Efficacy of antiseptic mouthrinses against SARS-CoV-2: A prospective randomized placebo-controlled pilot studyArticle Published on 2022-11-012022-11-15 Journal: American journal of otolaryngology [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] Adult patients Affect analyzed baseline chlorhexidine clinical collected COVID-19 detectable Disinfection effective Effectiveness groups Hospitalized hydrogen peroxide individual initial mouth negativity oral oral cavity Oral diseases Oral medicine Oral rinses Patient pilot study Placebo placebo-controlled Povidone‑iodine Public public health Randomized recruited reduced reducing Replication Research Saliva SARS-CoV-2 SARS-CoV-2 viral load swab specimens the placebo group viral copy number were measured [DOI] 10.1016/j.amjoto.2022.103549 PMC 바로가기
Efficacy and safety of ivermectin in the treatment of mild to moderate COVID-19 infection: a randomized, double-blind, placebo-controlled trialRandomized Controlled Trial Published on 2022-08-262022-10-05 Journal: Trials [Category] SARS, 임상, [키워드] acute respiratory syndrome adverse event adverse events age antiparasitic drug assigned caused coronavirus coronavirus disease COVID-19 double-blind duration of hospitalization Effectiveness Efficacy enrolment Frequency group hospitalized patient Ivermectin ivermectin treatment Mild Moderate COVID-19 n=36 negativity no difference outbreak overcome pandemic Patient PCR-positive PCR-positive patient Placebo placebo-controlled placebo-controlled trial polymerase chain Primary outcome proportion Randomized Randomized controlled trial Randomly receiving reported reverse transcription RT-PCR SARS-CoV-2 Secondary endpoints secondary outcome shown Side effects significant difference single-center standard care Standard of care survival symptomatic Symptoms therapeutic Treatment Trial worsening [DOI] 10.1186/s13063-022-06649-3 PMC 바로가기 [Article Type] Randomized Controlled Trial
Pathogen Profile of Children Hospitalised with Severe Acute Respiratory Infections during COVID-19 Pandemic in the Free State Province, South Africa남아프리카 공화국 프리 스테이트 주에서 COVID-19 팬데믹 기간 동안 중증 급성 호흡기 감염으로 입원한 어린이의 병원체 프로필Article Published on 2022-08-212022-09-11 Journal: International Journal of Environmental Research an [Category] SARS, 치료기술, 치료제, [키워드] absence Acute respiratory infection acute respiratory infections acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aetiology change children circulation Co-infection collected complicate contribute coronavirus coronavirus disease COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 transmission Ct values detection rate Diagnosis exacerbated Free Immunity infection control Influenza Influenza virus measure Mortality negativity Panel pathogen Pathogens profile QIAstat-Dx® Respiratory SARS-CoV-2 Panel respiratory respiratory infections respiratory pathogen Respiratory pathogens respiratory syncytial virus respiratory virus respiratory viruses SARI SARS-CoV-2 severe acute respiratory infections severe acute respiratory syndrome Coronavirus Severe infection severe infections South Africa state susceptibility Swab Treatment Viral detection virus waned Waves waves of COVID-19 pandemic. [DOI] 10.3390/ijerph191610418 PMC 바로가기 [Article Type] Article
