Antibody-Dependent Enhancement: ″Evil″ Antibodies Favorable for Viral Infections항체 의존적 증강: 바이러스 감염에 유리한 ″악″ 항체Review Published on 2022-08-082022-09-12 Journal: Viruses [Category] 진단, [키워드] acute respiratory syndrome ADE analyzed antibody Antibody-dependent enhancement caused Cell Characteristics complement coronavirus Diseases drug effective ENhance expressed facilitate Fc receptor Fc receptors immune immune response immune responses involved mechanisms modulation molecular mechanism myeloid cells NAbs neutralizing antibody Pandemics public health Transcription transcription modulation Vaccine viral infection viral pathogenicity virus virus entry virus infection [DOI] 10.3390/v14081739 PMC 바로가기 [Article Type] Review
Role of triggering receptor expressed on myeloid cells-1 (TREM-1) in COVID-19 and other viral pneumonias: a systematic review and meta-analysis of clinical studiesCOVID-19 및 기타 바이러스성 폐렴에서 골수 세포-1(TREM-1)에 발현된 트리거 수용체의 역할: 임상 연구의 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-06-012022-09-11 Journal: Inflammopharmacology [Category] MERS, 바이오마커, [키워드] 95% CI analyzed Biomarker clinical study conducted contributing to controls coronavirus coronavirus disease coronavirus disease-2019 COVID-19 Disease progression disease severity Diseases effect size elevated eligible evaluate Evidence expressed expression Google Scholar healthy healthy control healthy controls healthy individuals Human immune response infected patient infected patients Infection infections Inflammatory item marker material Meta-analysis Mild-to-moderate Mortality myeloid cells myeloid cells-1 no differences observational studies observational study outcome Patient patients with COVID-19 performed Pneumonia pneumonias PRISMA pro-inflammatory provided receptor Reporting review role SARS-CoV-2 severe COVID-19 severity shown significantly SMD standardized mean difference subgroup analysis systematic review systematic reviews the disease TREM-1 triggering Viral viral infections Viral pneumonia viral pneumonias viruses was performed were expressed [DOI] 10.1007/s10787-022-00972-6 PMC 바로가기 [Article Type] Meta-Analysis
Single-cell transcriptome profiling of the immune space-time landscape reveals dendritic cell regulatory program in polymicrobial sepsis면역 시공간 환경의 단일 세포 전사체 프로파일링은 다균성 패혈증에서 수지상 세포 조절 프로그램을 보여줍니다Article Published on 2022-05-292022-09-11 Journal: Theranostics [Category] 치료제, [키워드] activated adopted alteration Analysis applied available data Cancer canonical CD4 cDCs characterized co-cultured comprehensive view conserved COVID-19 patients Cytometry demonstrated dendritic dendritic cell dendritic cells described determined by dissect experiment experiments expression Flow flow cytometry generate Genes heterogeneity Host immune response hyperinflammation identify IFNGR2 immune Immune cell immune cell types immune cells immunofluorescence Immunosuppression indicated inhibitory initiated Intracellular majority maturation morbidity multiplex immunofluorescence myeloid cells naïve natural killer observation organ dysfunction pathway Pathways progression promoted protein level Puncture rationale Regulatory regulatory T cells reveal scRNA-seq ScRNA-seq analysis Sepsis septic septic patients signaling pathway single-cell single-cell analysis Single-cell RNA sequencing specific type staining STAT3 subset T cell T cells tissue tissue sites Transcriptome unique upregulation [DOI] 10.7150/thno.72760 PMC 바로가기 [Article Type] Article
