The current state of validated small molecules inhibiting SARS-CoV-2 nonstructural proteinsArticle Published on 2021-08-302022-10-29 Journal: Turkish Journal of Biology [Category] COVID-19, [키워드] approach component Compound COVID-19 COVID-19 outbreak COVID-19-specific treatments demonstrated described develop feasibility in vitro in vivo inhibiting inhibitor lack lead to fatality mechanism nonstructural protein nonstructural proteins Nsps pharmacological proteome public health SARS-CoV-2 small molecule small molecule inhibitor Small molecules vaccination [DOI] 10.3906/biy-2106-42 PMC 바로가기 [Article Type] Article
Dynamic landscape mapping of humoral immunity to SARS-CoV-2 identifies non-structural protein antibodies associated with the survival of critical COVID-19 patientsSARS-CoV-2에 대한 체액성 면역의 동적 지형 매핑은 중요한 COVID-19 환자의 생존과 관련된 비구조적 단백질 항체를 식별합니다Article Published on 2021-08-172022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 바이오마커, 임상, 진단, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis antibody Antibody Response Antibody responses binding epitope clinical variable clinical variables Cohort comprehensive analysis coronavirus correlation COVID-19 COVID-19 pathogenesis COVID-19 severity Critical critical COVID-19 patient diagnostics dynamic epitope Epitopes help high mortality high mortality rate humoral immune response Humoral immunity identify IgG antibodies IgG antibody IgM and IgG IgM antibodies IgM antibody immunogenic independent Infectious diseases innate immune response longitudinal analysis Microarray non-structural protein nonstructural protein nonstructural proteins Nsp3 Nsps nucleocapsid ORF3a Patient patients peptide peptide-based performed polyprotein Prognosis Proteases Protein respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 proteome SARS-CoV-2 replication serum serum sample serum samples severe acute respiratory syndrome Coronavirus severity spike structural protein structural proteins survival therapy Transcription Treatment with COVID-19 [DOI] 10.1038/s41392-021-00718-w PMC 바로가기 [Article Type] Article
Anti-HIV reverse transcriptase plant polyphenolic natural products with in silico inhibitory properties on seven non-structural proteins vital in SARS-CoV-2 pathogenesisResearch Published on 2021-07-162022-10-30 Journal: Journal of Genetic Engineering & Biotechnology [Category] COVID-19, [키워드] accelerated ADME ADMET alkaloid anti-SARS-CoV-2 binding affinity binding energy clinical trials complex Compound compounds COVID-19 COVID-19 vaccine distribution drug-likeness effective exhibited highlight HIV reverse transcriptase in silico in viral inhibitors of SARS-CoV-2 inhibitory investigated involved Ligand mechanism metabolism molecular molecular docking non-structural protein non-structural proteins non-toxic NSP Nsp3 Nsps Pathogenesis Pathways Polyphenolics predicted property Result SARS-CoV-2 SARS-CoV-2 pathogenesis Seven Structure supplementary material terpenoids Toxicity transcriptase Treatment vital role [DOI] 10.1186/s43141-021-00206-2 PMC 바로가기 [Article Type] Research
Hallmarks of Alpha- and Betacoronavirus non-structural protein 7+8 complexesResearch Article Published on 2021-03-032022-10-28 Journal: Science Advances [Category] COVID-19, [키워드] acute respiratory syndrome amino acid changes Cluster complementary complex complexes coronavirus enzyme exhibiting hallmark humans infect non-structural protein Nsps pandemic pathway plasticity protein concentrations regulate replication-transcription complex residue RTC SARS-CoV-2 Seven three groups topologies Topology zoonotic coronaviruses [DOI] 10.1126/sciadv.abf1004 PMC 바로가기 [Article Type] Research Article
Coronavirus replication–transcription complex: Vital and selective NMPylation of a conserved site in nsp9 by the NiRAN-RdRp subunit530 Published on 2021-02-092022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, [키워드] activity acute respiratory syndrome antiviral drug arterivirus Cell culture cellular complex conserved Coronaviridae coronavirus Coronavirus replication Critical cytidine dependent on domain Evidence family Coronaviridae functional generate HCoV-229E homolog Hypothesis in vitro Interaction Ion M pro marker monophosphate mutant N terminus N-terminal Nidovirale nidovirus NiRAN Nsp12 nsp12 protein Nsp9 Nsps nucleotide nucleotidyltransferase observation polyprotein protease Protein proteolytic provide RdRps released Replication reported residue RNA polymerase RNA synthesis RNA viruses RNA-dependent RNA polymerase selective sequence shown Significance subunit suggested transfer transferase activity virus virus replication Vital [DOI] 10.1073/pnas.2022310118 PMC 바로가기 [Article Type] 530
