Compassionate use of Pulmonary Vasodilators in Acute Severe Hypoxic Respiratory Failure due to COVID-19COVID-19로 인한 급성 중증 저산소성 호흡부전에서 폐혈관 확장제의 자비로운 사용Article Published on 2022-08-012022-09-11 Journal: Journal of Intensive Care Medicine [Category] COVID19(2023년), SARS, 신약개발, [키워드] acute hypoxic respiratory failure Adult patients analysed ARDS changes in Cohort cohort of patient collected data commenced COVID-19 death Evidence failure feasible Gradient hospital hypoxaemia hypoxic respiratory failure ICU ICU admission Iloprost implementation Inhaled intensive care intensive care unit lack less median nitric oxide non-survivor Non-survivors offer outcome Oxygenation PaO Patient patients with COVID-19 patients with SARS-CoV-2 PF ratio Potential treatment Primary outcome protocol pulmonary Pulmonary vasodilators. randomised receiving reduction in respiratory Respiratory failure robust severe COVID-19 significantly study period Support survivor the median therapeutic option therapeutic options therapy trials vasodilator [DOI] 10.1177/08850666221086521 PMC 바로가기 [Article Type] Article
Imbalance between alpha-1-antitrypsin and interleukin 6 is associated with in-hospital mortality and thrombosis during COVID-19Short communication Published on 2022-08-012022-10-05 Journal: Biochimie [Category] 바이오마커, 치료기술, [키워드] 95%CI adjusted Admission age alpha-1-antitrypsin Anti-inflammatory Anticoagulant BMI COVID-19 COVID-19 severity Critically ill cross-sectional D-dimer levels examined hallmark Hospitalization hospitalized patient IL-6 Imbalance in-hospital mortality Inflammation intensity involved Logistic regression marker mechanism Mortality multivariable analysis non-survivor Occurrence offer pathophysiology Patient patients performed phenotyped plasma predict Predictive proportion Protective protective factor Restoring severe COVID-19 severity Sex subset suffered survivor therapeutic thrombosis tissue variant with COVID-19 [DOI] 10.1016/j.biochi.2022.07.012 [Article Type] Short communication
COVID-19 Severity and Mortality in Two Pandemic Waves in Poland and Predictors of Poor Outcomes of SARS-CoV-2 Infection in Hospitalized Young Adults폴란드의 두 가지 유행성 전염병의 COVID-19 심각도 및 사망률과 입원한 젊은 성인의 SARS-CoV-2 감염의 나쁜 결과 예측Article Published on 2022-07-312022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] addition Adults adults hospitalized albumin Alpha Alpha variant analyzed blood cell blood cell counts C-reactive protein calcium Characteristics Clinical characteristics Comorbidities COVID-19 COVID-19 severity creatine creatine kinase creatinine D-dimer debatable decrease disease severity Factors filtration rate global public health glomerular filtration rate had no hematocrit hemoglobin Hospitalization identify increase in intensive care intensive care unit treatment interleukin interleukin-6 investigated Laboratory Lactate lactate dehydrogenase Leukocytosis Logistic regression lung involvement lymphocyte lymphopenia mechanical ventilation Mortality Myoglobin neutrophil Neutrophil-to-lymphocyte ratio neutrophilia no increase non-survivor obesity outcome pandemic Patient peptide performed Poland Poor predictor predictors procalcitonin red blood cell Retrospective study risk of death SARS-CoV-2 SARS-CoV-2 variants second wave severe COVID-19 severity survivor Treatment troponin I urea variant Vitamin Vitamin D3 Wave with COVID-19 young adults [DOI] 10.3390/v14081700 PMC 바로가기 [Article Type] Article
