Robust temporal map of human in vitro myelopoiesis using single-cell genomics Research Published on 2022-05-242022-10-05 Journal: Nature Communications [Category] 유전자 메커니즘, [키워드] Cell dendritic cell described develop Effect feature fetal generate Hematopoiesis Hematopoietic stem cell homeostasis Immunity immunotherapies imperative in vitro in vivo integration lineages Macrophage macrophages mast cell molecular Monocytes myeloid myeloid cell pluripotent stem cell protocol Regulatory Research resource single-cell single-cell genomics therapeutic transcription factor [DOI] 10.1038/s41467-022-30557-4 [Article Type] Research
Intranasal delivery of SARS-CoV-2 spike protein is sufficient to cause olfactory damage, inflammation and olfactory dysfunction in zebrafishSARS-CoV-2 스파이크 단백질의 비강 내 전달은 제브라피쉬에서 후각 손상, 염증 및 후각 기능 장애를 유발하기에 충분합니다Article Published on 2022-05-012022-09-11 Journal: Brain, behavior, and immunity [Category] COVID19(2023년), SARS, 치료기술, [키워드] animal animal models animals Anosmia bind cause Cell characterized cilia Cluster Combined damage Danio direct infection driven by edema endothelial EOG explained expression fish food functional hemorrhage hemorrhages Histopathology implication indicated Infection Inflammation Inflammatory response Inflammatory responses intranasal intranasally Loss of Smell mechanism myeloid cell nasal epithelium non-neuronal cell non-neuronal cells olfactory Olfactory damage olfactory dysfunction olfactory function Olfactory organ olfactory receptor Olfactory receptor expression organ prevalent Protein RBD receptor reduced response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S SARS-CoV-2 spike SARS-CoV-2 spike protein sensory neuron spike Spike protein Symptom treated Vaccine Viral protein Viral proteins widespread zebrafish Zebrafish (Danio rerio). [DOI] 10.1016/j.bbi.2022.03.006 PMC 바로가기 [Article Type] Article
Dysregulation of the leukocyte signaling landscape during acute COVID-19급성 COVID-19 동안 백혈구 신호 전달 환경의 조절 장애Article Published on 2022-04-142022-09-12 Journal: PLoS ONE [Category] 진단, [키워드] Activation acute COVID-19 approach Cell cellular activation circulating claimed correlated COVID-19 COVID-19 pandemic Cytometry driving dysregulated functional IFN-γ IL-6 level immune dysfunction immune effector cell immune function immune system immunology Immunosuppression Inflammation leukocyte lung lymphoid marker mechanism molecular mechanism monocyte myeloid cell pathogenesis of COVID-19 pathophysiologic phosphoproteome Phosphorylation populations Signaling signaling pathway STAT3 suppressed systemic inflammatory response T cell T cells These data tissue injury [DOI] 10.1371/journal.pone.0264979 PMC 바로가기 [Article Type] Article
Differential expression and regulation of MS4A family members in myeloid cells in physiological and pathological conditions생리학적 및 병리학적 조건에서 골수 세포에서 MS4A 패밀리 구성원의 차등 발현 및 조절Article Published on 2022-04-012022-09-11 Journal: Journal of leukocyte biology [Category] MERS, 바이오마커, [키워드] Analysis Arthritis Bioinformatics analysis CD20 cellular circulating monocyte circulating monocytes circulating neutrophils COVID-19 differentially expressed ENCODE expressed expression family family members functional gene expression regulation gene family glucocorticoid Hormones immature Immunity in vitro increase in marker monocyte Monocytes monocytes/Mϕs MS4A1 MS4A14 MS4A2 MS4A3 MS4A4A MS4A4E MS4A6A MS4A7 myeloid cell myeloid cells myeloid precursors Neutrophils pathological condition patients physiological Protein Proteins regulated Regulation reported rheumatoid arthritis RT-PCR severe disease therapeutic targets tissue were expressed [DOI] 10.1002/JLB.2A0421-200R PMC 바로가기 [Article Type] Article
Severe COVID-19 is characterised by inflammation and immature myeloid cells early in disease progressionResearch article Published on 2022-04-012022-10-05 Journal: Heliyon [Category] 바이오마커, 진단, [키워드] Analysis average Biomarkers carried cause CD10 COVID-19 CRP demonstrated diagnostic Disease progression disease severity eight elevated expression feature hospital identify identifying IL-6 immature Immune phenotype immunological immunological characteristics Inflammation Laboratory lymphoid machine learning management marker monocyte myeloid cell Neutrophil maturity Neutrophils Patient positive SARS-CoV-2 PCR pro-inflammatory cytokine progression recruited risk factor routine SARS-COV-2 infection severe COVID-19 severe disease soluble CD25 were measured [DOI] 10.1016/j.heliyon.2022.e09230 [Article Type] Research article