Anti-nucleocapsid antibodies enhance the production of IL-6 induced by SARS-CoV-2 N protein항-뉴클레오캡시드 항체는 SARS-CoV-2 N 단백질에 의해 유도된 IL-6의 생산을 향상시킵니다Article Published on 2022-05-162022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, 치료법, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition antibody cause of death cell lysate coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cultured macrophage cultured macrophages cytokine cytokine production Cytokine storm death disease ENhance IL-6 induce infected cells interleukin lysate macrophages mechanism myeloid cells N protein Patient patients Plasmid promote respiratory respiratory distress SARS-CoV-2 SARS-CoV-2 N protein SARS-CoV-2-infected cell SARS-CoV-2-infected cells Screening secreted sera severe acute respiratory syndrome Coronavirus syndrome the cell the cells the cytokine storm the disease [DOI] 10.1038/s41598-022-12252-y PMC 바로가기 [Article Type] Article
Differential expression and regulation of MS4A family members in myeloid cells in physiological and pathological conditions생리학적 및 병리학적 조건에서 골수 세포에서 MS4A 패밀리 구성원의 차등 발현 및 조절Article Published on 2022-04-012022-09-11 Journal: Journal of leukocyte biology [Category] MERS, 바이오마커, [키워드] Analysis Arthritis Bioinformatics analysis CD20 cellular circulating monocyte circulating monocytes circulating neutrophils COVID-19 differentially expressed ENCODE expressed expression family family members functional gene expression regulation gene family glucocorticoid Hormones immature Immunity in vitro increase in marker monocyte Monocytes monocytes/Mϕs MS4A1 MS4A14 MS4A2 MS4A3 MS4A4A MS4A4E MS4A6A MS4A7 myeloid cell myeloid cells myeloid precursors Neutrophils pathological condition patients physiological Protein Proteins regulated Regulation reported rheumatoid arthritis RT-PCR severe disease therapeutic targets tissue were expressed [DOI] 10.1002/JLB.2A0421-200R PMC 바로가기 [Article Type] Article
AMP5A modulates Toll-like receptors 7 and 8 single-stranded RNA immune responses in PMA-differentiated THP-1 and PBMCResearch Published on 2022-03-032022-10-29 Journal: Translational Medicine Communications [Category] COVID-19, [키워드] activate activated Activation acute respiratory syndrome addition agonist AhR AMP5A And Chemokines antagonist antiviral immunity Aryl hydrocarbon receptor Autoimmunity biologic chemokines clinical investigation condition coronavirus coronavirus disease Course COVID-19 CXCL10 cytokine Cytokines decrease detect differentially expressed dysregulated Effect ELISA enrichment analysis evaluate experiment fraction Human serum albumin hyperinflammation Hyperinflammatory IL-12 IL-1β IL-6 Imbalance Immune cell immune response immunomodulatory implicated Infection Inflammation inflammatory mediator Inflammatory response inhibit Intervention involved low molecular weight Lung disease mechanism modulate mononuclear cells myeloid cell myeloid cells NF-κB NF-κB activation Osteoarthritis pathway PBMC Peripheral blood PPARγ pro-inflammatory pro-inflammatory cytokine profiles progression Protective provided receptor REP Result resulting RNA Severe case Signaling single-stranded ssRNA suppresse Therapeutic approach THP-1 TLR TLR7 TLR7/8 Toll-like receptor toll-like receptor 7 Toll-like receptor 8 transcription factor transcription factors treat Treatment viral sequences were used with COVID-19 [DOI] 10.1186/s41231-022-00110-y PMC 바로가기 [Article Type] Research
Activation of Complement Components on Circulating Blood Monocytes From COVID-19 PatientsCOVID-19 환자의 순환 혈액 단핵구에 대한 보체 성분 활성화Immunology Published on 2022-02-172022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] Activation acute infection amyloid A Asymptomatic Biomarker blood monocyte C1q caused CD55 Cell cell surface cells cellular characterized circulating classical Coagulopathy complement Complement activation Complement inhibitor component coronavirus coronavirus disease COVID-19 COVID-19 disease COVID-19 pathogenesis COVID-19 patient COVID-19 patients CRP death downstream elevated HCs healthy control healthy controls highlight hyperinflammation implicated IMPROVE increase Increased Increases Inflammation Inflammatory marker inhibitor Interaction membrane membrane-bound monocyte Monocytes multi-organ failure myeloid cell myeloid cells plasma remained SARS-CoV-2 virus serum amyloid Severe infection surface expression the cell the SARS-CoV-2 virus upregulated upregulation with COVID-19 [DOI] 10.3389/fimmu.2022.815833 PMC 바로가기 [Article Type] Immunology