Mortality Predictors in Severe SARS-CoV-2 InfectionObservational Study Published on 2022-07-182022-10-05 Journal: Medicina [Category] COVID19(2023년), SARS, 임상, [키워드] Admission age Algorithm changes in Cluster Clusters Community COVID-19 CT scan density clusters element evaluate evaluated Evolution form hemoglobin high mortality hospital hypoxic respiratory failure IMPROVE include increase interstitial lactate dehydrogenase lesions less lung lung involvement lung lesion Lymphocytes material Mortality Myoglobin non-survivor Non-survivors objective Observational cohort study oxygen flow PaO parameter parameters Patient performed Platelets Prediction score Predictive predictor Prognosis pulmonary involvement pulmonary lesion Quantitative quantitative evaluation radiological raising Regression model Result retrospective risk factor SARS-CoV-2 SARS-CoV-2 pneumonia semi-quantitative Sensitivity and specificity serum albumin serum creatinine Severe case severe COVID-19 Survivors [DOI] 10.3390/medicina58070945 PMC 바로가기 [Article Type] Observational Study
Phylogenetic analysis and comparative genomics of SARS-CoV-2 from survivor and non-survivor COVID-19 patients in Cordoba, Argentina아르헨티나 코르도바에서 생존자와 비생존자 COVID-19 환자의 SARS-CoV-2 계통발생 분석 및 비교 유전체학Article Published on 2022-07-142022-09-11 Journal: BMC Genomics [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis association B.1 both groups carried Clinical characteristics Clinical outcome clinical outcomes Comorbidities Comorbidity Comparative Comparative genomics Complete Córdoba coronavirus cough COVID-19 COVID-19 disease COVID-19 pandemic COVID-19 patient COVID-19 patients Dyspnea Epidemiological study Evolution Evolution of SARS-CoV-2 Fever First wave functional Future Genes genome sequence Genome sequences genomes Genomic analysis genomic data groups Hospitalization in both groups incidence Infectious diseases Lineage majority Molecular epidemiology Mutation nasopharyngeal specimen Next-generation sequencing nine non-survivor Non-survivors Nsp3 outcomes pandemic Patient patients performed phylodynamic Prevalence Protein repertoire Research respiratory responsible SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 mutation SARS-CoV-2 pathogenesis SARS-CoV-2 strain SARS-CoV-2 strains SARS-CoV-2 variants SARS-CoV-2 virus Sequencing severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 South America Specific specific mutation specific mutations Spike protein Spread survivor Survivors Symptom Symptoms the SARS-CoV-2 the Spike variant Variation was performed [DOI] 10.1186/s12864-022-08756-6 PMC 바로가기 [Article Type] Article
Risk factors associated with in-hospital mortality patients with COVID-19 in Saudi ArabiaObservational Study Published on 2022-06-242022-10-05 Journal: PLoS ONE [Category] 임상, [키워드] 95% CI acute respiratory distress Admission adult COVID-19 patient age ALT ARDS Chronic kidney disease clinical variable comorbid conditions country COVID-19 patient COVID-19 patients creatinine D-dimer epidemiological Factor ferritin Gender glycosylated health condition heart failure hemoglobin hospital Hospitalized hospitalized patient hypertension ICU in-hospital mortality in-hospital mortality rate intensive care ischemic heart disease lactate dehydrogenase LDH Logistic regression analysis mean value Mechanical Mortality multivariate non-survivor Observational cohort study Older outcome patients with COVID-19 predictor prevalent retrospective Saudi Arabia significantly significantly higher survivor syndrome with COVID-19 [DOI] 10.1371/journal.pone.0270062 PMC 바로가기 [Article Type] Observational Study
Symptomatic, clinical and biomarker associations for mortality in hospitalized COVID-19 patients enriched for African Americans아프리카계 미국인을 위한 입원 COVID-19 환자의 사망률에 대한 증상, 임상 및 바이오마커 연관성Article Published on 2022-06-172022-09-11 Journal: BMC Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, [키워드] African African American African Americans age American Analysis analyzed Asian association AST Biomarker Cancer cardiac disease Cohort collected Comorbidities Comorbidity COPD correlated COVID-19 creatinine CRP D-dimer death demographics determine diabetes Diabetes Mellitus diarrhea disease severity elevated elevated liver enzymes Ethnicity European fatigue ferritin focus Frequency Gender Glucocorticoids high mortality Hispanic hospital Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients hypertension Immunosuppression increased risk Inflammatory biomarker laboratory data large cohort LAT Latinx liver enzyme liver enzymes Lymphocytes male Male sex mechanical ventilation Mortality mortality rates Multivariate analysis New York non-survivor Older age organ Organ failure outcome outcomes Patient patients hospitalized predictor Prevent procalcitonin progression race required SARS CoV-2 SARS-CoV-2 Sex Shortness of breath significant variable significant variables significantly study population subsequent Symptom troponin [DOI] 10.1186/s12879-022-07520-1 PMC 바로가기 [Article Type] Article
