multiorgan failure – Page 2 – Communicable Diseases Research

Gastrointestinal manifestations of COVID-19 in a single center in the Eastern Province of Saudi Arabia

Observational Study

Published on 2022-05-012022-10-04
Journal: Saudi journal of gastroenterology : official journ [Category] COVID19(2023년), SARS, 임상,

Laboratory Biomarkers for Diagnosis and Prognosis in COVID-19

COVID-19 진단 및 예후를 위한 실험실 바이오마커

Review

Published on 2022-04-272022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘,

[키워드] Admission Analysis aspartate Aspartate transaminase AST Biomarker Biomarkers BNP Brain brain natriuretic peptide cause clinical manifestations Clinical practice coronavirus disease Coronavirus disease 2019 COVID-19 creatine creatine kinase Cytokines D-dimer Diagnosis diagnostic disease severity focus Future Hospitalization ICU identify include Inflammation intensive care intensive care unit laboratory biomarker laboratory biomarkers Lactate lactate dehydrogenase LDH Lymphocytes metabolomic metabolomics Mortality multiorgan failure Myoglobin N-terminal Neuron-specific enolase neutrophil neutrophil count Neutrophils NT-proBNP outcome outcomes peptide predict Prognosis Prognostic value progression proinflammatory cytokines proteomic proteomics Research respiratory risk stratification SARS-CoV-2 Severe acute respiratory syndrome severe cases severe COVID-19 shown translated
[DOI] 10.3389/fimmu.2022.857573 PMC 바로가기 [Article Type] Review

SARS-CoV-2 Spike Protein 1 Activates Microvascular Endothelial Cells and Complement System Leading to Platelet Aggregation

SARS-CoV-2 스파이크 단백질 1은 미세혈관 내피 세포 및 보체 시스템을 활성화하여 혈소판 응집을 유도합니다

Article

Published on 2022-03-072022-09-11
Journal: Frontiers in Immunology [Category] SARS, 치료기술,

[키워드] ACE2 Activation addition adhesive molecule aggregate aggregation AMPK amplified Analysis angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 antibody blockade blocking antibody Blot C3a C5a circulating complement Complement activation complement inhibitors complement system complexity conditions coronavirus disease Coronavirus disease 2019 COVID-19 detection element ELISA endothelial Endothelial cell endothelial cells endothelial damage Endothelial dysfunction enzyme evaluated Exocytosis experiment expression human host immunofluorescence incubated induce infect Inflammation Inflammatory inhibitors investigated leading leukocyte lung Microvascular thrombosis microvasculature Mortality multiorgan failure P-selectin performed phenotype Platelet platelet aggregation pro-inflammatory recruitment replicate robust S1 protein SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 spike protein 1 selectin sera severe COVID-19 patient severe COVID-19 patients significant level spike Spike protein System thromboembolic thromboembolic complication thromboembolic complications thrombomodulin thrombosis thrombotic thrombotic complication Thrombotic complications viral infection von Willebrand factor were assessed western blot Western blot analysis
[DOI] 10.3389/fimmu.2022.827146 PMC 바로가기 [Article Type] Article

SARS-CoV-2 Infects Red Blood Cell Progenitors and Dysregulates Hemoglobin and Iron Metabolism

SARS-COV-2는 적혈구 전구체를 감염시키고 헤모글로빈과 철 대사를 조절시킨다

Article

Published on 2022-02-182022-09-10
Journal: Stem cell reviews and reports [Category] COVID19(2023년), MERS, SARS, 변종,

[키워드] accompanied ACE2 receptor acute respiratory distress aggravate Alpha analyzed Anemia Bilirubin Blood Blood samples cause CD147 Cell cells Coagulopathies Coagulopathy concentrations contribute Course COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients death Degradation diagnostic differentiation door dysregulation erythroid Erythroid precursors expansion Express ferritin HAMP healthy donor healthy donors heme hemoglobin Hemoglobin biosynthesis Hemoglobin degradation hepcidin homeostasis hospitalized COVID-19 patient hospitalized COVID-19 patients hypoxia identify impair in vitro infect inhibit iron Iron metabolism mass spectrometry metabolism Mortality mRNA expression multiorgan failure opens oxygen Peripheral blood precursor progenitor qPCR analysis Raman Trapping Microscopy RBC RBCs Red red blood cell red blood cells reduced respiratory distress Result SARS-CoV-2 SARS-COV-2 infection serum Serum ferritin severe COVID-19 disease severely ill COVID-19 patients severity Spectroscopy stem cell stem cells susceptible Therapeutic strategies total bilirubin Transferrin variant were infected Whole blood Zinc
[DOI] 10.1007/s12015-021-10322-8 PMC 바로가기 [Article Type] Article