Immune response pattern across the asymptomatic, symptomatic and convalescent periods of COVID-19COVID-19의 무증상, 증상 및 회복기에 걸친 면역 반응 패턴Article Published on 2022-02-012022-09-11 Journal: Biochimica et biophysica acta. Proteins and proteo [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] activated addition Analysis Asymptomatic asymptomatic infection causative agent cholesterol cholesterol metabolism clinical measurement clinical measurements complex convalescent COVID-19 COVID-19 infection Diagnosis disease disorder disorders dysregulated dysregulation identify immune defect immune defects immune response Immunopathogenesis Intervention mass mass spectrometry metabolism Mild myeloid cell myeloid cells Neutrophils pattern progression proteomics provide serum severe COVID-19 patients symptomatic the disease Urine [DOI] 10.1016/j.bbapap.2021.140736 PMC 바로가기 [Article Type] Article
A Structurally Conserved RNA Element within SARS-CoV-2 ORF1a RNA and S mRNA Regulates Translation in Response to Viral S Protein-Induced Signaling in Human Lung CellsSARS-CoV-2 ORF1a RNA 및 S mRNA 내의 구조적으로 보존된 RNA 요소는 인간 폐 세포에서 바이러스성 S 단백질 유도 신호에 대한 반응으로 번역을 조절합니다Article Published on 2022-01-262022-09-11 Journal: Journal of Virology [Category] SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 receptor activated Analysis bind Cell Cell signaling cis -acting element cis -acting elements Cohort complex conservation conserved control mechanism Critical dependent on effective element elements experiment Extracellular facilitate form functional Gait Genome genomes hairpin structure highlighting Host host cell Human human lung cell human lung cells IFN-γ in vitro inhibitor Interaction Intervention lentivirus mechanism mRNA mRNA vaccines myeloid cell myeloid cells NMR ORF1a Pathways Phosphorylation positive-sense pseudotyped regulate response ribosomal loading ribosomal protein ribosomal proteins ribosomal subunit RNA RNA genome RNA virus RNA viruses S protein S1 subunit SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 RNA Sequence alignment signal signaling pathway single-stranded small molecule Specific Spike protein target translation translational translational control Treatment Trigger triggered viral entry viral gene expression Viral protein Viral RNA viral RNA element virus Virus-host interactions Virus-like particle [DOI] 10.1128/JVI.01678-21 PMC 바로가기 [Article Type] Article
Postmortem high-dimensional immune profiling of severe COVID-19 patients reveals distinct patterns of immunosuppression and immunoactivation심각한 COVID-19 환자의 사후 고차원 면역 프로파일링은 면역 억제 및 면역 활성화의 독특한 패턴을 나타냅니다Article Published on 2022-01-122022-09-10 Journal: Nature Communications [Category] 바이오마커, 치료기술, 치료법, [키워드] activated Activation Analysis antigens approach Autopsy Cell cell type cell types cells Complete coronavirus disease Coronavirus disease 2019 correlation correlations COVID-19 COVID-19 disease Deceased dendritic cell diagnostic distal etiology function Gene regulation in immune cells hallmark histological Imaging the immune system immune profiling immune response immune responses Immunosuppression induce information lymphocyte Lymphocytes men multiple organs myeloid cell myeloid cells Pathogenesis PD-1 Postmortem prevalent progression proximal reveal SARS-COV-2 infection SARS-CoV-2 viral SARS-CoV-2 viral infection severe COVID-19 severe COVID-19 disease severe COVID-19 patient Systems analysis therapy these cell These cells transcriptional transcriptomic Viral Viral antigen viral antigens viral infection Viral load Wuhan Wuhan, China [DOI] 10.1038/s41467-021-27723-5 PMC 바로가기 [Article Type] Article