Past COVID-19 and immunosuppressive regimens affect the long-term response to anti-SARS-CoV-2 vaccination in liver transplant recipients과거의 COVID-19 및 면역억제 요법은 간 이식 수혜자의 항 SARS-CoV-2 백신 접종에 대한 장기 반응에 영향을 미칩니다Article Published on 2022-07-012022-09-11 Journal: Journal of hepatology [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] Affect anti-RBD anti-receptor-binding domain anti-SARS-CoV-2 anti-SARS-CoV-2 vaccination anti-SARS-CoV-2 vaccine anti-SARS-CoV-2 vaccines Antibody Response Antibody titer ascites baseline BNT162b2 BNT162b2 vaccine Control controls COVID-19 COVID-19 recovered patient daily dose dose effective enrolled Frequency IgG IgG antibody immunogenicity immunosuppressive independent predictor independent predictors less leukocyte liver liver transplant Liver transplantation median MMF mRNA mRNA vaccine mycophenolate mycophenolate mofetil naïve negative controls negativity patients positive Protein recipient recipients regimen second vaccination serum significantly lower tested U/mL vaccination vaccine dose [DOI] 10.1016/j.jhep.2022.02.015 PMC 바로가기 [Article Type] Article
Detectable Duration of Viable SARS-CoV-2, Total and Subgenomic SARS-CoV-2 RNA in Noncritically Ill COVID-19 Patients: a Prospective Cohort Study중증이 아닌 COVID-19 환자에서 생존 가능한 SARS-CoV-2, 전체 및 서브게놈 SARS-CoV-2 RNA의 감지 가능한 기간: 전향적 코호트 연구Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 바이오마커, 치료기술, [키워드] 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis clearance collected coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Culture Determination determine diagnosed Duration Evidence Factor feasibility gold gold standard hazard ratio Ill Immunocompromised Immunocompromised patients infection control Infectivity interquartile range investigated Isolation Kinetics marker median time N gene Nasopharyngeal swab nasopharyngeal swabs negativity Patient Prospective prospective cohort receipt Reinfection respiratory reverse transcription PCR RNA RNA RT-PCR RT-PCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 sgRNA SARS-CoV-2 sgRNAs severe acute respiratory syndrome Coronavirus sgRNA sgRNAs steroid subgenomic RNA subgenomic RNAs surrogate markers time Total total RNA transcript Viable Viral viral culture viral infectivity Viral RNA viral shedding [DOI] 10.1128/spectrum.00503-22 PMC 바로가기 [Article Type] Article
Anti-inflammatory response of cardamom extract and prediction of therapeutic window in COVID-19 patients by assessing inflammatory markers using RT-PCRRT-PCR을 사용한 염증 마커를 평가함으로써 COVID-19 환자에서 카 다몬 추출물의 항 염증 반응 및 치료 창의 예측Article Published on 2022-06-012022-08-31 Journal: Inflammopharmacology [Category] COVID19(2023년), MERS, SARS, 진단, 치료제, [키워드] addition alternative Anti-inflammatory anti-inflammatory action anti-inflammatory response Anti-viral association attending physician Awareness breathlessness can not Cardamom Clinical improvement Clinical practice clinician control group cough Course COVID-19 COVID-19 patient COVID-19 patients COVID-19 symptom COVID-19 symptoms CRP Ct values cycle threshold cytokine Cytokine storm dawn Diagnostic method diagnostic test diagnostic tests disease Disease progression dosage dose effective elevated end point enrolled Fever FORTE gene expression profile hospital IL-10 IL-6 India indicate Inflammation Inflammatory marker inflammatory markers inflammatory parameter intake Intervention lack LDH majority material molecular diagnostics morbidity morbidity and mortality multiplex negativity normalized onset of symptom outcome parameter Patient patients PCR test performed popularity potentiality predict Prednisolone prevalent Prognosis protein level provide reason for reducing reported RT-PCR RT-PCR analysis RT-PCR assay RT-PCR test SARS-CoV-2 SARS-CoV-2 RT-PCR SARS-CoV-2 RT-PCR test serum Serum IL-6 sore throat Standard of care standard treatment Steroids Symptom Tablet tested the cytokine storm the patient therapeutic window time TNF- α Treatment treatment arm treatment group were given worsening [DOI] 10.1007/s10787-022-00951-x PMC 바로가기 [Article Type] Article
