Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men안드로겐 신호는 SARS-CoV-2 수용체 수준을 조절하고 남성의 심각한 COVID-19 증상과 관련이 있습니다Article Published on 2020-12-032022-09-11 Journal: Cell Stem Cell [Category] Fulltext, MERS, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] 5-alpha reductase inhibitors ACE2 ACE2 expression ACE2 regulation Analysis androgen androgen signaling angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 binding Cell cell membrane Clinical data Compound COVID-19 COVID-19 patient COVID-19 risk factors COVID-19 sex bias deep learning demonstrated disease disease severity disease susceptibility Diseases drug drug re-purposing elevated embryonic embryonic stem cell enzyme Genetic variant genetic variants Health Health crisis high content screening hPSC-based disease modeling identify Infection Level lung organoid lung organoids mechanism men occur offer potential treatment option Prostate reduce reduced risk risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection model screening strategy Sex stem cell susceptibility target the cell the disease virtual drug screen. virus [DOI] 10.1016/j.stem.2020.11.009 PMC 바로가기 [Article Type] Article
Humanized COVID‐19 decoy antibody effectively blocks viral entry and prevents SARS‐CoV‐2 infection인간화 COVID-19 미끼 항체는 바이러스 침입을 효과적으로 차단하고 SARS-CoV-2 감염을 예방합니다Article Published on 2020-11-302022-09-11 Journal: EMBO Molecular Medicine [Category] SARS, 변종, 진단, [키워드] abrogate ACE2 ACE2‐Fc activate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin II antibody block cascade caused cells cellular receptor Characteristics circumvent coronavirus COVID‐19 COVID‐19 cytokine D614G variant D614G variants decoy antibody degranulation demonstrated develop domain effective enzyme fusion protein H1975 humanized immunology impairment Infection Interaction lung cell lung cells lung organoids Microbiology, Virology & Host Pathogen Interaction NK cell not affected pandemic peptidase preservation Prevent Pseudotyped virus reduce respiratory SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 spike SARS‐CoV‐2 severe acute respiratory syndrome Coronavirus shown Spike protein Strains therapeutic Treatment Viral viral entry viral spike protein virus infection virus replication virus variants [DOI] 10.15252/emmm.202012828 PMC 바로가기 [Article Type] Article