Nucleoside Analogs and Nucleoside Precursors as Drugs in the Fight against SARS-CoV-2 and Other CoronavirusesSARS-CoV-2 및 기타 코로나바이러스와의 싸움에서 약물로서의 뉴클레오사이드 유사체 및 뉴클레오사이드 전구체Review Published on 2021-02-132022-08-31 Journal: Molecules [Category] MERS, 신약개발, 치료제, [키워드] active against acute respiratory syndrome approach China colds common colds coronavirus coronavirus disease CoV COVID-19 CoVs derivative drug effective drug effective drugs effective therapy Epidemics family Coronaviridae Favipiravir focus growth HCoV Health Organization human CoV humans Infection infections inhibit lead main mechanism mammal mammals mass vaccination MERS MERS-CoV Middle East Middle East respiratory syndrome Mild molnupiravir nucleoside nucleoside drugs nucleosides Other pandemic positive result positive-sense precursor provide Remdesivir respiratory respiratory diseases respiratory infections responsible ribavirin RNA SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe respiratory disease severe respiratory diseases sofosbuvir Spread the SARS-CoV-2 therapy upper respiratory infection vaccination Viral diseases virus viruses while WHO World Health Organization [DOI] 10.3390/molecules26040986 PMC 바로가기 [Article Type] Review
COVID 19-Induced Smell and Taste Impairments: Putative Impact on PhysiologyPhysiology Published on 2021-01-262022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] Anosmia asymptomatic phase Central nervous system consequence country COVID COVID 19 COVID 19 patient Feeding behavior Impact impairment involved main mechanism management nasal Pathways physiological functions Physiology physiopathology receptor reported Smell Symptom Taste the patient virus [DOI] 10.3389/fphys.2020.625110 PMC 바로가기 [Article Type] Physiology
Overview of current adipose-derived stem cell (ADSCs) processing involved in therapeutic advancements: flow chart and regulation updates before and after COVID-19치료 발전과 관련된 현재 지방 유래 줄기 세포(ADSC) 처리 개요: COVID-19 전후의 흐름도 및 규정 업데이트Review Published on 2021-01-042022-09-12 Journal: Stem Cell Research & Therapy [Category] MERS, 진단, [키워드] absence added ADSCs agency ATMPs autocrine benefit Blood Bone marrow Cell Cell therapy cellular cGMP comparison Comparisons complexity Cord blood COVID-19 criteria damaged dependent on discrepancies discrepancy Efficiency flow chart GMP good manufacturing practice HCT/P 351-361 highlight Infection initial involved Laboratory limitation main mechanism main mechanisms management manifestation Medical devices occur outcome overcome paracrine parameter pathway Patient patient safety protocol protocols raised regeneration regenerative regenerative medicine Regulation security setup Specific Standardization stem cell Stem cell therapy stem cells the patient therapeutic therapy Variability virus widespread [DOI] 10.1186/s13287-020-02006-w PMC 바로가기 [Article Type] Review
Treatments in Covid-19 patients with pre-existing metabolic dysfunction-associated fatty liver disease: A potential threat for drug-induced liver injury?Short communication Published on 2020-12-012022-10-05 Journal: Biochimie [Category] 치료제, [키워드] acute respiratory distress Antibiotics antiretroviral antiviral agent Bacterial contributed coronavirus disease COVID-19 COVID-19 patients cytochrome P450 Cytokine storm death disease drug Drug hepatotoxicity Drug-induced liver injury Enzymes Epidemic Factors Fatty liver fibrosis fungal healthy individual hepatotoxic higher risk Hospitalized Hypothesis induce insulin resistance lipid homeostasis liver main mechanism mechanism metabolic disease mitochondrial dysfunction multi-organ failure NASH non-infected obese COVID-19 patient obese COVID-19 patients obesity other disease oxidative stress participated Patient patients receive Remdesivir required risk severity steatohepatitis steatosis syndrome systemic inflammation treat [DOI] 10.1016/j.biochi.2020.08.018 [Article Type] Short communication
I mmunosenescence and Inflammaging: Risk Factors of Severe COVID-19 in Older PeopleI 면역노화와 염증: 고령자의 중증 COVID-19 위험 요인Review Published on 2020-10-272022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, [키워드] Adaptive immune response addition advanced age aging aging process change condition coronavirus correlation COVID-19 Cytokines decrease decreases disease disease pathogenesis dysfunction exacerbated Factor immune responses immunological immunological change immunological changes immunosenescence include individual Infection inflammaging Inflammatory cytokines Influenza involved main mechanism main mechanisms mechanism occur Older SARS-CoV-2 SARS-COV-2 infection susceptibility susceptible the disease [DOI] 10.3389/fimmu.2020.579220 PMC 바로가기 [Article Type] Review
Probiotics in Medicine: A Long DebateImmunology Published on 2020-09-252022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, SARS, [키워드] allergy alveolar amplify approach autoimmune conditions Bacterial Bifidobacterium Central nervous system clinical study Clinical use clinician COVID-19 debate Defense diarrhea Diseases disorder disorders Efficacy and safety Evidence favor gut microbiota Health Host immune system include infections intestinal intestinal epithelium intestine Invasion lactobacillus large sample liver Long lung Macrophage main mechanism Medicine microbiota mucosal occur pandemic Pathogens Pneumonia Population Prevent Probiotics protective role provided reduce reduction Regulation respiratory infection respiratory infections Scientific community Symptom Therapeutic approach therapeutic potential therapy Treatment viral infection viral infections [DOI] 10.3389/fimmu.2020.02192 PMC 바로가기 [Article Type] Immunology
Current Findings Regarding Natural Components With Potential Anti-2019-nCoV ActivityCell and Developmental Biology Published on 2020-07-032022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] 2019-nCoV 2019-nCoV infection 3CL pro ACE2 activity addition approach candidate cause cellular receptor China Chinese component Compound contribute coronavirus COVID-19 current disease drug Effects element enzyme Evidence feasibility finding functional mechanisms functions Helicase inhibit M pro main mechanism Measures natural natural products Novel coronavirus pandemic plant compounds Pneumonia Potential Precaution preventing infection provided recent S protein Spread structural feature structural protein targeting therapeutic agent Therapeutic strategies Vaccine virus WHO World Health Organization [DOI] 10.3389/fcell.2020.00589 PMC 바로가기 [Article Type] Cell and Developmental Biology