Efficacy of high-dose intravenous immunoglobulin in severe and critical COVID-19: A retrospective cohort study중증 및 중증 코로나19에서 고용량 정맥 면역글로불린의 효능: 후향적 코호트 연구Article Published on 2022-05-012022-09-12 Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 진단, [키워드] 28-day mortality adjusted administration age analyses Analysis analyzed APACHE II score Care chronic respiratory disease COVID-19 COVID-19 disease COVID-19 severity Critical critical COVID-19 patients dysregulated immune response early administration Efficacy evaluate group High-dose hospital ICU ICU admission immunoglobulins immunomodulatory therapy IMPROVE in-hospital mortality initial intensive care Intravenous immunoglobulin invasive ventilation less Linear regression management mechanical ventilation Mortality negativity obesity outcome outcomes Oxygen requirements Patient patient selection performed reduced retrospective cohort study Retrospective study secondary Severe COVID-19 Infection significantly standard treatment supplemental oxygen Ventilation [DOI] 10.1016/j.intimp.2022.108615 PMC 바로가기 [Article Type] Article
Diagnosing COVID-19; towards a feasible COVID-19 rule-out protocolCOVID-19 진단; 실현 가능한 COVID-19 배제 프로토콜을 향해Article Published on 2022-04-012022-09-11 Journal: Acta clinica Belgica [Category] COVID19(2023년), SARS, 치료기술, [키워드] added Analysis antibody Antibody testing approach BAL BAL fluid bronchoalveolar Bronchoalveolar lavage bronchoscopy Chest CT COVID-19 COVID-19 in patient COVID-19 negative COVID-19 positive patients Critically ill Culture decrease diagnoses diagnostics etiological agent feasible Ghent identify IgA IgG implementation initial invasive low-dose microbial multiplex Multiplex PCR negativity non-critically ill patient Pathogens Patient positive protocol repeated respiratory pathogen Retrospective analysis rRT-PCR RT-PCR SARS-CoV-2 SARS-COV-2 infection selected Serological assay serological assays serology Symptom university [DOI] 10.1080/17843286.2021.1883362 PMC 바로가기 [Article Type] Article
Initial Experience With SARS-CoV-2-Neutralizing Monoclonal Antibodies in Kidney or Combined Kidney-Pancreas Transplant Recipients신장에서 SARS-CoV-2-중화 단일클론항체 또는 신장-췌장 결합 이식 환자에 대한 초기 경험Article Published on 2022-03-312022-09-11 Journal: Transplant International [Category] MERS, SARS, 변종, 진단, [키워드] Administered analyzed antibodies antiviral drugs appear bamlanivimab clinical outcomes co-primary endpoint co-primary endpoints Combined Contact coronavirus COVID-19 death drug effective Emergency use authorization EUA experience Hospitalization Hospitalized hospitalized patient identify Imdevimab Immunocompromised Immunosuppression IQR kidney Kidney transplantation lymphoma mAb median interval monoclonal antibodies monoclonal antibody Mortality negativity Organ transplant overall mortality Patient PCR negativity positive receive recipient recipients renal function respiratory Respiratory Coronavirus SARS-CoV-2 SARS-CoV-2 RT-PCR shown single dose single doses Spike protein Transplant treated Treatment U.S. FDA variant Viral viral spike viral spike protein virus-specific antibodies [DOI] 10.3389/ti.2022.10109 PMC 바로가기 [Article Type] Article
Autochthonous Outbreak of SARS-CoV-2 Omicron Variant in Booster-Vaccinated (3 Doses) Healthcare Workers in Southern Italy: Just the Tip of the Iceberg?Article Published on 2022-02-132022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] administration booster booster doses chronic condition consequence Coverage COVID-19 vaccine Epidemiology genomic HCW HCWs healthcare worker Hospitalization Hospitalized ICU treatment immune evasion Infection involved Italian population Italy mild symptoms mitigate molecular negativity omicron outbreak Patient Phylogenetic tree required S gene SARS-CoV-2 SARS-CoV-2 Omicron variant shown Spread subject Surveillance Transmissibility Vaccine variant VoC were infected whole-genome sequencing worker [DOI] 10.3390/vaccines10020283 PMC 바로가기 [Article Type] Article