The interplay of drug therapeutics and immune responses to SARS-CoV-2Review Article Published on 2023-11-142024-09-05 Journal: Cellular and Molecular Immunology [Category] update2024, [키워드] Adaptive immunity Antimicrobial responses Bisphosphonates Drug repurposing Nirmatrelvir SARS-CoV-2 viral infection [DOI] 10.1038/s41423-023-01098-7 PMC 바로가기 [Article Type] Review Article
Efficacy of the oral nucleoside prodrug GS-5245 (Obeldesivir) against SARS-CoV-2 and coronaviruses with pandemic potentialArticle Published on 2023-06-282024-09-05 Journal: bioRxiv [Category] update2024, [키워드] antivirals Broad-spectrum drugs GS-5245 Nirmatrelvir nucleoside obeldesivir Oral antiviral drugs pandemic preparedness PAXLOVID™ Remdesivir [DOI] 10.1101/2023.06.27.546784 PMC 바로가기 [Article Type] Article
Pharmacophore Oriented MP2 Characterization of Charge Distribution for Anti-SARS-CoV-2 Inhibitor NirmatrelvirArticle Published on 2023-05-302024-09-05 Journal: Journal of Molecular Structure [Category] update2024, [키워드] and Mulliken Electrostatic potential (ESP) Nirmatrelvir NPA theory (NPA) Second order Møller–Plesset (MP2) perturbation theory [DOI] 10.1016/j.molstruc.2023.135871 PMC 바로가기 [Article Type] Article
Design, synthesis and biological evaluation of covalent peptidomimetic 3CL protease inhibitors containing nitrile moietyArticle Published on 2023-05-082024-09-05 Journal: Bioorganic & Medicinal Chemistry [Category] update2024, [키워드] 3CL Protease COVID-19 Nirmatrelvir Peptidomimetic inhibitors SARS-CoV-2 [DOI] 10.1016/j.bmc.2023.117316 PMC 바로가기 [Article Type] Article
Evaluation of antiviral drugs against newly emerged SARS-CoV-2 Omicron subvariantsArticle Published on 2023-04-202024-09-05 Journal: Antiviral Research [Category] update2024, [키워드] antiviral activity molnupiravir Nirmatrelvir Omicron subvariant Remdesivir SARS-CoV-2 [DOI] 10.1016/j.antiviral.2023.105609 PMC 바로가기 [Article Type] Article
Global prevalence of SARS-CoV-2 3CL protease mutations associated with nirmatrelvir or ensitrelvir resistanceArticle Published on 2023-04-142024-09-05 Journal: eBioMedicine [Category] update2024, [키워드] antiviral resistance COVID-19 ensitrelvir Nirmatrelvir Protease inhibitor SARS-CoV-2 [DOI] 10.1016/j.ebiom.2023.104559 PMC 바로가기 [Article Type] Article
Viral target- and metabolism-based rationale for combined use of recently authorized small molecule COVID-19 medicines: molnupiravir, nirmatrelvir and remdesivirArticle Published on 2023-04-102024-09-05 Journal: Fundamental & clinical pharmacology [Category] update2024, [키워드] main protease molnupiravir Nirmatrelvir Remdesivir RNA-dependent RNA-polymerase SARS-CoV-2 [DOI] 10.1111/fcp.12889 PMC 바로가기 [Article Type] Article
Resistance to nirmatrelvir due to mutations in the Mpro in the subvariants of SARS-CoV-2 Omicron: Another concern?Editorial Published on 2023-04-062024-09-05 Journal: Molecular Therapy. Nucleic Acids [Category] update2024, [키워드] MPro Nirmatrelvir Omicron subvariant SARS-CoV-2 significant mutation [DOI] 10.1016/j.omtn.2023.03.013 PMC 바로가기 [Article Type] Editorial
Nirmatrelvir/ritonavir in COVID-19 patients with haematological malignancies: a report from the EPICOVIDEHA registryArticle Published on 2023-04-062024-09-05 Journal: EClinicalMedicine [Category] update2024, [키워드] COVID-19 Haematology malignancy Nirmatrelvir SARS-CoV-2 [DOI] 10.1016/j.eclinm.2023.101939 PMC 바로가기 [Article Type] Article
Time to negative PCR conversion amongst high-risk patients with mild-to-moderate Omicron BA.1 and BA.2 COVID-19 treated with sotrovimab or nirmatrelvirMulticenter Study Published on 2023-04-012023-07-11 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), [키워드] Anti-viral treatment COVID-19 monoclonal antibodies Nirmatrelvir Sotrovimab [DOI] 10.1016/j.cmi.2022.12.016 PMC 바로가기 [Article Type] Multicenter Study