Genetic effects on the commensal microbiota in inflammatory bowel disease patients염증성 장질환 환자의 공생 미생물에 대한 유전적 영향Research Article Published on 2019-03-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Analysis association associations Bacteria Bacterial case study cohorts disease risk Effect etiology Evidence Faecalibacterium fitness Genetic genetic susceptibility Genetic variant Genome-wide association studies gut microbiota Host host genetics IBD increased risk independent Inflammatory bowel disease Microbiome microbiota NOD2 Observational data Patient performed potential mechanism replicated resulting reverse causation risk risk allele robustness Sensitivity analyses sensitivity analysis shown significantly Simulation study Study design the disease variant [DOI] 10.1371/journal.pgen.1008018 PMC 바로가기 [Article Type] Research Article
Human β-defensin 2 plays a regulatory role in innate antiviral immunity and is capable of potentiating the induction of antigen-specific immunityResearch Published on 2018-08-082022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] activate Activation Adaptive immune response adaptive immune responses addition adjuvant AMP AMPs antibody Antigen antimicrobial peptide Antiviral antiviral immunity cells chemokine Defense dendritic cells domain effective elicited expressed expression expression level HBD Human Human β-defensin IFN-β IFN-γ IL-1β IL-6 immune Immunity immunization in vitro in vivo innate antiviral immunity innate immune innate immune response Innate immunity investigated leukocytes MERS-CoV mice microorganisms Middle East monocytes/macrophages Natural killer cells Neutralizing antibody response NOD2 PKR promote RBD Regulatory Research Result S RBD Spike protein Subunit vaccine suggested T cells THP-1 TNF-α treat Treatment viruses was used β-defensin [DOI] 10.1186/s12985-018-1035-2 PMC 바로가기 [Article Type] Research
NOD2-RIP2 contributes to the inflammatory responses of mice in vivo to Streptococcus pneumoniaearticle Published on 2018-04-302024-09-01 Journal: Neuroscience Letters [Category] 폐렴구균 감염증, [키워드] Cytokines Gram-positive bacteria Meningitis NOD2 RIP2 [Article Type] article
Involvement of Nod2 in the innate immune response elicited by malarial pigment hemozoinarticle Published on 2015-03-312024-09-01 Journal: Microbes and Infection [Category] 말라리아, [키워드] Cytokines Natural hemozoin nitric oxide NOD2 Plasmodium falciparum Synthetic hemozoin (β-hematin) [Article Type] article
Analysis of nucleotide-binding oligomerization domain proteins in a murine model of pneumococcal meningitis폐렴구균 수막염의 마우스 모델에서 뉴클레오타이드 결합 올리고머화 도메인 단백질 분석Research Article Published on 2014-12-022024-08-04 Journal: BMC Infectious Diseases [Category] 폐렴구균 감염증, [키워드] Cytokines Gram-positive bacteria Meningitis NOD2 [DOI] 10.1186/s12879-014-0648-3 PMC 바로가기 [Article Type] Research Article