AMP5A modulates Toll-like receptors 7 and 8 single-stranded RNA immune responses in PMA-differentiated THP-1 and PBMCResearch Published on 2022-03-032022-10-29 Journal: Translational Medicine Communications [Category] COVID-19, [키워드] activate activated Activation acute respiratory syndrome addition agonist AhR AMP5A And Chemokines antagonist antiviral immunity Aryl hydrocarbon receptor Autoimmunity biologic chemokines clinical investigation condition coronavirus coronavirus disease Course COVID-19 CXCL10 cytokine Cytokines decrease detect differentially expressed dysregulated Effect ELISA enrichment analysis evaluate experiment fraction Human serum albumin hyperinflammation Hyperinflammatory IL-12 IL-1β IL-6 Imbalance Immune cell immune response immunomodulatory implicated Infection Inflammation inflammatory mediator Inflammatory response inhibit Intervention involved low molecular weight Lung disease mechanism modulate mononuclear cells myeloid cell myeloid cells NF-κB NF-κB activation Osteoarthritis pathway PBMC Peripheral blood PPARγ pro-inflammatory pro-inflammatory cytokine profiles progression Protective provided receptor REP Result resulting RNA Severe case Signaling single-stranded ssRNA suppresse Therapeutic approach THP-1 TLR TLR7 TLR7/8 Toll-like receptor toll-like receptor 7 Toll-like receptor 8 transcription factor transcription factors treat Treatment viral sequences were used with COVID-19 [DOI] 10.1186/s41231-022-00110-y PMC 바로가기 [Article Type] Research
Activation of Complement Components on Circulating Blood Monocytes From COVID-19 PatientsCOVID-19 환자의 순환 혈액 단핵구에 대한 보체 성분 활성화Immunology Published on 2022-02-172022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] Activation acute infection amyloid A Asymptomatic Biomarker blood monocyte C1q caused CD55 Cell cell surface cells cellular characterized circulating classical Coagulopathy complement Complement activation Complement inhibitor component coronavirus coronavirus disease COVID-19 COVID-19 disease COVID-19 pathogenesis COVID-19 patient COVID-19 patients CRP death downstream elevated HCs healthy control healthy controls highlight hyperinflammation implicated IMPROVE increase Increased Increases Inflammation Inflammatory marker inhibitor Interaction membrane membrane-bound monocyte Monocytes multi-organ failure myeloid cell myeloid cells plasma remained SARS-CoV-2 virus serum amyloid Severe infection surface expression the cell the SARS-CoV-2 virus upregulated upregulation with COVID-19 [DOI] 10.3389/fimmu.2022.815833 PMC 바로가기 [Article Type] Immunology
Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challengeBCG의 정맥 투여는 치명적인 SARS-CoV-2 공격으로부터 마우스를 보호합니다Brief Definitive Report Published on 2022-02-072022-09-10 Journal: The Journal of Experimental Medicine [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] addition Administered alteration Analysis bacille Calmette-Guérin BCG BCG vaccination Cell cellular compartment clinically COVID-19 cytokine cytokine production Host immunopathology increase in Inflammatory inflammatory cell innate response intravenous Intravenous administration long-lasting mechanism mice Multivariate analysis myeloid cell nonspecific Pathogens pediatric phenomenon promote PROTECT provide pulmonary immune response recruitment reduced viral load reduced viral loads reducing reductions reductions in reported SARS-CoV-2 SARS-COV-2 infection subcutaneous route tissue pathology transgenic mice Tuberculosis vaccination variant Viral Viral load virus while [DOI] 10.1084/jem.20211862 PMC 바로가기 [Article Type] Brief Definitive Report
Immune response pattern across the asymptomatic, symptomatic and convalescent periods of COVID-19COVID-19의 무증상, 증상 및 회복기에 걸친 면역 반응 패턴Article Published on 2022-02-012022-09-11 Journal: Biochimica et biophysica acta. Proteins and proteo [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] activated addition Analysis Asymptomatic asymptomatic infection causative agent cholesterol cholesterol metabolism clinical measurement clinical measurements complex convalescent COVID-19 COVID-19 infection Diagnosis disease disorder disorders dysregulated dysregulation identify immune defect immune defects immune response Immunopathogenesis Intervention mass mass spectrometry metabolism Mild myeloid cell myeloid cells Neutrophils pattern progression proteomics provide serum severe COVID-19 patients symptomatic the disease Urine [DOI] 10.1016/j.bbapap.2021.140736 PMC 바로가기 [Article Type] Article
A Structurally Conserved RNA Element within SARS-CoV-2 ORF1a RNA and S mRNA Regulates Translation in Response to Viral S Protein-Induced Signaling in Human Lung CellsSARS-CoV-2 ORF1a RNA 및 S mRNA 내의 구조적으로 보존된 RNA 요소는 인간 폐 세포에서 바이러스성 S 단백질 유도 신호에 대한 반응으로 번역을 조절합니다Article Published on 2022-01-262022-09-11 Journal: Journal of Virology [Category] SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 receptor activated Analysis bind Cell Cell signaling cis -acting element cis -acting elements Cohort complex conservation conserved control mechanism Critical dependent on effective element elements experiment Extracellular facilitate form functional Gait Genome genomes hairpin structure highlighting Host host cell Human human lung cell human lung cells IFN-γ in vitro inhibitor Interaction Intervention lentivirus mechanism mRNA mRNA vaccines myeloid cell myeloid cells NMR ORF1a Pathways Phosphorylation positive-sense pseudotyped regulate response ribosomal loading ribosomal protein ribosomal proteins ribosomal subunit RNA RNA genome RNA virus RNA viruses S protein S1 subunit SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 RNA Sequence alignment signal signaling pathway single-stranded small molecule Specific Spike protein target translation translational translational control Treatment Trigger triggered viral entry viral gene expression Viral protein Viral RNA viral RNA element virus Virus-host interactions Virus-like particle [DOI] 10.1128/JVI.01678-21 PMC 바로가기 [Article Type] Article