Intradermal delivery of receptor‐binding domain of SARS‐CoV‐2 spike protein with dissolvable microneedles to induce humoral and cellular responses in miceRapid Communication Published on 2020-12-122022-10-27 Journal: Bioengineering & Translational Medicine [Category] COVID-19, [키워드] acute respiratory syndrome B‐cell bolus injection cellular response comparable coronavirus COVID‐19 demonstrated humoral immunogenic induce Intradermal intradermal delivery mice Microneedle outcome RBD receptor‐binding domain receptor‐binding domain S1 subunit SARS‐CoV‐2 SARS‐CoV‐2 Spike protein T‐cell response Vaccine [DOI] 10.1002/btm2.10202 PMC 바로가기 [Article Type] Rapid Communication
C-di-GMP with influenza vaccine showed enhanced and shifted immune responses in microneedle vaccination in the skinArticle Published on 2020-06-012023-06-24 Journal: Drug delivery and translational research [Category] 신종인플루엔자, [키워드] adjuvant Influenza Microneedle STING agonist vaccination [DOI] 10.1007/s13346-020-00728-1
Microneedle array delivered recombinant coronavirus vaccines: Immunogenicity and rapid translational developmentResearch paper Published on 2020-04-022022-11-01 Journal: EBioMedicine [Category] COVID-19, MERS, SARS, [키워드] 2019-nCoV agonists antibody antigen-specific antibody building characteristic clinical development clinical trials coronavirus Coronavirus infection COVID-19 COVID-19 disease COVID-19 vaccines develop Diseases domain effort elicited ELISA evidenced finding fused Health immune immune response immunization immunogenicity in vivo induce infectious agent injection long-lasting MERS MERS-CoV MERS-CoV S1 MERS-CoV vaccine MERS-CoV vaccines mice Microneedle microneedle array Middle East MNA MOST Novel coronavirus Outbreaks Pandemics produced Progressive Protein protein subunit vaccine respiratory response responses SARS-CoV SARS-CoV-2 SARS-CoV-2 S1 sequence serum specific IgG antibody subcutaneously Subunit vaccine subunit vaccines Support tested the SARS-CoV-2 TLR4 TLR5 translational trimeric trimerization Vaccine variant viral envelope virus virus neutralization assays [DOI] 10.1016/j.ebiom.2020.102743 PMC 바로가기 [Article Type] Research paper
Stable incorporation of GM-CSF into dissolvable microneedle patch improves skin vaccination against influenzaArticle Published on 2018-04-282023-06-14 Journal: Journal of controlled release : official journal o [Category] Fulltext, 신종인플루엔자, [키워드] adjuvant Co-delivery GM-CSF Influenza Microneedle skin [DOI] 10.1016/j.jconrel.2018.02.033 PMC 바로가기
Effect of zymosan and poly (I:C) adjuvants on responses to microneedle immunization coated with whole inactivated influenza vaccineArticle Published on 2017-11-102023-06-24 Journal: Journal of controlled release : official journal o [Category] 신종인플루엔자, [키워드] adjuvant Influenza Microneedle skin Vaccine Zymosan. [DOI] 10.1016/j.jconrel.2017.09.010
Effective humoral immune response from a H1N1 DNA vaccine delivered to the skin by microneedles coated with PLGA-based cationic nanoparticlesArticle Published on 2017-11-102023-06-24 Journal: Journal of controlled release : official journal o [Category] 신종인플루엔자, [키워드] Microneedle pH1N1 DNA vaccine. PLGA Polyethyleneimine (PEI) skin vaccination [DOI] 10.1016/j.jconrel.2017.04.027
Long-term stability of influenza vaccine in a dissolving microneedle patchArticle Published on 2017-04-012023-06-23 Journal: Drug delivery and translational research [Category] 신종인플루엔자, [키워드] influenza vaccine Microneedle Solid dosage form transdermal delivery vaccine delivery vaccine formulation vaccine stability [DOI] 10.1007/s13346-016-0282-2 PMC 바로가기
Microneedle delivery of trivalent influenza vaccine to the skin induces long-term cross-protectionArticle Published on 2016-12-012023-06-23 Journal: Journal of drug targeting [Category] 신종인플루엔자, [키워드] Influenza Microneedle protection Trivalent vaccine [DOI] 10.3109/1061186X.2016.1159213
Influenza nucleoprotein DNA vaccination by a skin targeted, dry coated, densely packed microprojection array (Nanopatch) induces potent antibody and CD8(+) T cell responsesArticle Published on 2016-09-102023-06-24 Journal: Journal of controlled release : official journal o [Category] 신종인플루엔자, [키워드] DNA vaccination Enhanced immunogenicity Microneedle Needle-free vaccination skin vaccination [DOI] 10.1016/j.jconrel.2016.06.045
Induction of broad immunity by thermostabilised vaccines incorporated in dissolvable microneedles using novel fabrication methodsArticle Published on 2016-03-102023-06-24 Journal: Journal of controlled release : official journal o [Category] 신종인플루엔자, [키워드] Broadly-neutralizing antibody influenza vaccine Microneedle stability Virus vector vaccine. [DOI] 10.1016/j.jconrel.2016.01.019