Expression analysis of miRNA hsa-let7b-5p in naso-oropharyngeal swabs of COVID-19 patients supports its role in regulating ACE2 and DPP4 receptorsArticle Published on 2022-10-012022-11-15 Journal: Journal of Cellular and Molecular Medicine [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, [키워드] ACE2 Analysis control sample coronavirus disease COVID-19 COVID-19 patient COVID-19 patients differential expression downregulation DPP4 enzyme Epigenetic functional Genes hsa-let7b-5p investigated involved low expression mechanism miRNA miRNAs miRNAs. modulation naso-oropharyngeal swab Novel coronavirus NPs overexpressed overexpression progression receptor Regulation reported respiratory responsible SARS-CoV-2 SARS-COV-2 infection significantly statistically significant Support the disease therapeutic target transcripts [DOI] 10.1111/jcmm.17492 PMC 바로가기
Anti-glutathione S-transferase omega 1-1 (GSTO1-1) antibodies are increased during acute and chronic inflammation in humansArticle Published on 2022-09-292022-11-15 Journal: Clinical and experimental immunology [Category] SARS, 바이오마커, 치료기술, [키워드] antibody Auto-antibodies Autoimmune Biomarker cancer progression Cell chronic inflammation COVID-19 Critical cytosolic enzyme glutathione glutathione S-transferase omega-1 Human Inflammation Inflammatory diseases inflammatory pathway involved marker modulation Patient Potential biomarker rheumatoid arthritis SARS-CoV-2 serum the disease tissue trichinellosis. variety [DOI] 10.1093/cei/uxac060 PMC 바로가기
RNA sequence analysis of nasopharyngeal swabs from asymptomatic and mildly symptomatic patients with COVID-19Research article Published on 2022-09-012022-10-05 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Analysis Asymptomatic autophagy Bacterial Cell changes in Coinfection complement COVID-19 Differential gene expression disease severity dysregulation Epigenetic gene expression profile Gene ontology group identify in both group investigated involved mildly symptomatic patient Modification modulation mRNA Nasopharyngeal swab objective outcome Patient patients performed profile progression proportion reduction in Result retrieved RNA RNA sequence SARS-CoV-2 SARS-COV-2 infection Sequence analysis Sequencing Streptococcus pneumoniae symptomatic symptomatic individuals Symptomatic patients the disease transcriptomic transcriptomics translation Transport upregulation Viral genome assembly viral variant with COVID-19 [DOI] 10.1016/j.ijid.2022.06.035 [Article Type] Research article
Repurposed anti-cancer epidermal growth factor receptor inhibitors: mechanisms of neuroprotective effects in Alzheimer’s disease용도 변경 항암 표피 성장 인자 수용체 억제제: 알츠하이머 병에서 신경 보호 효과의 메커니즘Review Published on 2022-09-012022-09-11 Journal: Neural Regen Res [Category] 비임상, [키워드] Alzheimer's disease Alzheimer’s disease animal model autophagy breath caused disease Disease progression downstream signaling pathway downstream signaling pathways drug drug re-positioning Effect effective enhancement epidermal epidermal growth factor epidermal growth factor receptor Evidence examined explained growth factor human epidermal growth factor receptor-2 kinase inhibitors mechanism modulation molecular mechanism neurodegeneration neurodegenerative Neurodegenerative diseases Neuroinflammation neurological manifestation neurological manifestations Numerous oxidative oxidative stress Perspective positioning Prospective clinical trial recent receptor receptor inhibitor Research shown signaling pathways therapeutic approach tyrosine tyrosine kinase inhibitors Tyrosine kinase inhibitors. [DOI] 10.4103/1673-5374.332132 PMC 바로가기 [Article Type] Review
Immune modulation as a consequence of SARS-CoV-2 infectionArticle Published on 2022-08-302022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, [키워드] adaptive Alter alteration B cells CD3 CD8 Clinical severity clinically COVID-19 COVID-19 pathogenesis Cytokine storm D-dimer levels Decreased detrimental effects diagnosed elevated Elevation enrolled Frame healthy controls IFN-γ IgA level IgG IL-10 IL-6 IL-8 ILCs immune immune response Immunity Mild moderate modulated modulation negative correlation NK cell NK cells Patient Plasma cell pro-inflammatory cytokine Protective reduced reduction SARS-CoV-2 SARS-COV-2 infection Serum level severe COVID-19 disease Severe patient severe patients significantly subset T cell T cells T cells. the disease TNF-α [DOI] 10.3389/fimmu.2022.954391 PMC 바로가기
