NADPH
[용어속성] Molecule
Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride
Article
[키워드] accompanied
Analysis
binding
catalyzed
clinically
conformational
Critical
cytosolic
deficiency
Dihydrotestosterone
disease-causing mutation
drug
drugs targeting
Effects
enzyme
Enzyme mechanisms
eukaryotic
facilitate
Finasteride
Human
information
inhibitors
lack
mapping
mechanism
membrane
metabolic pathways
metabolism
molecular dynamics
molecular mechanism
Mutagenesis
NADPH
offer
Prostate
Prostate cancer
Reductase
reduction
regulate
residue
SRD5A2
Steroid hormones
Structure
Topology
transmembrane domain
unique
X-ray crystallography
[DOI] 10.1038/s41467-020-19249-z PMC 바로가기 [Article Type] Article
[DOI] 10.1038/s41467-020-19249-z PMC 바로가기 [Article Type] Article
A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster
Drosophila melanogaster의 식이 의존성 요산 병리학에서 인슐린 유사 신호 전달 경로의 보존된 역할
Research Article
[키워드] affecting
AKT2
arising
association
Author
benefit
candidate gene
cascade
changes in
chronic disease
Chronic diseases
clinical
Clinical studies
component
components
conserved
Coronary artery
Coronary artery disease
correlation
Degradation
diabetes
disease
disorders
downstream
Drosophila
Drosophila melanogaster
drug target
Effect
elevated
expression
Factor
FOXO3
Genetic
Gout
Human
humans
Hyperuricemia
hyperuricosuria
insulin
kidney
kidney stone
kidney stones
knockdown
mechanism
metabolic syndrome
metabolism
modulating
Multiple
NADPH
NADPH oxidase
norm
obesity
Occurrence
opens
Pathogenesis
Pathologies
pathology
pathway
phenotype
plethora
potential therapeutic target
potential therapeutic targets
Protein
purine
purines
raise
reduced
Regulatory
rescued
Research
respond
risk factor
serum
shown
Signaling
signaling pathway
SNP
SNPs
sugar
Support
syndrome
to define
treat
uric acid
Urine
vascular disorder
yeast extract
[DOI] 10.1371/journal.pgen.1008318 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pgen.1008318 PMC 바로가기 [Article Type] Research Article
Heme peroxidase HPX-2 protects Caenorhabditis elegans from pathogens
Heme peroxidase HPX-2는 Caenorhabditis elegans를 병원체로부터 보호합니다
Research Article
[키워드] addition
Author
Caenorhabditis elegan
Caenorhabditis elegans
catalytic
cause
changes in
characterization
complexity
component
conditions
contribute
Defense
demonstrated
Disruption
DNA
domain
downstream
elegan
elegans
ENCODE
enzyme
exhibited
expression
fluorescent
function
generate
genes encoding
greater
heme
Host
host defense
host tissue
hydrogen
hydrogen peroxide
hypodermis
indicated
Infection
Infectious disease
Infectious diseases
information
Innate immunity
intestinal
involved
labeling
limit
mammalian
mechanism
microbe
microbial
microbial infection
morbidity
morbidity and mortality
Morphological
mutant
NADPH
NADPH oxidase
observation
organ
oxygen
pathogen
pathogenic
Pathogens
pathway
peroxidase
peroxidases
pharynx
previous study
PROTECT
Protective
Reactions
reactive oxygen species
regulated
required
residue
RNA interference
RNA-seq analysis
RNAi
ROS
ROS production
shown
survival
therapy
tissue
worm
[DOI] 10.1371/journal.pgen.1007944 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pgen.1007944 PMC 바로가기 [Article Type] Research Article
Diminished COX-2/PGE 2 -Mediated Antiviral Response Due to Impaired NOX/MAPK Signaling in G6PD-Knockdown Lung Epithelial Cells
Research Article
[키워드] A549 cell
A549 cells
addition
Affect
antiviral activity
antiviral response
Cell
cellular
chloride
coronavirus 229E
decrease
decreased expression
deficiency
diminished
downstream
DPI
dysregulated
expression
G6PD
glucose-6-phosphate dehydrogenase
homeostasis
Impaired
Infection
Inflammatory response
inhibitor
MAPK
NADPH
NADPH oxidase
NF-κB
occurred
oxidative stress
PGE
Phosphorylation
provide
reduced
reducing
Regulation
response
Signaling
subunit
susceptibility
These data
TNF-α
transcriptional level
Treatment
tumor necrosis factor-α
up-regulated
viral infections
viral replication
was determined
[DOI] 10.1371/journal.pone.0153462 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pone.0153462 PMC 바로가기 [Article Type] Research Article
Exploring NAD+ metabolism in host-pathogen interactions
article
[키워드] host-pathogen interaction
L-tryptophan
NAD+/NADH ratio
NADPH
Nicotinamide adenine dinucleotide (NAD+)
sirtuins
