Rotational thromboelastometry in patients with type 2 diabetes and mild COVID-19 pneumonia: A pilot prospective studyObservational Study Published on 2022-07-012022-10-05 Journal: Medicine [Category] 임상, [키워드] Blood donors blood sample changes in complex consecutive patient control group COVID-19 demonstrated diabete Diabetic enrolled healthy healthy donors Hemostasis higher risk Mild no significant difference not affected parameter Patient performed Pneumonia Prospective Study reagents Severe COVID-19 pneumonia significant difference T2D tested thromboembolic complications type 2 diabete Whole blood [DOI] 10.1097/MD.0000000000029738 PMC 바로가기 [Article Type] Observational Study
Helminth antigens differentially modulate the activation of CD4 + and CD8 + T lymphocytes of convalescent COVID-19 patients in vitro기생충 항원은 시험관 내에서 회복기 COVID-19 환자의 CD4 + 및 CD8 + T 림프구의 활성화를 차등적으로 조절합니다Article Published on 2022-06-282022-09-11 Journal: BMC Medicine [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Activation activation markers. addition African age analyzed Antigen antigens Ascaris lumbricoides Brugia malayi caused CD137 CD137 (4-1BB) CD4 CD4+ CD4+ helper and CD8+ T cytotoxic T cells CD69 CD8 CD8+ cell culture supernatants cell-mediated immune response convalescent COVID-19 patient coronavirus coronavirus disease Coronavirus disease 2019 country Course COVID-19 COVID-19 patient COVID-19 patients cytokine expression Cytotoxic T cell Cytotoxic T cells death Disease progression Effect Endemic evade expression Factors flow cytometry Frequency genetics helminth Helminth antigens helper human immune response Hypothesis IFN-γ IFNγ IL-10 IL-6 immune immune reactivity immune responses in vitro incidence of COVID-19 investigated mechanisms moderate modulate MONITOR Mortality not affected offer Onchocerca volvulus pandemic parasites PBMC PBMCs peptides Prevalence reactivity reduced reduction remained Respiratory disease SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides SARS-CoV-2 transmission significantly significantly increased Spread Stimulation sub-Saharan Africa Support suppress T cell T cell response T cells T helper cells T lymphocyte TNFα Vaccines virus was measured were used [DOI] 10.1186/s12916-022-02441-x PMC 바로가기 [Article Type] Article
Nucleopore Traffic Is Hindered by SARS-CoV-2 ORF6 Protein to Efficiently Suppress IFN-β and IL-6 SecretionIFN-β 및 IL-6 분비를 효율적으로 억제하기 위해 SARS-CoV-2 ORF6 단백질에 의해 핵공 이동이 방해됨Article Published on 2022-06-112022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Activation addition antagonistic antiviral response block cascade characterized clinical outcomes contributing to counteract Critical cytokine Cytokines cytoplasm cytoplasmic demonstrated ENCODE exacerbated Factors feature Genes Host host immune system IFN-β IL-6 immune immune evasion Infection Inflammation interferon interferon antagonist interleukin interleukin-6 MAVS MDA-5 mechanism Messenger RNA movement mRNA multifunctional NF-κB not affected novel SARS-CoV-2 virus nuclear translocation nucleus occurred ORF6 pro-inflammatory cytokine pro-inflammatory cytokines Protein reported RIG-I SARS-CoV-2 SARS-CoV-2 ORF6 protein SARS-CoV-2 virus Signaling STAT suppresse suppression the SARS-CoV-2 Traffic transcription factor transcription factors transcriptional viral infection viral pathogenesis virulence virus [DOI] 10.3390/v14061273 PMC 바로가기 [Article Type] Article
Association between dexamethasone treatment and the host response in COVID-19 patients admitted to the general ward일반병동에 입원한 코로나19 환자의 덱사메타손 치료와 숙주반응의 연관성Article Published on 2022-06-032022-09-11 Journal: Respiratory Research [Category] 바이오마커, [키워드] Activation Admission Biomarker Cell Clinical outcome clinical outcomes Coagulation comparable COVID-19 COVID-19 patient Dexamethasone Endothelial cell host response IL-1 IL-1 receptor antagonist implementation IMPROVE Inflammation investigated mechanism mechanism of action Modification not affected oxygen parameter Patient plasma receptor antagonist response Standard of care supplementary oxygen These data Treatment [DOI] 10.1186/s12931-022-02060-3 PMC 바로가기 [Article Type] Article
Altered hypoxia inducible factor regulation in hereditary haemorrhagic telangiectasia Research Published on 2022-04-072022-10-05 Journal: Scientific Reports [Category] 바이오마커, 변종, 유전자 메커니즘, [키워드] affecting Altered analysed BMP Brain characterized clinical phenotype consequence contribute decreased expression downregulated downregulation dysregulation Effect expression Factor Gene Expression growth HIF-1α HIF1a human disease hypoxia immune response indicate Inflammatory Inflammatory response interact Interaction liver lung malformation mechanism mRNA Mutation no correlation not affected pathway Patient patients protein level rare disease Regulation severity Shunt significantly Structure structures syndrome target gene telangiectasia TGF-β upstream vessel whole blood sample [DOI] 10.1038/s41598-022-09759-9 [Article Type] Research
