Mefloquine for malaria prophylaxis in military personnelarticle Published on 2020-11-302024-09-01 Journal: BMJ Mil Health [Category] 말라리아, [키워드] anti-malarial chemoprophylaxis mefloquine military neurotoxicity Side effects [Article Type] article
Identification of Potent and Safe Antiviral Therapeutic Candidates Against SARS-CoV-2SARS-CoV-2에 대한 강력하고 안전한 항바이러스 치료 후보의 식별Immunology Published on 2020-11-252022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 신약개발, 치료제, [키워드] activities Against amlodipine amlodipine besylate anti-SARS-CoV-2 Antiviral arbidol hydrochloride candidate Cell Cell fusion Combination Compound Concentration coronavirus COVID-19 COVID-19 infection COVID-19 infections COVID-19 pandemic death dronedarone dronedarone hydrochloride drug effective Effectiveness experiments FIVE HCl help human coronavirus Hydroxychloroquine identification identify identifying inhibit inhibiting mefloquine monensin monensin sodium monensin sodium salt Mortality OC43 pandemic performed potent Prevent Replication reported SARS-CoV-2 SARS-CoV-2 S SARS-CoV-2 S protein screened sertraline sertraline HCl severe disease sodium therapeutic agent therapeutic agents therapeutic option therapeutic window therapy thioridazine thioridazine hydrochloride tilorone treat US Food and Drug Administration-approved compounds virus vortioxetine [DOI] 10.3389/fimmu.2020.586572 PMC 바로가기 [Article Type] Immunology
Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial)증상이 있는 SARS-CoV-2 감염(COVID-19)이 있는 고령자의 가정 치료: 여러 가지 실험적 치료의 효능과 내약성을 평가하기 위한 MAMS(Multi-Arm Multi-Stage) 무작위 시험에 대한 연구 프로토콜의 구조화된 요약 65세 이상 외래 환자의 입원 또는 사망 위험 감소(COVERAGE 시험)Letter Published on 2020-10-132022-08-13 Journal: Trials [Category] MERS, SARS, 임상, [키워드] 6-mercaptopurine Abnormalities ACEi added age amodiaquine Analysis antrafenine approved ARB ARBs Arm azathioprine Blinding Bordeaux Caregivers Chloroquine chronic hepatitis Chronic kidney disease citalopram clinical Colitis Combination comparator complex conducted Control control arm COVID-19 COVID-19 pandemic criteria CYP3A4 cytochrome P450 Dasatinib death Dementia dialysis dissemination Domperidone drug Duchy Efficacy element enrolled enrolment Enterocolitis escitalopram EudraCT Evidence exclusion criteria experimental arm experimental drug Experimental drugs Favipiravir feasibility Final final analysis first symptom first symptoms floctafenine France French futility galactose GFR glafenine Glucose Glucose-6-phosphate glucose-6-phosphate dehydrogenase glucose-6-phosphate dehydrogenase deficiency Grand duchy halofantrine Health Insurance heart rate hepatic Hepatic porphyria home hospital hospitalisation Hydroxychloroquine hydroxyzine hypersensitivity Hyperuricemia Ileus Imatinib immunological incidence Inclusion increase in inducer inhibitor Interim analyses interim analysis intervals investigator investigators Isoenzyme Kidney disease Lactase Lactose liver failure Long Long QT syndrome Luxembourg malabsorption mefloquine mercaptopurine metabolism multi multi-arm nasopharyngeal Nasopharyngeal swab New Nilotinib not blinded number nursing home nursing homes objective Older Open-label open-label trial other treatment other treatments outcome Outpatient P450 Paris participant Patient performed phase Piperaquine Positive test Prevent primary care Primary outcome proportion protocol pyrazinamide QTc interval randomisation randomised Randomized Randomly receive recruited Region Registered regulatory authority repaglinide replaced REPLACED BY reported Repurposed drug residence Safety Monitoring Board Sample size SARS-CoV-2 SARS-COV-2 infection scale Stage Standard statistician statisticians status stratified Study protocol submitted symptomatic SARS-CoV-2 infection Tablet telmisartan tested theophylline Toxicity Trace element trace elements treated Treatment treatment arm Trial Trial registration Version virus Virus Disease Vitamin vitamins Warfarin [DOI] 10.1186/s13063-020-04619-1 PMC 바로가기 [Article Type] Letter
IV artesunate for severe malariaArticle Published on 2020-08-102024-08-28 Journal: Med Lett Drugs Ther [Category] 말라리아, [키워드] adverse effects Artemether artemether-lumefantrine artesunate atovaquone/proguanil Chloroquine Clindamycin Coartem dosage doxycycline Drug interactions Efficacy Krintafel lactation malaria malarone mefloquine Pregnancy primaquine Quinine Safety tafenoquine Tetracycline
Malaria in the pregnant travelerArticle Published on 2020-07-142024-08-28 Journal: Journal of Travel Medicine [Category] 말라리아, [키워드] Atovaquone-proguanil doxycycline insect repellent malarone mefloquine primaquine tafenoquine
