Glucose 6-P Dehydrogenase-An Antioxidant Enzyme with Regulatory Functions in Skeletal Muscle during ExerciseArticle Published on 2022-09-282024-08-29 Journal: Cells [Category] 말라리아, [키워드] aging G6PD NADPH pentose phosphate pathway physical training Skeletal muscle
Dysregulated miRNAs network in the critical COVID-19: An important clue for uncontrolled immunothrombosis/thromboinflammation중요한 COVID-19에서 조절되지 않는 miRNA 네트워크: 통제되지 않는 면역혈전증/혈전염증에 대한 중요한 단서Review Published on 2022-09-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] accompanied activated Activation adenine affecting anti-inflammatory factors Anticoagulant cause clinical complication Coagulation Coagulation system complement complement system Complication components conserved coronavirus disease Coronavirus disease 2019 COVID-19 Critical Cytokine storm Defensive mechanism deviation diffusion Effect expression expression level facilitate Factor function Genetic higher risk homeostasis hyperinflammation immune immunothrombosis incidence Interaction involved life-threatening mechanism microRNA MicroRNAs miRNA miRNAs miRNAs-based therapy. molecules Mortality NADPH nicotinamide nicotinamide adenine dinucleotide Nicotinamide adenine dinucleotide phosphate Non-coding RNAs nucleotide oxygen Pathogens Patient phosphate reactive oxygen species reactive oxygen specy reduction response restrict SARS-CoV-2 severe complications Therapeutic approach therapy Thromboinflammation thrombotic underlie vicious cycle [DOI] 10.1016/j.intimp.2022.109040 PMC 바로가기 [Article Type] Review
G6PD deficiency: imbalance of functional dichotomy contributing to the severity of COVID-19G6PD 결핍: COVID-19의 중증도에 기여하는 기능적 이분법의 불균형Review Published on 2022-09-012022-09-11 Journal: Future Microbiology [Category] 유전자 메커니즘, [키워드] adenine affected cause caused contributing to Control COVID-19 COVID-19 patients death Defense defense mechanism deficiency dysregulation enzyme functional G6PD G6PD deficiency Genetic genetic factor highlight Human illnesses Inflammation Inflammatory response Inflammatory responses mechanism NADPH nicotinamide nicotinamide adenine dinucleotide Nicotinamide adenine dinucleotide phosphate oxidative stress oxygen phosphate reactive oxygen species reactive oxygen specy reduced regulated Regulation removal ROS severity severity of COVID-19 Trigger [DOI] 10.2217/fmb-2021-0299 PMC 바로가기 [Article Type] Review
Drug repurposing for the treatment of COVID-19COVID-19 치료를 위한 약물 용도 변경Review Published on 2022-07-012022-09-11 Journal: Journal of pharmacological sciences [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료법, 치료제, [키워드] activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age aggravation approved Cancer cardiomyocyte cardiovascular disease coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 diabetes drug Drug repurposing Eco-pharma global effort global efforts heart failure hypertension increase mammalian cells mechanism Mortality NADPH NADPH oxidase outcome Patient prevalent protein-protein interaction Protein–protein interaction receptor receptor potential reported Research risk Safe SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe COVID-19 severity of COVID-19 shown therapeutic therapeutic agent therapeutic agents Transient Transient receptor potential channel. Treatment vaccine-resistant variant Vaccine-resistant variants virus Wuhan Wuhan, China [DOI] 10.1016/j.jphs.2022.04.007 PMC 바로가기 [Article Type] Review
Imaging of innate immunity activation in vivo with a redox-tuned PET reporter Research Published on 2022-02-212022-10-05 Journal: Nature biotechnology [Category] 바이오마커, [키워드] abrogated activated Activation Arthritis bind blocked by product caused Cell cells cellular contact dermatitis effector molecule Enzymes foci H2O2 HL-60 human cell imaging in vivo Inflammatory inhibitor Innate immunity less MPO murine model myeloperoxidase NADPH NOX2 oxidized pet PET/CT phorbol ester PMA Protein reactive nitrogen specy reactive oxygen specy reporter robust Shock signaling molecules tomography [DOI] 10.1038/s41587-021-01169-y [Article Type] Research
