Recent Advances in the Molecular Design and Delivery Technology of mRNA for Vaccination Against Infectious Diseases감염성 질환 백신을 위한 mRNA의 분자 설계 및 전달 기술의 최근 발전Review Published on 2022-07-152022-09-11 Journal: Frontiers in Immunology [Category] MERS, 변종, 진단, [키워드] addition advance Against Attenuated vaccines can not cellular combating COVID-19 COVID-19 epidemic Critical delivery effective delivery effort Emerging infectious diseases highlight illness illnesses inactivated Infectious disease Infectious diseases Live attenuated vaccine logistics molecular mRNA mRNA delivery mRNA structure design mRNA vaccine mRNA vaccines mutant mutants mutate outbreak Pandemics Prevent producing protective effect protein expression recent required stability storage technology time-consuming Transmissibility Vaccine Vaccines variety Viral virulence virus [DOI] 10.3389/fimmu.2022.896958 PMC 바로가기 [Article Type] Review
Probing the mutation independent interaction of DNA probes with SARS-CoV-2 variants through a combination of surface-enhanced Raman scattering and machine learning표면 강화 라만 산란 및 기계 학습의 조합을 통해 SARS-CoV-2 변이체와 DNA 프로브의 돌연변이 독립적 상호작용 조사Article Published on 2022-07-152022-09-11 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antigenicity antisense Antisense oligonucleotide Antisense oligonucleotides ASO binding efficiency Characteristics characterized clinically Combination Concentration coronavirus described detect develop diagnostic diagnostic test DNA Evolution Genetic human population hypothetical Immune profile independent Interaction mechanism mutate Mutation Mutation resistant probe mutations N gene negative sample nucleocapsid Nucleocapsid phosphoprotein Point mutation positive probe probes Probing reveal RNA SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus scattering Selective and ultrasensitive diagnosis sensitivity sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specificity Surface-enhanced Raman scattering technique the SARS-CoV-2 virus therapeutic Transmissibility unique variants virus [DOI] 10.1016/j.bios.2022.114200 PMC 바로가기 [Article Type] Article
Receptor-Binding-Motif-Targeted Sanger Sequencing: a Quick and Cost-Effective Strategy for Molecular Surveillance of SARS-CoV-2 Variants수용체 결합 모티브 표적 생어 시퀀싱: SARS-CoV-2 변이체의 분자 감시를 위한 빠르고 비용 효율적인 전략Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] Coronavirus, COVID19(2023년), SARS, 변종, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adopted aligned Alpha Alpha variant B.1.1.529 B.1.1.7 B.1.617.2 causative agent changes in CLC Clinical use coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic Critical death Delta delta variant develop disease spread Genome gold gold standard Infection involved Lineage lineages modifications molecular mutate Mutation mutations nasal nasal swab nasal swabs nucleocapsid omicron Omicron variant Omicron variants pandemic prevalent Prevent public health receptor-binding motif Receptor-binding motif (RBM) resource Saliva Sanger sequencing SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sequence sequences Sequencing severe acute respiratory syndrome Coronavirus Spike protein Spread Strategy Surveillance swab samples the disease variant variant surveillance. variants WGS whole-genome sequencing [DOI] 10.1128/spectrum.00665-22 PMC 바로가기 [Article Type] Article
ORFeome Phage Display Reveals a Major Immunogenic Epitope on the S2 Subdomain of SARS-CoV-2 Spike ProteinORFeome 파지 디스플레이, SARS-CoV-2 스파이크 단백질의 S2 하위 도메인에 대한 주요 면역원성 에피토프 공개Article Published on 2022-06-172022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] Amino acid amino acid sequence anti-SARS-CoV-2 antibodies antibodies antibody Antibody Response Antibody responses applied approved binding binding site blocking cell entry cleave COVID-19 COVID-19 pandemic COVID-19 patients Diseases display Efficacy epitope epitope mapping Epitopes fusion peptide genomic genomic library Host host cell identify immunogenic library Major mechanism monoclonal antibody mutate Mutation neutralization neutralize NGS Open reading frame open reading frames ORFeome ORFs Particle peptide phage phage display RBD RBD region Receptor binding domain representing SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variant SARS-CoV-2 variants sequence Serine serine protease serine protease TMPRSS2 spike the cell the RBD the SARS-CoV-2 genome therapeutic therapy TMPRSS2 Vaccine virus variants [DOI] 10.3390/v14061326 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Accessory Protein ORF8 Decreases Antibody-Dependent Cellular CytotoxicitySARS-CoV-2 액세서리 단백질 ORF8은 항체 의존성 세포 세포 독성을 감소시킵니다Article Published on 2022-06-072022-09-12 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Accessory accessory protein accessory proteins ADCC addition antibody-dependent cellular cytotoxicity bind CD16 CD8+ T cell coronavirus decrease disease evade Fc-mediated effector function help host immune responses humoral responses identify immune evasion monocyte Monocytes mononuclear cell mutate nanomolar affinity Neutralizing antibodies NK cells ORF8 PBMC Peripheral blood Protein reduce reducing SARS-CoV-2 SARS-CoV-2-infected cell significantly spike susceptibility [DOI] 10.3390/v14061237 PMC 바로가기 [Article Type] Article
