Structural determination of an antibody that specifically recognizes polyethylene glycol with a terminal methoxy group Research Published on 2022-08-012022-10-05 Journal: Communications Chemistry [Category] 변종, [키워드] analysis antibodies antibody antigenicity bind binding circulation complex cross-reactivity glycol humanized hydrogen bond interaction hydrogen bond interactions hydrophobic hydroxyl groups IMPROVE induce mechanism Neutral offer polar Polymer recognize replacement residue resulting Serine specificity therapeutic effects therapeutic efficacy Therapeutic molecule Van [DOI] 10.1038/s42004-022-00709-0 [Article Type] Research
Systematic review and meta-analysis on coronary calcifications in COVID-19코로나19의 관상동맥 석회화에 대한 체계적 고찰 및 메타분석Review Published on 2022-08-012022-09-11 Journal: Emergency Radiology [Category] COVID19(2023년), SARS, 치료기술, [키워드] 95% CI appear Biomarker Biomarker imaging CAC CAC-DRS CACS calcium cardiovascular Cardiovascular calcifications cardiovascular disease Cardiovascular events Chest CT Clinical outcome clinical outcomes Coronary Coronary calcifications. COVID-19 COVID-19 patient COVID-19 patients detect disease Evidence hospital Hospital mortality Hospitalization Infection Meta-analysis Mortality Neutral Non-pulmonary observational study outcome Predictive prognostic pulmonary involvement radiological finding reported respiratory outcomes SARS-CoV2 SARS-CoV2 infection ventilatory support [DOI] 10.1007/s10140-022-02048-y PMC 바로가기 [Article Type] Review
Engineered disulfide reveals structural dynamics of locked SARS-CoV-2 spike설계된 이황화물은 잠긴 SARS-CoV-2 스파이크의 구조적 역학을 보여줍니다Article Published on 2022-07-292022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), SARS, 변종, [키워드] Acidic Alter analysis cellular compartment change changes in conformation conformational change conformations D614G D614G mutation Disulfide disulfide bond domain extracellular space functional high-resolution structure hinge interact modulate Mutation Neutral pre-fusion Protein provide RBD Receptor binding domain Regulation reveal SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 spike SARS-CoV-2 spikes sequence Structure structures transition variants of concern viral fitness virion virus wild-type SARS-CoV-2 [DOI] 10.1371/journal.ppat.1010583 PMC 바로가기 [Article Type] Article
Using prosocial behavior to safeguard mental health and foster emotional well-being during the COVID-19 pandemic: A registered report of a randomized trialRandomized Controlled Trial Published on 2022-07-282022-10-04 Journal: PLoS ONE [Category] 임상, [키워드] Act analysis Anxiety assigned benefit blind Canada Compliance condition conditions Control COVID-19 COVID-19 pandemic Depression Effect emotional flexible Follow-up Future Intervention lockdown Measures Mechanical mental health negatively affected Neutral not differ outcome pandemic participant public health randomized trial Randomly recruited reduced Registered replicate the United State Treatment [DOI] 10.1371/journal.pone.0272152 PMC 바로가기 [Article Type] Randomized Controlled Trial
Exploring the Chinese Public’s Perception of Omicron Variants on Social Media: LDA-Based Topic Modeling and Sentiment Analysis소셜 미디어에서 오미크론 변종에 대한 중국 대중의 인식 탐색: LDA 기반 주제 모델링 및 감정 분석Article Published on 2022-07-082022-09-11 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Analysis analyzed Beijing category caused China Chinese Chinese government collected country COVID-19 COVID-19 pandemic Economy FIVE Government Infection knowledge media modeling negative emotions Neutral omicron Omicron variant Omicron variants pandemic Perception positive emotions Prevention and control promote provide Public public health authorities recommendation RNA viruses SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sentiment analysis Seven Sina Weibo social media Strains Topic topic modeling. Vaccine [DOI] 10.3390/ijerph19148377 PMC 바로가기 [Article Type] Article
SpySwitch enables pH- or heat-responsive capture and release for plug-and-display nanoassemblySpySwitch는 플러그 앤 디스플레이 나노 어셈블리를 위한 pH 또는 열 반응성 캡처 및 릴리스를 지원합니다.Article Published on 2022-06-282022-09-12 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] antibodies Bacterial binding site Culture determine ENhance EY6A Final flexible generate histidine mammalian moderate Neutral New coronavirus pandemic Protein Proteins purification Receptor-binding domain Resilience Sarbecoviruses SARS-CoV-2 tested Threats Vaccine development [DOI] 10.1038/s41467-022-31193-8 PMC 바로가기 [Article Type] Article