[Article Type] article
[Article Type] article
Glucose-6-Phosphate Dehydrogenase Enhances Antiviral Response through Downregulation of NADPH Sensor HSCARG and Upregulation of NF-κB Signaling
Article
[키워드] activity
Alpha
Analysis
Antiviral
antiviral response
Cell
cells
coronavirus
Degradation
dehydrogenase
DNA binding
downregulated
enterovirus
examined
Exogenous
expression
G6PD
glucose-6-phosphate dehydrogenase
GTPase
HCoV-229E
HSCARG
human coronavirus 229E
IDH1
increased expression
Infection
inhibited
IκB
mechanism
MX1
NADPH
Necrosis
NF-κB
NF-κB signaling
nicotinamide adenine dinucleotide
overexpression
phosphate
promoter
Protein
reduced
response
resulting
sensor
siRNA
suppressed
susceptibility
susceptible
TNF- α
upregulated
viral gene expression
viral infection
virus infection
[DOI] 10.3390/v7122966 PMC 바로가기 [Article Type] Article
[DOI] 10.3390/v7122966 PMC 바로가기 [Article Type] Article
The NLRP3 Inflammasome and IL-1β Accelerate Immunologically Mediated Pathology in Experimental Viral Fulminant Hepatitis
Research Article
[키워드] activated
Activation
Acute inflammation
ameliorated
appear
association
benefit
blocking
cascade
cause
CD45
characterized
clinical
complex
component
Control
deficiency
Deletion
disease
Disease progression
exacerbated
excessive inflammation
exhibited
experiment
expression
Fgl2
fulminant
Gr-1
Hepatic encephalopathy
Hepatitis
hepatocyte
high mortality
Host
IL-1β
inefficient
Infection
Inflammasome
Inflammatory
Inflammatory diseases
Inflammatory response
Intervention
knowledge
lack
life-threatening
limit
liver
Macrophage
macrophages
Mediated
mice
Mortality
murine hepatitis virus
NADPH
Necrosis
neutrophil
neutrophil infiltration
nicotinamide adenine dinucleotide
NLRP3
NLRP3 inflammasome
pathogen invasion
Pathogenesis
pathway
phosphate
Prevent
Protein
reactive oxygen specy
recruitment
reduce
reduced
reduction in
reductions in
Resilience
responsible
resulting
ROS
ROS production
secretion
serum
severe disease
severe liver disease
Signaling
signaling pathway
subsequent
subunit
syndrome
the disease
treated
Treatment
viral infection
virus infection
virus replication
wild-type
[DOI] 10.1371/journal.ppat.1005155 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1005155 PMC 바로가기 [Article Type] Research Article
In vitro antiviral activity of hypothiocyanite against A/H1N1/2009 pandemic influenza virus
Article
[키워드] 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide
5-thio-2-nitrobenzoic acid
5′5 dithio-bis-2-nitrobenzoate
A/H1N1/2009
American tissue culture collection
ATCC
carbon dioxide
CO(2)
Deoxyribonucleic acid
Disinfection
DNA
DTNB
dual oxidase
DUOX
FBS
fetal bovine serum
HA
hemagglutinin
HIV
HOSCN
Human immunodeficiency virus
hypothiocyanite
hypothiocyanite anion
hypothiocyanous acid
in vitro
infection control
Influenza prophylaxis
influenza treatment
l-1-tosylamide-2-phenylethyl chloromethyl ketone
lactoperoxidase
LPO
Madin-Darby Canine kidney
MDCK
MEM
minimal essential medium
MTT
NA
NADPH
neuraminidase
Neuroaminidase
Nicotinamide adenine dinucleotide phosphate
OD
optical density
OSCN(−)
OSCN(−) lactoperoxidase
PBS
Phosphate Buffered Saline
respiratory syncytial virus
reverse transcriptase real-time polymerase chain reaction
Ribonucleic acid
RNA
rRT-PCR
RSV
SCN(−)
SDS
sequence detection systems software
TCID
thiocyanate
tissue culture infectious dose.
TNB
TPCK
[DOI] 10.1016/j.ijheh.2013.03.001
[DOI] 10.1016/j.ijheh.2013.03.001
A novel chitosan based antimalarial drug delivery against Plasmodium berghei infection
article
[키워드] 5′5′-dithio(bis)-2-nitrobenzoic acid
anti-malarial drug
C-reactive proteinase
chitosan
Chloroquine
CQ
CRP
DTNB
EDTA
ethylene diamine tetra acetate
FACS
fluorescence activated cell sorter
glutathione reductase
GR
GSH
GSSG
H(2)O(2)
hydrogen peroxide
IC
infected control
lactate dehydrogenase
LDH
Lymphocytes
malaria
malondialdehyde
MDA
NADPH
Nanochloroquine
NCQ
Nicotinamide adenine dinucleotide phosphate
O-diamisidine
OPD
oxidized glutathione
PBS
Phosphate buffer saline
Plasmodium berghei
reactive oxygen species
reduced glutathione
ROS
serum glutamate oxalate transaminase
serum glutamate pyruvate transaminase
SGOT
SGPT
TBA
TBARS
TCA
thiobutiric acid
thiobutiric acid reactive substance
trichloro acetic acid
[Article Type] article
[Article Type] article