MUC5AC – Page 2 – Communicable Diseases Research

The therapeutic promises of Lianhuaqingke in the mice model of coronavirus pneumonia (HCoV-229E and SARS-CoV-2)

Research

Published on 2021-10-182022-11-01
Journal: Chinese Medicine [Category] COVID-19,

[키워드] 16HBE cell acute pneumonia airway alleviate Anti-HCoVs therapy Anti-viral Antiviral effect approved BALB/c mice caused Cell cells ciliary Coronavirus pneumonia COVID-19 dose-dependent Effect ELISA epithelial expression expression level flow cytometry H&E staining hACE2 HCoV-229E human coronaviruses (HCoVs) identify immune response immunofluorescence staining immunomodulation immunomodulatory in vitro in vivo indicated inhibit inhibited inhibiting Injury Lianhuaqingke (LHQK) lung lung tissue lung tissues mice morphological change MUC5AC Peripheral blood Pneumonia positive pro-inflammatory cytokine reduce reduced reducing Replication Result SARS-CoV-2 staining subset Th cell Th1 Th17 Th2 the SARS-CoV-2 virus therapeutic therapeutic effect Therapies TNFα Transgenic mouse treated Treatment Treg Vero E6 viral replication virus virus titer was measured was used weight loss were measured
[DOI] 10.1186/s13020-021-00513-3 PMC 바로가기 [Article Type] Research

Alteration of Colonic Mucin Composition and Cytokine Expression in Acute Swine Dysentery

Article

Published on 2021-05-312024-09-07
Journal: Vet Pathol [Category] 세균성이질,

[키워드] Brachyspira hyodysenteriae MUC2 MUC5AC sialomucin sulfomucin.
PMC 바로가기

The therapeutic potential of inorganic polyphosphate: A versatile physiological polymer to control coronavirus disease (COVID-19)

무기다인산의 치료 가능성: 코로나바이러스(COVID-19)를 제어하는 다목적 생리학적 고분자

Review

Published on 2021-04-152022-09-10
Journal: Theranostics [Category] MERS, SARS, 신약개발, 치료제,

[키워드] ACE2 receptor addition airway airway epithelia airways alkaline phosphatase anhydride attachment binding cationic cause caused ciliary Combination coronavirus disease Course COVID-19 damages drug therapy epithelial epithelial cell epithelial cells form Gene Expression glycoprotein help hydrolysis IMPROVE Inhaled initial life cycle metabolic energy molecule MUC1 MUC5AC mucin multiorgan failure Nanoparticles Novel coronavirus novel coronavirus SARS-CoV-2 pandemic Particle phosphatase phosphate physiological Polymer polyp polyphosphate Prevent rationale Research residues SARS-CoV-2 significantly subsequent Support target cells the disease the RBD therapeutic potential therapy transported viral receptor-binding domain virus Virus life cycle
[DOI] 10.7150/thno.59535 PMC 바로가기 [Article Type] Review

Elevated MUC1 and MUC5AC mucin protein levels in airway mucus of critical ill COVID-19 patients

중증 COVID-19 환자의 기도 점액에서 MUC1 및 MUC5AC 점액 단백질 수준 상승

Article

Published on 2021-02-012022-08-31
Journal: Journal of medical virology [Category] Fulltext, MERS, 바이오마커,

[키워드] Abstract airway coronavirus COVID-19 patient Critical Immunity MUC1 MUC5AC Protein protein extraction protein level systemic immunity.
[DOI] 10.1002/jmv.26406 PMC 바로가기 [Article Type] Article

Caged Dexamethasone/Quercetin Nanoparticles, Formed of the Morphogenetic Active Inorganic Polyphosphate, are Strong Inducers of MUC5AC

Article

Published on 2021-01-272022-10-30
Journal: Marine Drugs [Category] COVID-19,

Morphogenetic (Mucin Expression) as Well as Potential Anti-Corona Viral Activity of the Marine Secondary Metabolite Polyphosphate on A549 Cells

A549 세포에 대한 해양 2차 대사산물 폴리포스페이트의 형태유전학적(뮤신 발현) 및 잠재적인 항-코로나 바이러스 활성

Article

Published on 2020-12-142022-09-10
Journal: Marine Drugs [Category] MERS, SARS, 바이오마커,

[키워드] A549 A549 cell ACE2 receptor activity addition adenylate kinase ADK alkaline phosphatase ALP alveolar antiviral response ATP attachment Bacteria binding block Blood Blood platelets Bronchial epithelium Cell cell growth cells cellular collagen coronavirus coronavirus SARS-CoV-2 epithelial Express expression Extracellular extracellular ATP growth human alveolar cells hydrogel immunostaining in vitro in vivo Inhaled inhibiting Innate immunity involved metabolic energy MUC1 MUC5AC mucin mucins nasopharynx nontoxic pathogen Pathogens phosphatase physiological Platelets Polymer polyp polyphosphate Potential protective effect Proteins RBD Receptor binding domain reduction in released SARS-CoV-2 spike protein secondary secreted significantly increased stimulated strength the cells These cells Viral viral RBD virus well
[DOI] 10.3390/md18120639 PMC 바로가기 [Article Type] Article

Defensive Properties of Mucin Glycoproteins during Respiratory Infections—Relevance for SARS-CoV-2

Minireview

Published on 2020-11-122022-10-29
Journal: mBio [Category] COVID-19, SARS,

[키워드] activate acute respiratory syndrome adhesin age airway Bacterial boost clearance component Contact coronavirus Defense dependent on downregulation efficient clearance example expressed expression facilitate Factor female glycan glycans glycoprotein glycosylation Inflammatory inflammatory state Interaction Invasion ligands microbe microbial microbial infections Motile cilia MUC1 MUC16 MUC4 MUC5AC MUC5B mucin mucin-microbe interactions mucins mucosal mucosal barrier Mucus Novel coronavirus O -glycosylated O-linked glycans pathogen Pathways Prevent Proinflammatory cytokine property receptors regulated respiratory respiratory infections Respiratory pathogens respiratory tract SARS-CoV-2 sex hormone estradiol Signal transduction the healthy therapy transmembrane understanding upregulated viral infection virulence
[DOI] 10.1128/mBio.02374-20 PMC 바로가기 [Article Type] Minireview