Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease Research Published on 2022-08-162022-10-05 Journal: Nature Communications [Category] 유전자 메커니즘, 진단, 치료기술, [키워드] accompanied alteration arise Cell cellular ciliary detect dysfunction environmental factors Gene Expression Genetic hedgehog impairment inhibition mitochondrial dysfunction morphology mouse model neurodegenerative disorder neurons observé overactive Parkinson’s disease pathological mechanism pathway patients phenotype precursor required SHH Signal transduction Signaling single-cell therapy transcriptomics [DOI] 10.1038/s41467-022-32229-9 [Article Type] Research
Early Isolates of SARS-CoV-2 Result in Different Pathogenesis in the Transduced Mouse Model of COVID-19SARS-CoV-2의 초기 분리물은 COVID-19의 형질도입된 마우스 모델에서 다른 병인을 초래합니다Article Published on 2022-08-132022-09-11 Journal: Viruses [Category] SARS, 변종, [키워드] Adenovirus alveolar inflammation BALB/c mice body weight Body weight loss Clinical sign Clinical signs COVID-19 dissemination expression followed by hACE2 hACE2 receptor Histopathology in vivo Infection isolate isolates kidney liver lung Lung histopathology Lungs mice Model mouse mouse model peaking post infection provide response Result resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus SARS-CoV-2 virus variant spleen subsequent recovery susceptible the SARS-CoV-2 virus transduced transduction undetectable Victoria viral variant Viral variants virulence virulence. virus weight loss [DOI] 10.3390/v14081769 PMC 바로가기 [Article Type] Article
Red blood cell distribution width is associated with increased interactions of blood cells with vascular wall Research Published on 2022-08-112022-10-05 Journal: Scientific Reports [Category] 유전자 메커니즘, [키워드] accelerated Affect analyzed animal model applied Artery association Atherosclerosis atherosclerotic lesion Blood blood cell carotid change circulating circulating cell contribute dependent on disease distribution element elevated Flow Hypothesis imaging increased expression Inflammation Interaction Local marker mechanism mouse model pathology Patient plaque poor prognosis Protein red blood cell Red cell researcher resonance subject Variation variety Vascular vessel wall [DOI] 10.1038/s41598-022-17847-z [Article Type] Research
SARS-CoV-2 infection impairs the insulin/IGF signaling pathway in the lung, liver, adipose tissue, and pancreatic cells via IRF1SARS-CoV-2 감염은 IRF1을 통해 폐, 간, 지방 조직 및 췌장 세포의 인슐린/IGF 신호 전달 경로를 손상시킵니다Article Published on 2022-08-012022-09-11 Journal: Metabolism: clinical and experimental [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Activation adeno-associated virus adipose Adipose tissue AKT ameliorated analyzed association Autopsy Calu3 Calu3 cell CaLu3 cells Cell cell survival cells condition contribute COVID-19 COVID-19 pathology COVID-19 patient COVID-19 patients COVID-19 severity Critical critical patient critical patients cytokine determine Dexamethasone diabetes Diabetic diabetic patients Dihydrotestosterone Endocrine energy metabolism European population evaluate Evidence exacerbated exhibited Gain Gene Expression Genes GFP HEK293T Hospitalized Host human ACE2 human cells hyperglycemia impair impairment infected with SARS-CoV-2 insulin insulin resistance Insulin signaling Insulin/IGF signaling pathway interferon regulatory factor Interferone intron IRF1 liver lung Lungs male Male sex MAPK metabolic metabolic abnormalities Metabolic abnormality metabolism mouse model mTOR Multiorgan dysfunction Multiple organ damage Non-COVID-19 Non-COVID-19 patients obese obesity Older Older age Organoid overexpressing pancreatic Pancreatic cell pancreatic islets pathology patients patients with COVID-19 PI3K potential mechanism Prevalence provide Regulation reported Repository risk factor Risk factors SARS-CoV-2 SARS-CoV-2 infected cell SARS-CoV-2 infected cells SARS-COV-2 infection serotype severe COVID-19 severity Signaling signaling pathway significantly stem cell survival tissue tissue damage Tissue damage. tissues Transcriptome transcriptome dataset transcriptome datasets Transgenic mouse variant Whole blood whole blood transcriptome with COVID-19 [DOI] 10.1016/j.metabol.2022.155236 PMC 바로가기 [Article Type] Article
Induction of Cross-Reacting Antibodies Against the COVID-19 by BCG Vaccination in the Mouse Model마우스 모델에서 BCG 백신 접종에 의한 COVID-19에 대한 교차 반응 항체 유도Article Published on 2022-07-302022-09-11 Journal: Current microbiology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Against antibodies antibody Antibody Response approach BCG BCG vaccination boost COVID-19 cross-reacting antibodies demonstrated explain help humoral immune response Immune escape immune responses Immunity induce induction investigated latent tuberculosis latent tuberculosis infection Model mouse mouse model non-specific potential tool potential tools rabies reducing reported SARS-CoV-2 SARS-CoV-2 spike spike tested the antibody response the SARS-CoV-2 Tuberculosis vaccination Vaccines variants [DOI] 10.1007/s00284-022-02971-w PMC 바로가기 [Article Type] Article
