Exploration of the Mechanism of Lianhua Qingwen in Treating Influenza Virus Pneumonia and New Coronavirus Pneumonia with the Concept of “Different Diseases with the Same Treatment” Based on Network PharmacologyResearch Article Published on 2022-02-082022-10-31 Journal: Evidence-based Complementary and Alternative Medicine : eCAM [Category] COVID-19, [키워드] 3CL ACE2 angiotensin-converting enzyme 2 Apoptosis binding biological process biological processes cell proliferation component components concept COX2 cytokine Cytoscape database DAVID docking docking result emodin enrichment analysis exploration FIVE IL-17 IL-6 immune system Influenza virus interleukin-6 Intervention Invasion involved KEGG Kyoto Luteolin MAPK mechanism metabolism Necrosis network New Novel coronavirus Occurrence Ontology pathway Pathway enrichment analysis Pathways Pharmacology Pneumonia protease Protein quercetin Regulation Result rutin screened Seven T cell receptor target targets TNF Toll-like receptor treating Treatment was used [DOI] 10.1155/2022/5536266 PMC 바로가기 [Article Type] Research Article
Luteolin Potentially Treating Prostate Cancer and COVID-19 Analyzed by the Bioinformatics Approach: Clinical Findings and Drug Targets전립선암 및 COVID-19를 잠재적으로 치료하는 루테올린, 생물정보학 접근법으로 분석: 임상 결과 및 약물 표적Endocrinology Published on 2022-02-012022-09-11 Journal: Frontiers in Endocrinology [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] Anti-inflammatory effects anticancer bioinformatics characterized clinical clinical feature conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 treatment curative demonstrated Differential gene expression downregulated gene drug drug target Efficiency enhancement enrichment Epidemic evidenced expression finding FOS function Genes Immunity Infection Luteolin malignancies mechanism metabolism molecular docking MPO Mutation network pharmacology Patient patients pharmacological mechanism Prostate cancer RNA sequencing SARS-COV-2 infection signaling pathways target targets the SARS-CoV-2 treating Treatment Vaccine was determined [DOI] 10.3389/fendo.2021.802447 PMC 바로가기 [Article Type] Endocrinology
A Practical Strategy for Exploring the Pharmacological Mechanism of Luteolin Against COVID-19/Asthma Comorbidity: Findings of System Pharmacology and Bioinformatics AnalysisCOVID-19/천식 동반 질환에 대한 루테올린의 약리학적 메커니즘 탐색을 위한 실용적인 전략: 시스템 약리학 및 생물정보학 분석 결과Immunology Published on 2022-01-072022-09-11 Journal: Frontiers in Immunology [Category] 치료제, [키워드] activities Against AKT1 ALB Anti-inflammatory Antiviral approach Asthma binding binding activity Bioactivity Bioinformatics analysis biological activity Biological functions blood circulation Cancer Cell cell growth Comorbidity coronavirus disease Coronavirus disease 2019 COVID-19 Defense disease drug candidate Effect effective EGFR enrichment analysis ErbB evaluate Evidence experiments finding growth Health HIF-1 IL-6 immune regulation immune responses indicate indicated Inflammation Luteolin MAPK mechanism molecular docking analysis molecular mechanism oxidative stress pathway Patient PD-1 PD-L1 performed Pharmacology Physicochemical properties physicochemical property poor prognosis predicted Protein–protein interaction RAGE reducing Regulation Replication Research SARS-COV-2 infection Signaling Strategy suggested susceptibility System system pharmacology target targets TNF Toll-like receptor TP53 VEGFA virus [DOI] 10.3389/fimmu.2021.769011 PMC 바로가기 [Article Type] Immunology
Yindan Jiedu granules exhibit anti-inflammatory effect in patients with novel Coronavirus disease (COVID-19) by suppressing the NF-κB signaling pathwayYindan Jiedu 과립은 NF-κB 신호 전달 경로를 억제하여 신종 코로나바이러스 감염증(COVID-19) 환자에서 항염증 효과를 나타냅니다.Randomized Controlled Trial Published on 2022-01-012022-09-11 Journal: Phytomedicine : international journal of phytother [Category] SARS, 유전자 메커니즘, 임상, [키워드] accompanied Activation acute lung injury amyloid A Analysis animals anti-inflammatory effect Anti-inflammatory effects assigned caused CD4 cells clinical Clinical research Compound compounds control group coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 progression Cytokines death decrease disease dissipation docking Effect enrichment analysis erythrocyte sedimentation erythrocyte sedimentation rate evaluate evaluated Factor Granule high-performance liquid chromatography histological HPLC IL-1β IL-6 immune in vitro increase in Inflammation Inflammatory Inflammatory cytokine Inflammatory cytokines inflammatory factors inhibit inhibiting Interaction IκBα kaempferol lesion Ligand ligands lipopolysaccharide lung Lung injury Luteolin mass spectrometry mechanism mechanism of action molecular docking Negative conversion network model NF-κB NF-κB pathway NF-κB signaling NF-κB signaling pathway nuclear translocation nucleic acid overlapping p65 pandemic participant pathway Patient Pharmacology Pharmacology analysis Phosphorylation progression propensity score matching PSM quercetin Randomly recruited sedimentation rate serum serum amyloid significantly strong interaction suppressed T cell Tandem mass spectrometry target targets therapeutic effect therapeutic effects TNF-α viral nucleic acid were measured Yindan jiedugranules. [DOI] 10.1016/j.phymed.2021.153784 PMC 바로가기 [Article Type] Randomized Controlled Trial
