SARS-CoV-2-reactive IFN-γ-producing CD4 + and CD8 + T cells in blood do not correlate with clinical severity in unvaccinated critically ill COVID-19 patients혈액 내 SARS-CoV-2 반응성 IFN-γ 생성 CD4 + 및 CD8 + T 세포는 백신 접종을 받지 않은 중환자 COVID-19 환자의 임상 중증도와 상관관계가 없습니다Article Published on 2022-08-222022-09-11 Journal: Scientific Reports [Category] SARS, 바이오마커, 진단, 치료기술, 치료법, [키워드] anti-RBD Anti-RBD IgG association Biomarker Biomarkers Blood blood levels C-reactive protein CD4 CD8 Clinical outcome Clinical severity comparable Concentration correlation COVID-19 patient COVID-19 patients Critically ill critically ill COVID-19 patients D-dimer Deceased detectable died different time point different time points ELISA Enumeration enzyme enzyme-linked immunosorbent assay examined ferritin flow cytometry greater magnitude IFN-γ IgG level increased mortality interleukin interleukin-6 investigated Kinetics Lactose Lower respiratory tract male median age membrane protein Mortality no correlation Patient patients Peripheral blood predict respiratory RNA loads SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 S sera Serum level serum levels specimens spike Spike protein survived Survivors T cell T cell subset T cells T-cell T-cell Response T-cell responses tracheal aspirate Viral viral clearance [DOI] 10.1038/s41598-022-18659-x PMC 바로가기 [Article Type] Article
Structure of SARS-CoV-2 membrane protein essential for virus assembly바이러스 조립에 필수적인 SARS-CoV-2 막 단백질의 구조Article Published on 2022-08-052022-09-11 Journal: Nature Communications [Category] SARS, 변종, 치료법, [키워드] Analysis component composed conformational changes conformations conserved coronavirus cryo Cryo-electron microscopy domain domains electron microscopy form hinge region Interaction ion channel M protein mechanism membrane protein morphogenesis nucleocapsid protein oligomers ORF3a Protein recruitment RNA SARS-CoV-2 SARS-CoV-2 ORF3a structural protein Structure the SARS-CoV-2 therapeutic intervention transmembrane virus [DOI] 10.1038/s41467-022-32019-3 PMC 바로가기 [Article Type] Article
An improved Fuzzy based GWO algorithm for predicting the potential host receptor of COVID-19 infectionResearch article Published on 2022-08-012022-10-05 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 protein acute respiratory syndrome ADAM17 Affect affected Algorithm analyzed ASGR1 Asialoglycoprotein Basigin Bone marrow Brain caused CD147 Cell CLEC4M Cluster Clustering Coronavirus-2 COVID-19 COVID-19 infection cytoplasm Differential evolution algorithm disease disintegrin domain drug effective Effectiveness eliminating entry of SARS-CoV-2 enzyme Evolution population dynamics exploratory expresse expression profile EXT1 EXT2 EXT3 Factor fusing Fuzzy clustering G protein-coupled receptor genetic diversity GLCE Glucuronic acid GPR78 Grey Grey wolf optimizer help Host host cell host cell membrane host receptor humans hybridizing I, II identify identifying IHC immunohistochemistry individual Infection inhibiting Interaction intestine kidney KREMEN1 Kringle liver lung mechanism membrane protein Membrane proteins Mutation NDST2 neuropilin NRP1 operator pathogenesis of COVID-19 pathogenesis of SARS-CoV-2 pathogenicity protease Protein PVR receptor replication of SARS-CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 virus serine protease Seurat shown Single cell RNA sequencing data single-cell Spike protein spleen Spread therapeutic target TMPRSS2 toolkit transcriptionally transcriptomics transmembrane protein Transmission virus XYLT1 XYLT2 [DOI] 10.1016/j.compbiomed.2022.106050 [Article Type] Research article
TMED3 Complex Mediates ER Stress-Associated Secretion of CFTR, Pendrin, and SARS-CoV-2 SpikeTMED3 복합체는 CFTR, Pendrin 및 SARS-CoV-2 스파이크의 ER 스트레스 관련 분비를 매개합니다Article Published on 2022-08-012022-09-11 Journal: Advanced Science [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Analysis CFTR complex conditions Critical cystic fibrosis ER stress Evidence expression fibrosis gene silencing improves involved mechanism membrane protein Membrane proteins pathway pendrin pendrin. plasma membrane Protein Proteins recognize reduce reduces SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 viral secretion spike syndrome TMED TMED10 TMED2 TMED3 TMED9 transmembrane transmembrane protein Transport UPS [DOI] 10.1002/advs.202105320 PMC 바로가기 [Article Type] Article