Influence of statin treatment in a cohort of patients admitted for COVID-19Observational Study Published on 2022-06-242022-10-05 Journal: Medicina clínica [Category] COVID19(2023년), SARS, 임상, [키워드] Admission Adverse adverse effect adverse effects age all-cause mortality association Clinical outcome cohort of patient consequence COVID-19 Critical care dose Efectos adversos Estatinas events Follow-up Hospital admission hospitalized COVID-19 patients hospitalized patient host response influence large cohort material modulating morbidity Morbilidad Mortalidad Mortality Neutral Patient patients died patients treated recommendation Retirada medicación SARS-COV-2 infection significantly statin statins Treatment Treatment withdrawal. whole sample Withdrawal [DOI] 10.1016/j.medcli.2021.07.003 PMC 바로가기 [Article Type] Observational Study
Urine metabolomics links dysregulation of the tryptophan-kynurenine pathway to inflammation and severity of COVID-19소변 대사체학은 트립토판-키누레닌 경로의 조절 장애를 COVID-19의 염증 및 중증도와 연결합니다Article Published on 2022-06-152022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, 치료기술, 치료법, [키워드] 3-hydroxykynurenine alteration Amino acid amino acids association Biomarker Biomarkers cause changes in Control coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 severity Critical disease severity dysfunction dysregulation healthy controls; Host immune response Increased Inflammation investigated Kynurenine kynurenines metabolism metabolite metabolomic profiling metabolomics Neutral pathway patients hospitalized performed proline proximal proximal tubule Quantitative SARS-CoV-2 SARS-CoV-2 infected patients SARS-COV-2 infection serum severity severity of COVID-19 Support systemic inflammation Transport Tryptophan Urine with COVID-19 [DOI] 10.1038/s41598-022-14292-w PMC 바로가기 [Article Type] Article
Influence on study outcomes of an inpatient study by the behavior of the study staff (PINgPOng): study protocol for a randomized clinical trial연구 직원의 행동이 입원 환자 연구의 연구 결과에 미치는 영향(PINGPOng): 무작위 임상 시험을 위한 연구 프로토콜Article Published on 2022-06-132022-09-11 Journal: Trials [Category] COVID19(2023년), SARS, 임상, [키워드] administration Affect Alpha amylase analgesic Analgesic therapy analyzed Anxiety Behavior characteristic classical clinical clinical development clinical study clinical trial cold pressor test conducted cortisol covariate covariates cross-over Declaration of Helsinki Depression double-blind Drug efficacy Effect Effects Factor fixed healthy volunteer help Helsinki ICH-GCP influence intensity Neutral Oxycodone Pain pain intensity pharmacological phase Placebo Placebo effect Placebo response placebo-controlled study pressor test primary endpoint question Randomized randomized clinical trial RCT RCTs reaction response responses salivary single-center specific effect specific effects Stress study outcome Study protocol Study team. Symptom tested treated Treatment university [DOI] 10.1186/s13063-022-06436-0 PMC 바로가기 [Article Type] Article
Artificial Intelligence-Enabled Social Media Analysis for Pharmacovigilance of COVID-19 Vaccinations in the United Kingdom: Observational Study영국의 코로나19 백신 약물 감시를 위한 인공 지능 기반 소셜 미디어 분석: 관찰 연구Observational Study Published on 2022-05-272022-09-11 Journal: JMIR Public Health and Surveillance [Category] Coronavirus, COVID19(2023년), SARS, 임상, 치료기술, [키워드] adverse effect adverse effects allergy Analysis analyzed Appetite approach approaches artificial artificial intelligence Bell complementary COVID-19 COVID-19 vaccines death debates deep learning diarrhea Facebook Fever filtered Frequency Government Guillain-barrè syndrome headache Health health informatics hospitalizations immunization infections infodemiology injection injection site investigated knowledge media MONITOR National natural language natural language processing Neutral pharmacovigilance positive public health reduction in Regulatory reported sentiment analysis Side effect social media study period subsequent Support Symptom Twitter unique United Kingdom uptake vaccinated individuals vaccination vaccination. Vaccine Vaccine hesitancy variations [DOI] 10.2196/32543 PMC 바로가기 [Article Type] Observational Study