The chemical constituents of Sterculia comosa (wall) Roxb woods for arginase inhibitory, antioxidant activity, and molecular docking against SARS CoV-2 proteinResearch Article Published on 2022-01-192022-10-31 Journal: Heliyon [Category] COVID-19, [키워드] Sterculia comosa (wall) Roxb. antioxidant arginase binding affinity docking DPPH flavonoid inhibitory inhibitory activity Interaction isolate methanol molecular docking Nsp12 PLPro predicted Protein SARS CoV-2 scavenging spike was determined [DOI] 10.1016/j.heliyon.2022.e08798 PMC 바로가기 [Article Type] Research Article
Scalable, methanol‐free manufacturing of the SARS‐CoV‐2 receptor‐binding domain in engineered Komagataella phaffiiCommunication Published on 2021-11-152022-10-27 Journal: Biotechnology and bioengineering [Category] COVID-19, [키워드] Antigen approach candidate Cell clinical trial COVID‐19 COVID‐19 Elimination genetic engineering Health Host methanol microbial microbial engineering other variant Pichia pastoris platform prevention Protein Protein subunit RBD receptor‐binding domain Recombinant protein removal reported SARS‐CoV‐2 secreted secreted protein Spike protein Stress Subunit vaccine the RBD protein transfer Vaccine vaccine antigen vaccine candidate vaccine candidates Vaccines yeast [DOI] 10.1002/bit.27979 PMC 바로가기 [Article Type] Communication
Naturally Available Flavonoid Aglycones as Potential Antiviral Drug Candidates against SARS-CoV-2Article Published on 2021-10-292022-10-30 Journal: Molecules [Category] COVID-19, SARS, [키워드] Anastatica hierochuntica Citrus reticulate in vitro screening Kickxia aegyptiaca aglycone Analysis Anastatica candidate carried Citrus co-crystallized Combination Compound drug Effects evaluated examined flavonoid flavonoid aglycones highest hydrolyzed identify in vitro in vivo inflammatory disease inhibitor metabolite methanol molecular docking Molecular docking study MPro Naturally Potential reference standard SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 Mpro Structure therapeutic potential these compound virus inhibition [DOI] 10.3390/molecules26216559 PMC 바로가기 [Article Type] Article
Event-Based Surveillance of Poisonings and Potentially Hazardous Exposures over 12 Months of the COVID-19 PandemicArticle Published on 2021-10-222022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] alcohol Border Canada changes in Chemical chlorine dioxide contributed COVID-19 COVID-19 infections COVID-19 pandemic death exposure facilitated function Government hand sanitiser hazard Hydroxychloroquine increasingly India International Ivermectin lockdown Measures media methanol misinformation MONITOR Month occurred PHE Poison poisoning Prevent provided Public public health Public Health England public health threat report reported service toxicovigilance treat [DOI] 10.3390/ijerph182111133 PMC 바로가기 [Article Type] Article
Transformation of antiviral ribavirin during ozone/PMS intensified disinfection amid COVID-19 pandemicCOVID-19 전염병 속에서 소독을 강화한 오존/PMS 중 항바이러스 리바비린의 변환Article Published on 2021-10-102022-09-11 Journal: The Science of the total environment [Category] SARS, 치료제, [키워드] accelerated accounted Advanced oxidation process amide Antiviral Bicarbonate bromide chloride Concentration condition coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic Degradation Disinfection dominant dosage ecosystem Efficiency ENhance followed by Health hospital hydroxyl hydroxyl group hydroxyl groups investigated Iodide methanol organic matter Oxidation Oxidation by-products Ozonation Ozone Peroxymonosulfate potential risk rate constant reaction rate reduced released ribavirin risk significantly higher Spread transformation wastewater [DOI] 10.1016/j.scitotenv.2021.148030 PMC 바로가기 [Article Type] Article
High-throughput RNA sequencing of paraformaldehyde-fixed single cellsArticle Published on 2021-09-242022-10-04 Journal: Nature Communications [Category] 유전자 메커니즘, [키워드] Cell cell sorting current detect droplet Express fixation gene expression level Gene expression profiling High-throughput screening Host human betacoronavirus identify inactivation incompatible Infection information methanol OC43 paraformaldehyde pathogen pathogenic pathway permeabilized phenotypic pro-inflammatory Protein RNA RNA sequencing second Single Cell single cells single-cell Single-cell RNA sequencing staining subpopulation subpopulations tissue TMEM119 transcript transcriptomic transcriptomic method Treatment upregulation viral genes viral infection viral reactivation virus [DOI] 10.1038/s41467-021-25871-2 PMC 바로가기 [Article Type] Article