SARS-CoV-2-Specific T Cell Immunity in HIV-Associated Kaposi Sarcoma Patients in Zambia잠비아의 HIV 관련 카포시 육종 환자의 SARS-CoV-2-특이적 T 세포 면역Article Published on 2022-07-282022-09-11 Journal: Journal of Immunology Research [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Affect affecting baseline level baseline levels Cancer caused CD4 CD4 count Cell-mediated immunity Chemotherapy coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 death Depletion detectable Factor Follow-up Frame had no higher risk HIV infection immune response Immunity Immunosuppression impair increase individual Infection investigated Kaposi sarcoma leads malignancies malignancy membrane protein nucleoprotein Open reading frame Patient peptide peptide pool Population Protein reported respiratory response risk Sarcoma SARS-CoV-2 SARS-COV-2 infection seropositive Severe acute respiratory syndrome severe disease significant effect statistically significant symptomatic SARS-CoV-2 infection T cell T cell response T cell responses T cells Viral viral infection viral infections virus with HIV [DOI] 10.1155/2022/2114285 PMC 바로가기 [Article Type] Article
The global succinylation of SARS-CoV-2-infected host cells reveals drug targetsSARS-CoV-2에 감염된 숙주 세포의 세계적인 숙시닐화는 약물 표적을 드러낸다Article Published on 2022-07-262022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] Coronavirus, COVID19(2023년), SARS, 변종, 치료법, 치료제, [키워드] Analysis Antiviral antiviral drug antiviral drug target antiviral effects antiviral therapies Caco-2 Caco-2 cells causative agent cellular cellular pathway cellular pathways conserved COVID-19 COVID-19 pandemic demonstrated drug target enzyme Evolution highlighting Host host cell host protein inhibit inhibitor Interaction mechanism membrane protein Membrane proteins metabolic pathways Modification nsp14 overexpressed promote Protein Quantitative regulated Regulatory reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid SIRT5 sirtuin succinylproteomics. variants Viral proteins virus replication [DOI] 10.1073/pnas.2123065119 PMC 바로가기 [Article Type] Article
Effect of cannabidiol on apoptosis and cellular interferon and interferon-stimulated gene responses to the SARS-CoV-2 genes ORF8, ORF10 and M proteinSARS-CoV-2 유전자 ORF8, ORF10 및 M 단백질에 대한 세포 사멸 및 세포 인터페론 및 인터페론 자극 유전자 반응에 대한 칸나비디올의 효과Article Published on 2022-07-152022-09-11 Journal: Life sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] 2′-5′-oligoadenylate synthetase (OAS) family activating acute respiratory syndrome acute respiratory syndrome coronavirus anti-viral response Apoptosis cannabidiol cause Cell cellular Combination component control cell control cells coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 Effect expressing expression HEK293 cell HEK293 cells IFNγ immune responses Innate innate immune response innate immune system Innate immunity interferon interferon-stimulated gene interferons M protein marker membrane protein OAS OAS1 OAS2 OAS3 OASL ORF10 ORF8 Plasmid plasmids Prophylaxis Protein readiness respond response SARS-CoV-2 SARS-CoV-2 gene SARS-CoV-2 genes severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) the SARS-CoV-2 transfected cells transfected with treated Treatment vehicle viral gene viral genes viral infection [DOI] 10.1016/j.lfs.2022.120624 PMC 바로가기 [Article Type] Article
Genetic variation of Golgi membrane protein 1 is associated with COVID-19 diseaseCorrespondence Published on 2022-07-012022-10-05 Journal: The Journal of Infection [Category] 바이오마커, 유전자 메커니즘, [키워드] disease Golgi membrane protein Variation with COVID-19 [DOI] 10.1016/j.jinf.2022.07.013 [Article Type] Correspondence
Antigenic Determinants of SARS-CoV-2-Specific CD4+ T Cell Lines Reveals M Protein-Driven Dysregulation of Interferon SignalingArticle Published on 2022-06-302023-07-10 Journal: Frontiers in Immunology [Category] COVID19(2023년), [키워드] immune regulation interferon signaling membrane protein SARS-CoV-2 spike (S) glycoprotein [DOI] 10.3389/fimmu.2022.883159 PMC 바로가기
High and Sustained Ex Vivo Frequency but Altered Phenotype of SARS-CoV-2-Specific CD4 + T-Cells in an Anti-CD20-Treated Patient with Prolonged COVID-19장기간의 COVID-19가 있는 항-CD20 치료를 받은 환자에서 높고 지속되는 생체외 빈도이지만 SARS-CoV-2-특이적 CD4 + T-세포의 변경된 표현형Article Published on 2022-06-102022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, [키워드] abrogate Altered Analysis anti-CD20 anti-CD20 therapy anti-CD20 therapy. B-cell CD39 CD4 CD4+ CD4+ T-cells CD45 CD45RA CD73 Cell circulating COVID-19 CRP CXCR5 effector cells epitope Ex vivo expression follicular Frequency help helper cell IL-6 Infection inflammation marker Interaction lack LAG-3 membrane protein memory MHC class MHC class II MHC class II Tetramer Patient patients PD-1 phenotype Prolonged receptor reduced robust SARS-CoV-2 skewed T follicular helper cell T-cell T-cell memory T-cell Response T-cells tetramer the patient TIGIT viral replication [DOI] 10.3390/v14061265 PMC 바로가기 [Article Type] Article