Alterations in gut microbiome and metabolomics in chronic hepatitis B infection-associated liver disease and their impact on peripheral immune responseArticle Published on 2023-01-012023-06-13 Journal: Gut Microbes [Category] B형 간염, Fulltext, [키워드] Antiviral treatment Chronic hepatitis B virus infection-associated liver disease cirrhosis metabolome Microbiome peripheral immunity. [DOI] 10.1080/19490976.2022.2155018 PMC 바로가기
Identification of serum metabolites enhancing inflammatory responses in COVID-19Article Published on 2022-10-012022-11-15 Journal: Science China. Life sciences [Category] COVID19(2023년), SARS, 치료제, [키워드] activate Activation acute respiratory syndrome Administered agmatine alleviate Antiviral caused changed characterized circulating metabolite coronavirus Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients cytokine production drug Effect effector elevated elicit embryonic exhibiting fibroblast identification IFNs IL-6 IL-6 level Inflammation Inflammatory cytokine Inflammatory response interferon regulatory factor interferons IRFs macrophages metabolite metabolites metabolites. metabolome mice molecular mechanism NF-κB NF-κB pathway Proinflammatory cytokine putrescine responsible resulting SARS-CoV-2 serum severity significantly stages strong immune response systemic inflammatory responses Tandem mass spectrometry tested the disease TNF type I interferon underlie wildtype [DOI] 10.1007/s11427-021-2099-7 PMC 바로가기
Metabolomics-based investigation of SARS-CoV-2 vaccination (Sinovac) reveals an immune-dependent metabolite biomarkerArticle Published on 2022-09-282022-11-15 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 변종, 진단, [키워드] analyses Analysis antibodies and cytokines antibody association AUC Biomarker boost butanoate collected COVID-19 COVID-19 vaccine Cytokines determine effective fatality FDR Fold change GABA Glutamate greater help Host host immunity IgA IgG IgM immune Immunity IMPROVE individual indole Infection L-glutamic acid metabolism metabolite metabolome metabolomic metabolomic analysis metabolomics mutant strain mutated Pathways positive pre-vaccination provide respond reveal SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 virus infection sera serum serum antibody Sinovac Spread Taurine vaccination Vaccine VIP Volunteer was performed [DOI] 10.3389/fimmu.2022.954801 PMC 바로가기
Integrated microbiome and metabolome analysis reveals the potential therapeutic mechanism of Qing-Fei-Pai-Du decoction in mice with coronavirus-induced pneumoniaArticle Published on 2022-08-262022-11-16 Journal: Frontiers in Cellular and Infection Microbiology [Category] 유전자 메커니즘, [키워드] 16S rRNA addition affected amino acids Analysis bile acids change China Clinical treatment coronavirus disease Coronavirus disease 2019 correlated correlation COVID-19 current Eicosanoids evaluated fatty acids Gut gut microbiota Host Host immune response immune immune function immune response IMPROVE Inflammation lipid metabolism lung tissue mechanism metabolism metabolite metabolome metabolomic analysis mice Microbiome modulating patients with COVID-19 performed Pneumonia Qing-Fei-Pai-Du decoction reduce reveal Sequencing serum severity shown significantly Spearman correlation analysis Staphylococcus therapeutic therapeutic effect Treatment was performed [DOI] 10.3389/fcimb.2022.950983 PMC 바로가기
Combining metabolome and clinical indicators with machine learning provides some promising diagnostic markers to precisely detect smear-positive/negative pulmonary tuberculosis대사체와 임상 지표를 기계 학습과 결합하면 도말 양성/음성 폐결핵을 정확하게 감지하는 몇 가지 유망한 진단 마커를 제공합니다.Article Published on 2022-08-252022-09-11 Journal: BMC Infectious Diseases [Category] Coronavirus, 바이오마커, 치료기술, [키워드] Amino acid Analysis best Biomarker Biomarkers cause Characteristics Combination conducted Control controls COVID-19 death death case death cases detect Diagnosis diagnostic diagnostic biomarker Diagnostic biomarkers discriminant analysis dysfunction enriched pathways fatty Fatty acid feature global pandemic high accuracy Infectious disease machine machine learning marker metabolisms metabolite metabolome metabolomic metabolomic analysis metabolomic profiling metabolomics Mycobacterium tuberculosis Mycobacterium tuberculosis (Mtb) offer Patient patients performed plasma Precision provide pulmonary tuberculosis R package random Random forest Seven significant enrichment smear Smear-positive/negative pulmonary tuberculosis Support SVM TB patient three group three groups Tuberculosis Tuberculosis (TB) was performed [DOI] 10.1186/s12879-022-07694-8 PMC 바로가기 [Article Type] Article
