no effect – Page 2 – Communicable Diseases Research

Major candidate variables to guide personalised treatment with steroids in critically ill patients with COVID-19: CIBERESUCICOVID study

Observational Study

Published on 2022-07-012022-10-04
Journal: Intensive care medicine [Category] 임상,

Beneficial and harmful effects of monoclonal antibodies for the treatment and prophylaxis of COVID-19: a systematic review and meta-analysis of randomized controlled trials

Meta-Analysis

Published on 2022-07-012022-10-05
Journal: The American journal of medicine [Category] COVID19(2023년), SARS, 임상, 진단, 치료법,

[키워드] 95% CI 95% confidence interval acute respiratory syndrome adverse event all-cause mortality antibody assessment Bacteremia certainty of evidence coronavirus coronavirus disease COVID-19 COVID-19 patients COVID-19-related death determine development Effect Efficacy and safety Evidence Hospitalization Hospitalized hospitalized patient hospitalized patients individual inverse mean difference mechanical ventilation meta-analyses Meta-analysis methodology moderate monoclonal antibodies monoclonal antibody no effect outcome outcomes Patient patients Prophylaxis random effect Randomized controlled trial reduce reduced Result risk searched Serious Adverse Event symptomatic systematic review Treatment Viral load was used were used with COVID-19
[DOI] 10.1016/j.amjmed.2022.06.019 [Article Type] Meta-Analysis

Ivermectin for preventing and treating COVID-19

COVID-19 예방 및 치료를 위한 이버멕틴

Review

Published on 2022-06-212022-09-11
Journal: The Cochrane database of systematic reviews [Category] COVID19(2023년), SARS, 임상,

[키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Admission adverse event adverse events all-cause mortality antiparasitic Antiviral approach ARMS Asymptomatic certainty certainty of evidence citation classification Clinical improvement clinical trial Cochrane COVID-19 Study Register coronavirus coronavirus disease COVID-19 COVID-19 diagnosis COVID-19 symptoms COVID-19 treatment Data collection database death discharged disease disease severity double-blind duration of symptom early stage early stages Efficacy Efficacy and safety eligible Evidence excluded for inclusion GRADE hospital identify in vitro include increase index Infection infection with SARS-CoV-2 inhibit inhibitory effect initial symptom Inpatient Inpatients Intervention Invasive mechanical ventilation investigated Ivermectin life mean difference Mental Meta-analysis Mild Moderate COVID-19 moderate-to-severe COVID-19 molecular hypothesis Mortality no effect non-randomized ongoing trial ongoing trials Open-label outcome Outpatient outpatients participant Participants people with COVID-19 physical Placebo placebo-controlled Postexposure Prophylaxis Prevent Quality of life question Randomized controlled trial Randomized controlled trials RCT RCTs receiving reduce Registered Replication Reporting request Research resolved risk Risk of bias risk ratio RoB 2 SARS-CoV-2 SARS-COV-2 infection Science Citation Index searched Selection Serious Adverse Event Serious Adverse Events Seven severe acute respiratory syndrome Coronavirus Standard of care treat treated treating COVID-19 Treatment Trial trials viral clearance virus Web of Science WHO WHO guideline worsening
[DOI] 10.1002/14651858.CD015017.pub3 PMC 바로가기 [Article Type] Review

Experimental pre-tests of public health communications on the COVID-19 vaccine: A null finding for medical endorsement, risk and altruism

Randomized Controlled Trial

Published on 2022-06-152022-10-05
Journal: Vaccine [Category] COVID19(2023년), SARS, 임상,

Scutellarein Inhibits LPS-Induced Inflammation through NF-κB/MAPKs Signaling Pathway in RAW264.7 Cells

스쿠텔라레인은 RAW264.7 세포에서 NF-κB/MAPK 신호 전달 경로를 통해 LPS 유도 염증을 억제합니다

Article

Published on 2022-06-122022-09-11
Journal: Molecules [Category] 유전자 메커니즘,

[키워드] addition Anti-inflammatory can be used Cell cells Chinese composed Compound COVID-19 Cyclooxygenase cytokine Cytokines determine diploid endotoxin ERK expression Extracellular family Gram-negative bacteria Helicase IL-1β Immune cell immune cells immune system Inflammation Inflammatory inflammatory disorder inflammatory disorders inhibit interleukin interleukin-1β involved IκBα JNK kinases lipopolysaccharide LPS LPS-induced inflammation MAPK mechanism mitogen NF-kB NF-кB nitric oxide nitric oxide synthase no effect nuclear outer membrane p65 pathway Pathways pro-inflammatory mediators proinflammatory mediators protein kinase required SARS Coronavirus SCU scutellarein scutellarein (SCU). secretion shown stimulate stimulated TNF-α Topic treat Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-α was reduced western blot
[DOI] 10.3390/molecules27123782 PMC 바로가기 [Article Type] Article

The Link between Subjective Religiosity, Social Support, and Mental Health among Young Students in Eastern Europe during the COVID-19 Pandemic: A Cross-Sectional Study of Poland and Ukraine

