The CoRisk-Index: a data-mining approach to identify industry-specific risk perceptions related to Covid-19 Research Published on 2022-02-022022-10-05 Journal: Humanities & Social Sciences Communications [Category] 치료기술, [키워드] approach average caused consequence dimension effective granular help identify mitigate negativity pandemic provide quantification raw data representing researcher response Risk perception Spread Support Topic [DOI] 10.1057/s41599-022-01039-1 [Article Type] Research
Phase III, Randomized, Double-blind, Placebo controlled trial of Efficacy, Safety and Tolerability of Antiviral drug Umifenovir vs Standard care of therapy in non-severe COVID-19 patients심각하지 않은 COVID-19 환자를 대상으로 항바이러스제 Umifenovir 대 표준 요법의 효능, 안전성 및 내약성에 대한 III상, 무작위, 이중 맹검, 위약 대조 시험Clinical Trial Published on 2022-02-012022-09-11 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 신약개발, 임상, 치료제, [키워드] 1:1 average baseline Care carried Controlled trial COVID-19 adult patients COVID-19 patient COVID19 patients criteria dosage double-blind Efficacy exhibit meet moderate multicenter Nasopharyngeal swab negativity Ordinal Scale Patient patients PCR test phase phase III trial Placebo placebo-controlled primary endpoint Randomized recruited RT-PCR RT-PCR test Safe Safety secondary endpoint Standard Standard-of-care statistically significant tested the WHO therapy Tolerability umifenovir WHO ordinal scale [DOI] 10.1016/j.ijid.2021.11.025 PMC 바로가기 [Article Type] Clinical Trial
First Case of a COVID-19 Patient Infected by Delta AY.4 with a Rare Deletion Leading to a N Gene Target Failure by a Specific Real Time PCR Assay: Novel Omicron VOC Might Be Doing Similar Scenario?Case Report Published on 2022-01-252022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] Analysis Antigen Atypical circulating COVID-19 Deletion Delta delta variant Diagnosis diagnostic assay diagnostic tests Europe failure Genes GISAID sequence globe highlight Hospitalized Infection Interpretation Italian leading Lineage male MiSeq molecular N gene N gene target failure Nasopharyngeal swab negativity NGS novel nucleocapsid deletion nucleotides omicron Omicron variant Patient PCR performed positive result Prevalence responsible SARS-CoV-2 SARS-CoV-2 genome sequencing SARS-CoV-2 sequencing sequence Specific target time variant VoC [DOI] 10.3390/microorganisms10020268 PMC 바로가기 [Article Type] Case Report
Ivermectin shows clinical benefits in mild to moderate COVID19: a randomized controlled double-blind, dose-response study in LagosRandomized Controlled Trial Published on 2022-01-052022-10-05 Journal: QJM: An International Journal of Medicine [Category] SARS, 임상, [키워드] 95%CI ANOVA clinical benefit Clinical management conducted Control controls correlated COVID COVID 19 COVID19 Day dose dose response double blind double-blind Efficacy Efficacy and safety group high risk inhibit Lago Lopinavir/ritonavir Mild moderate negativity parallel group Patient Placebo Platelet positive patients Prophylaxis question Randomized reduced remained repeated measure reported SAE shown significantly the SARS-CoV-2 translational Treatment treatment groups viral replication [DOI] 10.1093/qjmed/hcab035 PMC 바로가기 [Article Type] Randomized Controlled Trial
Prolonged viral shedding of SARS-CoV-2 and related factors in symptomatic COVID-19 patients: a prospective studyResearch Published on 2021-12-272022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, SARS, [키워드] 95% CI Admission antibody antibody production average clinical information collected contribute COVID-19 COVID-19 patient COVID-19 patients declined enrolled Factor female female gender highest hospital Hospital admission identify IgM antibody initial median time multivariate Cox regression nasopharyngeal negativity Older Older age outbreak Patient population level progression Prolonged prolonged viral shedding Prospective Study quantified quantitative PCR remained respiratory sample Result risk factor RT-qPCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral load significant effect significantly significantly higher supplementary material symptom onset symptomatic symptomatic patient transcriptase viral kinetics Viral load viral shedding Wuhan, China [DOI] 10.1186/s12879-021-07002-w PMC 바로가기 [Article Type] Research