Plasma metabolome and cytokine profile reveal glycylproline modulating antibody fading in convalescent COVID-19 patients혈장 대사체 및 사이토카인 프로필은 회복기 COVID-19 환자에서 글리실프롤린 조절 항체 퇴색을 나타냅니다Article Published on 2022-08-232022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 바이오마커, 진단, [키워드] accumulated Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alteration antibody association catalyzed cleavage conducted convalescent convalescent COVID-19 patient convalescent COVID-19 patients convalescent patient Convalescent patients coronavirus COVID-19 COVID-19 convalescent patients COVID-19 pandemic cytokine cytokine profile cytokine profiling Cytokines demonstrated dipeptide dipeptidyl peptidase Dipeptidyl peptidase 4 domain down-regulate DPP4 experiment feature Feature selection glycylproline healthy healthy subjects IL-12p40 immune response immune responses individual inhibitor inhibitory effect Inhibitory effects M-CSF machine-learning mechanism metabolite metabolites metabolome metabolomics mice modulating neutralizing antibody outcome peptide plasma Plasma cytokine product public health Quantitative respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination severe acute respiratory syndrome Coronavirus sitagliptin suppresse therapeutic Treatment vaccination Vaccination strategy with COVID-19 [DOI] 10.1073/pnas.2117089119 PMC 바로가기 [Article Type] Article
NMR spectroscopy spotlighting immunogenicity induced by COVID-19 vaccination to mitigate future health concernsReview article Published on 2022-08-222022-10-05 Journal: Current Research in Immunology [Category] 바이오마커, 유전자 메커니즘, [키워드] affected Analysis approach BALF biological samples Biomarker Blood breast milk Bronchoalveolar-lavage fluid cerebrospinal fluid chemometrics complex COVID-19 COVID-19 vaccination CSF described detect disease examined example explain Health immunogenicity IMPROVE management metabolome mitigate molecular NMR NMR spectroscopy nuclear Nuclear magnetic resonance spectroscopy PCA Saliva Semen statistical the disease Treatment Urine vaccination Vaccine [DOI] 10.1016/j.crimmu.2022.08.006 [Article Type] Review article
Targeting ACLY efficiently inhibits SARS-CoV-2 replicationACLY를 표적으로 SARS-CoV-2 복제를 효율적으로 억제Article Published on 2022-07-112022-09-11 Journal: International Journal of Biological Sciences [Category] COVID19(2023년), SARS, 변종, [키워드] ACLY acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyses Analysis ATP caused citrate coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Delta Factor help Host identify in vitro in vivo inhibit Intervention involved metabolome metabolomic metabolomics Mutation omicron pandemic public health replication of SARS-CoV-2 required SARS-CoV-2 SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus susceptibility targeting targets Therapeutics Transmissibility Treatment Vaccine variants variants of concern virulence virus replication VOCs wild-type [DOI] 10.7150/ijbs.72709 PMC 바로가기 [Article Type] Article
Small-molecule metabolome identifies potential therapeutic targets against COVID-19소분자 대사체는 COVID-19에 대한 잠재적인 치료 표적을 식별합니다Article Published on 2022-06-152022-09-12 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] Accuracy biochemical change characterized composed Concentration controls COVID-19 COVID-19 infected individual COVID19 COVID19 patient disease severity evaluate host cell identify Infection metabolome metabolomic signature microbes nasal nasal mucosa nasopharyngeal Patient potential therapeutic target potential therapeutic targets primer produced qRT-PCR R 2 respiratory respiratory syncytial virus RSV SARS-CoV-2 significantly significantly increased small molecule tested transmitted unique viral infection Viral load virus [DOI] 10.1038/s41598-022-14050-y PMC 바로가기 [Article Type] Article
Tuaimenal A, a Meroterpene from the Irish Deep-Sea Soft Coral Duva florida, Displays Inhibition of the SARS-CoV-2 3CLpro Enzyme아일랜드 심해 연성 산호 Duva florida의 메로테르펜인 Tuaimenal A, SARS-CoV-2 3CLpro 효소 억제 표시Review Published on 2022-05-272022-09-11 Journal: Journal of natural products [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CLpro Bioactivity biochemical assay carbon Cold collected Continental margin Coral display docking experiment exploration human disease in silico inhibit inhibition invertebrate margin Meroterpene metabolome protease representing SARS-CoV-2 Soft the SARS-CoV-2 was determined water [DOI] 10.1021/acs.jnatprod.2c00054 PMC 바로가기 [Article Type] Review