rVSV-ΔG-SARS-CoV-2-S vaccine: repeated intramuscular (IM) toxicity, local tolerance, immunogenicity and biodistribution study in NZW rabbitsrVSV-ΔG-SARS-CoV-2-S 백신: NZW 토끼에서 반복되는 근육내(IM) 독성, 국소 내성, 면역원성 및 생체 분포 연구Article Published on 2022-08-012022-09-11 Journal: Archives of Toxicology [Category] COVID19(2023년), MERS, SARS, 비임상, 진단, 치료기술, [키워드] Administered animals antibody antibody levels Antibody titers Antigen assigned binding biodistribution biodistribution study body temperature body weight breath C-reactive protein change Clinical pathology Clinical signs clinical trial clinical trials correlated COVID-19 detection elicited evaluate Express followed by Gross High-dose high-dose group histopathological iliac lymph node immunogenicity inflammatory reaction injection intervals intramuscular intramuscularly Local local reactions Lymph node mesenteric lymph nodes Necrosis Neutralizing antibodies Neutralizing antibody titer neutralizing antibody titers New Nonclinical ophthalmology pathology Phase 2 platform Reactions repeated RNA Safe Safety SARS-CoV-2 SARS-CoV-2-S significant increase spleen stomatitis supported systemic the vaccine Tolerance Toxicity two group two groups Urinalysis vaccination Vaccine vaccine doses Vector-based vaccine vesicular stomatitis vesicular stomatitis virus Viremia VSV was performed [DOI] 10.1007/s00204-022-03302-5 PMC 바로가기 [Article Type] Article
Vaccination with Omicron Inactivated Vaccine in Pre-vaccinated Mice Protects against SARS-CoV-2 Prototype and Omicron Variants사전 백신 접종된 마우스에서 오미크론 비활성화 백신을 사용한 백신 접종은 SARS-CoV-2 프로토타입 및 오미크론 변이체로부터 보호합니다Article Published on 2022-07-192022-09-11 Journal: Vaccines (Basel) [Category] 비임상, [키워드] addition antibody BBIBP-CorV breath clinical trial Delta dose effective Genetic immune response immune responses inactivated Inactivated vaccine Inactivated Vaccines inactivated vaccines. induce Neutralizing antibody titer neutralizing antibody titers omicron Omicron variant PROTECT prototype Safe SARS-CoV-2 stability Support Vaccine vaccine candidate variant virus VoC [DOI] 10.3390/vaccines10071149 PMC 바로가기 [Article Type] Article
Induction of Broadly Cross-Reactive Antibody Responses to SARS-CoV-2 Variants by S1 Nanoparticle VaccinesS1 나노입자 백신에 의한 SARS-CoV-2 변이체에 대한 광범위한 교차 반응성 항체 반응의 유도Article Published on 2022-07-132022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antibody titers betacoronaviruses Characteristics comparable coronavirus COVID-19 cross-protective immunity cross-reactive cross-reactivity effective elicit elicited exhibited homogeneity humoral immune evasion Immunity induction Infection MERS-CoV mice Middle East Middle East respiratory syndrome Coronavirus monomer nanoparticle nanoparticle vaccine Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers novel vaccines omicron pathogenic respiratory respiratory syndrome coronavirus response S1 SARS-CoV SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus Spike protein spike protein S1 stability Vaccine vaccine candidate vaccine candidates Vaccines variant variants variants of concern variants of interest wild-type wild-type SARS-CoV-2 [DOI] 10.1128/jvi.00383-22 PMC 바로가기 [Article Type] Article
The magnitude and timing of recalled immunity after breakthrough infection is shaped by SARS-CoV-2 variantsSARS-CoV-2 변종에 의해 형성되는 돌발성 감염 후 면역 회수의 규모와 시기Article Published on 2022-07-122022-09-11 Journal: Immunity [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Activation antibody Antibody titers B cell B cell immunity B cells Breakthrough infection breakthrough infections CD4 CD4 T cell immunity CD8 CD8 T cell immunity cellular immunity Clinical outcome clinical outcomes COVID-19 COVID-19 vaccines Delta humoral immune Immunity Immunological memory IMPROVE increase in infecting Infection lack magnitude Neutralizing Neutralizing antibodies neutralizing antibody titers omicron phenotypic potential mechanism PROTECT protective effect Protective effects provide recall recalled response robust SARS-CoV-2 SARS-CoV-2 variant seropositive individual seropositive individuals severe COVID-19 T cell the timing vaccinated individuals vaccination variant Viral viral clearance viral replication while [DOI] 10.1016/j.immuni.2022.05.018 PMC 바로가기 [Article Type] Article
