Evidence of previous SARS-CoV-2 infection in seronegative patients with long COVID장기간 코로나바이러스에 감염된 혈청 음성 환자의 이전 SARS-CoV-2 감염의 증거Article Published on 2022-07-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acute illness antibody assay Cambridge Cohort Consensus COVID COVID-19 illness Definition detectable Diagnosis diagnostic Evidence evidence of IFN-γ IL-2 Immunity infected with SARS-CoV-2 Innovation Long Long COVID Medical Research Council MRC NHSBT NIHR non-hospitalised Patient patients peptides positive PCR test Research reveal SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 peptide SARS-CoV-2 peptides seronegative patient seronegative patients supported Symptoms T cell T cell response T cell responses T cell. T cells tested Trust United Kingdom Wellcome Trust [DOI] 10.1016/j.ebiom.2022.104129 PMC 바로가기 [Article Type] Article
COVID-19 vaccine waning and effectiveness and side-effects of boosters: a prospective community study from the ZOE COVID StudyCOVID-19 백신 약화 및 부스터의 효과 및 부작용: ZOE COVID 연구의 전향적 커뮤니티 연구Article Published on 2022-07-012022-09-11 Journal: The Lancet. Infectious Diseases [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI Adverse reaction Adverse reactions Alpha Analysis B.1.1.7 BNT162b2 booster booster dose booster doses ChAdOx1 ChAdOx1 nCoV-19 chronic chronic disease Community community setting Comorbidities completion confounder confounders Control country COVID COVID-19 COVID-19 vaccine dose effective Effectiveness fatigue foundation group Heterologous heterologous schedule heterologous schedules homologous schedule individual Infection investigated Local local symptom Medical Research Council mRNA mRNA-1273 mRNA1273 nCoV new SARS-CoV-2 Odds ratio Older participant Participants Pfizer-BioNTech Poisson regression model positive reactogenicity receiving regimens remained reported SARS-CoV-2 SARS-CoV-2 positivity SARS-CoV-2 test second dose self-reported systemic Side-effect Side-effects Symptom systemic systemic side-effect Systemic side-effects systemic symptom tenderness test result tested those with comorbidities vaccinated individual vaccinated individuals vaccination Vaccine vaccine dose variant variants waned Wellcome Trust [DOI] 10.1016/S1473-3099(22)00146-3 PMC 바로가기 [Article Type] Article
Chronic lung lesions in COVID-19 survivors: predictive clinical modelCOVID-19 생존자의 만성 폐 병변: 예측 임상 모델Article Published on 2022-06-132022-09-11 Journal: BMJ Open [Category] COVID19(2023년), SARS, 치료기술, [키워드] Abnormalities abnormality architectural distortion automated Brazil bronchiectasis build Chest Chest CT chest imaging chest X-ray chronic Complete country COVID-19 COVID-19 infection CXR detect Dyspnoea e parameters Early detection eligible forced vital capacity FVC Ground-glass opacities hospital hospital discharge hospitalised joint lung lung lesion lung lesions Medical Research Council mMRC outcome oximetry parameter parenchymal Patient Predictive prospective cohort study protocol Pulmonary function pulmonary involvement pulmonary lesion pulmonary lesions respiratory medicine (see thoracic medicine). reticulation RT-PCR SARS-COV-2 infection SARS-CoV-2-infected patient sensitivity specificity spirometry survivor Thoracic traction bronchiectasis vital capacity were used [DOI] 10.1136/bmjopen-2021-059110 PMC 바로가기 [Article Type] Article
A group resilience training program for people with multiple sclerosis: Study protocol of a multi-centre cluster-randomized controlled trial (multi-READY for MS)다발성 경화증을 가진 사람들을 위한 그룹 회복력 훈련 프로그램: 다기관 클러스터 무작위 대조 시험의 연구 프로토콜(다중 READY for MS)Article Published on 2022-05-022022-09-11 Journal: PLoS ONE [Category] 임상, [키워드] 1:1 acceptance activities activity Administered Arm baseline booster change clinical settings Cluster collected commitment Complete Complex interventions composed conducted contribute Controlled trial COVID-19 Effectiveness Efficacy eight Evidence expected FIVE Follow-up followed by Hierarchical information Intention intention-to-treat Intervention Italy life linear longitudinal longitudinal changes Medical Research Council mood multiple sclerosis outcome participant peer-reviewed Primary outcome protocol Psychological Quality of life Randomized controlled trial RCT rehabilitation Relaxation Resilience Result Support Trial Trial registration Well-being [DOI] 10.1371/journal.pone.0267245 PMC 바로가기 [Article Type] Article