Does Oxidative Stress Management Help Alleviation of COVID-19 Symptoms in Patients Experiencing Diabetes?Review Published on 2022-01-132022-10-31 Journal: Nutrients [Category] COVID-19, SARS, [키워드] ACE-2 acute respiratory syndrome alleviation angiotensin-converting enzyme 2 antioxidant binding blood vessels cause clinical trial Comorbidities Comorbidity COVID-19 COVID-19 symptoms death diabete diabetes Diabetes Mellitus Diabetic diabetic patients Disease progression effective end-stage renal failure explain help hyperglycemia in silico indicated inflammatory pathway inhibiting interact kidney damage membrane NADPH nephropathy nicotinamide adenine dinucleotide novel coronavirus disease oxidative damage oxidative stress Patient phosphate Prevent PROTECT renal SARS-CoV-2 severe complication therapy Vascular virus [DOI] 10.3390/nu14020321 PMC 바로가기 [Article Type] Review
The role of NADPH oxidases in infectious and inflammatory diseases감염성 및 염증성 질환에서 NADPH 산화효소의 역할Review Published on 2021-12-012022-09-12 Journal: Redox Biology [Category] MERS, SARS, 진단, [키워드] acute lung injury adaptive antigen processing Autoimmune disease Autoimmunity biological function caused Cell contribute COVID-19 diabete disease Donor DUOX1 DUOX2 enzyme epithelial expression free radical generate Human hydrogen peroxide Immunity implicated infection with SARS-CoV-2 Inflammasome inflammatory disease Innate immune defense involved lung molecular NADPH NADPH oxidase normal physiological processe NOx NOX2 oxidative stress oxygen pathology phagocytosis phosphate Regulation scavenging Seven Signaling Superoxide Superoxide. targeting therapy tissue type I interferons [DOI] 10.1016/j.redox.2021.102159 PMC 바로가기 [Article Type] Review
Crosstalk of TLR4, vascular NADPH oxidase, and COVID-19 in diabetes: What are the potential implications?Review article Published on 2021-08-012022-10-05 Journal: Vascular pharmacology [Category] SARS, 변종, [키워드] appear cardiovascular diseases contribute COVID-19 Critical Crosstalk diabetes Diabetic diabetic patients disrupt enzyme experimental evidence explain help higher risk Hypothesis implication Increased Interaction lack likelihood mechanism modulate NADPH NADPH oxidase oxidative stress pathophysiology patients with diabete progression receptor ROS severe coronavirus disease severe COVID-19 shown Signaling structures TLR4 Vascular vasculature [DOI] 10.1016/j.vph.2021.106879 [Article Type] Review article
Progress in aorta and peripheral cardiovascular disease research대동맥 및 말초 심혈관 질환 연구의 진행 상황Article Published on 2021-07-272022-09-11 Journal: Cardiovascular Research [Category] 비임상, [키워드] 2019 added affecting Antithrombotic Antithrombotics Aorta aortic aneurysm Aspirin benefit Blood blood test breath cardiovascular disease Cell Cell therapy Clinical practice clinical trial coronavirus disease Coronavirus disease 2019 COVID disease Dissection Endothelial cell fibromuscular dysplasia highlight imaging Kinase inhibitor kinase inhibitors lower extremity magnetic resonance imaging Major NADPH NADPH oxidase pathophysiology peripheral Peripheral artery disease plaque Progress proof provided Research rivaroxaban shown stroke therapeutic options therapy Thromboembolism Topic Treatment Vascular vascular disease vascular diseases Venous Thromboembolism [DOI] 10.1093/cvr/cvab144 PMC 바로가기 [Article Type] Article
Inhibition of drug-metabolizing enzymes by Qingfei Paidu decoction: Implication of herb-drug interactions in COVID-19 pharmacotherapyQingfei Paidu 달인에 의한 약물 대사 효소 억제: COVID-19 약물 요법에서 허브-약물 상호 작용의 의미Article Published on 2021-03-012022-08-31 Journal: Food and chemical toxicology : an international jo [Category] SARS, 치료제, [키워드] AUC caused China Chinese clinical settings clinically clinician combating Combination concomitant use Corona COVID-19 COVID-19 treatment CYP3A substrate-drugs cytochrome P450 Cytochrome P450 enzymes Cytochrome P450 enzymes (CYPs/P450s) demonstrated Effect enzyme half-life Health Herb Herb-drug interactions (HDIs) in vivo inactivated inhibited inhibition inhibitory Interaction interactions Lopinavir medication modulated NADPH P450s pharmacokinetic pharmacokinetics Qingfei Paidu decoction (QPD). RATs risk significantly Spread the patient Treatment Trigger Virus Disease [DOI] 10.1016/j.fct.2021.111998 PMC 바로가기 [Article Type] Article