COVID-19 팬데믹 기간 동안 동유럽 젊은 학생들의 주관적 종교, 사회적 지원 및 정신 건강 사이의 연관성: 폴란드와 우크라이나에 대한 단면 연구

Article

Published on 2022-05-262022-09-11
Journal: International Journal of Environmental Research an [Category] COVID19(2023년), SARS, 변종,

Persistence of Anti SARS-CoV-2 Antibodies in Breast Milk from Infected and Vaccinated Women after In Vitro-Simulated Gastrointestinal Digestion

체외 모의 위장 소화 후 감염 및 백신 접종 여성의 모유 내 항 SARS-CoV-2 항체 지속성

Article

Published on 2022-05-192022-09-12
Journal: Nutrients [Category] COVID19(2023년), MERS, SARS, 진단,

[키워드] anti-SARS-CoV-2 antibodies antibody approach BNT162b2 mRNA Breast breast milk Breastfeeding colonic colonic fermentation Compound control group COVID-19 cut-off value demonstrated digested digestion ELISA expected fecal Gastrointestinal gastrointestinal tract group growth Gut gut microbiota IgA IgG IgG antibody immunization in vitro in vitro digestion Infant Infection intestinal lactating women lactation lactation. microbial microbiota milk mRNA vaccination mRNA-1273 no effect pathway persistence positive qPCR receiving recent reduced remained SARS-CoV-2 SARS-CoV-2 antibody significantly Specific stages tested the antibody the study group vaccination virus was determined was tested women
[DOI] 10.3390/nu14102117 PMC 바로가기 [Article Type] Article

Covid-19 Vaccine Effectiveness against the Omicron (B.1.1.529) Variant

오미크론(B.1.1.529) 변이체에 대한 코로나19 백신 효과

Article

Published on 2022-04-212022-09-11
Journal: The New England Journal of Medicine [Category] COVID19(2023년), SARS, 변종,

[키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 AstraZeneca B.1.1.529 B.1.617.2 BNT162b2 BNT162b2 vaccine booster booster dose booster vaccines calculated Case-control caused ChAdOx1 ChAdOx1 nCoV-19 Combination Control coronavirus coronavirus disease Coronavirus disease 2019 Course declining delta variant dose doses Effectiveness eligible England immunization investigated Moderna mRNA mRNA-1273 mRNA-1273 booster no effect of BNT162b2 omicron Omicron variant Pfizer-BioNTech Population provided rapid increase recipients security severe acute respiratory syndrome Coronavirus symptomatic disease Vaccine Vaccines variant waned
[DOI] 10.1056/NEJMoa2119451 PMC 바로가기 [Article Type] Article

Functional Analysis of Spike from SARS-CoV-2 Variants Reveals the Role of Distinct Mutations in Neutralization Potential and Viral Infectivity

SARS-CoV-2 변이체의 스파이크 기능 분석, 중화 가능성 및 바이러스 감염성에서 뚜렷한 돌연변이의 역할 밝혀

Article

Published on 2022-04-132022-09-11
Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 진단,

[키워드] Affect Analysis approach carried circulating viral variants cleavage site conjunction COVID-19 defined Delta Disease progression dose E484K Efficacy enhanced escape FCS functional furin furin cleavage site furin–cleavage site in viral Infectivity Lota Mutation N501Y neutralization neutralization antibodies Neutralizing antibodies neutralizing antibody no effect no effects P681H P681R Pfizer Pfizer–BTN162b2 vaccine Potential promote pseudovirus pseudoviruses RBD RBD mutation RBD mutations Receptor binding domain receptor binding domain (RBD) reduce reveal role SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sensitivity sera Site specific spike mutation specific spike mutations spike spike mutation spike mutations Spread vaccinated individuals Vaccine Viral viral infectivity Viral transmission viral variant Viral variants
[DOI] 10.3390/v14040803 PMC 바로가기 [Article Type] Article

SMYD2 Inhibition Downregulates TMPRSS2 and Decreases SARS-CoV-2 Infection in Human Intestinal and Airway Epithelial Cells

SMYD2 억제는 인간 장 및 기도 상피 세포에서 TMPRSS2를 하향 조절하고 SARS-CoV-2 감염을 감소시킵니다

Article

Published on 2022-04-082022-09-11
Journal: Cells [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제,

[키워드] antiviral activity Antiviral treatment antiviral treatment. AZ505 BAY598 block caused cellular circulating COVID-19 COVID-19 pandemic cultured cell cultured cells curtail decrease deficiency delta variant detectable downregulate effective antiviral treatment Effective vaccines exhibit expresse had no Human infect inhibited inhibition inhibitor lysine mRNA Neutralizing antibodies neutralizing antibody no effect not express pharmacological priming protein levels reporter SARS-CoV-2 SARS-COV-2 infection significantly SMYD2 Spike protein target cells targeting the spike protein TMPRSS2 TMPRSS2 expression Treatment variant Vero E6 VERO E6 cells Viral viral replication virus virus replication virus variant virus variants
[DOI] 10.3390/cells11081262 PMC 바로가기 [Article Type] Article