SARS-CoV-2-specific antibody and T-cell responses 1 year after infection in people recovered from COVID-19: a longitudinal cohort studyCOVID-19에서 회복된 사람들의 감염 1년 후 SARS-CoV-2-특이 항체 및 T-세포 반응: 종단 코호트 연구Article Published on 2022-05-012022-09-11 Journal: The Lancet. Microbe [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] Academy age analysed antibody Antibody Response antibody titres B.1.351 B.1.617.2 Beta Beta variant breadth caused center Chinese collected communicable disease Communicable Disease Diagnosis COVID-19 Critical cross-reactive cytokine cytokine profile D614G D614G variant delta variant Delta variants detect detectable discharged disease disease severity ELISA ELISPOT enrolled enzyme evaluated Follow-up Follow-up visit follow-up visits foundation humoral humoral and T-cell response ICS IFN-γ IFNγ IgA IgG antibodies IgG antibody IgM IL-2 immune immune response In-vitro individual individuals Infection initial interferon interferon γ interleukin interleukin-2 intracellular cytokine staining longitudinal cohort study magnitude Medical Research Council Medical Sciences memory memory immune response memory T-cell response memory T-cell responses microneutralisation assay natural Necrosis neutralising Neutralising Antibodies neutralising antibody neutralising antibody response Neutralising antibody responses neutralising antibody titre neutralising antibody titres no difference not disrupted participant Patient patients patients with moderate PBMC PBMCs plasma plasma sample plasma samples Protein Receptor-binding domain recovered patient recovered patients recruited reduce reduced reducing reduction Reinfection remained retained robustness SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleoprotein SARS-CoV-2 strain SARS-CoV-2 viral SARS-CoV-2-specific T-cell response Science severe disease spike Spike protein subset symptom severity Symptoms T-cell Response T-cell responses tested the interferon the receptor-binding domain the SARS-CoV-2 titre TNFα tumour necrosis factor Tumour Necrosis Factor α variant variants variants of concern Viral proteins viral strain viral strains Wuhan Wuhan, China [DOI] 10.1016/S2666-5247(22)00036-2 PMC 바로가기 [Article Type] Article
Multivariate profile and acute-phase correlates of cognitive deficits in a COVID-19 hospitalised cohortResearch article Published on 2022-04-282022-10-05 Journal: EClinicalMedicine [Category] 바이오마커, [키워드] Academy Accuracy acute illness acute phase age Anxiety association Attention calculated Cambridge characteristic clinical feature Clinical research Cognition cognitive Cognitive assessment cognitive deficit Cognitive function Cohort condition controls COVID-19 Critical care datasets Dementia demographic factor Department Depression determine deviation Effect expected expressed facility finding foundation funding highlighting hospital Hospital admission hospitalised Imperial College London individual less magnitude mechanically ventilated Medical Research Council memory mental health multivariate NHS NIHR Planning Post-traumatic stress disorder predicted preliminary evidence profile Reasoning reduced required Research response scientist severe COVID-19 severity significantly Standard deviation statistical significance supported survivor technology Trust Wellcome Trust with COVID-19 [DOI] 10.1016/j.eclinm.2022.101417 [Article Type] Research article
