Systematic virtual screening in search of SARS CoV-2 inhibitors against spike glycoprotein: pharmacophore screening, molecular docking, ADMET analysis and MD simulationsArticle Published on 2022-10-012022-11-15 Journal: Molecular diversity [Category] COVID19(2023년), SARS, 치료제, [키워드] absence acting acute respiratory syndrome Amino acid Analysis Anti-viral binding site catalytic coronavirus disease Coronavirus-2 COVID-19 distribution docking score effective Entry inhibitor glycoprotein host cell in silico inhibitor Interaction less Ligand MD simulation MD simulations medications metabolism molecular molecular docking nucleic acid offered performed Precision research finding residue SARS CoV-2 spike spike glycoprotein stability starting point target Toxicity viral entry Virtual screening [DOI] 10.1007/s11030-022-10394-9 PMC 바로가기
Prolonged COVID-19 symptom duration in people with systemic autoimmune rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance Vaccine SurveyArticle Published on 2022-09-012022-11-16 Journal: RMD Open [Category] 변종, [키워드] 95% CI age Alliance analysed association Autoimmune baseline characteristics Clinical characteristics Comorbidity Complete COVID-19 COVID-19 severity COVID-19 symptom defined Factor female Future higher odd hospitalisation hospitalised identify immunomodulating Inflammation investigated IQR Logistic regression median medications Mild MOST Osteoarthritis participant patient reported outcome Patient reported outcome measures Prolonged proportion reported reported symptom rheumatic disease rheumatoid arthritis survey Symptom symptom duration symptom resolution vaccination vaccine dose viral variant [DOI] 10.1136/rmdopen-2022-002587 PMC 바로가기
Different humoral but similar cellular responses of patients with autoimmune inflammatory rheumatic diseases under disease-modifying antirheumatic drugs after COVID-19 vaccinationArticle Published on 2022-09-012022-11-15 Journal: RMD Open [Category] SARS, 진단, [키워드] activated Activation antibody Autoimmune Autoimmune diseases Cellular immune response cellular response Combination correlated COVID-19 COVID-19 vaccination csDMARD cytokine cytokine profile drug drugs evaluated female first vaccination Frequency Heterologous highest humoral IgG immunosuppressive immunosuppressive therapy Inflammatory inhibitor investigated majority marker median age medications methotrexate monotherapy mRNA-based vaccine MTX Neutralising Antibodies neutralising antibody no difference not significant outcome Patient psoriatic arthritis quantification receiving rheumatic disease rheumatoid arthritis SARS-CoV-2 second vaccination Seroconversion spike-protein spondyloarthritis T-cell T-cell immunity T-lymphocyte T-lymphocyte subsets Therapies therapy titre treated vaccination [DOI] 10.1136/rmdopen-2022-002293 PMC 바로가기
Adverse outcome and severity of COVID-19 in patients with autoimmune bullous diseases: A historical cohort studyArticle Published on 2022-09-012022-11-15 Journal: Dermatologic therapy [Category] COVID19(2023년), SARS, 진단, [키워드] Adverse age attenuate Autoimmune autoimmune blistering disease benefit blistering bullous cohort study Comorbidity cough COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 severity death determinant disorders dosage dose drug evaluated Follow-up Generalized linear model Hospitalization Immunosuppression Infection medications myalgia outcome pandemic Patient physician predictor Prednisolone Prednisone raised risk SARS-CoV-2 severe COVID-19 severity severity of COVID-19 significantly increased Symptom the patient tiredness treat vaccination was performed [DOI] 10.1111/dth.15672 PMC 바로가기
Analysis of potential risk factors associated with COVID-19 and hospitalizationObservational Study Published on 2022-08-052022-10-05 Journal: Frontiers in Public Health [Category] SARS, 임상, [키워드] addition adjusted administration age Analysis analyzed association Care carried clearance Clinical characteristics comorbid patient Comorbidities Comorbidity Complication complications conducted Coronavirus disease 2019 COVID-19 COVID-19 pandemic cross-sectional database determine Factor Fever Gender group help hospital Hospitalization hypertension ICU admission ICU Patients indicated intensive care majority male medication medications non-ICU obesity Odds ratio outcome Patient patients hospitalized patients older Pneumonia potential risk predictor Prednisolone reduce Remdesivir retrieved retrospective risk factor Risk factors significantly statistically suggested Symptoms syndrome type 2 diabete understanding with COVID-19 [DOI] 10.3389/fpubh.2022.921953 PMC 바로가기 [Article Type] Observational Study
