammatory properties Anti-viral association Care Coronavirus disease 2019 COVID-19 decrease Effect Enrollment event Evidence Hospitalization hospitalized patient In-hospital in-hospital mortality increased survival less lower mortality metformin Mortality multivariable Odds ratio offer outcome pandemic patients with COVID-19 Primary outcome Probability propensity score matching Retrospective study risk factor severe disease significantly therapy treated Treatment type 2 diabete Weighting with COVID-19 [DOI] 10.1038/s41598-022-09639-2 [Article Type] Research
Clinical characteristics, systemic complications, and in-hospital outcomes for patients with COVID-19 in Latin America. LIVEN-Covid-19 study: A prospective, multicenter, multinational, cohort studyObservational Study Published on 2022-03-312022-10-04 Journal: PLoS ONE [Category] 임상, [키워드] affected age carried Characteristics clinical Clinical characteristics cohort study collected Complication complications country COVID-19 COVID-19 pandemic described Descriptive statistics discharge Factor functional globe hospital hospital discharge ICU ICU admission ICU patient identify In-hospital lack Latin Latin America lower mortality material Mortality mortality rate Most patient multicenter obesity Observational cohort study outcome outcomes Patient patients patients with COVID-19 patients with SARS progression reported risk factor self-care severe COVID-19 Shortness of breath Spread subject systemic were used [DOI] 10.1371/journal.pone.0265529 PMC 바로가기 [Article Type] Observational Study