natural killer cell – Page 2 – Communicable Diseases Research

Specific Antibody and the T-Cell Response Elicited by BNT162b2 Boosting After Two ChAdOx1 nCoV-19 in Common Variable Immunodeficiency

공통 가변성 면역 결핍증에서 2개의 ChAdOx1 nCoV-19 후 BNT162b2 부스팅에 의해 유도된 특정 항체 및 T-세포 반응

Article

Published on 2022-06-172022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, 치료기술,

mRNA-1273 and BNT162b2 COVID-19 vaccines elicit antibodies with differences in Fc-mediated effector functions

mRNA-1273 및 BNT162b2 COVID-19 백신은 Fc 매개 효과기 기능에 차이가 있는 항체를 유도합니다

Article

Published on 2022-05-182022-09-11
Journal: Science Translational Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody approved binding BNT162b2 cell activation Cohort Concentration coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine Efficacy elicit epitope evade Fc-mediated effector function function functional functional capacity Hospital staff humoral immune response humoral immune responses IgA immune response immune responses Killer cell morbidity morbidity and mortality mRNA mRNA vaccines mRNA-1273 mRNA-1273 vaccine mRNA-1273 vaccines N-terminal N-terminal domain natural killer natural killer cell neutralization Neutralizing antibodies neutrophil phagocytosis potential differences protective immunity RBD Receptor binding domain recipient recipients reduced Region respiratory responses robust SARS-CoV-2 the vaccine the vaccines These data Vaccine Vaccines variants variants of concern Variation Viral viral variant Viral variants wake wild-type
[DOI] 10.1126/scitranslmed.abm2311 PMC 바로가기 [Article Type] Article

Off-the-shelf CAR natural killer cells secreting IL-15 target spike in treating COVID-19

Research

Published on 2022-05-112022-10-05
Journal: Nature Communications [Category] COVID19(2023년), SARS, 임상, 치료기술, 치료법, 치료제,

B Cell Aplasia Is the Most Powerful Predictive Marker for Poor Humoral Response after BNT162b2 mRNA SARS-CoV-2 Vaccination in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation

B 세포 무형성은 동종 조혈모세포 이식 환자에서 BNT162b2 mRNA SARS-CoV-2 백신 접종 후 불량한 체액 반응에 대한 가장 강력한 예측 마커입니다

Article

Published on 2022-05-012022-09-11
Journal: Transplantation and cellular therapy [Category] COVID19(2023년), MERS, SARS, 바이오마커, 치료기술,

[키워드] 95% confidence interval absence administration age allo-HSCT Allogeneic allogeneic hematopoietic stem cell transplantation Analysis analyzed anti-SARS-CoV-2 vaccination Antibody Response Antibody responses aplasia B cell B cells B-cell BNT162b2 BNT162b2 mRNA CD4 CD8 characteristic close monitoring Cohort COVID-19 Donor Efficacy entire cohort evaluate evaluated Factor hematopoietic Hematopoietic stem cell highest HSCT humoral Humoral response immune response Immune status Immunosuppressed immunosuppressed patients injection lymphocyte Lymphocyte count lymphopenia median MOST mRNA natural killer cell Natural killer cells Odds ratio of BNT162b2 Patient Poor predict provided recipient recipients reported responders response response rate SARS-CoV-2 SARS-CoV-2 mRNA SARS-CoV-2 vaccination SARS-CoV-2 vaccine Specific STEM stem cell Stem cell transplantation T cell T cells the antibody response transplantation Treatment Univariate analysis Vaccine were assessed
[DOI] 10.1016/j.jtct.2022.02.018 PMC 바로가기 [Article Type] Article

The effect of immunization with inactivated SARS-CoV-2 vaccine (CoronaVac) and/or SARS-CoV-2 infection on antibody levels, plasmablasts, long-lived-plasma-cells, and IFN-γ release by natural killer cells

비활성화된 SARS-CoV-2 백신(CoronaVac) 및/또는 SARS-CoV-2 감염이 항체 수준, 형질모세포, 수명이 긴 형질 세포 및 자연 살해 세포에 의한 IFN-γ 방출에 미치는 영향

