Systemic autoimmune myopathies: a prospective phase 4 controlled trial of an inactivated virus vaccine against SARS-CoV-2전신 자가면역 근병증: SARS-CoV-2에 대한 비활성화된 바이러스 백신의 전향적 4상 대조 시험Clinical Trial Published on 2022-08-032022-09-12 Journal: Rheumatology (Oxford, England) [Category] SARS, 임상, 진단, [키워드] 95%CI adverse event age All participant anti-SARS-CoV-2 anti-SARS-CoV-2 vaccine Autoimmune baseline Comorbidity comparable control group Controlled trial CoronaVac COVID-19 CTRL disease disease status dose drug evaluate Frequency geometric mean titre GMT HIV/AIDS IgG immune response immunogenicity immunogenicity analysis Immunosuppression in both group inactivated interquartile range IQR less median Mild moderate Myopathy myositis Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody parameters participant Patient positive pre-vaccination protocol reduced RT-PCR S1/S2 Safe Safety SAM SARS-CoV-2 SARS-CoV-2 vaccine second dose Seroconversion serology Sex significantly lower systemic therapy Type Vaccine vaccine dose virus were excluded [DOI] 10.1093/rheumatology/keab773 PMC 바로가기 [Article Type] Clinical Trial
Anti-MDA5 Antibody Linking COVID-19, Type I Interferon, and Autoimmunity: A Case Report and Systematic Literature ReviewCOVID-19, I형 인터페론 및 자가면역을 연결하는 항MDA5 항체: 증례 보고 및 체계적인 문헌 검토Case Reports Published on 2022-06-272022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] Activation anti-MDA5 syndrome antibody antiviral role Autoimmune Autoimmune disease Autoimmune diseases Cardiomyopathy Clinical features constitutional symptoms contribute correlated COVID-19 COVID-19 severity Cytokines differentiation antigen disease Disease activity elevated example explain Features IFN immune immune response immunological immunology in some induce Inflammatory inflammatory myositis interferons literature lung involvement Manifestations MDA5 mechanisms Melanoma myositis Patient Pattern recognition pattern recognition receptor protective effect Protective effects recognizing report review SARS-CoV-2 infected patients SARS-COV-2 infection searched severity signature similarities similarity skin manifestations Symptoms syndrome synthesis Trigger Type Type I IFN type I interferon type I interferon signature. type I interferons Viral viral infections virus viruses while with COVID-19 [DOI] 10.3389/fimmu.2022.937667 PMC 바로가기 [Article Type] Case Reports
A New Approach to Drug Repurposing with Two-Stage Prediction, Machine Learning, and Unsupervised Clustering of Gene Expression2 단계 예측, 기계 학습 및 유전자 발현의 감독되지 않은 클러스터링으로 약물 용도에 대한 새로운 접근 방식Article Published on 2022-06-012022-08-31 Journal: Omics : a journal of integrative biology [Category] MERS, 신약개발, 유전자 메커니즘, [키워드] Acetate affected alvocidib analyzed approach approximation big data bioinformatics BMS-387032 candidate Candidates characteristic clinical trial clinical trials Cluster Clusters Compound conditions Consistency Control COVID-19 pandemic Critical dermatomyositis develop dimension disease Diseases drug Drug development Drug discovery Drug efficacy Drug repurposing drug research and OMICS effective enrichment enrichment analysis examined expected expression pattern expression patterns followed by for inclusion function functions Gene Expression gene set enrichment analysis Health human diseases identify Inclusion Inclusion body inclusion body myositis Infectious disease Infectious diseases Innovation Intervention machine learning Manifold mitoxantrone myositis New offer pathway phorbol phorbol-12-myristate-13-acetate polymyositis prediction premise Probability projection repurposing Research reversed Reversibility targets Uniform variety vorinostat [DOI] 10.1089/omi.2022.0026 PMC 바로가기 [Article Type] Article