New tale on LianHuaQingWen: IL6R/IL6/IL6ST complex is a potential target for COVID-19 treatmentLianhuaqingwen에 대한 새로운 이야기 : IL6R/IL6/IL6ST 복합체는 COVID-19 치료의 잠재적 목표입니다.Research Paper Published on 2021-11-152022-08-31 Journal: Aging (Albany NY) [Category] MERS, SARS, 유전자 메커니즘, 치료제, [키워드] Activation addition Affect affecting AGE-RAGE signaling pathway alleviate Analysis approach Beta binding binding activity biological process clinical symptom Clinical symptoms complex COVID-19 cytokine Cytokines docking downstream enrichment analysis GeneCard hydrogen hydrogen bonds IL6 IL6R IL6R/IL6/IL6ST complex IL6ST IMPROVE Inflammatory response ingredient inhibit Interaction interleukin interleukin 6 LianhuaQingwen LianHuaQingWen (LHQW) lipopolysaccharide Luteolin mechanism molecular docking analysis N-terminal domain New Ontology pathogenic Pathways potential molecular Protein protein-protein interaction quercetin RAGE receptor regulate Regulation S protein screened severity of COVID-19 Signal transduction signaling pathway spike Spike protein subunit target TCMSP the S protein therapeutic target therapeutic targets treating COVID-19 Treatment UniProt wogonin [DOI] 10.18632/aging.203666 PMC 바로가기 [Article Type] Research Paper
A Review of Medicinal Plants with Antiviral Activity Available in Bangladesh and Mechanistic Insight Into Their Bioactive Metabolites on SARS-CoV-2, HIV and HBVPharmacology Published on 2021-11-082022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] activity Antiviral antiviral activity antiviral drug antiviral drug discovery antiviral drugs apigenin bioassay component Compound death demonstrated effective EGCG Epigallocatechin-3-gallate exhibiting HBV Health Hepatitis hesperidin HIV Human immunodeficiency virus in silico in vitro in vivo inhibit insight kaempferol Luteolin medicinal plants molecular target natural antiviral piperine plant plants quercetin reported response review rosmarinic acid SARS-CoV-2 SARS-CoV-2 viral replication strain Toxicity Treatment variety Viral diseases viral infection virus viruses [DOI] 10.3389/fphar.2021.732891 PMC 바로가기 [Article Type] Pharmacology
Ways to Address Perinatal Mast Cell Activation and Focal Brain Inflammation, including Response to SARS-CoV-2, in Autism Spectrum DisorderReview Published on 2021-08-292022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] ACE2 activated Activation address affected allergens allergies Amygdala angiotensin-converting enzyme 2 anti-inflammatory cytokine approach ASD association Asthma atopic dermatitis autism Autism Spectrum Disorder binding block Brain changes children Comorbidity complicate COVID-19 Cytokines Deceased decreased expression disorder disrupting drug effective electrical Epidemiological study expression flavonoids Focal gestation IL-18 increased expression Inflammation Inflammatory inhibit inhibitor Luteolin mast cell Mast cells microglia mother neurodegenerative neuronal Pathogenesis Patient Perinatal Pregnancy Prevalence Proinflammatory cytokine receptor regulate reported response SARS-CoV-2 Spectrum Stress threshold tissue toxins Treatment triggered virus [DOI] 10.3390/jpm11090860 PMC 바로가기 [Article Type] Review
Ugonin J Acts as a SARS-CoV-2 3C-like Protease Inhibitor and Exhibits Anti-inflammatory PropertiesPharmacology Published on 2021-08-262022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] 3CL protease inhibitor 3CLpro 50% effective concentration A549 cells Act activities acute respiratory distress acute respiratory syndrome addition alveolar Anti-inflammatory anti-inflammatory activity Antioxidative Antiviral antiviral agent ARDS block cause Concentration coronavirus COVID-19 death direct-acting epithelial form in viral Infection inhibitory activity Interaction investigated kaempferol Lung inflammation Luteolin Perspective Pneumonia property protease Protein renal Replication reported SARS-CoV-2 SARS-COV-2 infection Symptom syndrome therapeutic therapeutic activity therapeutic potential ugonin J van der Waal VERO E6 cells [DOI] 10.3389/fphar.2021.720018 PMC 바로가기 [Article Type] Pharmacology
Luteolin: a blocker of SARS-CoV-2 cell entry based on relaxed complex scheme, molecular dynamics simulation, and metadynamicsLUTEOLIN : 편안한 복합 체계, 분자 역학 시뮬레이션 및 Metadynamics에 기초한 SARS-CoV-2 세포 진입의 차단제Article Published on 2021-07-082022-08-31 Journal: Journal of molecular modeling [Category] SARS, 치료제, [키워드] African antimalarial Antiviral bioassay biological property carried claimed Community complex Compound computational method Computational methods COVID-19 docking free energy inhibited life Luteolin mechanism mechanism of action medication medications Metadynamics molecular molecular dynamics Molecular dynamics simulation natural outbreak Result SARS-CoV-2 SARS-CoV-2 cell tested Tetradenia Viral viral cell [DOI] 10.1007/s00894-021-04833-x PMC 바로가기 [Article Type] Article
Antiviral Activity of Vitis vinifera Leaf Extract against SARS-CoV-2 and HSV-1Article Published on 2021-06-292022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] activity acute respiratory syndrome antimicrobial Antiviral antiviral activity antiviral drug apigenin Bacteria biological activity biological property Compound Concentration coronavirus derivative derivatives early stage Extract flavonoids fungi herpes simplex virus highlight HSV-1 Infection inhibit kaempferol LC-MS leaf leaf extract Luteolin molecular networking natural extract pandemic Pathogens Protein quercetin SARS-CoV-2 SARS-CoV-2 replication Vaccines viral surface viruses Vitis Vitis vinifera widespread Wine [DOI] 10.3390/v13071263 PMC 바로가기 [Article Type] Article