Abstract
Coronavirus disease 2019 (COVID-19) remains prevalent worldwide since its onset was confirmed in Wuhan, China in 2019. Vaccines against the causative virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have shown a preventive effect against the onset and severity of COVID-19, and social and economic activities are gradually recovering. However, the presence of vaccine-resistant variants has been reported, and the development of therapeutic agents for patients with severe COVID-19 and related sequelae remains urgent. Drug repurposing, also called drug repositioning or eco-pharma, is the strategy of using previously approved and safe drugs for a therapeutic indication that is different from their original indication. The risk of severe COVID-19 and mortality increases with advancing age, cardiovascular disease, hypertension, diabetes, and cancer. We have reported three protein-protein interactions that are related to heart failure, and recently identified that one mechanism increases the risk of SARS-CoV-2 infection in mammalian cells. This review outlines the global efforts and outcomes of drug repurposing research for the treatment of severe COVID-19. It also discusses our recent finding of a new protein-protein interaction that is common to COVID-19 aggravation and heart failure.
Keywords: Cardiomyocyte; Eco-pharma; NADPH oxidase; Protein–protein interaction; Transient receptor potential channel.
【저자키워드】 Protein–protein interaction, cardiomyocyte, Eco-pharma, NADPH oxidase, Transient receptor potential channel., 【초록키워드】 COVID-19, Treatment, coronavirus disease, Drug repurposing, SARS-CoV-2, Coronavirus disease 2019, coronavirus, Mortality, severe COVID-19, SARS-COV-2 infection, Cancer, risk, cardiovascular disease, drug, diabetes, outcome, severe acute respiratory syndrome Coronavirus, virus, hypertension, activity, heart failure, severity of COVID-19, Wuhan, therapeutic, Research, Patient, age, therapeutic agent, therapeutic agents, aggravation, receptor, protein-protein interaction, mechanism, Protein–protein interaction, NADPH oxidase, Safe, receptor potential, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, global efforts, NADPH, mammalian cells, prevalent, Vaccine-resistant variants, Wuhan, China, Transient, shown, reported, approved, increase, global effort, vaccine-resistant variant, 【제목키워드】 COVID-19, Treatment,