Investigating the structure-activity relationship of marine polycyclic batzelladine alkaloids as promising inhibitors for SARS-CoV-2 main protease (M pro)SARS-CoV-2 주요 프로테아제(M pro)의 유망한 억제제로서 해양 다환식 batzelladine 알칼로이드의 구조-활성 관계 조사Article Published on 2022-08-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] active sites antiviral therapeutics antivirals approved Batzelladines binding affinity China Compound computational tool drugs effective examined feature form fused guanidine Guanidine alkaloids H-I Health highlighting inhibitor investigated M pro Marine sponges MD simulation medications molecular docking molecular dynamics Novel coronavirus over pandemic polycyclic position primary source protease protein-ligand interaction residues SAR SARS SARS-CoV-2 SARS-CoV-2 main protease side chain spacer span stability the SARS-CoV-2 unsaturation Vaccine variants Virtual screening virus [DOI] 10.1016/j.compbiomed.2022.105738 PMC 바로가기 [Article Type] Article
Risk Stratification Models for Stroke in Patients Hospitalized with COVID-19 InfectionResearch article Published on 2022-08-012022-10-05 Journal: Journal of stroke and cerebrovascular diseases : t [Category] 바이오마커, [키워드] 95% CI Admission adults hospitalized afebrile AHA assigned build C-statistic c-statistics cardiovascular Cerebrovascular disease coefficient Comorbidities covariates COVID-19 Cox regression cross demographics elevated Factor generate groups help high risk hypertension identify Intracerebral hemorrhage Laboratory Leukocytosis machine material medications medium Model multivariable analyses objective outcome patients hospitalized patients with COVID-19 pulmonary disease registry Result risk Risk-stratification second stratified stroke Systolic blood pressure temperature thrombosis univariable used data with COVID-19 [DOI] 10.1016/j.jstrokecerebrovasdis.2022.106589 [Article Type] Research article
Plasmatic renin-angiotensin system in normotensive and hypertensive patients hospitalized with COVID-19Research article Published on 2022-08-012022-10-05 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] 바이오마커, 치료기술, [키워드] ACE ACE2 ACE2 expression ACE2 protein acute respiratory syndrome Analysis Ang II angiotensin Angiotensin receptor blockers Angiotensin-converting enzyme angiotensin-converting enzyme 2 angiotensin-converting enzyme inhibitors blockade cause circulating control group coronavirus COVID-19 COVID-19 group COVID-19 patient COVID-19 patients enzymatic activity etiological agent healthy healthy subjects Hospitalized hypertension hypertensive hypertensive patient investigated medications normotensive not different Patient patients protein level RAS receptor remained renin-angiotensin system reported Result significantly Support treated Treatment were excluded were measured with COVID-19 [DOI] 10.1016/j.biopha.2022.113201 [Article Type] Research article
JAK inhibition as a new treatment strategy for patients with COVID-19Review article Published on 2022-08-012022-10-05 Journal: Biochemical pharmacology [Category] COVID19(2023년), SARS, 바이오마커, 신약개발, 임상, 치료법, [키워드] AAK1 ACE-2 acute respiratory syndrome adverse outcomes angiotensin-converting enzyme 2 Bacterial infection blockers caused clinical trial clinical trials Combination coronavirus coronavirus disease Corticosteroids Course COVID-19 Critical cytokine Cytokine storm Cytokines Cytokines storm develop discharge Disease progression dysregulated effective Epidemic Future GAK greater herpes zoster Host ICU admission IL-2 IL-6 IL-6 receptor immune improve clinical outcome increased risk Infection Inflammation inhibit inhibiting involved Jak JAK inhibition JAK inhibitor Jak-STAT JAK/STAT JAK/STAT signaling janus medication medications Mortality MOST new treatment strategy offer pathway Patient patients with COVID-19 pro-inflammatory cytokine raised regulate released SARS-CoV-2 severe pneumonia significantly Spread Thromboembolic events TNF-α Transcription transmembrane protein Treatment upregulated viral endocytosis virus virus infection WHO guideline [DOI] 10.1016/j.bcp.2022.115162 [Article Type] Review article
Systematic lupus erythematous patients following COVID-19 vaccination: Its flares up and precautionsShort communication Published on 2022-08-012022-10-05 Journal: Annals of Medicine and Surgery [Category] 치료제, [키워드] adenovirus vaccine adverse effect adverse effects antibody antiviral response Autoimmune adverse effects Autoimmune disease boost caused Central nervous system clinical Comorbidities Complication COVID-19 COVID-19 vaccination COVID-19 vaccine cytokine diagnose Disease activity dsDNA erythematous immune Inflammatory interfere interferons intrinsic joints kidneys likelihood Lupus flare-up majority medications mRNA mRNA vaccination mRNA vaccine multiple organs notable organ damage pathophysiology Patient Precaution required Rheumatic diseases SARS-CoV-2 SARS-CoV-2 vaccine serological shown significantly SLE SLE patient Spread Symptom systemic systemic lupus erythematosus type I interferon Vaccinations with COVID-19 [DOI] 10.1016/j.amsu.2022.104282 [Article Type] Short communication