Understanding the Driving Forces That Trigger Mutations in SARS-CoV-2: Mutational Energetics and the Role of Arginine Blockers in COVID-19 TherapySARS-CoV-2에서 돌연변이를 유발하는 원동력 이해: 돌연변이 에너지와 COVID-19 치료에서 아르기닌 차단제의 역할Article Published on 2022-05-112022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] 3CLpro accelerated ACE2 ACE2 protein Alpha Amino acid amino acids angiotensin Angiotensin receptor blockers angiotensin type1 receptor Angiotensin-converting enzyme anionic antiviral drug arginine assist association Beta binding biphenyl bisartans blocker blockers candidate drug cleavage site cleavage sites complex complexes Computational approaches conformation conformational contribute COVID-19 COVID-19 therapy Critical Delta delta variant driving drug energetics ENhance equilibrium Evolution of SARS-CoV-2 force furin furin cleavage site Gamma human clinical trials human population hydrolysis hydropathy hydrophilic hydrophobic interaction in silico Infection Interaction interactions interface investigated Lambda molecular Molecular biology molecular dynamic simulations molecular dynamics mutant mutants mutate Mutation omicron Omicron variants pharmacophores polar Protein RBD RBD binding RBD-ACE2 receptor Receptor-binding domain referred to replacement Replication Research residue residues role S-protein salt salt bridges SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 variants SARS-CoV-2 virus sartans Spread suggested target targets tetrazole the RBD the receptor-binding domain the SARS-CoV-2 virus Therapies translation Treatment treatment of COVID-19 Trigger understanding variant variants viral infection virus wild-type virus π-π interaction [DOI] 10.3390/v14051029 PMC 바로가기 [Article Type] Article
Challenges of the Omicron (B.1.1.529) Variant and Its Lineages: A Global Perspective오미크론(B.1.1.529) 변종 및 그 계보의 과제: 글로벌 관점Review Published on 2022-05-042022-09-11 Journal: Chembiochem [Category] COVID19(2023년), SARS, 변종, [키워드] Alpha B.1.1.529 BA.1 BA.2 BA.3 Beta challenge country Delta VOC delta VoCs Gamma genome sequence GISAID highlight Influenza initiative lineages mutate omicron Omicron lineages Receptor binding Region SARS-CoV-2 SARS-CoV-2 virus SARS-CoV-2 VoC shown Spike protein the spike protein variant VoC [DOI] 10.1002/cbic.202200059 PMC 바로가기 [Article Type] Review
Strain wars 2: Binding constants, enthalpies, entropies, Gibbs energies and rates of binding of SARS-CoV-2 variants스트레인 워즈 2: 결합 상수, 엔탈피, 엔트로피, 깁스 에너지 및 SARS-CoV-2 변이체의 결합 속도Article Published on 2022-05-012022-09-11 Journal: Virology [Category] COVID19(2023년), SARS, 변종, [키워드] Alpha strain B.1.1.529 Beta Beta strain binding binding constant calculated changes in characterized competition COVID-19 pandemic Delta Delta strain explained Gamma Gamma strain greater Hu-1 strain Interference kinetic Mutant strains mutate mutated Mutation mutations omicron Omicron strain. phenomenon RNA viruses SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2 virus shown Standard strain Strains suppression the SARS-CoV-2 virus thermodynamic virus wild type [DOI] 10.1016/j.virol.2022.03.008 PMC 바로가기 [Article Type] Article
Computer-Based Immunoinformatic Analysis to Predict Candidate T-Cell Epitopes for SARS-CoV-2 Vaccine DesignSARS-CoV-2 백신 디자인을 위한 후보 T-세포 에피토프를 예측하기 위한 컴퓨터 기반 면역정보 분석Article Published on 2022-03-302022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affinity allele Antigen B.1.1.7 B.1.351 B.1.617.1 B.1.617.2 binding free energy Brazil candidate caused change Chinese clinical trial collected coronavirus coronavirus disease Coronavirus disease 2019 country COVID-19 effective epitope Epitopes evaluated Evidence experimental validation free energy HLA HLA-A human leukocyte antigen immune mechanism IMPROVE Inclusion India less leukocyte molecular molecular docking mutate mutated Mutation neutralizing antibody New outbreak overlapping P.1 pandemic peptide peptides predict predicted Prevalence problem residue S protein S-protein SARS-CoV-2 SARS-CoV-2 virus SARS-CoV-2 virus infection selected severe acute respiratory syndrome Coronavirus South Africa Spike protein strain T-cell T-cell epitopes therapy United Kingdom Vaccine Vaccine design Vaccine development Vaccines virus virus genomes virus infection was used [DOI] 10.3389/fimmu.2022.847617 PMC 바로가기 [Article Type] Article
Omicron Variant of SARS-CoV-2 Virus: In Silico Evaluation of the Possible Impact on People Affected by Diabetes MellitusSARS-CoV-2 바이러스의 오미크론 변종: 당뇨병의 영향을 받는 사람들에게 미칠 수 있는 영향에 대한 실리코 평가Article Published on 2022-03-072022-09-11 Journal: Frontiers in Endocrinology [Category] SARS, 변종, 유전자 메커니즘, [키워드] ACE-2 receptor ACE2 ACE2 receptor affected Analysis approach asparagine B.1.1.529 binding cause Cell Characteristics computational analysis COVID-19 COVID-19 disease demonstration diabete diabetes Diabetes Mellitus entry routes evidenced feature finding Glycation higher affinity human ACE2 receptor human ACE2 receptor. Impact in silico Interaction interactivity lysine Maillard reaction maintain mechanism molecular Molecular mechanics mutant mutate Mutation omicron Omicron variant outcome Pathways RBD Receptor-binding domain residue risk SARS-CoV-2 severity shift shifting spike Spike protein surface area the disease the receptor-binding domain variant variant of SARS-CoV-2 virus virus attack wild-type [DOI] 10.3389/fendo.2022.847993 PMC 바로가기 [Article Type] Article