SARS-CoV-2 VOCs, Mutational diversity and clinical outcome: Are they modulating drug efficacy by altered binding strength?Research article Published on 2022-09-012022-10-05 Journal: Genomics [Category] SARS, 변종, [키워드] Analysis binding comprehensive analysis coronavirus COVID-19 pandemic Delta disease disease severity Drug efficacy Efficacy Genomic surveillance indicate less modulating molecular docking Mortality mutant Mutation mutation analysis NTD omicron outcome patients performed Protein RBD recovered recovered patients respiratory SARS-CoV-2 SARS-CoV-2 genome sequenced significantly spike syndrome T19R the patient the RBD variants of concern VoC VOCs [DOI] 10.1016/j.ygeno.2022.110466 [Article Type] Research article
Challenges of addressing neglected tropical diseases amidst the COVID-19 pandemic in Africa: A case of Chagas DiseaseCorrespondence Published on 2022-09-012022-10-05 Journal: Annals of Medicine and Surgery [Category] 진단, [키워드] affected Africa approaches article Atrial fibrillation Cardiomyopathy caused Chagas disease challenge change chronic heart failure clinical guideline Clinical management Co-infection Comorbidity condition coronavirus disease coronavirus SARS-CoV-2 country COVID-19 COVID-19 pandemic diagnostic disease effort exacerbate Google Scholar higher risk Impact inclusion criteria mitigate neglected tropical diseases NTD NTDs pandemic Patient patients preventive measure public health resources Spread subsequent treat Treatment tropical Vaccine [DOI] 10.1016/j.amsu.2022.104414 [Article Type] Correspondence
A neutralizing epitope on the SD1 domain of SARS-CoV-2 spike targeted following infection and vaccination감염 및 백신 접종 후 표적화된 SARS-CoV-2 스파이크의 SD1 도메인에 대한 중화 에피토프Article Published on 2022-08-232022-09-12 Journal: Cell Reports [Category] SARS, 진단, [키워드] acute respiratory syndrome antibody bind canonical coronavirus CP: Immunology CP: Microbiology Cryo-electron microscopy cryo-EM cryogenic electron microscopy domain elicited epitope glycoprotein hydrogen-deuterium exchange identify Immune escape Infection N-terminal domain neutralization Neutralizing Neutralizing antibodies neutralizing antibody neutralizing epitope NTD omicron predominant prefusion RBD Receptor binding domain Region Research SARS-CoV-2 SARS-CoV-2 spike shown spike subdomain 1. target the SARS-CoV-2 vaccination Vaccine development while [DOI] 10.1016/j.celrep.2022.111276 PMC 바로가기 [Article Type] Article
SARS-CoV-2 variants of concern: spike protein mutational analysis and epitope for broad neutralization우려되는 SARS-CoV-2 변이체: 스파이크 단백질 돌연변이 분석 및 광범위한 중화를 위한 에피토프Article Published on 2022-08-182022-09-11 Journal: Nature Communications [Category] SARS, 변종, 진단, 치료기술, [키워드] Analysis antibody Antibody neutralization antigenic binding circulating variants Comparative analysis consequence convalescent sera cryo-EM Effect ENhance epitope exhibit functional Gamma highlight identify mutated Mutation N-terminal domain neutralization neutralize NTD omicron RBD SARS-CoV-2 spike SARS-CoV-2 spike mutations SARS-CoV-2 variant SARS-CoV-2 variants shown spike glycoprotein spike glycoproteins Spike protein structural rearrangements unique variant variant spike [DOI] 10.1038/s41467-022-32262-8 PMC 바로가기 [Article Type] Article
SARS-CoV-2 spike N-terminal domain modulates TMPRSS2-dependent viral entry and fusogenicitySARS-CoV-2 스파이크 N-말단 도메인은 TMPRSS2 의존성 바이러스 진입 및 융합원성을 조절합니다Article Published on 2022-08-162022-09-11 Journal: Cell Reports [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 airway B.1.617 cell-cell fusion characterized chimeric spike chimeric spikes coronavirus CP: Microbiology Delta enrichment Entry exhibit function Fusogenicity increase Infection Interaction lentivirus Lineage lung cell lung cells Microbiology modulate Mutation N-terminal domain NTD NTDs omicron Organoid organoids pseudotyped Region S1/S2 cleavage S1/S2 cleavage efficiency SARS-CoV-2 SARS-CoV-2 spike severe acute respiratory syndrome Coronavirus spike Spike. TMPRSS2 transfer variants variants of concern viral entry virus entry VOCs wild-type [DOI] 10.1016/j.celrep.2022.111220 PMC 바로가기 [Article Type] Article
Insights into the structural peculiarities of the N-terminal and receptor binding domains of the spike protein from the SARS-CoV-2 Omicron variantSARS-CoV-2 Omicron 변이체의 스파이크 단백질 N-말단 및 수용체 결합 도메인의 구조적 특성에 대한 통찰력Article Published on 2022-08-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, [키워드] Accessibility ACE2 addition Analysis antibody B.1.1.529 BA.1) binding binding domain binding efficiency changes in computational analysis COVID-19 COVID-19 vaccines Effect Epitopes evaluated free energy glycan glycans higher infectivity insight Interaction mAb molecular dynamics molecular dynamics simulations Mutation N-terminal N-terminal domain N-terminal domain (NTD) Neutralizing NTD NTDs omicron Omicron (B.1.1.529 Omicron variant performed Protein provide raised RBD RBD domain RBDs Receptor binding domain receptor binding domain (RBD) reduce reducing residue SARS-CoV-2 SARS-CoV-2. specific antibodies Spike protein stability the RBD the SARS-CoV-2 the spike protein variant variant of SARS-CoV-2 Wuhan [DOI] 10.1016/j.compbiomed.2022.105735 PMC 바로가기 [Article Type] Article
