Characterization of SARS-CoV-2 replication complex elongation and proofreading activitySARS-CoV-2 복제 복합체 신장 및 교정 활성의 특성화Article Published on 2022-06-102022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료제, [키워드] Antiviral base pairs biochemical characterization complex coronavirus Critical dATP degrade drug elongation exonuclease experiment feature genomic sequence groups highlight incorporation inefficient inhibitor Mutation nsp10 nsp14 nucleotide nucleotides oligonucleotide promote Proofreading RdRP reduced Replication resulting ribose RNA RNA-dependent RNA polymerase RNA-dependent RNA polymerases SARS-CoV-2 SARS-CoV-2 RdRp SARS-CoV-2 replication sequence shown target the SARS-CoV-2 Viral protein [DOI] 10.1038/s41598-022-13380-1 PMC 바로가기 [Article Type] Article
SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodiesSARS-CoV-2 숙주 차단은 타고난 NK 세포 기능에 영향을 미치지만 항체 의존적 NK 활성은 스파이크가 아닌 항체를 통해 강력하게 활성화됩니다Article Published on 2022-05-192022-09-11 Journal: eLife [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료법, [키워드] a minor activated activating Activation ADCC ADNKA Analysis antibody Cell cellular immunity correlated cytokine dependent on Depletion Disease progression dominant downregulation Effect Efficacy epithelial cells evade expression functions genetic risk factors identify immune response Immunity immunology Impact implication infected cell Infection Infectious disease Inflammation Innate immunity interferon interferon response Ligand Lung epithelial cells mechanism membrane MHC-I MICA Microbiology minor Most patients natural infection Nectin1 neutralisation NK cell NK cells nsp1 nsp14 nucleocapsid occurred ORF3a outcome overcome Pathogenesis patients pro-inflammatory cytokine protein synthesis Proteins proteomic reduction in response SARS-CoV-2 SARS-CoV2 second dose specific antibodies spike-specific antibodies Spike-specific antibody surface protein sustained the disease ULBP2 understanding vaccination Vaccine Vaccine design vaccine efficacy Vaccine-induced immunity virus viruses [DOI] 10.7554/eLife.74489 PMC 바로가기 [Article Type] Article
Opportunities and Challenges in Targeting the Proofreading Activity of SARS-CoV-2 Polymerase ComplexReview Published on 2022-05-032023-07-02 Journal: Molecules [Category] COVID19(2023년), SARS, [키워드] coronavirus ExoN exonuclease inhibitor nsp14 nucleoside polymerase Proofreading SARS-CoV-2 [DOI] 10.3390/molecules27092918 PMC 바로가기 [Article Type] Review
SARS-CoV-2 circulation in Croatian wastewaters and the absence of SARS-CoV-2 in bivalve molluscan shellfish크로아티아 폐수에서 SARS-CoV-2 순환 및 이매패류 연체동물 조개에서 SARS-CoV-2 부재Article Published on 2022-05-012022-09-11 Journal: Environmental research [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] absence amplification Bioaccumulation Bivalve molluscan shellfish BMS circulation collected Community Concentration Contamination criterion Croatia eight Epidemic epidemic wave food safety knowledge mengovirus nine nsp14 plant processed Protein provided real-time RT-PCR Research risk rotavirus Rotavirus A RT-PCR assay SARS-CoV-2 SARS-CoV-2 detection Sequencing shellfish surface Surface water Surface waters Treatment virus warty was performed Wastewaters. water [DOI] 10.1016/j.envres.2021.112638 PMC 바로가기 [Article Type] Article
Potent Inhibition of SARS-CoV-2 nsp14 N 7-Methyltransferase by Sulfonamide-Based Bisubstrate Analogues설폰아미드 기반 이기질 유사체에 의한 SARS-CoV-2 nsp14 N 7-메틸트랜스퍼라제의 강력한 억제Article Published on 2022-04-282022-09-11 Journal: Journal of medicinal chemistry [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] analogue Antiviral agents cofactor Compound demonstrated docking Enzymes human RNA inhibition inhibitor inhibitory activity Innate immunity involved mechanism of action methyl group molecular docking mRNAs nsp14 nucleoside potent RNA SAM SARS-CoV-2 significantly stability supported synthesis target the SARS-CoV-2 transfer translation Viral RNA virus [DOI] 10.1021/acs.jmedchem.2c00120 PMC 바로가기 [Article Type] Article