Efficacy and safety of sofosbuvir plus daclatasvir or ravidasvir in patients with COVID-19: A randomized controlled trialCOVID-19 환자에서 소포스부비르와 다클라타스비르 또는 라비다스비르의 효능 및 안전성: 무작위 대조 시험Clinical Trial Published on 2021-12-012022-09-11 Journal: Journal of medical virology [Category] 신약개발, 임상, 치료제, [키워드] added addition Admission Antiviral antiviral drugs Antiviral treatment approved ARMS clinical impact coronavirus coronavirus disease COVID-19 COVID-19 infection COVID-19 infections daclatasvir Day DCV Deterioration distress effective therapy Efficacy Efficacy and safety eligible patient endpoints evaluate Evidence evidence of Fever headache ICU ICU admission identify improvement incidence infections intensive care intensive care unit mechanical ventilation moderate moderate to severe Mortality negativity no evidence of Open-label open-label trial oxygen oxygen saturation Patient patients with moderate positive Randomized Randomized controlled trial ravidasvir RDV repurposing repurposing antiviral drugs respiratory distress Severe COVID-19 Infection severe COVID-19 infections significantly significantly lower sofosbuvir sofosbuvir plus daclatasvir standard care Standard of care Support Symptom Treatment Trial [DOI] 10.1002/jmv.27264 PMC 바로가기 [Article Type] Clinical Trial
Comparison of chest HRCT severity score in PCR positive and PCR negative clinically suspected COVID-19 PatientsArticles Published on 2021-12-012022-10-27 Journal: African Health Sciences [Category] COVID-19, [키워드] Accuracy association Chest High resolution computed tomography (HRCT) chest HRCT Chi-square Clinical symptoms clinically suspected COVID-19 COVID-19 infection COVID-19 patients cross-sectional determine diagnosing diagnosis of COVID-19 diagnostic false-negative guideline help HRCT IMPROVE Infection limitation lung lung damage Negative PCR negativity not significant objective Patient PCR PCR positive PCR testing polymerase chain reaction Polymerase chain reaction (PCR) positive Result RT-PCR severity Severity Score suspected patient upper lobe variable were used [DOI] 10.4314/ahs.v21i4.9 PMC 바로가기 [Article Type] Articles
Comparison of chest HRCT severity score in PCR positive and PCR negative clinically suspected COVID-19 PatientsArticles Published on 2021-12-012022-10-27 Journal: African Health Sciences [Category] Coronavirus, COVID-19, SARS, [키워드] Accuracy association Chest High resolution computed tomography (HRCT) chest HRCT Chi-square Clinical symptoms clinically suspected COVID-19 COVID-19 infection COVID-19 patients cross-sectional determine diagnosing diagnosis of COVID-19 diagnostic false-negative guideline help HRCT IMPROVE Infection limitation lung lung damage Negative PCR negativity not significant objective Patient PCR PCR positive PCR testing polymerase chain reaction Polymerase chain reaction (PCR) positive Result RT-PCR severity Severity Score suspected patient upper lobe variable were used [DOI] 10.4314/ahs.v21i4.9 PMC 바로가기 [Article Type] Articles
Single-dose oral ivermectin in mild and moderate COVID-19 (RIVET-COV): A single-centre randomized, placebo-controlled trialRandomized Controlled Trial Published on 2021-12-012022-10-05 Journal: Journal of infection and chemotherapy : official j [Category] SARS, 신약개발, 임상, [키워드] acute respiratory syndrome administration Analysis antiparasitic drug Arm assigned Coronavirus-2 COVID-19 dose double blind Efficacy enrolment hospitalized patient in viral In-vitro intention-to-treat population Intervention Ivermectin Mild Mild-to-moderate Moderate COVID-19 modified intention-to-treat negativity occurred outcome Patient patients randomized Placebo placebo-controlled trial positive RT-PCR Primary outcome Randomized Randomized controlled trial reducing RT-PCR Safety SARS-CoV-2 Serious Adverse Event Serious Adverse Events significantly Single-dose statistical significance treating COVID-19 Viral load were assessed [DOI] 10.1016/j.jiac.2021.08.021 PMC 바로가기 [Article Type] Randomized Controlled Trial
Observational study on the benefit of a nutritional supplement, supporting immune function and energy metabolism, on chronic fatigue associated with the SARS-CoV-2 post-infection progressObservational Study Published on 2021-12-012022-10-05 Journal: Clinical nutrition ESPEN [Category] SARS, 임상, [키워드] affected Amino acid analyzed association benefit characterized chronic Chronic fatigue components conducted discharged disease Dyspnea Effect Effects energy metabolism enrolled evaluate evaluated fatigue general health status headache Health status hospital immune function IMPROVE Infection Italy life long-COVID Mental Mild Minerals negativity Nutritional Supplement observational study participant Patient Post-infection Quality Quality of life questionnaire Questionnaires recent reduce relative SARS-CoV-2 Severe infection severity statistic statistically significant subject subsequent Symptom synergistic the SARS-CoV-2 tiredness vitamins weakness were measured [DOI] 10.1016/j.clnesp.2021.08.031 PMC 바로가기 [Article Type] Observational Study