Vaccines and Dementia: Part I. Non-Specific Immune Boosting with BCG: History, Ligands, and ReceptorsReview Published on 2024-02-202024-09-05 Journal: Journal of Alzheimer's disease : JAD [Category] update2024, [키워드] adjuvant Alzheimer’s disease Bacille Calmette–Guerin Freund immunopotentiation muramyl dipeptide mycobacteria NOD2 trained immunity Vaccine YB-1 [DOI] 10.3233/JAD-231315 PMC 바로가기 [Article Type] Review
MIS-C: A COVID-19-as sociated condition between hypoimmunity and hyperimmunityArticle Published on 2022-10-032022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 바이오마커, 변종, [키워드] activated Activation acute phase Admission Analysis ATM Autoimmune Autoimmune disease Autoimmune diseases autoimmune pathogenesis autoinflammatory disease Autoinflammatory diseases B cell cellular Characteristics children clearance complication of COVID-19 contribute Critical cytokine response Cytokine storm Cytokines Cytometry demonstrated develop diagnostic biomarker DOCK8 event FCN3 Flow flow cytometry Genetic Genetic variant healthy control help heterogeneity Hospital admission identified variant IFN IFN-α IFN-β IFN-γ IFNγ IL-10 IL-12p70 IL-17A IL-6 immune dysregulation immunodeficiency immunological induce Inflammatory inflammatory pathway involved knowledge lymphocyte lymphopenia management MCM4 MIS-C MOST multisystemic mutated NCF1 NGS NOD2 organ Pathogenesis pathway Patient patients Population PRF1 reduction serum serum cytokine significant increase syndrome Th1 the disease therapeutic Therapies tissue damage TNF Type variant was increased [DOI] 10.3389/fimmu.2022.985433 PMC 바로가기
SARS-CoV-2/COVID-19 and its relationship with NOD2 and ubiquitinationReview article Published on 2022-05-012022-10-05 Journal: Clinical immunology (Orlando, Fla.) [Category] COVID19(2023년), SARS, 바이오마커, 변종, 치료제, [키워드] activate activation pathway Alter Autoimmune autoinflammatory disease binding Combination COVID-19 COVID-19 infection disease Diseases downstream effector proteins facilitate Factor Genetic Host immune system inflammatory process Interaction Mutation NOD2 Protein recruit SARS-CoV-2 Signaling syndrome UBA1 ubiquitination VEXAS syndrome viral infection Yao syndrome [DOI] 10.1016/j.clim.2022.109027 [Article Type] Review article
New insights into genetic characteristics between multiple myeloma and COVID-19: An integrative bioinformatics analysis of gene expression omnibus microarray and the cancer genome atlas data다발성 골수종과 COVID-19 사이의 유전적 특성에 대한 새로운 통찰력: 유전자 발현 옴니버스 마이크로어레이와 암 게놈 아틀라스 데이터의 통합 생물정보학 분석Comparative Study Published on 2021-12-012022-09-11 Journal: International journal of laboratory hematology [Category] SARS, 유전자 메커니즘, [키워드] 95% CI association bioinformatics Bioinformatics analysis Cancer Characteristics Cohort Control coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection Cox regression analysis COX6C Cytochrome C cytochrome c oxidase data set DEGs differentially expressed gene Differentially expressed genes domain downregulated expression Factor Features FIVE Functional enrichment analysis Gene Expression Genetic Genome Hematological malignancy identify independent Infection Microarray Mild mild illness Multiple Multiple myeloma New NOD2 nucleotide oligomerization overall survival Patient performed Prognosis prognostic biomarker Prognostic biomarkers protein-protein interaction screened severe COVID-19 subunit survival upregulated with COVID-19 [DOI] 10.1111/ijlh.13717 PMC 바로가기 [Article Type] Comparative Study
Thrombosis in COVID-19 infection: Role of platelet activation-mediated immunityReview Published on 2021-08-232022-10-29 Journal: Thrombosis Journal [Category] COVID-19, [키워드] Activation acute respiratory distress acute respiratory syndrome binding cascade Complication component coronavirus COVID-19 Critical damage-associated molecular pattern damaged downstream Endothelial cell ENhance expression Factor glycoprotein Immunity indicated Infection Injury Innate immunity involved leukocyte ligands marker monoclonal antibody Multiple Myocardial infarction NOD2 oxygen P-selectin PAMP PAMPs pathogen pathogen-associated molecular pattern pathogenic Platelet platelet activation Platelets platelets activation proinflammatory proinflammatory cytokines receptor recognize recruitment reported RNA role SARS-CoV-2 Signaling syndrome the patient therapeutic therapy thrombosis tissues TLR TLR-mediated TLRs Toll-like receptor Vascular [DOI] 10.1186/s12959-021-00311-9 PMC 바로가기 [Article Type] Review