Concurrent myopathy and inflammatory cardiac disease in COVID-19 patients: a case series and literature reviewReview Published on 2022-05-012023-07-08 Journal: Rheumatology International [Category] COVID19(2023년), [키워드] Cardiac inflammatory disease COVID-19 myocarditis Myopathy myositis [DOI] 10.1007/s00296-022-05106-3 PMC 바로가기 [Article Type] Review
Post-COVID-19 Unusual Inflammatory Syndromes Detected on 18F-FDG PET/CT Scan18F-FDG PET/CT 스캔에서 코로나19 이후 비정상적인 염증 증후군 발견Case Reports Published on 2022-04-012022-09-11 Journal: Clinical nuclear medicine [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute coronary syndromes COVID-19 pandemic disorders FDG Features gastrointestinal symptoms Inflammatory kidney Liver injury manifestation Musculoskeletal Myocardial dysfunction myositis neurological panniculitis PET/CT respiratory symptoms SARS-CoV-2 thromboembolic [DOI] 10.1097/RLU.0000000000004088 PMC 바로가기 [Article Type] Case Reports
Neurological autoimmune diseases following vaccinations against SARS-CoV-2: a case seriesArticle Published on 2022-02-012023-07-06 Journal: European journal of neurology [Category] COVID19(2023년), [키워드] Autoimmune cerebral venous sinus thrombosis COVID-19 Guillain-barrè syndrome multiple sclerosis Myelitis myositis [DOI] 10.1111/ene.15147 PMC 바로가기
Dermatomyositis Following BNT162b2 mRNA COVID-19 VaccinationArticle Published on 2022-01-072023-06-15 Journal: Journal of Korean medical science [Category] COVID19(2023년), MERS, SARS, [키워드] Adverse event following immunization COVID-19 creatinine phosphokinase dermatomyositis mRNA vaccines Myopathy myositis vaccination [DOI] 10.3346/jkms.2022.37.e32 PMC 바로가기
Home-based exercise program for adolescents with juvenile dermatomyositis quarantined during COVID-19 pandemic: a mixed methods studyResearch Article Published on 2021-11-132023-06-12 Journal: Pediatric Rheumatology Online Journal [Category] MERS, [키워드] COVID-19 lifestyle myositis Pediatric rheumatologic diseases physical activity Well-being [DOI] 10.1186/s12969-021-00646-7 PMC 바로가기 [Article Type] Research Article
Severe Rhabdomyolysis in a Child With Multisystem Inflammatory Syndrome: An Autoimmune Mechanism?다기관 염증 증후군 아동의 심한 횡문근 융해증: 자가면역 기전?Case Reports Published on 2021-11-012022-09-12 Journal: Pediatric neurology [Category] MERS, 진단, [키워드] Abstract cardiac cardiac injury Child COVID-19 MIS-C myositis rhabdomyolysis [DOI] 10.1016/j.pediatrneurol.2021.07.015 PMC 바로가기 [Article Type] Case Reports
New-onset IgG autoantibodies in hospitalized patients with COVID-19COVID-19로 입원한 환자에서 새로 발병한 IgG 자가항체Multicenter Study Published on 2021-09-142022-09-12 Journal: Nature Communications [Category] SARS, 변종, 비임상, 임상, 진단, 치료기술, 치료법, [키워드] anti-cytokine anti-viral antibody anti-viral antibody response anti-viral antibody responses antibodies autoantibodies autoantibody autoantigen Autoantigens Autoimmune Autoimmunity cause clinical manifestations Connective tissue diseases coronavirus disease Coronavirus disease 2019 COVID-19 cytokine Cytokines de novo develop disorder feature healthy controls hospitalised patient Hospitalised patients hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient IgG IgG antibodies IgG antibody immune response immune responses Influenza less magnitude myositis non-structural proteins overlap pathogenic viruses Patient positively correlated proportion Protein recognizing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 proteins SARS-CoV2 seasonal coronavirus seasonal coronaviruses serum structural protein structural proteins subset Systemic sclerosis viral infection with COVID-19 [DOI] 10.1038/s41467-021-25509-3 PMC 바로가기 [Article Type] Multicenter Study