ChemoPROphyLaxIs with hydroxychloroquine For covId-19 infeCtious disease (PROLIFIC) to prevent covid-19 infection in frontline healthcare workers: A structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-07-022022-10-29 Journal: Trials [Category] Coronavirus, SARS, [키워드] active treatment phase Amiodarone anticipated Arm ARMS assessment baseline blinded Block randomisation block size Blood Group Breastfeeding Cambridge Care Chemoprophylaxis Chloroquine Chronic kidney disease ciprofloxacin clarithromycin clinical clinical testing Compliance Contact coronavirus disease COVID-19 COVID-19 case COVID-19 disease COVID-19 disease severity COVID-19 infection COVID-19 patients criteria current cyclosporin Daily Daily-dosing Date Day deficiency defined described determine diagnosed with COVID-19 Diagnosis digoxin disease dissemination dose dosed element enrolled enrolment epilepsy EU Clinical Trial EudraCT evaluated Factor File fluconazole Follow-up foundation frontline healthcare workers G6PD Genetic Glucose-6-phosphate halofantrine HCQ healthcare Healthcare workers heart failure hospital Hydroxychloroquine hypersensitivity reaction increase Infection Intervention investigator Laboratory Liver disease maintenance Matched mefloquine moxifloxacin National Health Service NHS number objective oral outcome participant Participants Patient patients with COVID-19 pharmacokinetic phase Placebo placebo tablet placebo-controlled trial porphyria positive COVID-19 positive individual Positive test Praziquantel predicted Prevent problem prochlorperazine protocol randomised randomised controlled trial recruited recruitment regimen Registered reported Research Retinal disease Sample size Secondary objective serology serum biomarker Standard statistical analysis status Stratification stratified Study protocol susceptibility symptoms onset syndrome table Tablet tablets time Treatment treatment period Trial Trust university Variation website Weekly Weekly-dosing work [DOI] 10.1186/s13063-020-04543-4 PMC 바로가기 [Article Type] Letter
In vitro hepatic metabolism of mefloquine using microsomes from cats, dogs and the common brush-tailed possum ( Trichosurus vulpecula )Research Article Published on 2020-04-142022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] canine caused clearance clinically cofactor determine Efficacy and safety evaluate Feline infectious peritonitis hepatic function immune-mediated disease in vitro inhibit intrinsic LC-MS liquid mefloquine metabolism negative controls Phase I positive control Protein shown tramadol Treatment viral-induced virus was used [DOI] 10.1371/journal.pone.0230975 PMC 바로가기 [Article Type] Research Article
Association of Lipid Levels with Mefloquine and Carboxy-Mefloquine Concentrations in Patients with Uncomplicated Falciparum MalariaArticle Published on 2020-02-212024-08-28 Journal: Med Instrum [Category] 말라리아, [키워드] Infectious diseases lipids Lipoproteins malaria mefloquine
Drug interactions with antimalarial medications in older travelers: a clinical guideArticle Published on 2020-02-032024-08-28 Journal: Journal of Travel Medicine [Category] 말라리아, [키워드] Artemether artemisinins artesunate Atovaquone-proguanil Chloroquine doxycycline hepatic enzyme induction mefloquine Older traveler primaquine QT prolongation tafenoquine
Advice for travelersArticle Published on 2019-10-072024-08-28 Journal: Med Lett Drugs Ther [Category] 말라리아, [키워드] acetazolamide Adalat adverse effects Aemcolo Alertec altitude illness Ambien Antihistamines Arakoda armodafinil atovaquone/proguanil Azithromycin bismuth subsalicylate Bonamine Ceralyte Chikungunya Chloroquine Cialis Cipro ciprofloxacin Decadron Deep vein thrombosis DEET Dengue Dengvaxia Dexamethasone dimenhydrinate dosage doxycycline Dramamine Duranon DVT Efficacy Escherichia coli fluoroquinolones Gastrolyte Gravol Hetlioz Histanil ibuprofen Imodium insect bites insect repellents Insomnia jet lag ketoconazole Krintafel leptospirosis Levaquin levofloxacin loperamide malaria malarone meclizine mefloquine melatonin modafinil motion sickness Nifedipine Nuvigil ofloxacin ORS Pepto-Bismol Permanone Permethrin Phenergan Pregnancy primaquine Procardia Promethazine Provigil ramelteon rifamycin rifaximin Rozerem Safety Scopolamine Sublinox sunburn sunscreens Tadalafil tafenoquine tasimelteon Transderm Scop Transderm V Travel Travelers' diarrhea Vaccines Venous Thromboembolism Vibramycin Xifaxan Zaxine Zika Zithromax zolpidem.