Elevated Cytokine Levels in Plasma of Patients with SARS-CoV-2 Do Not Contribute to Pulmonary Microvascular Endothelial Permeability

SARS-CoV-2 환자의 혈장에서 증가된 사이토카인 수준은 폐 미세혈관 내피 투과성에 기여하지 않습니다

Research Article

Published on 2022-02-162022-09-10
Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘,

[키워드] accounted ACE-2 receptor ACE2 antibody acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 acute SARS-CoV-2 infection angiopoietin antagonists antiinflammatory cytokines appear approach ARDS barrier dysfunction C3a C5a cause Cell changes in circulating Combination complement complements factors consecutive patient Control controls coronavirus cytokine Cytokines death demonstrated determine disrupt Effect eight Elevation endothelial Endothelial cell endothelial injury endothelial permeability enrolled evaluated Evidence evidence of Frequency greater growth factor heat inactivation human lung in vitro infections inhibitors labile Level lung magnitude mechanism Microvascular damage morbidity morbidity and mortality multiorgan failure Neutralizing antibodies neutralizing antibody occur patients patients hospitalized patients with SARS-CoV-2 permeability plasma positive control predicted produced proinflammatory cytokines provide pulmonary receptor receptor antagonists respiratory respiratory distress SARS-CoV-2 SARS-CoV-2 infected patients SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 patient SARS-CoV-2 patients SARS-CoV-2 plasma selected severe acute respiratory syndrome Coronavirus severe complication severe complications Spike protein subsequent susceptible syndrome the SARS-CoV-2 thrombin TNF-α Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-alpha Variability Vascular vascular endothelial growth factor Vascular injury vascular permeability VEGF
[DOI] 10.1128/spectrum.01671-21 PMC 바로가기 [Article Type] Research Article

Biomarkers during COVID-19: Mechanisms of Change and Implications for Patient Outcomes

Review

Published on 2022-02-162022-10-31
Journal: Diagnostics [Category] COVID-19,

[키워드] addition asymptomatic to mild biochemical Biomarker can be used Care change clinical implications Complication complications coronavirus disease 19 country COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients Critical Cytokine storm develop disease disease severity Efficacy effort Guidance healthcare Healthcare provider help identifying include induce infected with SARS-CoV-2 information Intervention life-threatening mechanism mild symptoms moderate MONITOR MOST multiorgan failure outcome pandemic spread Patient point-of-care testing Potential biomarker prognostic Prognostic value recognize respiratory manifestations risk SARS-CoV-2 SARS-COV-2 infection severe COVID-19 significantly Stage therapeutic therapeutic approaches therapeutic interventions Treatment turn
[DOI] 10.3390/diagnostics12020509 PMC 바로가기 [Article Type] Review

Heparin-Functionalized Adsorbents Eliminate Central Effectors of Immunothrombosis, including Platelet Factor 4, High-Mobility Group Box 1 Protein and Histones

Article

Published on 2022-02-052022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, COVID19(2023년), MERS, SARS,

Longitudinal prediction of hospital-acquired acute kidney injury in COVID-19: a two-center study

Article

Published on 2022-02-012023-07-06
Journal: Infection [Category] COVID19(2023년),

[키워드] AKI Chronic kidney disease Cytokine storm D-dimer lactate dehydrogenase multiorgan failure Predictive model SARS-CoV-2
[DOI] 10.1007/s15010-021-01646-1 PMC 바로가기

Exophiala dermatitidis, ‘the real black fungus’ fungemia in a patient with COVID-19

Case report

Published on 2022-01-292022-10-05
Journal: IDCases [Category] 변종,

Spontaneous Intracerebral Hemorrhage (ICH) associated with pregnancy and SARS-CoV-2 infection: a case report

Case Report

Published on 2022-01-062022-10-28
Journal: BMC Pregnancy and Childbirth [Category] COVID-19,