Potential use of convalescent plasma for SARS-CoV-2 prophylaxis and treatment in immunocompromised and vulnerable populations면역 저하 및 취약 집단에서 SARS-CoV-2 예방 및 치료를 위한 회복기 혈장의 잠재적 사용Article Published on 2022-07-012022-09-11 Journal: Expert review of vaccines [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Administered anti-SARS-CoV-2 Antibody titers Area case reports Case series case sery convalescent plasma COVID-19 effective Efficacy expert Health hyperimmune hyperimmune serum iatrogenic Immunocompromised Immunocompromised patients immunodeficiency Immunoglobulin immunoglobulins Neutralizing Neutralizing antibodies neutralizing antibody titers Patient patients plasma polyclonal polyclonal immunoglobulins Population Potential Prophylaxis Safe SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 variants Treatment [DOI] 10.1080/14760584.2021.1932475 PMC 바로가기 [Article Type] Article
Nanoparticle-delivered TLR4 and RIG-I agonists enhance immune response to SARS-CoV-2 subunit vaccine나노입자 전달 TLR4 및 RIG-I 작용제는 SARS-CoV-2 소단위 백신에 대한 면역 반응을 향상시킵니다Article Published on 2022-07-012022-09-11 Journal: Journal of controlled release : official journal o [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] activated Adaptive immune response adjuvant adjuvants agonist Anti-spike anti-Spike IgG Antibody titer Antibody titers Antigen antigen-presenting cell antigen-presenting cells APC APCS B cell B cells BAL Bcl6 Blood bronchoalveolar CD4 CD44 Cell cell population characterized Combination adjuvant COVID-19 COVID-19 protein subunit vaccine CpG DLNs draining lymph node draining lymph nodes Efficacy ENhance follicular Germinal center GL7 helper cell humoral immune responses IgA IgG immune immune response immune responses Immunity IMPROVE in vitro in vivo Increases increases in Infection intramuscular intramuscular vaccination intranasal Intranasal versus intramuscular vaccination intranasally lead lung Lungs lymphocyte memory T memory T cell mice molecular Monophosphoryl lipid A MPLA Native neutralizing antibody titers Pattern recognition pattern recognition receptor Pattern recognition receptors Polymer Population Proinflammatory cytokine Protein subunit protein subunit vaccine Protein subunit vaccines PRR PRRs PUUC reaction receptor receptors responses against retinoic acid retinoic acid-inducible gene I RIG-I robust S1 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein secretion spike IgA Spike protein stabilized spike protein stimulate subunit Subunit vaccine T cell T cell proliferation the S1 subunit TLR TLR4 TLR7 TLR7/8 TLR9 TLRs Toll-like receptor Toll-like receptors Transmission unique Vaccine vaccine availability vaccine responses variants [DOI] 10.1016/j.jconrel.2022.05.023 PMC 바로가기 [Article Type] Article
Ethnoracial Disparities in SARS-CoV-2 Seroprevalence in a Large Cohort of Individuals in Central North Carolina from April to December 20202020년 4월부터 12월까지 중부 노스캐롤라이나의 대규모 개인 집단에서 SARS-CoV-2 혈청 유병률의 인종적 격차Article Published on 2022-06-292022-09-11 Journal: mSphere [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus analyzed Antibody titers asymmetric Bayesian inference calculate caused collected coronavirus Course COVID-19 cross-sectional cross-sectional study death dependent on detectable disparity estimate Factor Health Health disparities highest hospital Immunoglobulin increase in individual Latinx likelihood