Cross-reactive immunity against SARS-CoV-2 N protein in Central and West Africa precedes the COVID-19 pandemic중부 및 서부 아프리카의 SARS-CoV-2 N 단백질에 대한 교차 반응성 면역은 COVID-19 전염병보다 앞서 있습니다Article Published on 2022-07-282022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus African antibody anticipated circulation coronavirus COVID-19 pandemic cross-reactive death defense mechanisms Donor Efficacy ELISA Europe examined explain Gabon human immune defense Humoral immunity hypothese Immunity in vitro in vivo indicate investigated involved mechanism mouse model N protein N proteins neutralization neutralize North America nucleocapsid pandemic Population pre-existing immunity presence of antibody prevalent Protective Protein public health respiratory rodent rodents SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 N protein SARS-CoV-2 S SARS-CoV-2 spike severe acute respiratory syndrome Coronavirus South specific antibodies specific antibody the N protein Viral viral fitness virus was tested West [DOI] 10.1038/s41598-022-17241-9 PMC 바로가기 [Article Type] Article
BSL2-compliant lethal mouse model of SARS-CoV-2 and variants of concern to evaluate therapeutics targeting the Spike proteinSARS-CoV-2의 BSL2 호환 치명적인 마우스 모델 및 Spike 단백질을 표적으로 하는 치료제 평가를 위한 우려 변종Article Published on 2022-07-282022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 transgenic mice acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 animal model antibody both virus both viruses brains BSL-2 BSL-2 mouse model BSL2 BSL3 BST2 can be used CCL5 change competent concern conditions coronavirus COVID-19 COVID19 CXCL10 disease Disease progression drugs Encephalitis evaluate experimental therapeutics facilitate faster generate GFP glycoprotein hACE2 host-pathogen interactions in vivo increased expression Infection interferon IRF7 K18-hACE2 K18-hACE2 transgenic mice lethal infection LILRB4 lung Lungs mass vaccination mice modulate mouse model mutations Neonatal neuronal infection neurotropism pathogenicity prophylactic treatment Protein pseudotyped Pseudotyped virus Receptor binding domain replaced REPLACED BY Replication reported SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variants SARS-CoV-2 viruses SARS2 severe acute respiratory syndrome Coronavirus Spike protein spike protein. stomatitis successive wave successive waves the SARS-CoV-2 the Spike the spike protein therapeutic Therapeutics transgenic transgenic mice Transmission vaccination Vaccine development variant variants of concern vesicular vesicular stomatitis vesicular stomatitis virus virulence virus virus VoC VSV VSV (vesicular stomatitis virus) [DOI] 10.3389/fimmu.2022.919815 PMC 바로가기 [Article Type] Article
Short-Term Effect of SARS-CoV-2 Spike Protein Receptor-Binding Domain-Specific Antibody Induction on Neutrophil-Mediated Immune Response in Mice쥐의 호중구 매개 면역 반응에 대한 SARS-CoV-2 스파이크 단백질 수용체 결합 도메인 특이적 항체 유도의 단기 효과Article Published on 2022-07-262022-09-12 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Activation Affect airway alteration antibodies antibody antibody formation Antibody Response Blood bone marrow cell CD101 Control COVID-19 CXCR2 domain Effect elevate excessive inflammation immunized induction injection Innate immunity investigated mice mimicking mouse model NETs neutrophil Neutrophil extracellular trap neutrophil recruitment Neutrophils Particle phenotype phosphate buffer PROTECT RBD RBD-specific antibodies RBD-specific antibody receptor-binding domain. respiratory inflammation response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus spike stimulate the RBD the spike protein triggering [DOI] 10.3390/ijms23158234 PMC 바로가기 [Article Type] Article
Development of an aerosol intervention for COVID-19 disease: Tolerability of soluble ACE2 (APN01) administered via nebulizerCOVID-19 질병에 대한 에어로졸 중재 개발: 분무기를 통해 투여되는 가용성 ACE2(APN01)의 내약성Article Published on 2022-07-112022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 비임상, 임상, [키워드] ACE2 Administered administration aerosol aerosolization airways Ang II angiotensin binding binding activity breath catalytic caused cleavage clinical trial Concentration conducted COVID-19 Critical deregulated development Efficacy enzymatic activity evaluated Evidence evidence of feasible healthy volunteer healthy volunteers in vitro individual Infection initiated Intervention Kinin limit lung lung damage mitigate mouse model neutralization neutralize notable Pathways phase preliminary evidence RAS RAS activity recombinant ACE2 Renin SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor Signaling soluble ACE2 Spread subsequent Tolerability toxicities virus [DOI] 10.1371/journal.pone.0271066 PMC 바로가기 [Article Type] Article
Nanoligomers Targeting Human miRNA for the Treatment of Severe COVID-19 Are Safe and Nontoxic in Mice심각한 COVID-19 치료를 위해 인간 miRNA를 표적으로 하는 나노 올리고머는 마우스에서 안전하고 독성이 없습니다Article Published on 2022-07-112022-09-11 Journal: ACS Biomaterials Science & Engineering [Category] COVID19(2023년), SARS, 치료제, [키워드] accumulation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration antisense therapy Antiviral strategies Antiviral treatment bind biodistribution biodistribution study body weight Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease Effect fatality Histopathology Host Host immune response Human human cell human cells immune immunogenicity Infection Inflammation intranasal intraperitoneal intravenous Intravenous administration kidney kidneys liver Lungs mice microRNA miRNA MOST mouse model organ organs pandemic parameters produced question response Safe Safety. SARS-CoV-2 serum biomarker serum biomarkers severe acute respiratory syndrome Coronavirus Severe case severe cases spleen targeting tested Urine with infection [DOI] 10.1021/acsbiomaterials.2c00510 PMC 바로가기 [Article Type] Article