GC-MS, LC-MS/MS, Docking and Molecular Dynamics Approaches to Identify Potential SARS-CoV-2 3-Chymotrypsin-Like Protease Inhibitors from Zingiber officinale RoscoeGC-MS, LC-MS/MS, 도킹 및 분자 역학 접근법은 Zingiber Officinale Roscoe로부터 잠재적 인 SARS-COV-2 3- chymotrypsin- 유사 프로테아제 억제제를 식별하기위한 접근법.Article Published on 2021-08-282022-08-31 Journal: Molecules [Category] SARS, 치료제, [키워드] Zingiber officinale 24-Methylcholesta-7-en-3β-on 3CL 3CL Protease absence Analysis binding energy chymotrypsin complex Compound compounds docking Dynamics enzyme evaluate GC-MS identify inhibitory activity inhibitory potency Isolation LC-MS/MS MD simulation MD simulations metabolite methanol molecular molecular docking molecular dynamics molecular interaction NMR nootkatone positive control Potential Predictive protease SARS-CoV-2 Secondary Metabolite secondary metabolites spinasterol stability steroid Steroids suggested Zingiber [DOI] 10.3390/molecules26175230 PMC 바로가기 [Article Type] Article
Evaluation of stability and inactivation methods of SARS-CoV-2 in context of laboratory settings실험실 환경에서 SARS-CoV-2의 안정성 및 비활성화 방법 평가Original Investigation Published on 2021-07-012022-09-12 Journal: Medical Microbiology and Immunology [Category] MERS, SARS, 진단, [키워드] acetone acute respiratory disease addition Analysis analyzed Bio safety biosafety level Biosafety Level 3 BSL-3 Caco-2 causative agent Cell culture Corona virus COVID-19 Crystal violet Culture culture media denaturation dose effective Ethanol evaluated guanidine handling heat inactivation inactivation infected cell infected cells Infection Laboratory level 3 lysate lysates lysed lysis buffer media methanol Microscopy molecular Molecular biology Novel coronavirus novel coronavirus SARS-CoV-2 PFA Proteins removal required Research RT-qPCR SARS-CoV-2 Spread stability staining subsequent supernatant supplementary material susceptible TCID tested tissue tissue culture Vero Cell Vero cells viral sample virus [DOI] 10.1007/s00430-021-00716-3 PMC 바로가기 [Article Type] Original Investigation
Development and validation of a sensitive, fast and simple LC-MS / MS method for the quantitation of favipiravir in human serum인간 혈청에서 favipiravir의 정량을 위한 민감하고 빠르고 간단한 LC-MS/MS 방법의 개발 및 검증Article Published on 2021-06-302022-09-11 Journal: Journal of chromatography. B, Analytical technolog [Category] 치료제, [키워드] applicability applied biological samples clinical trial Concentration coronavirus disease Coronavirus disease 2019 correlation coefficient COVID-19 COVID-19 patient develop development drug level electrospray ionization extraction Favipiravir Formic acid human serum inhibitor LC-MS less linear mass spectrometry methanol patients with COVID-19 performed Phenomenex pilot study plasma samples polymerase positive protein precipitation quantitation receiving reported robust simple tandem Tandem mass spectrometry Treatment validation validation study Viral RNA was performed was used water [DOI] 10.1016/j.jchromb.2021.122768 PMC 바로가기 [Article Type] Article
Development and Validation of a Method for Quantification of Favipiravir as COVID-19 Management in Spiked Human Plasma스파이크 인간 혈장에서 COVID-19 관리로서 Favipiravir의 정량화 방법의 개발 및 검증Article Published on 2021-06-222022-09-10 Journal: Molecules [Category] MERS, 치료제, [키워드] Accuracy acetonitrile acyclovir bio-analytical Bioanalytical Method Validation blank calibration curve Concentration concerning COVID-19 COVID-19 pandemic development dichloromethane evaluated Favipiravir flow rate Guidance heteroscedasticity HPLC Human Human plasma isocratic linear Linear regression LLOQ maximum methanol no significant difference phosphate phosphate buffer plasma Precision proportion reduced regression coefficient researcher resolved selectivity sensitivity separated solvent spiked human plasma stability US-FDA validation was obtained Weighting [DOI] 10.3390/molecules26133789 PMC 바로가기 [Article Type] Article