A cross-sectional multicenter linkage study of hospital admissions and mortality due to methanol poisoning in Iranian adults during the COVID-19 pandemic Research Published on 2022-06-132022-10-05 Journal: Scientific Reports [Category] 치료법, [키워드] Admission age alcohol alcohol poisoning average collected conducted coronavirus disease COVID-19 COVID-19 infection COVID-19 pandemic cross-sectional deaths Diagnosis died East Epidemiology evaluate facilitate Hemodialysis hospital Hospital admission Hospitalization Hospitalized ingestion initial Iran Medicine methanol morbidity Mortality mortality data multicenter non-survivor not significantly different occurred organization outbreak outcome pandemic Patient Prevent raising reduce reduction risk scale significantly lower study period survivor Symptom Treatment [DOI] 10.1038/s41598-022-14007-1 [Article Type] Research
Dynamic blood oxygen indices in mechanically ventilated COVID-19 patients with acute hypoxic respiratory failure: A cohort studyObservational Study Published on 2022-06-102022-10-04 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 임상, [키워드] Admission adult COVID-19 patient adult COVID-19 patients age AHRF analysed averaged baseline characteristics Blood blood oxygen BMI changes in Clinical outcome clinical outcomes clinical variable cohort of patient cohort study collected COVID-19 COVID-19 patient COVID-19 patients dynamic evaluate evaluated exhibited exploratory study hallmark help homogenous hypoxaemia hypoxic hypoxic respiratory failure IMPROVE intensive care Invasive mechanical ventilation IQR kPa less majority mean difference mechanical ventilation mechanically ventilated men morbidity and mortality non-survivor Non-survivors Observational cohort study offer outcome oxygen PaO2 PaO2/FiO2 ratio Patient performed retrospective Severe COVID-19 pneumonia significantly higher significantly lower supplementary oxygen survival survivor therapy understanding unique while [DOI] 10.1371/journal.pone.0269471 PMC 바로가기 [Article Type] Observational Study
Complete blood cells count abnormalities in COVID-19 patients and their prognostic significance: Single center study in Makkah, Saudi Arabia전체 혈액 세포는 COVID-19 환자의 이상과 그 예후 중요성을 계산합니다: 사우디 아라비아 Makkah의 단일 센터 연구Article Published on 2022-06-012022-09-11 Journal: Saudi medical journal [Category] COVID19(2023년), SARS, 치료기술, [키워드] abnormality Admission age Anemia Blood blood cell blood count C-reactive protein clinical disease clinically Complete complete blood count coronavirus disease COVID-19 COVID-19 patient COVID-19 severity CRP Decision making decrease detectable disease effective intervention elevated evaluate feature female ferritin force group Inclusion Inflammation Inflammatory marker inflammatory markers leucocyte leucocytosis lymphopenia male management moderate N/L N/L ratio neutrophil neutrophil count neutrophilia non-survivor Non-survivors occurred Older age Organ failure outcome parameter Patient patients Peripheral blood Platelets platelets count prognostic prognostic significance. Rapid test regimen regimens Respiratory disease respiratory diseases Saudi Arabia security Serum ferritin Serum level Severe case severe COVID-19 disease severity Significant significant decrease significantly viral infection were excluded [DOI] 10.15537/smj.2022.43.6.20210893 PMC 바로가기 [Article Type] Article