Vitamin D, infections and immunity비타민 D, 감염 및 면역Review Published on 2021-07-292022-09-10 Journal: Reviews in Endocrine & Metabolic Disorders [Category] 유전자 메커니즘, [키워드] β-defensin 2 25-hydroxyvitamin D accelerate Analysis Antibacterial antimicrobial peptide antimicrobial peptides Antiviral antiviral responses arising autophagy benefit best CAMP caries cascades Cathelicidin characterized condition COVID-19 COVID-19 crisis COVID-19 pandemic Critical CYP27B1 deficiency Dental caries disease severity Diseases downstream dysregulation epidemiological Evidence expression expression of gene greater handling Health identify Immune cell immune cells immune responses Immunity in some induce Infection Infectious diseases Inflammation Inflammatory bowel disease inflammatory bowel diseases innate immune innate immune response innate immune responses innate immune system intestinal flora intracellular pathogens knowledge Laboratory Local macrophages mechanism microbial Mortality NOD2 pathogen Pathogens Pattern recognition Pattern recognition receptors peptide peptides Poor promote provide reduce respiratory respiratory tract severity Signaling signaling cascade signaling cascades skeletal stimulate Strong susceptibility therapeutic intervention therapeutic interventions therapeutic potential Tuberculosis turn upstream Vaccines Viral viral infections Vitamin D vitamin D deficiency Vitamin D status Vitamin D supplementation [DOI] 10.1007/s11154-021-09679-5 PMC 바로가기 [Article Type] Review
Nodosome Inhibition as a Novel Broad-Spectrum Antiviral Strategy against Arboviruses, Enteroviruses, and SARS-CoV-2아르보바이러스, 엔테로바이러스 및 SARS-CoV-2에 대한 새로운 광범위한 항바이러스 전략으로서의 Nodosome 억제Article Published on 2021-07-162022-09-11 Journal: Antimicrobial Agents and Chemotherapy [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alphaviruses Antiviral antiviral activity Antiviral effect arbovirus Arboviruses Brain broad spectrum broad-spectrum antiviral broad-spectrum antivirals causative agent Cell coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 coxsackievirus downstream drug enhancement expression fetal function Host induce Infection inhibit inhibition inhibitor interferon interferon response NOD2 nodosome. novel nucleotide observation oligomerization pathogenic promote Protein protein kinase Replication RIPK2 RNA viruses SARS-CoV-2 Serine severe acute respiratory syndrome Coronavirus shown small molecule Spread Strategy target the interferon threonine Zika virus ZIKV [DOI] 10.1128/AAC.00491-21 PMC 바로가기 [Article Type] Article
[BCG, muramylpeptides, trained immunity (part I): linkages in the light of the COVID-19 pandemic]Classical Article Published on 2020-12-152023-07-12 Journal: Terapevticheskiĭ arkhiv [Category] SARS, [키워드] BCG COVID-19 glucosaminylmuramyl dipeptide muramylpeptides NOD2 non-specific prophylaxis respiratory infections SARS-CoV-2 trained immunity [DOI] 10.26442/00403660.2020.12.200464 [Article Type] Classical Article
Tobacco, but Not Nicotine and Flavor-Less Electronic Cigarettes, Induces ACE2 and Immune DysregulationArticle Published on 2020-07-312022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] ACE2 ASC caused CCL20 CCL5 CCR1 cellular receptor chemokine COVID-19 COVID-19 infection COVID-19 pandemic CXCL1 CXCL2 CXCL8 Cytokine dysregulation Cytokine storm Cytokines dataset demonstrated dysregulation Electronic cigarettes Epidemics exacerbate Genes hallmark IL-1B immune response implicated independent Infection Inflammasome inflammasome activation inflammasomes Inflammation Nicotine NOD2 outcome overlap pathway pro-inflammatory cytokine Release risk RNA expression SARS-CoV-2 severe cases smoker Smokers smoking susceptibility the SARS-CoV-2 virus Tobacco upregulate upregulated upregulation vaping [DOI] 10.3390/ijms21155513 PMC 바로가기 [Article Type] Article
First-in-human phase I clinical trial of the NY-ESO-1 protein cancer vaccine with NOD2 and TLR9 stimulants in patients with NY-ESO-1-expressing refractory solid tumorsarticle Published on 2020-01-242024-09-02 Journal: Cancer Immunology, Immunotherapy [Category] 대상포진, [키워드] Cancer vaccine NOD2 NY-ESO-1 antigen TLR9 [DOI] 10.1007/s00262-020-02483-1 PMC 바로가기 [Article Type] article