Characterization of SARS-CoV-2 Escape Mutants to a Pair of Neutralizing Antibodies Targeting the RBD and the NTDRBD 및 NTD를 표적으로 하는 한 쌍의 중화 항체에 대한 SARS-CoV-2 탈출 돌연변이의 특성화Article Published on 2022-07-252022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] active immunization Affect antibodies antibody binding Cell culture characterization Clinical use Cluster Combination Efficacy escape escape mutant escape mutants escape mutation gene segments Genetic human immunoglobulin identify immunization immunization strategies Immunoglobulin indicate lead mice monoclonal monoclonal antibodies monoclonal antibody more difficult Mutation mutations neutralization Neutralization assay Neutralizing Neutralizing antibodies neutralizing antibody neutralizing monoclonal antibodies neutralizing monoclonal antibody nine not affected NTD pair passage pseudotype RBD RBD mutations reduced SARS-CoV-2 SARS-CoV-2 escape mutations SARS-CoV-2 variant SARS-CoV-2 variants selected Spike protein targeting the RBD the spike protein variable region variant variants variants of concern variants of concern. VoC [DOI] 10.3390/ijms23158177 PMC 바로가기 [Article Type] Article
Peptide-Antibody Fusions Engineered by Phage Display Exhibit an Ultrapotent and Broad Neutralization of SARS-CoV-2 Variants파지 디스플레이가 조작한 펩티드-항체 융합은 SARS-CoV-2 변이체의 초강력 및 광범위한 중화를 나타냅니다Article Published on 2022-07-152022-09-11 Journal: ACS chemical biology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] affinities affinity approach approved B.1.1.529 Bivalent bivalent IgG breadth clinically Coverage COVID-19 demonstrated display domain dominant ENhance exacerbated fused fusion fusions generate implicated IMPROVE Infection infection assay low potency Mutation N-terminal domain N-terminus NAb NAbs naïve neutralization neutralization potency neutralize neutralizing antibody NTD omicron peptide peptides phage RBD RBD mutation RBD mutations S-protein SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Spike protein spread of COVID-19 tetravalent the RBD the spike protein therapeutic Therapeutics trimer variant variants variants of concern vulnerability [DOI] 10.1021/acschembio.2c00411 PMC 바로가기 [Article Type] Article
Pre-Omicron Vaccine Breakthrough Infection Induces Superior Cross-Neutralization against SARS-CoV-2 Omicron BA.1 Compared to Infection AlonePre-Omicron 백신의 획기적인 감염은 단독 감염에 비해 SARS-CoV-2 Omicron BA.1에 대해 우수한 교차 중화를 유도합니다Article Published on 2022-07-122022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] antibody antibody levels Antibody Response Antibody responses B.1 boost Breakthrough infection comparable convalescent convalescent sera convalescent serum correlated COVID-19 patient cross-neutralization cross-neutralizing antibodies cross-neutralizing antibody Delta disease elicited evade form Gamma had no higher affinity highlight Immunity individuals induce infecting Infection Live virus Mild moderate disease N-terminal domain neutralization neutralize Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody neutralizing capacity NTD nucleocapsid omicron Omicron BA.1 Patient patients with moderate Protein Proteins raise RBD Receptor-binding domain remained retained SARS-CoV-2 SARS-CoV-2 variants sera spike Spike protein Spike proteins strain Strains Superior the disease the RBD the receptor-binding domain the Spike the spike protein Transmissibility vaccination Vaccine Variability variant variants variants of concern variants of concern (VOCs). virus-induced antibodies VoC VOCs [DOI] 10.3390/ijms23147675 PMC 바로가기 [Article Type] Article
A panel of nanobodies recognizing conserved hidden clefts of all SARS-CoV-2 spike variants including OmicronOmicron을 포함한 모든 SARS-CoV-2 스파이크 변이체의 보존된 숨겨진 틈을 인식하는 나노바디 패널Article Published on 2022-07-062022-09-11 Journal: Communications Biology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] Accessibility analysis antibodies antibody caused clone conserved Contact coronavirus COVID-19 detect diagnostics ELISA epitope Epitopes FIVE flow cytometric hidden Human Imbalance Infectious disease kinetic lateral flow Medicines Microscopy N-terminal domain nanobodies nanobody neutralize NTD omicron pandemic populations pseudotyped RBD Receptor-binding domain recognizing regions SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 spike proteins SARS-CoV-2 spike variant SARS-CoV-2 variant Spike proteins spike variants target the receptor-binding domain the spike protein Vaccines Viral viral infection VOCs western blotting [DOI] 10.1038/s42003-022-03630-3 PMC 바로가기 [Article Type] Article