nasal mucosa – Page 2 – Communicable Diseases Research

Egg-Derived Anti-SARS-CoV-2 Immunoglobulin Y (IgY) With Broad Variant Activity as Intranasal Prophylaxis Against COVID-19

COVID-19에 대한 비강내 예방으로서 광범위한 변이 활성을 갖는 계란 유래 항-SARS-CoV-2 면역글로불린 Y(IgY)

Clinical Trial

Published on 2022-06-012022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단,

Dealing with a mucosal viral pandemic: lessons from COVID-19 vaccines

점막 바이러스 전염병 대처: COVID-19 백신의 교훈

Review

Published on 2022-04-012022-09-12
Journal: Mucosal Immunology [Category] COVID19(2023년), SARS, 임상, 진단,

Poxvirus MVA Expressing SARS-CoV-2 S Protein Induces Robust Immunity and Protects Rhesus Macaques From SARS-CoV-2

SARS-CoV-2 S 단백질을 발현하는 폭스바이러스 MVA는 강력한 면역을 유도하고 SARS-CoV-2로부터 붉은털원숭이를 보호합니다

Article

Published on 2022-03-162022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단,

[키워드] BAL Bronchoalveolar lavage caused Cell clinical trials Computed tomography COVID-19 COVID-19 pandemic cytokine Cytokine storm domain effective vaccine Effective vaccines Efficacy elicited expressing favor Fever full-length SARS-CoV-2 histological histological examination IFNγ IgG antibodies IgG antibody IL-4 immunogenic immunogenicity lung Lung pathology Lungs macaque macaques modified vaccinia virus MVA vaccine nasal mucosa Neutralizing antibodies neutralizing antibody novel Protein Receptor-binding domain reduced reduction rhesus rhesus macaque rhesus macaques robust Safe Safety SARS-CoV-2 SARS-CoV-2 S several variant several variants spike tomography vaccination Vaccine virus load
[DOI] 10.3389/fimmu.2022.845887 PMC 바로가기 [Article Type] Article

The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in nonhuman primates and has an extended half-life in humans

SARS-CoV-2 단일클론항체 조합인 AZD7442는 인간이 아닌 영장류를 보호하고 인간에서 반감기가 연장됩니다.

Article

Published on 2022-03-092022-09-11
Journal: Science Translational Medicine [Category] MERS, SARS, 변종, 비임상, 진단, 치료기술,

[키워드] accelerated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration angiotensin angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 receptor antibody benefit binding cell entry cilgavimab Combination Concentration convalescent serum coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 death Epitopes extrapolation fold functions geometric geometric mean greater half-live healthy Human individual Infection Initially Intramuscular injection lung mAb mAbs monoclonal antibodies monoclonal antibody combination nasal mucosa neutralize Neutralizing titer nonoverlapping epitope nonoverlapping epitopes participant Phase 1 phase 1 study Prevent prevented Prophylactic Protective provided receptor Receptor binding domain reduce remained respiratory risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant serum severe acute respiratory syndrome Coronavirus severe disease Spike protein Spike protein receptor binding domain tested the spike protein therapeutic Tixagevimab treat Treatment Vaccines Viral viral spike protein virus virus clearance
[DOI] 10.1126/scitranslmed.abl8124 PMC 바로가기 [Article Type] Article

Early reduction of SARS-CoV-2-replication in bronchial epithelium by kinin B 2 receptor antagonism

키닌 B 2 수용체 길항작용에 의한 기관지 상피의 SARS-CoV-2 복제의 조기 감소

Original Article

Published on 2022-03-052022-09-10
Journal: Journal of Molecular Medicine (Berlin, Germany) [Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] ACE2 ACE2 receptor airway airway epithelial cell airway epithelial cells Airway inflammation Analysis analyzed antagonism antagonist antagonists approved assays B₂R-antagonist Bronchial epithelium cellular clinical study complex controls COVID-19 Critical cytotoxicity early-stage COVID-19 entry receptor epithelial epithelial cells Evidence Ex vivo expression of SARS-CoV-2 Future G protein Host Icatibant immune regulation in vitro in vivo in vivo model induction Infection information inhibiting inhibiting viral replication Interference Kallikrein Kinin Kinin-kallikrein-system mechanism murine nasal nasal mucosa negative nose pathway performed Plaque assay plaque assays PROTECT protection provide receptor receptor signaling reduce reduced reduction Replication RT-qPCR SARS-CoV-2 SARS-CoV-2 entry receptor SARS-CoV-2 replication SARS-CoV-2 RNA SARS-CoV-2-positive patients Signaling Spread study participant Study participants supplementary material symptomatic Transcriptome transcriptomes translational Transport treated Treatment upregulation Vero-E6 cells Viral viral replication were infected
[DOI] 10.1007/s00109-022-02182-7 PMC 바로가기 [Article Type] Original Article

