Host Predictors of Broadly Cross-Reactive Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants of Concern Differ Between Infection and Vaccination중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2)에 대한 광범위한 교차 반응성 항체의 숙주 예측 인자는 감염과 예방 접종 사이에 차이가 있습니다.Observational Study Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, 임상, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Against antibody Antibody Response B.1.1.7 B.1.351 B.1.617.2 BMI booster Clinical characteristics clinician Clinicians Cohort collected concern contributed coronavirus coronavirus 2 cross-reactive cross-reactive antibodies cross-reactive antibody disease severity enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Factor Health healthy highest Host identify IgG IgG antibodies IgG antibody IgG level immunization Immunocompromised Immunoglobulin Immunoglobulin G individual Infection information metabolic health mounted mRNA vaccination P.1 participant plasma sample plasma samples Population populations predict prospective observational cohort Protective Protective antibody RBD Receptor binding domain Regression model regression models researchers respiratory responses SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant severe acute respiratory syndrome Coronavirus Spike receptor binding domain tested These data vaccination Vaccine Variability variants variants of concern Viral Viral variants virus variants Wuhan younger people [DOI] 10.1093/cid/ciab996 PMC 바로가기 [Article Type] Observational Study
Perinatally Human Immunodeficiency Virus-Infected Adolescents and Young Adults Demonstrate Distinct BNT162b2 Messenger RNA Coronavirus Disease 2019 Vaccine Immunogenicity주산기 인간 면역결핍 바이러스에 감염된 청소년 및 젊은 성인은 뚜렷한 BNT162b2 메신저 RNA 코로나바이러스 질병 2019 백신 면역원성을 나타냅니다.Article Published on 2022-08-152022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adolescent anti-SARS-CoV-2 humoral antibody Antigen Antigen-specific T cells Antiretroviral therapy ART baseline BNT162b2 BNT162b2 mRNA BNT162b2 mRNA COVID-19 vaccine CD4+ T cell CD4+ T-cell CD40L Cellular responses characterized Cluster collected coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 demonstrated dose Efficacy eligibility evaluated expand feature Follow-up group HCs healthy control HIV HIV-infected patient HIV-infected patients Human Human immunodeficiency virus humoral immune response Immunity immunization immunodeficiency virus immunogenicity involved messenger Messenger RNA molecules mononuclear cell mononuclear cells mounted mRNA of BNT162b2 Olink perinatally HIV-infected patients. Peripheral blood Peripheral blood mononuclear cells plasma samples Population populations profile protein level protein levels proteomic proximity extension assay Regulation respiratory response responses RNA RNA coronavirus Safety Sample SARS-CoV-2 SARS-CoV-2 antibody second dose severe acute respiratory syndrome Coronavirus study groups T cell T cells vaccination Vaccine Vulnerable populations were assessed [DOI] 10.1093/cid/ciac408 PMC 바로가기 [Article Type] Article
Persistent but atypical germinal center reaction among 3rd SARS-CoV-2 vaccination after rituximab exposureArticle Published on 2022-08-102022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] accompanied analyzed anti-SARS-CoV-2 IgG Anti-spike antibody level antigen-specific B cell Atypical B cell CD4 CD4 T cell Cell cellular cellular response circulating control groups correlated effector memory evaluated germinal center (GC) healthy volunteer humoral immune response Immunity induce long-lived plasma cell MBC memory memory B memory B cell memory B cell (MBC) mounted mRNA vaccination neutralizing capacity Patient patients persistent plasmablast Reactions recall reduction rheumatoid arthritis rituximab (RTX) RTX SARS-CoV-2 SARS-CoV-2 IgG antibody SARS-CoV-2 vaccination second vaccination seroconverted Seven significantly spike-specific T cell Steady state therapy treated patient Treatment vaccination vaccine-mediated immunity [DOI] 10.3389/fimmu.2022.943476 PMC 바로가기
Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope우성 SARS-CoV-2 킬러 T 세포 에피토프에서 면역 탈출의 출현Article Published on 2022-08-042022-09-11 Journal: Cell [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antigen CD8 CD8 T cell Cohort cohorts convalescent patient Convalescent patients coronavirus COVID-19 dominant emergence epitope Epitopes for inclusion Frequency glycoprotein highlighting HLA human leukocyte antigen immune Immune escape individual leukocyte Lineage lineages mounted Mutation new SARS-CoV-2 Next generation vaccine next generation vaccines peptide-HLA Phylogenetic prevalent Protein response SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 spike SARS-CoV-2 variants sequence severe acute respiratory syndrome Coronavirus spike spike glycoprotein T cell T cell epitope T cell epitopes T cell receptors vaccine immunity variants viral escape Viral protein Viral proteins [DOI] 10.1016/j.cell.2022.07.002 PMC 바로가기 [Article Type] Article