majority neutralization Neutralizing antibodies Neutralizing antibody titer neutralizing antibody titers North observation observé Odds ratio PCR-confirmed Population Prevalence respiratory respiratory infection robust SARS-CoV-2 SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike protein seropositive individual seropositive individuals seropositive sample Seropositivity Seroprevalence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity of symptom skewed Spike protein subset Symptoms the United State unique United States university vaccination [DOI] 10.1128/msphere.00841-21 PMC 바로가기 [Article Type] Article
mRNA vaccine boosting enhances antibody responses against SARS-CoV-2 Omicron variant in individuals with antibody deficiency syndromesmRNA 백신 부스팅은 항체 결핍 증후군이 있는 개인에서 SARS-CoV-2 Omicron 변이체에 대한 항체 반응을 향상시킵니다Article Published on 2022-06-212022-09-11 Journal: Cell Reports Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Anti-spike antibody antibody deficiency syndrome Antibody Response Antibody titer Antibody titers binding combined variable antibody deficiency comparable coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 deficiency Delta develop domain ENhance Fcγ receptor FcγR healthy donors humoral immune response Hypogammaglobulinemia immune immune response immune responses Immunity immunization Immunoglobulin immunoglobulin replacement therapy individual MOST mRNA mRNA vaccination mRNA vaccine mRNA vaccines neutralization neutralizing activities Neutralizing activity neutralizing antibody titers omicron primary antibody Protective RBD receptor replacement therapy respiratory response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants serum severe acute respiratory syndrome Coronavirus specific antibody deficiency sustained syndrome tested titers vaccinated individual vaccination Vaccine variant virus [DOI] 10.1016/j.xcrm.2022.100653 PMC 바로가기 [Article Type] Article
Pre-existing antibody levels negatively correlate with antibody titers after a single dose of BBV152 vaccination기존 항체 수준은 단일 용량의 BBV152 백신 접종 후 항체 역가와 음의 상관관계가 있습니다Article Published on 2022-06-152022-09-11 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] antibody antibody levels Antibody Response Antibody titer Antibody titers baseline COVID-19 vaccine Delta dose Immunity immunization inactivated India individual information Lineage natural infection negative correlation neutralize Neutralizing antibodies neutralizing antibody neutralizing antibody titers omicron Omicron variant Omicron variants remained SARS-CoV-2 SARS-CoV-2 delta SARS-COV-2 infection SARS-CoV-2 vaccine second wave significantly lower single dose vaccination variant variants [DOI] 10.1038/s41467-022-31170-1 PMC 바로가기 [Article Type] Article
IgG Anti-Spike Antibodies and Surrogate Neutralizing Antibody Levels Decline Faster 3 to 10 Months After BNT162b2 Vaccination Than After SARS-CoV-2 Infection in Healthcare WorkersIgG 항스파이크 항체 및 대리 중화 항체 수준은 의료 종사자의 SARS-CoV-2 감염 후보다 BNT162b2 백신 접종 후 3~10개월 더 빠르게 감소합니다Article Published on 2022-06-152022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE-2 anti-S Anti-spike antibody Antibody titers Beta Beta variant binding BNT162b2 Cohort concern COVD-19 COVD-19 serological testing COVID-19 Decline dose expressed faster HCW Health care Health care worker health care workers highest humoral immune response hybrid IgG Immunity Infection Level linear linear relationship Live virus Month natural infection neutralization Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers of BNT162b2 omicron predicted Randomly ranged reduced resulting SARS-CoV-2 SARS-COV-2 infection selected sensitivity serological Serological testing spike surrogate the strongest Type vaccination variant VoC wild type worker [DOI] 10.3389/fimmu.2022.909910 PMC 바로가기 [Article Type] Article