Monitoring fusion kinetics of viral and target cell membranes in living cells using a SARS-CoV-2 spike-protein-mediated membrane fusion assayArticle Published on 2022-09-262022-11-15 Journal: STAR protocols [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome approach cell membrane cell types Cell-based Assays Complete coronavirus functional living cell living cells membrane fusion Microbiology Microbiology. MONITOR monitoring pathogenicity Protein protocol reporter SARS-CoV-2 Spike protein Suzuki target cells triggering variants viral entry virus [DOI] 10.1016/j.xpro.2022.101773 PMC 바로가기
SARS-CoV-2 requires acidic pH to infect cellsArticle Published on 2022-09-202022-11-15 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 치료기술, 치료제, [키워드] 3D imaging Acidic acidic pH acute respiratory syndrome cathepsin Cell cell entry cleavage coronavirus detect endosomal furin Genome infect cell Infection Infection route live-cell imaging membrane membrane fusion nasal occurred penetration producing SARS-CoV-2 target cells TMPRSS2 TMPRSS2-expressing cell virion virus entry Virus entry. [DOI] 10.1073/pnas.2209514119 PMC 바로가기
Photochemical Identification of Auxiliary Severe Acute Respiratory Syndrome Coronavirus 2 Host Entry Factors Using μMapArticle Published on 2022-09-142022-11-16 Journal: Journal of the American Chemical Society [Category] SARS, 변종, [키워드] ACE2 ACE2 expression acute respiratory syndrome auxiliary cell entry complex coronavirus coronavirus 2 COVID-19 pandemic Critical Delta eight engage ENhance enzyme expression facilitate Factor Genetic Host human cell identification identify identifying labeling lymphocyte membrane fusion pathophysiology platform powerful tool Protein receptor receptors respiratory SARS-CoV-2 significantly spike variant systemically the spike protein tissues transmembrane serine protease viral entry Wuhan [DOI] 10.1021/jacs.2c06806 PMC 바로가기
The Bovine Seminal Plasma Protein PDC-109 Possesses Pan-Antiviral ActivityArticle Published on 2022-09-132022-11-15 Journal: Viruses [Category] SARS, 치료제, [키워드] accompanied activity affected antiviral activity bovine Bovine seminal plasma Cell component components concentrations COVID-19 Cytokines cytotoxicity demonstrated elements etiological agent experiment Fn-type 2 proteins function Glucose glycoprotein Growth factors impair Infection infections Infectious disease Influenza virus inhibit investigated limit lipids mammalian membrane fusion metabolites Particle PDC-109 plasma plasma protein Proteins reporter respiratory SARS-CoV-2 Seminal sexual transmission significantly spike treatment regimen viability viral infection virus virus virus inhibition virus particles VSV VSV replicon. without affecting [DOI] 10.3390/v14092031 PMC 바로가기
Metalloproteinase-Dependent and TMPRSS2-Independent Cell Surface Entry Pathway of SARS-CoV-2 Requires the Furin Cleavage Site and the S2 Domain of Spike ProteinArticle Published on 2022-08-302022-11-16 Journal: mBio [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACE2 ADAM10 addition bind Cell cell death cell interaction cleavage cleaved complex condition contributed coronavirus SARS-CoV COVID-19 develop domain effective element endosomal pathway entry pathway evade furin furin cleavage motif highly pathogenic Host host protease human coronaviruses identify Immunity independent Infection infection mechanism inhibitor involved membrane membrane fusion metalloproteinase organ damage Pathogenesis pathogenesis of COVID-19 pathway Prevent priming provide required S1/S2 boundary S2 domain SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein selective sequence siRNAs Site spike Spread surface surface receptor syncytium formation the spike protein therapeutic agent therapeutic target Therapies TMPRSS2 unique vaccination variants virus entry Virus entry. virus variant [DOI] 10.1128/mbio.00519-22 PMC 바로가기