Deep Learning-Aided Automated Pneumonia Detection and Classification Using CXR ScansCXR 스캔을 사용한 딥 러닝 지원 자동화된 폐렴 감지 및 분류Article Published on 2022-08-042022-09-11 Journal: Computational Intelligence and Neuroscience [Category] 치료기술, [키워드] Accuracy artificial intelligence caused Chain Reaction Chest chest X-ray chest X-rays classification CNN common disease conditions contributing to COVID-19 COVID-19 pandemic COVID-19 virus CXR deep deep learning desperation detect detection Diagnosis Experimental result experimental results false discovery rate False negative False negative rate false positive rate gold group Healthcare system Impact infections Inspection limitation lung Lungs mounted overlap pandemic Panic Pneumonia polymerase chain reaction Precision pressure recall Research Reverse transcription-polymerase chain reaction RT-PCR SACs shown specificity Standard Model subsequent transfer Treatment Variation Visual widespread [DOI] 10.1155/2022/7474304 PMC 바로가기 [Article Type] Article
Nonproductive exposure of PBMCs to SARS-CoV-2 induces cell-intrinsic innate immune responsesSARS-CoV-2에 대한 PBMC의 비생산적 노출은 세포 고유의 타고난 면역 반응을 유도합니다Article Published on 2022-08-012022-09-11 Journal: Molecular Systems Biology [Category] SARS, 치료기술, [키워드] absence ACE2 receptor analyzed baseline bystander cell bystander cells Cell COVID-19 Culture Cytokines detectable Ex vivo experiment exposure to expression expression profile expression profiles healthy donor healthy donors human PBMC immune responses in vivo induce infected cell Infection innate immune response Interaction interferon interferon-stimulated gene interferon-stimulated genes interferon-stimulated genes. Invasion ISG ISGs Mild monocyte Monocytes mounted Particle Patient PBMC PBMCs physical proinflammatory cytokines respiratory tract response RT-PCR SARS-CoV SARS-CoV-2 severe COVID-19 Single-cell RNA sequencing STAT stimulate susceptibility triggered virus particle virus particles [DOI] 10.15252/msb.202210961 PMC 바로가기 [Article Type] Article
Video laryngoscope versus USB borescope-aided endotracheal intubation in adults with anticipated difficult airway: a prospective randomized controlled studyRandomized Controlled Trial Published on 2022-08-012022-10-05 Journal: Korean journal of anesthesiology [Category] 임상, [키워드] airway airway management airways anticipated approved can be used changes comparable complications coronavirus disease COVID-19 Elective surgery Endotracheal intubation equipment Frequency general anesthesia groups hemodynamic incidence intratracheal Intratracheal intubation introduced intubation intubations investigated laryngoscope blade Laryngoscopy less limit mounted Patient Primary outcome provided Randomized randomized controlled study Satisfaction secondary outcome Trachea two group [DOI] 10.4097/kja.22222 PMC 바로가기 [Article Type] Randomized Controlled Trial
Optical Biosensor for the Detection of Infectious Diseases Using the Copolymer F8T2 with Application to COVID-19COVID-19에 적용한 공중합체 F8T2를 사용한 감염성 질환 검출을 위한 광학 바이오센서Article Published on 2022-07-292022-09-11 Journal: Sensors (Basel, Switzerland) [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] accelerated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-RBD anti-RBD/RBD binding anti-SARS-CoV-2 antibody antibody Antibody binding Antibody detection Antigen application biosensor caused Concentration Copolymer coronavirus COVID-19 COVID-19 negative detection develop effort F8T2 human serum hydrophobic IgG Infectious disease Interaction layer mounted negative sample optical pandemic Photoluminescence photoluminescence. polyclonal Polymer positive positive individuals promote Protein RBD Reactions respiratory SARS-CoV-2 SARS-CoV-2 spike protein secondary antibody sensitivity serum severe acute respiratory syndrome Coronavirus specificity Spike protein the SARS-CoV-2 Volume [DOI] 10.3390/s22155673 PMC 바로가기 [Article Type] Article
Antibody response following the third and fourth SARS-CoV-2 vaccine dose in individuals with common variable immunodeficiencyObservational Study Published on 2022-07-282022-10-05 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 임상, [키워드] Affect antibody Antibody Response booster booster doses Capsule clinical Concentration corona vaccination COVID-19 CVID dose examined IgG antibody immunodeficiency immunoglobulin replacement therapy IMPROVE increase in individual Kruskal-Wallis tests median monoclonal antibody mounted mRNA Multiple non-responder non-responders Patient patients proportion SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARS-CoV2 Seroconversion seroconverted spike receptor-binding domain stimulate the antibody response Treatment vaccination Vaccinations Vaccine vaccine dose [DOI] 10.3389/fimmu.2022.934476 PMC 바로가기 [Article Type] Observational Study
The anti-SARS-CoV-2 monoclonal antibody bamlanivimab minimally affects the endogenous immune response to COVID-19 vaccination항SARS-CoV-2 단일클론항체 밤라니비맙은 코로나19 백신에 대한 내인성 면역 반응에 최소한의 영향을 미친다Randomized Controlled Trial Published on 2022-07-272022-09-12 Journal: Science Translational Medicine [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료제, [키워드] acute respiratory syndrome Affect age Analysis anti-SARS-CoV-2 Antibody Response benefit clinical trial collected coronavirus coronavirus disease Course COVID-19 COVID-19 mRNA vaccines COVID-19 vaccination dose enrolled evaluated immune response Infection magnitude Moderna monoclonal antibody mounted over pandemic participant Placebo placebo recipient Prophylactic public health Randomized receiving Risk category robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein serological serum sample subset Treatment Trial vaccination Vaccine were assessed [DOI] 10.1126/scitranslmed.abn3041 PMC 바로가기 [Article Type] Randomized Controlled Trial