Genetic Surveillance of Five SARS-CoV-2 Clinical Samples in Henan Province Using Nanopore Sequencing나노포어 시퀀싱을 사용한 허난성 5개 SARS-CoV-2 임상 샘플의 유전적 감시Article Published on 2022-04-042022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Amplicon Analysis B.1.617.2 cDNA synthesis China circulating clinical coronavirus Coverage COVID-19 dataset FIVE Frequency Genetic Genome genome sequence Government Missense multiplex Multiplex PCR Mutation Nanopore nanopore sequencing Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples nsp14 NSP2 Nsp3 nucleotide nucleotide mutation occurred ORF10 overlapped Patient Phylogenetic Phylogenetic analysis platform Prevention and control primer profiles provided public health Region RNA extraction Sample SARS-CoV-2 Sequencing sequencing coverage severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spread subclade subclades Support Surveillance variant variants viral genome viral genomes Viral transmission virus virus surveillance was performed whole genome Whole genome sequencing Zhengzhou [DOI] 10.3389/fimmu.2022.814806 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Nsp14 mediates the effects of viral infection on the host cell transcriptomeArticle Published on 2022-03-162023-06-15 Journal: eLife [Category] MERS, SARS, [키워드] circRNA CXCL8 Human IMPDH2 nsp14 SARS-CoV-2 Transcription [DOI] 10.7554/eLife.71945 PMC 바로가기
In Silico Screening of Natural Products as Potential Inhibitors of SARS-CoV-2 Using Molecular Docking Simulation분자 도킹 시뮬레이션을 사용한 SARS-CoV-2의 잠재적 억제제로서의 천연물 스크리닝Article Published on 2022-03-012022-09-11 Journal: Chinese journal of integrative medicine [Category] SARS, 치료제, [키워드] 3CL 3CL pro ABL1 acting activated acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin angiotensin converting enzyme anti-SARS-CoV-2 berbamine betulinic acid binding affinity calcineurin carried Cepharanthine chymotrypsin Chymotrypsin-like protease Compound compounds coronavirus derivative drug emodin enzyme glucogallin homolog human coronaviruses in-silico juglanin leukemia molecular molecular docking molecular docking studies Molecular docking study MOST murine natural natural products-derived anti-SARS-CoV-2 candidates NFAT non-structural protein nonstructural proteins nsp10 nsp13 nsp14 Nsp15 Other Papain Papain-like protease performed Potential product protease Protein quercetin RdRP receptor RNA-dependent RNA polymerase S protein SARS-CoV-2 screened Screening Serine serine 2 severe acute respiratory syndrome Coronavirus Simulation spike glycoprotein structural proteins T-cell T-cells tanshinone tanshinone I target target protein target proteins these compound these compounds transmembrane [DOI] 10.1007/s11655-021-3504-5 PMC 바로가기 [Article Type] Article
Characterization of the SARS-CoV-2 ExoN (nsp14 ExoN –nsp10) complex: implications for its role in viral genome stability and inhibitor identificationAcademicSubjects/SCI00010 Published on 2022-02-222022-10-31 Journal: Nucleic Acids Research [Category] COVID-19, COVID19(2023년), SARS, [키워드] Antiviral assays blocked characterization classical complex coronavirus CoV COVID-19 Ebselen functional Genome genome replication global pandemic HIV identify implication in viral inhibit inhibitor M pro multifunctional non-structural protein nsp14 Proofreading protease RdRP Replication replication fidelity reveal RNA RNA genomes RNA structures RNA-dependent RNA polymerase RNase SARS-CoV-2 SARS-CoV-2 coronavirus stability the SARS-CoV-2 Treatment variety viral genome [DOI] 10.1093/nar/gkab1303 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010
Structure and dynamics of SARS-CoV-2 proofreading exoribonuclease ExoN408 Published on 2022-02-142022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, MERS, SARS, [키워드] 3′ end acute respiratory syndrome analyses antiviral drug attenuate bind binding biochemical assay biochemically cofactor complex coronavirus CoV CoVs crystal structure demonstrated double-stranded RNA drug enzyme exonuclease Exoribonuclease extension function high-resolution structure host immune responses implicated in viral inhibitors Innate immunity mechanism modeling molecular Molecular dynamics simulation molecular dynamics simulations N-terminal nonstructural protein 14 nsp14 nsp14-ExoN nucleotide platform polymerase Proofreading RdRP regulated Replication residue RNA RNA genome RNA primer RNA recombination RNA synthesis RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 replication Significance Structure substrate Support the SARS-CoV-2 Viral protein Viral RNA viral RNA synthesis Viral virulence X-ray crystallography [DOI] 10.1073/pnas.2106379119 PMC 바로가기 [Article Type] 408