Article

Published on 2022-04-202022-09-11
Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술,

[키워드] anti-S anti-SARS-CoV-2 spike protein anti-spike antibody antibody Antibody Response B cell CD138 CD19 CD27 Cell CoronaVac COVID-19 detectable dose Elecsy elicited ELISA kit evaluated flow cytometry four groups Germinal center group groups HCW HCWs healthcare worker Healthcare workers IAV IFN-gamma IFN-γ immunization inactivated Inactivated vaccine interferon gamma İstanbul Killer cell long-lived plasma cell long-lived plasma cells Lymph node lymph nodes median memory B cell memory B cells Migration natural infection natural killer natural killer cell no difference not differ patients percentage phenotype Plasma cells plasmablast plasmablasts qPCR RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine significantly higher significantly lower Spike protein study groups Test the antibody response the study group Turkey uninfected Vaccine Version virion was performed were measured Whole virion inactivated vaccine.
[DOI] 10.1016/j.vaccine.2022.03.001 PMC 바로가기 [Article Type] Article

Safety, tolerability, and efficacy of monoclonal CD38 antibody felzartamab in late antibody-mediated renal allograft rejection: study protocol for a phase 2 trial

article

Published on 2022-04-082024-09-02
Journal: Trials [Category] 대상포진,

[키워드] Antibody-mediated rejection CD38 Donor-specific antibody Felzartamab Kidney transplantation monoclonal antibody natural killer cell Plasma cell
[DOI] 10.1186/s13063-022-06198-9 PMC 바로가기 [Article Type] article

Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine

Research

Published on 2022-03-142022-10-05
Journal: Nature Immunology [Category] 치료제,

A Detailed Overview of Immune Escape, Antibody Escape, Partial Vaccine Escape of SARS-CoV-2 and Their Emerging Variants With Escape Mutations

면역 탈출, 항체 탈출, SARS-CoV-2의 부분 백신 탈출 및 탈출 돌연변이가 있는 이들 변이체에 대한 자세한 개요

Review

Published on 2022-02-092022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종,

Aging whole blood transcriptome reveals candidate genes for SARS-CoV-2-related vascular and immune alterations

노화된 전혈 전사체는 SARS-CoV-2 관련 혈관 및 면역 변화에 대한 후보 유전자를 나타냅니다

Article

Published on 2022-02-012022-09-11
Journal: Journal of Molecular Medicine (Berlin, Germany) [Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition adhesion affected age aging alteration anti-apoptotic BAG3 Blood Blood clots blood component blood components candidate candidate gene cascade cathepsin Cathepsins CCL4L2 CD14 CD4 CD8 Cell changes in clinical manifestation coronavirus COVID-19 CTSE CTSW database DEGs differentially expressed gene Differentially expressed genes DUSP4 expressed expression expression levels expression profile FASL FASLG female genders gene expression profile high viral load highest HLA-DRA Hyperinflammatory identify IFN IFN signaling immune immune response increase increase in increased expression individual Inflammation interact Interaction interferon investigated involved LAG3 Monocytes naïve T cells natural killer cell Natural killer cells Older older patient older patients overexpress overexpression PDCD1 Peripheral blood Platelet prediction Protein reveal RGS2 risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected patient SARS-CoV-2-infected patients sequencing data severe acute respiratory syndrome Coronavirus severe COVID-19 Signaling Single-cell RNA-sequencing T cell T cell exhaustion T cells T lymphocytes target targets therapeutic TIGIT TOX Transcriptome translated type I interferon Vascular VCAM1 Viral load Viral protein Viral proteins Whole blood whole blood transcriptome
[DOI] 10.1007/s00109-021-02161-4 PMC 바로가기 [Article Type] Article

Identifying SARS-CoV-2 ‘memory’ NK cells from COVID-19 convalescent donors for adoptive cell therapy

Clinical Trial

Published on 2022-02-012022-10-05
Journal: Immunology [Category] COVID19(2023년), SARS, 임상,