Seropositivity to Nucleoprotein to detect mild and asymptomatic SARS-CoV-2 infections: A complementary tool to detect breakthrough infections after COVID-19 vaccination?경증 및 무증상 SARS-CoV-2 감염을 감지하기 위한 핵단백질에 대한 혈청양성: COVID-19 백신 접종 후 획기적인 감염을 감지하기 위한 보완 도구?Article Published on 2022-04-012022-09-11 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] 95% confidence interval Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Asymptomatic asymptomatic individual Asymptomatic individuals Blood Breakthrough infection breakthrough infections complementary Concentration coronavirus country COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines described detect determine explained first dose help IgG IgG response IgG responses immune response immunoassay Immunoglobulin Immunoglobulin G individual induce Infection median Mild multiplex immunoassay not affected nucleoprotein participant Participants Pfizer/BioNTech positive produced Protein qPCR respiratory response RT-qPCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections second dose sensitivity Seropositivity Serosurveillance severe acute respiratory syndrome Coronavirus spike Spike protein symptom onset target the Spike vaccinated individual vaccination virus were used [DOI] 10.1016/j.vaccine.2022.03.009 PMC 바로가기 [Article Type] Article
How (not) to mobilize health workers in the fight against vaccine hesitancy: Experimental evidence from Germany’s AstraZeneca controversyRandomized Controlled Trial Published on 2022-03-162022-10-05 Journal: BMC Public Health [Category] 임상, [키워드] approach AstraZeneca conducted contribute COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines European Evidence experiment female Germany Health Health authority health worker information Johnson & Johnson less majority misinformation Moderna not affected Open Science Framework OSF Pfizer/BioNTech promote public health Randomized controlled trial receive recommendation reduce Registered Repository risk Side effect Sinopharm Support treatment arm Trial vaccination Vaccine Vaccine hesitancy women [DOI] 10.1186/s12889-022-12725-9 PMC 바로가기 [Article Type] Randomized Controlled Trial
COVID-19 and resilience of healthcare systems in ten countries Research Published on 2022-03-142022-10-05 Journal: Nature Medicine [Category] 치료기술, 치료법, [키워드] affected antiretroviral Child children country COVID-19 Decline declined declines Disruption Effect effort Haiti Health Health Service Health services health system healthcare Healthcare system HIV HIV testing illness immediate effect intensity lockdown magnitude maintain Maternal National Nepal not affected pandemic predicted reached reflect remained Resilience screenings South Africa South Korea Total vaccination [DOI] 10.1038/s41591-022-01750-1 [Article Type] Research
Quantifying the indirect impact of COVID-19 pandemic on utilisation of outpatient and immunisation services in Kenya: a longitudinal study using interrupted time series analysisHealth Services Research Published on 2022-03-102022-10-28 Journal: BMJ Open [Category] COVID-19, Fulltext, MERS, SARS, [키워드] 95% CI analysed Analysis antenatal care carried changes changes in COVID-19 COVID-19 outbreak COVID-19 pandemic DHIS2 diabete Effect estimates expected exposure Health health information Health Service healthcare facility HIV testing hypertension immunisation immunization indirect effect Intervention Kenya longitudinal study measure Mortality Multiple Non-COVID-19 not affected objective outpatient services Pneumonia Result SARS-CoV-2 sensitivity analysis setting targeted intervention was used [DOI] 10.1136/bmjopen-2021-055815 PMC 바로가기 [Article Type] Health Services Research
Anti-SARS-CoV-2 IgG and IgA antibodies in COVID-19 convalescent plasma do not enhance viral infectionCOVID-19 회복기 혈장의 항-SARS-CoV-2 IgG 및 IgA 항체는 바이러스 감염을 강화하지 않습니다Research Article Published on 2022-03-082022-09-12 Journal: PLoS ONE [Category] MERS, SARS, 진단, [키워드] absence ACE2 addressed ADE Alpha analyzed anti-S IgG antibodies antibody Antibody-dependent enhancement approach cause CCP clinical outcomes convalescent plasma correlated COVID-19 death elicit ENhance expressing Fc receptor Fc receptors IgA IgA antibody IgG IgM response IgM responses immunization Infection isotype monoclonal antibody neutralization activity Neutralizing activity Neutralizing titer not affected Novel coronavirus observation pandemic passive immunization passive transfer Prophylactic protective immune response question receptor SARS-CoV-2 Spike protein Support target cell target cells the spike protein theoretical risk therapeutic use therapy transfer transfusion Treatment vaccination Vaccine vaccine platform viral infection Virus neutralization virus receptor while [DOI] 10.1371/journal.pone.0257930 PMC 바로가기 [Article Type] Research Article