Long-lasting, dissociable improvements in working memory and long-term memory in older adults with repetitive neuromodulation Research Published on 2022-08-222022-10-05 Journal: Nature Neuroscience [Category] 유전자 메커니즘, [키워드] baseline benefit Brain Cognitive function cortical ENhance improvement Improvements individual Intervention memory modulation Older parameter plasticity predicted PROTECT protocol selective synchronous translational [DOI] 10.1038/s41593-022-01132-3 [Article Type] Research
Gene Network Analysis of the Transcriptome Impact of SARS-CoV-2 Interacting MicroRNAs in COVID-19 DiseaseCOVID-19 질병에서 SARS-CoV-2 상호작용 MicroRNA의 전사체 영향에 대한 유전자 네트워크 분석Review Published on 2022-08-172022-09-11 Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘, [키워드] affected Analysis biochemical biological processes Cell cell cycle cell surface receptor changes characterized COVID-19 COVID-19 disease cytokine death DEGs differentially expressed differentially expressed gene Differentially expressed genes downregulated exploratory FIVE functional enrichment Functional enrichment analysis Gene Expression gene network Health Organization heart Impact involved kidneys list lung Lymph node microRNA MicroRNAs mitochondrial mitotic mitotic cell modulation molecular Multiorgan multiorgan disease network network analysis network analysis. pathological mechanism Pathways Perspective predicted provide reported SARS-CoV-2 SARS-CoV-2 virus signaling pathway submitted surface receptor target tissue tissues transcriptomes translated upregulated WHO with COVID-19 World Health Organization [DOI] 10.3390/ijms23169239 PMC 바로가기 [Article Type] Review
Detection of Intestinal Dysbiosis in Post-COVID-19 Patients One to Eight Months after Acute Disease Resolution급성 질환 해결 후 1~8개월 후 코로나19 환자의 장내 세균총 이상 감지Article Published on 2022-08-172022-09-11 Journal: International Journal of Environmental Research an [Category] 치료제, [키워드] acute COVID-19 acute disease acute phase adaptive immune responses addition alopecia anti-SARS-CoV-2 antibody Antibiotic therapy Antibiotics Anxiety bidirectional Bifidobacterium C-reactive protein Clinical data clinical manifestations controls COVID-19 severity Cytokine storm Depression Desulfovibrio detection disease DNA Dysbiosis Dyspnea evaluate fatigue Hypothesis immune response immune responses Immune status Interaction intestinal intestinal microbiota memory memory loss microbes microbiota modulating modulation Month myalgia pandemic Patient post-COVID-19 Post-COVID-19 patients Prevotella quantified reported symptoms Resolution Sequelae. sequenced severity significant difference significant differences Stool stool samples target the patient Therapeutic approach These data use of antibiotics viral infections with COVID-19 [DOI] 10.3390/ijerph191610189 PMC 바로가기 [Article Type] Article
How does age determine the development of human immune-mediated arthritis? Reviews Published on 2022-08-102022-10-05 Journal: Nature reviews. Rheumatology [Category] 유전자 메커니즘, 진단, [키워드] Adults Affect age Arthritis autoantibody children chronic inflammation contribute controls Critical determine develop disease driven by Drivers environmental exposure Epigenetic expand facilitate Factor Factors Genetic genetics hypothese immune immune system immune tolerance Immune-mediated individual Inflammation involved juvenile idiopathic arthritis maturation mechanism mechanisms microbial modulation Numerous Pathogenesis Patient Phenotypes pro-inflammatory similarity tolerogenic [DOI] 10.1038/s41584-022-00814-3 [Article Type] Reviews
Antibody-Dependent Enhancement: ″Evil″ Antibodies Favorable for Viral Infections항체 의존적 증강: 바이러스 감염에 유리한 ″악″ 항체Review Published on 2022-08-082022-09-12 Journal: Viruses [Category] 진단, [키워드] acute respiratory syndrome ADE analyzed antibody Antibody-dependent enhancement caused Cell Characteristics complement coronavirus Diseases drug effective ENhance expressed facilitate Fc receptor Fc receptors immune immune response immune responses involved mechanisms modulation molecular mechanism myeloid cells NAbs neutralizing antibody Pandemics public health Transcription transcription modulation Vaccine viral infection viral pathogenicity virus virus virus entry Virus entry. virus infection [DOI] 10.3390/v14081739 PMC 바로가기 [Article Type] Review