Olfactory dysfunction as a post-infectious symptom of SARS-CoV-2 infection

Review

Published on 2022-02-112022-10-28
Journal: Annals of Medicine and Surgery [Category] COVID-19,

[키워드] addition affecting Anosmia COVID-19 COVID-19 patients Diagnosis disease dry cough dysfunction epidemiological Evidence Fever headache Hypothesis impairment infected with SARS-CoV-2 Inflammation Inflammatory response initial inoculated intranasal less life-threatening Loss Loss of Smell mice nasal nasal mucosa occur olfactory olfactory dysfunction olfactory neuroepithelium Other other COVID-19 symptoms parainfluenza Pathognomonic symptom pathological mechanism pathophysiology Patient patients with COVID-19 reduced required Research resulting rhinovirus SARS-CoV-2 SARS-COV-2 infection Shortness of breath significantly Smell loss Symptom syndrome Taste loss Treatment unique virus virus infection
[DOI] 10.1016/j.amsu.2022.103352 PMC 바로가기 [Article Type] Review

Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8+ T cell responses following COVID-19

Research

Published on 2021-12-222022-10-05
Journal: Nature Immunology [Category] SARS, 유전자 메커니즘, 임상, 치료법, 치료제,

Enhanced replication fitness of MERS-CoV clade B over clade A strains in camelids explains the dominance of clade B strains in the Arabian Peninsula

Coronaviruses

Published on 2021-12-172022-10-31
Journal: Emerging Microbes & Infections [Category] COVID-19,

[키워드] adaptive alpaca Amino acid amino acid substitution Analysis animal Antiviral Arabian Peninsula binding caused clade decrease difference double-stranded elicited enhanced Epidemic explain Frame hosts Human Hypothesis IFN IFN response immunological parameters in vivo infecting Infection inoculated interferon-stimulated gene ISGs MERS-CoV Middle East Middle East respiratory syndrome Coronavirus moderate motif nasal nasal mucosa orf4a post inoculation Protein Replication replicative reported respiratory syndrome coronavirus respiratory tract RNA S proteins strain subsequent Transcription Transmission variant viral loads viral shedding Virological virus while
[DOI] 10.1080/22221751.2021.2019559 PMC 바로가기 [Article Type] Coronaviruses

SARS-CoV-2 deregulates the vascular and immune functions of brain pericytes via Spike protein

SARS-CoV-2는 스파이크 단백질을 통해 뇌 혈관주위세포의 면역 기능과 면역 기능을 완화합니다.

Article

Published on 2021-12-012022-09-11
Journal: Neurobiology of disease [Category] SARS, 유전자 메커니즘,

[키워드] accompanied accumulated ACE2 ACE2 expression acquisition Actin Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 assays binding Brain brain damage calcium cause caused cerebrovascular cerebrovascular disorders change characterized collagen Comorbidity contractile coronavirus disease coronavirus disease 19 Coronavirus-2 COVID-19 COVID-19 pathogenesis Cytokines deregulated develop disorder enzyme exacerbate Express expressing expression Fibronectin fluctuations function functional homolog host cell host cells human ACE2 Human brain hypoxia immune Immune cell immune function immune reaction impair infect infection with SARS-CoV-2 Inflammation inhibitory intranasal involved lipid peroxidation locus Macrophage mechanism mechanisms mice MIF Migration morphology Myofibrogenic transition nasal mucosa Neurological disorder Neurological disorders Neurovascular Neurovascular interface NF-κB NOTCH3 nuclear oxidative pericyte pericytes phenotypic pro-inflammatory cytokine pro-inflammatory cytokines promoted Protein Proteins provide reached reactivity receptor recognize Regulatory Respiratory illness S protein SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 S protein. Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus shown signaling pathway spike Stress therapeutic interventions transgenic mice translated transmembrane triggered Vascular viral spike was increased
[DOI] 10.1016/j.nbd.2021.105561 PMC 바로가기 [Article Type] Article

Low pH Hypromellose (Taffix) nasal powder spray could reduce SARS-CoV-2 infection rate post mass-gathering event at a highly endemic community: an observational prospective open label user survey

Observational Study

Published on 2021-10-012022-10-05
Journal: Expert review of anti-infective therapy [Category] SARS, 임상,

[키워드] 95%CI addition cells Community COVID-19 infection COVID19 effective Efficacy Endemic gel Hypromellose infecting Infection ITT low pH Masks Measures Mortality nasal nasal mucosa Nasal spray New objective open label participated prevention Protective reached reduce reduction reported Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 PCR Side effect Spread virus was tested were infected Year
[DOI] 10.1080/14787210.2021.1908127 PMC 바로가기 [Article Type] Observational Study