Molecular docking studies of Indian variants of pathophysiological proteins of SARS-CoV-2 with selected drug candidates선택된 약물 후보를 사용한 SARS-CoV-2의 병태생리학적 단백질의 인도 변이체에 대한 분자 도킹 연구Article Published on 2021-01-012022-09-11 Journal: Journal of genetics [Category] 변종, 유전자 메커니즘, 치료제, [키워드] A97V ACE2 ACE2 binding binding Combination COVID-19 drug drug candidate drugs greater GRP78 hour India investigated involved molecular docking studies Molecular docking study Mutation Nsp12 Nsps P323L pandemic pathophysiological pathophysiology Protein SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 pandemic second selected spike Spike protein standstill subpopulation the SARS-CoV-2 genome therapeutic TMPRSS2 variant variants virus ΔΔG [DOI] 10.1007/s12041-021-01313-2 PMC 바로가기 [Article Type] Article
Spatial and temporal roles of SARS-CoV PL pro -A snapshotSARS-CoV PL pro -A 스냅샷의 공간적 및 시간적 역할Review Published on 2021-01-012022-09-11 Journal: FASEB journal : official publication of the Federa [Category] 치료법, [키워드] 3CL pro accessory protein accessory proteins Antiviral appear autocleavage C-terminus can not cleave cleaved CoV replication cysteine cysteine protease dilemma domain E3 ubiquitin ligase envelope Factor inhibit inhibitor innate immune response Interaction interferon interferon-stimulated gene ISG15 its target protein its target proteins IκBα membrane motif NF-κB nonstructural protein nsp1 Nsp3 Nsps Nucleocapsid proteins p53 Papain Papain-like protease PLPro polyprotein polyproteins pp1a pp1ab promote protease Protein provide RCHY1 released Replication SARS-CoV SARS-CoV-2 SARS-CoV-2 infections stimulator STING TNF ubiquitin unique Viral Zinc [DOI] 10.1096/fj.202002271 PMC 바로가기 [Article Type] Review
The RNA Architecture of the SARS-CoV-2 3′-Untranslated RegionSARS-CoV-2 3'-미번역 영역의 RNA 아키텍처Article Published on 2020-12-212022-09-10 Journal: Viruses [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] 3′ UTR 3′ untranslated region 3′ UTR absence acute respiratory syndrome acute respiratory syndrome coronavirus Analysis architecture binding BSL can not Cell coronavirus covariation COVID-19 COVID-19 pandemic dimethyl sulfate DMS DMS-MaPseq DREEM element equilibrium functional genetic study include minigene molecular Nsps Phylogenetic Plasmid polymerase pseudoknot Region Replication respiratory responsible RNA SARS-CoV-2 Sequencing severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 ShapeKnots Structure sulfate supported the SARS-CoV-2 three-helix junction Transcription transfected cells untranslated region UTR Viral viral genome viral nonstructural protein viral nonstructural proteins Viral RNA virion β-CoV [DOI] 10.3390/v12121473 PMC 바로가기 [Article Type] Article
1 H, 13 C, and 15 N backbone chemical shift assignments of coronavirus-2 non-structural protein Nsp10Article Published on 2020-11-072022-10-27 Journal: Biomolecular Nmr Assignments [Category] COVID-19, [키워드] backbone Coronavirus-2 COVID19-NMR drugs element ENCODE function genomic in viral innate immune system Interaction International involved Ligand methyltransferase molecular component NMR non-structural protein nsp14 Nsps PROTECT Protein Proteins Replication replication-transcription complex RNA RNA genome RNA-dependent RNA polymerase RTC SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 RNA Solution NMR-spectroscopy structural proteins Structure subgenomic RNAs transcriptional variety Via viral envelope viral life cycle Viral RNA virus [DOI] 10.1007/s12104-020-09984-1 PMC 바로가기 [Article Type] Article
1 H, 13 C, and 15 N backbone chemical shift assignments of coronavirus-2 non-structural protein Nsp10Article Published on 2020-11-072022-10-27 Journal: Biomolecular Nmr Assignments [Category] Coronavirus, COVID-19, SARS, [키워드] backbone Coronavirus-2 COVID19-NMR drugs element ENCODE function genomic in viral innate immune system Interaction International involved Ligand methyltransferase molecular component NMR non-structural protein nsp14 Nsps PROTECT Protein Proteins Replication replication-transcription complex RNA RNA genome RNA-dependent RNA polymerase RTC SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 RNA Solution NMR-spectroscopy structural proteins Structure subgenomic RNAs transcriptional variety Via viral envelope viral life cycle Viral RNA virus [DOI] 10.1007/s12104-020-09984-1 PMC 바로가기 [Article Type] Article