Symptom prevalence, duration, and risk of hospital admission in individuals infected with SARS-CoV-2 during periods of omicron and delta variant dominance: a prospective observational study from the ZOE COVID Study오미크론 및 델타 변이가 우세한 기간 동안 SARS-CoV-2에 감염된 개인의 증상 유병률, 기간 및 입원 위험: ZOE COVID 연구의 전향적 관찰 연구Observational Study Published on 2022-04-232022-09-11 Journal: Lancet (London, England) [Category] COVID19(2023년), SARS, 변종, 임상, [키워드] 1:1 95% CI age appear body-mass body-mass index chronic chronic disease collected data COVID dose Eligible participants foundation Hospital admission individual infected with SARS-CoV-2 Infection infectiousness lateral flow result less likelihood Loss Loss of Smell Lower respiratory tract Medical Research Council observational study Odds ratio omicron participant Patient PCR positive Positive test Prevalence prevalent Primary outcome Probability prospective observational study public health reduced reported symptom reported symptoms risk SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variant Sex sore sore throat study period Symptom symptom duration symptomatic tested vaccination variant Wellcome Trust [DOI] 10.1016/S0140-6736(22)00327-0 PMC 바로가기 [Article Type] Observational Study
Comparative analysis of the risks of hospitalisation and death associated with SARS-CoV-2 omicron (B.1.1.529) and delta (B.1.617.2) variants in England: a cohort study영국에서 SARS-CoV-2 오미크론(B.1.1.529) 및 델타(B.1.617.2) 변이와 관련된 입원 및 사망 위험 비교 분석: 코호트 연구Article Published on 2022-04-022022-09-11 Journal: Lancet (London, England) [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI adjusted adjusted hazard ratio Admission affected age Analysis B.1.1.529 B.1.617.2 booster booster vaccination Cohort cohort study Comparative analysis Council COVID-19 case dataset death decile delta variant demonstrated Department Deprivation dose doses Effectiveness Endpoint Engineering England estimate Ethnicity Evidence evidence of examined hazard hospital Hospital admission hospitalisation index individuals Infection infections Innovation intrinsic laboratory-confirmed maintain Medical Research Council moderate Mortality mRNA vaccine mRNA vaccines National offered omicron Omicron variant outcome primary analysis Protective provided reduction reduction in Relative risk resulting risk SARS-CoV-2 SARS-COV-2 infection Science severity Severity of infection Sex stratified the vaccine Transmissibility vaccinated individual vaccinated individuals vaccination Vaccination Status Vaccine variant variants Variation [DOI] 10.1016/S0140-6736(22)00462-7 PMC 바로가기 [Article Type] Article
Global, regional, and national minimum estimates of children affected by COVID-19-associated orphanhood and caregiver death, by age and family circumstance up to Oct 31, 2021: an updated modelling study2021년 10월 31일까지 COVID-19 관련 고아 및 간병인 사망의 영향을 받는 어린이의 연령 및 가족 상황에 따른 전 세계, 지역 및 국가 최소 추정치: 업데이트된 모델링 연구Article Published on 2022-04-012022-09-11 Journal: The Lancet. Child & adolescent health [Category] Fulltext, MERS, 변종, [키워드] affected age Caregiver challenge children Council COVID-19 CrI cumulative death defined distribution Engineering estimate estimates European country exceeded excess mortality fixed foundation Imperial College London include Increases increases in Innovation interval Logistic regression Medical Research Council Mortality mortality data National New coronavirus number of children Oak on children over pandemic parent parental Prevalence proliferation responses Science study period Support Vaccine variants [DOI] 10.1016/S2352-4642(22)00005-0 PMC 바로가기 [Article Type] Article
Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort studyObservational Study Published on 2022-04-012022-10-04 Journal: International Journal of Environmental Research an [Category] 임상, 치료법, [키워드] adjusted odds ratio administration Care chronic neurological disease clinical clinical decision Clinical practice cohort study Corticosteroid Corticosteroids COVID-19 Critical care Dementia demographics Dexamethasone discrepancy evaluate hospital Hydrocortisone identify Illness severity implementation independent Intervention ISARIC ISRCTN less likelihood Medical Research Council Methylprednisolone Older Patient patients with COVID-19 Prednisolone pregnant women Primary outcome Rate receive RECOVERY trial reduce mortality Registered significantly supplementary oxygen treated Treatment WHO [DOI] 10.1016/S2589-7500(22)00018-8 PMC 바로가기 [Article Type] Observational Study