Carbohydrate-binding protein from stinging nettle as fusion inhibitor for SARS-CoV-2 variants of concernArticle Published on 2022-08-302022-11-15 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 변종, 치료제, [키워드] addition Antiviral antiviral activity assays Beta binding block Cell cell cultures cell types cell-cell fusion cells circulating Coronaviruses Deletion Delta demonstrated fusion inhibitor Gamma inhibit inhibited inhibitor interface investigated lectin lung epithelial membrane fusion monomeric mutant N-acetylglucosamine (GlcNAc) N-glycosylation omicron Prevent Protein pseudotyped SARS-CoV-2 remained Replication replication of SARS-CoV-2 S2 subunit SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant Spike protein spike protein. SPR subsequent surface plasmon resonance tested the spike protein UDA Urtica variant variants of concern variants of SARS-CoV-2 Vero E6 cell viral replication viral spike protein virus entry viruses Wuhan-Hu-1 [DOI] 10.3389/fcimb.2022.989534 PMC 바로가기
Historical Evolutionary Dynamics and Phylogeography Analysis of Transmissible Gastroenteritis Virus and Porcine Deltacoronavirus: Findings from 59 Suspected Swine Viral Samples from ChinaArticle Published on 2022-08-292022-11-16 Journal: International Journal of Molecular Sciences [Category] 유전자 메커니즘, [키워드] adaptive addition America Analysis analyzed Asia Bayesian Bayesian inference caused Characteristics China coronavirus COVID-19 epidemic Cross-species transmission distribution Dynamics event Evolution evolutionary dynamics finding genetic diversity Genome sequence data genotypes highlighting Human humans infect likelihood lineages maximum measure membrane fusion Migration Pandemics PDCoV phylogeography phylogeography. Porcine deltacoronavirus Positive selection recent Sample spatiotemporal Spike protein Surveillance Suspected TGEV transmissible gastroenteritis virus Transmission transmission rate transmitted [DOI] 10.3390/ijms23179786 PMC 바로가기
Identification, optimization, and biological evaluation of 3-O-β-chacotriosyl ursolic acid derivatives as novel SARS-CoV-2 entry inhibitors by targeting the prefusion state of spike protein스파이크 단백질의 융합 전 상태를 표적으로 하는 신규 SARS-CoV-2 진입 억제제로서의 3-O-β-chacotriosyl ursolic acid 유도체의 식별, 최적화 및 생물학적 평가Article Published on 2022-08-052022-09-11 Journal: European journal of medicinal chemistry [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] antiviral activity Antiviral agents Cavity COVID-19 pandemic Delta derivative effective generate identification Infection inhibitor inhibitors membrane fusion Mutation offer omicron Pentacyclic triterpenoid saponins prefusion pseudotyped SARS-CoV-2 public health S protein S1 and S2 saponins SARS SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 S protein SARS-CoV-2 variant SARS. Spike protein subunit the S protein the SARS-CoV-2 Vaccine variant variants Vero-E6 cell Vero-E6 cells virus-cell membrane fusion [DOI] 10.1016/j.ejmech.2022.114426 PMC 바로가기 [Article Type] Article
Structural Evolution of Delta (B.1.617.2) and Omicron (BA.1) Spike Glycoproteins델타(B.1.617.2) 및 오미크론(BA.1) 스파이크 당단백질의 구조적 진화Article Published on 2022-08-042022-09-11 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, 진단, [키워드] accumulated alteration B.1.617.2 binding caused conservation coronavirus COVID-19 COVID-19 pandemic Delta elements Evolution fusion genomic data glycan glycans glycoprotein host cell human ACE2 receptor involved membrane fusion molecular molecular dynamics monomer mutants Mutation offer omicron proximal RBD receptor ACE2 Receptor binding domain receptor binding motif Region S glycoprotein SARS-CoV-2 spike structural evidence Transmissibility unique variants variants. virus entry [DOI] 10.3390/ijms23158680 PMC 바로가기 [Article Type] Article
Molecular adaptations during viral epidemicsReview Published on 2022-08-032023-06-23 Journal: EMBO Reports [Category] COVID19(2023년), SARS, 신종인플루엔자, [키워드] Epidemic membrane fusion molecular adaptations Receptor-binding domain recombination. [DOI] 10.15252/embr.202255393 PMC 바로가기 [Article Type] Review